Anti-adhesion gel for postoperative uterine cavity as well as preparation method and application of anti-adhesion gel

Abstract

The invention relates to the technical field of biomedical materials, and particularly discloses anti-adhesion gel for a postoperative uterine cavity as well as a preparation method and application ofthe anti-adhesion gel. The anti-adhesion gel for the postoperative uterine cavity is prepared from the following components in percentage by weight of 0.1-1.0 percent of gellan gum, 0.2-2 percent offunctional auxiliary materials, 2-6 percent of osmotic pressure regulator and the balance of water for injection. The anti-adhesion gel for the postoperative uterine cavity is ionic phase-change gellan gum, and when the anti-adhesion gel is injected into the uterine cavity of a body, the viscosity is relatively low, the fluidity and the adhesiveness are good, and coating is uniform and rapid. After contact with uterine cavity liquid and ion phase change occurs, curing time is short, relatively high strength, elasticity and toughness are achieved, in-vivo adhesion can be maintained for 14 daysor longer, a good anti-adhesion effect is achieved in the recovery period, and the gel is gradually and safely degraded after 14 days and is absorbed or discharged by the human body.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a postoperative anti-adhesion gel for uterine cavity, a preparation method and application thereof. Background technique [0002] Intrauterine adhesions are also known as intrauterine adhesions and intrauterine adhesions syndrome. Any trauma-induced loss and damage of the endometrial basal layer can cause the uterine walls to adhere to each other and form adhesions. According to statistics, the incidence rate of intrauterine adhesions in the population of routine hysteroscopy is 2.2%, and the incidence rate of intrauterine adhesions is 37.6% after 3 to 12 months after curettage. Residual placental tissue or repeated curettage after abortion can cause as many as 40 % of intrauterine adhesions. [0003] However, the actual clinical incidence of intrauterine adhesions is much higher than the above data, which may be related to some factors such as no clinical symptoms ...

AI Technical Summary

Problems solved by technology

Although it avoids the damage to the remaining endometrium caused by blind adhesion separation and reduces the occurrence of uterine perforation, in order to reduce the risk of re-adhesion after surgery, most patients need to repeat hysteroscopic surgery 2 to 3 times or even multiple times to prevent the occurrence of uterine perforation. New dense adhesions not only greatly increase the pain and financial burden of patients, but most of the patients with severe intrauterine adhesions are difficult to return to normal menstruation, and the postoperative pregnancy rate is extremely low

[0006] In order to prevent the formation of intrauterine adhesions, most of them currently choose to place water-filled silicone balloons or IUDs after intrauterine operations to prevent intrauterine adhesions. However, according to statistics, these two methods cannot prevent local scar formation and reduce the incidence of intrauterine adhesions. rate, and prone to secondary infection or local inflammatory state

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