394 results about "Bronchitis copd" patented technology

The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

The present invention discloses II kinds of andrographolide sulfonated derivatives with the actions of resisting bacteria, relieving inflammation and reducing fever and medicine composition containing them. They can be used for preparing freeze-dried powder, injection or oral preparation, and can be used for curing the diseases of pneumonia, bronchitis, tonsillitis and bacillary dysentery, etc.

Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation. The compounds are useful in treating PI 3-kinase-dependent conditions including cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, vascular restenosis, atherosclerosis, and unstable angina; respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), and bronchitis; inflammatory disorders; neoplasms including cancers such as glioma, prostate cancer, small cell lung cancer, and breast cancer, and diseases linked to disordered white blood cell function, such as autoimmune and inflammatory diseases.

Compositions comprising DNase encapsulated in a liposome are provided. Additionally, provided are compositions comprising a free enzyme and empty liposomes, compositions comprising a free enzyme and an antiinfective encapsulated in a liposome, compositions comprising a free enzyme, a free-antiinfective, and empty liposomes, compositions comprising a free enzyme, a free antiinfective, and an antiinfective encapsulated in a liposome, and a composition comprising a free enzyme, empty liposomes, and an antiinfective encapsulated in a liposome, and compositions comprising a free enzyme, a free antiinfective, empty liposomes, an antiinfective encapsulated in a liposome, and pharmaceutical compositions comprising the aforementioned compositions. The Also provided are methods of treating pneumonia, bronchitis, cystic fibrosis, or emphysema comprising administering to a subject in need thereof a therapeutically effective amount of the aforementioned pharmaceutical composition.

The invention relates to a method for preparing fermenting olive wine from olive fruit juice and olive fruit pomace. The fermenting olive wine mainly comprises the olive fruit juice, the olive fruit pomace, citric acid, an additive A and wine microzyme in different percentages by weight, wherein the olive fruit juice is mixed concentrated solution of a fruit juice generated in the oil extraction of olive and a water juice obtained after fruit pomace leaching, and the olive fruit pomace is the remaining fruit pomace which remains after oil exaction of the olive and is subjected leaching, drying and smashing. The olive fruit juice after removal of bitter taste and the de-oiling olive fruit pomace is stirred evenly, predistilled, mixed with yeast, fermented, reserved, blended, and processed by other preparation methods to obtain the fermenting olive wine. The fermenting olive wine prepared by the method combines the sweetness and fragrance of olive fruit and rice wine, has pure taste, is rich in nutrition, and has the health care functions of building up a sound body, preventing cardiovascular disease, treating bronchitis and chronic pharyngolaryngitis disease.

The invention discloses a Chinese medicine composition for treating exogenous febrile diseases and an application thereof, belonging to the technical field of traditional Chinese medicines. The Chinese medicine composition is prepared from the raw medicinal materials in certain proportions: honeysuckle, cicada slough, batryticated silkworm, fructus forsythiae, radix scutellariae, herba schizonepetae, fructus arctii, radix bupleuri, fried gardenia, mint, platycodon grandiflorum, fermented soybean, licorice and other raw materials. The Chinese medicine composition has the efficacies of clearing away heat and elevating clear qi to lower turbid qi and has remarkable curative effects on acute bronchitis, acute laryngitis, suppurative tonsillitis, pneumonia, influenza and other exogenous fever symptoms.

