297 results about "Phenethylamines" patented technology

The present invention provides, according to an aspect thereof, a novel process for the preparation of dronedarone [1] and pharmaceutically acceptable salts thereof. According to a preferred embodiment, the process comprises N-acetylating of p-anisidine or p-phenetidine with acetic anhydride, reacting of the obtained N-(4-alkoxyphenyl)acetamide with 2-bromohexanoyl chloride or bromide in the presence of aluminum chloride or bromide to obtain N-[3-(2-bromohexanoyl)-4-hydroxyphenyl]acetamide [6a], converting the compound [6a] into 2-butyl-5-benzofuranamine hydrochloride [12a] and subsequently converting [12a] into [1] or pharmaceutically acceptable salts thereof. In accordance with another aspect of this invention, there are provided novel intermediates, inter alia the novel compounds [6a] and [12a]. The novel intermediates of the present invention are stable, solid compounds, obtainable in high yields, which can be easily purified by crystallization and stored for long periods of time.

This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-phenylalanine, styrene or substituted styrene to a plurality of enzyme catalyzed chemical transformations in a one-pot reaction system, using recombinant microbialcells overexpressing the enzymes. To produce phenylacetaldehyde from styrene, the cells are modified to overexpress styrene monooxygenase (SMO) and styrene oxide isomerase (SOI). To produce phenylacetic acid from styrene, SMO, SOI and aldehyde dehydrogenase are overexpressed. Alternatively, to produce 2-phenylethanol, SMO, SOI and aldehyde reductase or alcohol dehydrogenase are overexpressed, while to produce phenylethylamine, SMO, SOI and transaminase are overexpressed.

The invention discloses a preparation method and application of a dibenzylamine quaternary ammonium salt high-temperature-resistant acidizing corrosion inhibitor. The preparation is as follows: (1) anamine reactant, such as benzene methanamine, phenylethylamine, morpholine or indole, is dissolved in an organic solvent, epoxy chloropropane is slowly dropwise added, a stirring reaction is performedfor 12 to 14 h at the normal temperature, and then reduced pressure distillation and washing are carried out to obtain an intermediate I; (2) the intermediate I is dissolved in the organic solvent, dibenzylamine is added into the organic solvent, then an acid-binding agent is added, heating is carried out to a temperature of 60 to 80 DEG C to perform a reaction for 14 to 16 h, and after cooling is carried out to the room temperature, filtering, extraction and reduced pressure distillation are carried out to prepare an intermediate II; (3) the intermediate II is dissolved in the organic solvent, a quaternization reagent is added into the organic solvent, heating is carried out to a temperature of 80 to 110 DEG C to perform a reaction for 12 to 15 h, cooling is carried out to the room temperature, and filtering, extraction and reduced pressure distillation are carried out to prepare the dibenzylamine quaternary ammonium salt high-temperature-resistant acidizing corrosion inhibitor. Thepreparation method is simple and feasible and is reliable in principle; and the prepared acidizing corrosion inhibitor has an obvious inhibition effect on acid corrosion of oil-gas well carbon steel.