290 results about "Phenethylamines" patented technology

The invention belongs to the technical field of microorganisms and discloses lactobacillus plantarum with a function of reducing contents of biogenic amines in foods and application of the lactobacillus plantarum. The lactobacillus plantarum is resistant to acids and capable of strongly removing eight types of biogenic amines (including tryptamine, phenethylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine) in vitro. After 1*1010CFU / ml of the lactobacillus plantarum and the eight types of biogenic amines are co-cultured for 24h, wherein the concentration of each type of the biogenic amines is 100mg / L, and the total amine concentration is 800mg / L, the total amine content is reduced by 70% approximately, the content of each type of the biogenic amines is reduced by 30%-100%, and the removal rate of histamine highest in toxicity is up to 96.69%. Further, the lactobacillus plantarum is capable of lowering pH to 4 in eight hours owing to quickness in acid generation, thereby having favorable fermentation potential. The lactobacillus plantarum is used for degradation of the biogenic amines in foods, especially in fermented foods and extensive in application prospect.

The present invention provides, according to an aspect thereof, a novel process for the preparation of dronedarone [1] and pharmaceutically acceptable salts thereof. According to a preferred embodiment, the process comprises N-acetylating of p-anisidine or p-phenetidine with acetic anhydride, reacting of the obtained N-(4-alkoxyphenyl)acetamide with 2-bromohexanoyl chloride or bromide in the presence of aluminum chloride or bromide to obtain N-[3-(2-bromohexanoyl)-4-hydroxyphenyl]acetamide [6a], converting the compound [6a] into 2-butyl-5-benzofuranamine hydrochloride [12a] and subsequently converting [12a] into [1] or pharmaceutically acceptable salts thereof. In accordance with another aspect of this invention, there are provided novel intermediates, inter alia the novel compounds [6a] and [12a]. The novel intermediates of the present invention are stable, solid compounds, obtainable in high yields, which can be easily purified by crystallization and stored for long periods of time.

The invention mainly relates to intermediates of Sitagliptin and a preparation method thereof. The intermediates of the Sitagliptin have chemical structures shown as II and III, wherein definitions of Ar, R1 and R2 are shown in the specifications. The compounds shown as the II and the III are prepared by reacting a compound shown as a formula I with a substituent of phenylethylamine, which serve as raw materials, under hydrogen pressure. The intermediates are used for synthetizing the Sitagliptin, so synthetic difficulty is reduced, purity of a product is improved, the using amount of a high-price catalyst is reduced, production cost is effectively reduced, and the intermediates and the method are suitable for industrialized production.

The invention discloses a method for full chemical synthesis of a fibrauretin anti-bacterial anti-inflammatory medicine. The method adopts 3,4-dimethoxyphenylethylamine and 2,3-dimethoxybenzaldehyde as initial raw material, and prepares a target product by three-step chemical reaction including heat condensation, sodium borohydride reduction and cyclization reaction. The full chemical synthesis method of fibrauretin in the invention has the advantages of simple reaction steps, mild reaction conditions, low cost and high yield, and is suitable for industrial production.

This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-phenylalanine, styrene or substituted styrene to a plurality of enzyme catalyzed chemical transformations in a one-pot reaction system, using recombinant microbialcells overexpressing the enzymes. To produce phenylacetaldehyde from styrene, the cells are modified to overexpress styrene monooxygenase (SMO) and styrene oxide isomerase (SOI). To produce phenylacetic acid from styrene, SMO, SOI and aldehyde dehydrogenase are overexpressed. Alternatively, to produce 2-phenylethanol, SMO, SOI and aldehyde reductase or alcohol dehydrogenase are overexpressed, while to produce phenylethylamine, SMO, SOI and transaminase are overexpressed.

A method for sealing a container having an opening by contacting the opening with a mixture including a phenethylamine and a first polymer, adding a fluid to be contained to the container, and then adding a second mixture, comprising a second polymer, whereupon an interaction between the first and second polymer mixtures result in a seal being formed over the opening, thereby containing the fluid. The first polymer is typically a water-swellable polymer and the second polymer is typically a hydrophilic polymer that will form an interpenetrating network with the swellable polymer.

The invention discloses a preparation method and application of a dibenzylamine quaternary ammonium salt high-temperature-resistant acidizing corrosion inhibitor. The preparation is as follows: (1) anamine reactant, such as benzene methanamine, phenylethylamine, morpholine or indole, is dissolved in an organic solvent, epoxy chloropropane is slowly dropwise added, a stirring reaction is performedfor 12 to 14 h at the normal temperature, and then reduced pressure distillation and washing are carried out to obtain an intermediate I; (2) the intermediate I is dissolved in the organic solvent, dibenzylamine is added into the organic solvent, then an acid-binding agent is added, heating is carried out to a temperature of 60 to 80 DEG C to perform a reaction for 14 to 16 h, and after cooling is carried out to the room temperature, filtering, extraction and reduced pressure distillation are carried out to prepare an intermediate II; (3) the intermediate II is dissolved in the organic solvent, a quaternization reagent is added into the organic solvent, heating is carried out to a temperature of 80 to 110 DEG C to perform a reaction for 12 to 15 h, cooling is carried out to the room temperature, and filtering, extraction and reduced pressure distillation are carried out to prepare the dibenzylamine quaternary ammonium salt high-temperature-resistant acidizing corrosion inhibitor. Thepreparation method is simple and feasible and is reliable in principle; and the prepared acidizing corrosion inhibitor has an obvious inhibition effect on acid corrosion of oil-gas well carbon steel.

A compound containing o-naphthalene quinone structure for preparing medicines to prevent and treat hyperammonemia and hepatic encephalopathy is prepared from natural Masonate F through structure reformation and optimization.