The invention discloses a traditional Chinese medicinal composition for treating bronchitis and bronchial asthma. The composition is characterized in that the composition comprises, by weight, 12 parts of Cordyceps sinensis, 15 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae (stir-fried with bran), 15 parts of Poria cocos, 10 parts of Radix Ophiopogonis, 12 parts of Malaytea Scurfpea Fruit (stir-fried with salt), 10 parts of Chinese magnoliavine (processed with vinegar), 12 parts of Chinese angelica, 9 parts of Rhizoma Pinelliae Preparatum, 12 parts of snakegourd peel, 9 parts of bitter apricot kernel, 9 parts of Rhizoma Coptidis, 6 parts of jujube, 10 parts of perilla fruit, 10 parts of Aster tataricus, 10 parts of lily, 6 parts (calcined) gypsum, 9 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Peucedani, 6 parts of dried orange peel, 9 parts of Chinese Eaglewood, 6 parts of ginger, 9 parts of loquat leaf, 10 parts of Fritillaria cirrhosa, 12 parts of prepared rehmannia root, 10 parts of Radix Scrophulariae, 6 parts of Arisaema Cum Bile, 10 parts of Radix Platycodonis, 10 parts of White Mulberry Root-bark (processed with honey), 9 parts of Rhizoma Anemarrhenae, 12 parts of Common Coltsfoot Flower, 15 parts of honeysuckle flower, 12 parts of Herba Schizonepetae, 12 parts of Weeping Forsythia and 6 parts of honey-fried licorice root.

The invention discloses an ambroxol hydrochloride oral solution and a preparation method thereof, and relates to a preparation method of western medicine, in particular to a medical production formula used for curing bronchitis and a preparation method thereof; the preparation method comprises the following steps: sucrose, preservatives and purified water are dissolved in a mixing mode so as to prepare simple syrup; the ambroxol hydrochloride, corrigents and preservatives are dissolved by the purified water so as to prepare ambroxol hydrochloride solution; the ambroxol hydrochloride solution and the simple syrup are stirred and mixed evenly, the corrigents and the preservatives are added successively and discontinuously and then the purified water is added to adjust the concentration. The invention has simple and reasonable process, and is easy to operate practically and the produced products have good stability; the products can used as common phlegm-eliminating drugs, has functions of increasing the liquid level of the respiratory tract, reducing mucus secretion, enhancing the secretion of pulmonary surfactant and the movement of cilium and preventing cough to a certain extent, and is applicable to acute respiratory disease and chronic respiratory disease, such as ropy sputum and difficult cough caused by acute bronchitis and chronic bronchitis, bronchial asthma and pulmonary tuberculosis, etc.

The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.

The present invention relates to a compound represented by the formula (I),wherein all symbols are as defined in the description,a salt thereof, a solvate thereof, or a prodrug thereof, which has a leukotriene receptor antagonistic activity which is expected to be more effective than those of the leukotriene receptor antagonists currently used in clinical trials. Therefore, it is useful as an agent for the prevention and / or treatment of a leukotriene-mediated disease such as a respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, pulmonary emphysema, chronic bronchitis, pneumonia (e.g. interstitial pneumonia etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g. acute sinusitis, chronic sinusitis, etc.), or the like, or as an expectorant or an antiitussive.

Compositions comprising therapeutically effective amounts of lamellar bodies for the modification of linear macromolecules are disclosed. These lamellar compositions are useful in the treatment of conditions or diseases characterized by a preponderance of heavy mucous secretions, such as otitis media, cystic fibrosis, bronchitis, sinusitis and nasal congestion. Methods of treating these diseases and conditions by administering a therapeutically effective amount of a composition to a patient requiring such treatment are also disclosed.

The invention relates to a compound immunoenhancement agent and an application thereof on preparing a vaccine for birds. The compound immunoenhancement agent contains 5ng-10mg / mL of poly IC, 10ng-10mg / mL of muramyl dipeptide, 10ng-5mg / mL of levamisole, 10ng-5mg / mL of resiquimod and 10ng-5mg / mL of imiquimod. After the immunoenhancement agent and H5 hypotype bird flu inactivated vaccine are mixed together, antibody can be produced one week earlier, and the antibody titer is improved above 1.8log2. After chicken are immunized through H5 hypotype bird flu inactivated vaccine, H9 hypotype bird flu vaccine or infectious bronchitis vaccine which contains the compound vaccine immunoenhancement agent, the window phases of the antibody production are shortened, the antibody titer of the vaccine is improved, the immunization duration is prolonged, and the probability of infection disease is reduced.

