Medical silver-loaded gauze and preparation method thereof

A gauze and silver-loading technology, applied in plant fibers, fiber processing, textiles and papermaking, etc., can solve problems such as damage, and achieve the effects of high safety performance, good aqueous solution stability, and excellent bacteriostatic performance.

Active Publication Date: 2021-06-25
长沙海润生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, nano-silver can not only cause direct damage to the cell membrane through the silver ions released from its surface, but also play a role in the cell. It has clear antibacterial and cytotoxicity, and is not suitable for wounds.

Method used

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  • Medical silver-loaded gauze and preparation method thereof
  • Medical silver-loaded gauze and preparation method thereof
  • Medical silver-loaded gauze and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of medical silver-loaded gauze of the present invention is loaded with polyamide complexed silver in degreasing gauze; Modified polyamide complexed silver is made of silver ion and modified polyamide (see figure 1 ) of the amino complex, the amino group of the modified polyamide only exists in the interior of its molecular structure.

[0040] The medical silver-loaded gauze of the present embodiment is prepared by the following method:

[0041](1) Synthesis and modification of polyamide: polycondensation reaction between polyamino monomer (triethylenetetramine) and olefinic acid (acrylic acid); specifically, triethylenetetramine is cooled to 5-10°C in an ice-water bath, and then Use a funnel to slowly add acrylic acid to it. After the addition, react at room temperature for 4 hours to form a light yellow intermediate. Place the intermediate on a rotary evaporator to remove unreacted monomers and other solvents under reduced pressure, and then raise the temperatur...

Embodiment 2

[0048] A kind of medical silver-loaded gauze of the present invention is loaded with polyamide complexed silver in degreasing gauze; Modified polyamide complexed silver is made of silver ion and modified polyamide (see figure 1 ) of the amino complex, the amino group of the modified polyamide only exists in the interior of its molecular structure.

[0049] The medical silver-loaded gauze of the present embodiment is prepared by the following method:

[0050] (1) Synthesis and modification of polyamide: polycondensation reaction between polyamino monomer (diethylenetriamine) and olefinic acid (methyl acrylate); specifically, diethylenetriamine is cooled to 5-10°C in an ice-water bath , and then use a funnel to slowly drop methyl acrylate to it, after the dropwise addition, react at room temperature for 4 hours to generate a light yellow intermediate, place the intermediate on a rotary evaporator to remove unreacted monomers and other solvents under reduced pressure, and then he...

Embodiment 3

[0057] A kind of medical silver-loaded gauze of the present invention is loaded with polyamide complexed silver in degreasing gauze; Modified polyamide complexed silver is made of silver ion and modified polyamide (see figure 1 ) of the amino complex, the amino group of the modified polyamide only exists in the interior of its molecular structure.

[0058] The medical silver-loaded gauze of the present embodiment is prepared by the following method:

[0059] (1) Synthesis and modification of polyamide: polycondensation reaction between polyamino monomer (diethylenetriamine and tetraethylenepentamine mixture) and olefinic acid (methyl acrylate); specifically, diethylenetriamine and tetraethylenepentamine Cool the 1:1 mixture of ethylenepentamine to 5-10°C in an ice-water bath, then slowly add methyl methacrylate dropwise to it with a funnel, after the dropwise addition, react at room temperature for 4 hours to form a light yellow intermediate, and place the intermediate Remove...

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Abstract

The invention discloses medical silver-loaded gauze. Modified polyamide complexing silver is loaded in the gauze. The modified polyamide complexing silver is mainly formed by complexing silver ions and amino groups of modified polyamide, and the amino groups of the modified polyamide only exist in the molecular structure of the modified polyamide. The silver ions are wrapped in the modified polyamide and are further tightly combined with the gauze without falling off, so that the silver ions can be fixedly released in a trace manner, and the release is stable; the release duration of silver ions is 8 days or more, and the release is lasting; the antibacterial performance is excellent; and the non-nano silver is adopted, so that no stimulation, no sensitization, no acute and chronic systemic toxicity and no genetic toxicity are realized, and good biocompatibility is realized. The invention further discloses a preparation method of the medical silver-loaded gauze. The preparation method is easy to operate, low in cost, environmentally friendly and high in safety performance, and new impurity elements cannot be introduced.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a medical silver-loaded gauze and a preparation method thereof. Background technique [0002] Silver Dressing is a dressing change dressing for chronic refractory wounds. The current silver-containing dressings are easy to oxidize due to the characteristics of silver ions themselves, so that the dressing itself is easy to change color and loses the antibacterial effect, and the uncontrollable release of silver easily leads to silver deposition and the antibacterial effect is not long-lasting. [0003] In order to overcome the problems of easy oxidation and uncontrollable release of silver ions, a cationic closed-space network structure polyamide dendrimer polymer-stabilized nano-silver aqueous solution is designed in the prior art, and it is combined with gauze infiltration. However, silver nanoparticles can enter cells in the form of particles through the endocytic pathway and ...

Claims

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Application Information

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IPC IPC(8): D06M15/59D06M11/00C08G73/02D06M101/06
CPCD06M15/59D06M11/00C08G73/028D06M2101/06
Inventor 何杰熊翰超史丙华姜志华
Owner 长沙海润生物技术有限公司
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