The present invention discloses one kind of dry AAA emulsion and its preparation and application, and the dry AAA emulsion has asarol as effective component, emulsifier and other supplementary material. The dry AAA emulsion has mature technological process, easy industrial production, high stability, high curative effect and other advantages. It is applied mainly in clinical treatment of bronchitis, lung infection, asthma and other diseases.

The invention discloses a triple egg yolk antibody against newcastle disease virus, avian influenza virus and infectious bronchitis virus and a preparation method and application thereof. The preparation method of the egg yolk antibody comprises the following steps of: (1) selecting a hen; (2) performing triple inactivation immunization of the hen obtained by the step (1) by use of newcastle disease virus, infectious bronchitis virus and avian influenza virus; (3) taking the egg laid by the hen and separating the egg yolk liquid; and (4) separating and purifying an egg yolk antibody from the egg yolk liquid obtained by the step (3). The triple egg yolk antibody disclosed by the invention is of great value in treating and preventing newcastle disease, avian influenza and infectious bronchitis.

The invention discloses a compound cefaclor suspension and a preparation method thereof, belonging to the field of pharmaceutical preparations. The compound cefaclor suspension comprises the following components in percentage by weight: 4-50 percent of cefaclor, 0.14-1.75 percent of bromhexine hydrochloride, 0.5-6 percent of macromolecule suspending agent, 0.1-1.8 percent of sweetener, 38.45-95.256 percent of cane sugar, 0.003-1 percent of sunset yellow and 0.001-1 percent of flavoring orange essence. The preparation method comprises the following steps of: after uniformly mixing the macromolecule suspending agent sodium carboxymethylcellulose with the cane sugar, adding an ethanol-water solution containing the sunset yellow and the sweetener saccharin sodium; and after preparing a soft material, granulating and drying, uniformly mixing with the cefaclor, the bromhexine hydrochloride and the flavoring orange essence to obtain the compound cefaclor suspension. The compound cefaclor suspension can be used for treating respiratory tract mild-to-severe infection caused by sensitive bacteria, tonsillitis, chronic bronchitis acute exacerbation, pneumonia, nasosinusitis, and the like.

The invention discloses an atomized inhalant for treating respiratory system diseases. The atomized inhalant mainly prepared from, by mass, 1%-2% of 1,8-cineole, 1%-4% of solubilizers and 20%-90% of water. The inhalant is used through the steps that a medicine solution is atomized into small particles, and the small particles are inhaled into the nose, the throat, the respiratory tract and the lung, so that the medicine is deposited on the lesions to treat the diseases. The atomized inhalant for treating the respiratory system diseases treats patients who suffer from acute and chronic faucitis, rhinitis, asthma, obstructive (spastic) bronchitis, chronic bronchitis, bronchiectasia, mucoviscidosis, cysticfibrosis and chronic obstructive pneumonia and need to humidify the tracheae and dilute the sputum. The inhalant has the advantages that the effect is achieved quickly, the medicine using amount is little, use is convenient, and the safety is high.

The invention relates to a complex traditional Chinese medicine preparation for treating upper respiratory tract infection and a preparation method thereof. The complex traditional Chinese medicine preparation comprises the following raw materials: 10-25 parts of picria felterrae lour, 5-15 parts of herba sarcandrae, 5-15 parts of senecio, 5-13 parts of pubescent holly root and 1-5 parts of liquorice. The preparation method comprises the following steps: pulverizing a proper amount of picria felterrae lour into fine powders; adding water into residual picria felterrae lour, the herba sarcandrae, the senecio, and the like and extracting to obtain extracts; adding alcohol into the extracts to carry out alcohol deposition, filtration and concentration to form thick paste; uniformly mixing, drying and pulverizing the thick paste and the picria felterrae lour fine powder to form fine powders; and adding a proper number of auxiliary materials and uniformly mixing to prepare particles or adding general preparation auxiliary materials to prepare general solid oral administration preparation. According to clinical observation for many years, the traditional Chinese medicine preparation benzyrin tablet has the obvious treating effects on a patient with upper respiratory tract infection diseases, such as upper respiratory tract inflammation, bronchitis, rhinitis, pharyngolaryngitis, tonsillitis, and the like.

The invention belongs to the field of infectious disease detection of animals, and concretely relates to a triple rapid detection kit of three avian respiratory diseases, and an application thereof. The kit comprises a test paper strip, a test card shell and a sample dilution, and the test paper strip is formed by sequentially pasting an absorbing pad, a cellulose nitrate membrane, a colloidal-gold pad and a sample pad on a non-absorbent support slice; a combination pad is coated with an anti-avian influenza virus monoclonal antibody-colloidal gold marker, an anti-Newcastle disease virus monoclonal antibody-colloidal gold marker and an anti-chicken infectious bronchitis virus monoclonal antibody-colloidal gold marker mixture, detection lines T1, T2 and T3 are coated with the anti-avian influenza monoclonal antibody, the anti-Newcastle disease virus monoclonal antibody and the chicken infectious bronchitis monoclonal antibody, and the cellulose nitrate membrane is coated with a rabbit anti-rat IgG quality control line. The kit can simultaneously complete the disease cause detection of bird flu H5 type, H9 subtype, Newcastle diseases and chicken infectious bronchitis, and has strong specificity and high sensitivity.

The invention discloses a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for curing infantile acute bronchitis. The composition contains the effective ingredients of honeysuckle, Fructus Forsythiae, great Burdock Achene, Ephedraceae, almond, gypsum, Belamcanda chinensis, Pericarpium Trichosanthis, pumice, draba nemorosa linnei, plantain seed and the like. The composition can be decocted to medicinal broth for taking and can also be prepared into tablets, capsules, granules, pills or oral liquid for taking; the composition has obvious therapeutic effect on infantile acute bronchitis. The invention also discloses the preparation method of the traditional Chinese medicine composition.

The invention relates to a primer used in RT-PCR detection of chicken infectious bronchitis virus, a kit comprising the primer and a detection method thereof. The primer includes a specific primer pair used for amplifying a 5-terminal non-coding region conserved sequence of chicken infectious bronchitis virus (IBV). The specific primer pair is composed of a primer 1 and a primer 2, wherein the primer 1 is a single-chain DNA represented in the Seq ID No.1, the Seq ID No.2 or the Seq ID No.3 in the sequence table, and the primer 2 is a single-chain DNA represented in the Seq ID No.4, the Seq ID No.5 or the Seq ID No.6 in the sequence table. Tests comprising specificity, sensitivity, stability and repeatability prove that the kit can only specifically amplify IBV nucleic acid and is excellent in linearity relationship within the range of 1*10<2>-1*10<7> copies / [mu]L. The sensitivity of the primer reaches 10<2> copies / [mu]L. The primer is suitable for quantitative detection of various tissue, cell, body fluid samples and vaccine production intermediate products.

The invention relates to a method for producing a quadruple inactivated vaccine for newcastle disease, infectious bronchitis, avian influenza (H9 subtype) and infectious bursal disease. In the method, the inactivated vaccine is prepared by adopting a newcastle disease virus La Sota strain, an infectious bronchitis virus M41 strain, an avian influenza virus (H9 subtype) YBF003 strain, and an Escherichia coli genetic engineering bacteria E. coil BL21 / pET28a-VP2 strain which expresses an infectious bursal disease virus VP2 protein serving as production bacteria toxic species, a super concentration process and a high-quality adjuvant. After immunizing animals, antibodies are produced rapidly; the potency is high; the protection period is long; and the outbreak and the spreading of epidemic diseases are reduced.

The invention discloses an oral preparation of ginkgo leaf total flavonoid aglycone, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total flavonoid glycosides extracted from ginkgo leaves are hydrolyzed to obtain ginkgo leaf total flavonoid aglycone which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the ginkgo leaf total flavonoid aglycone. The preparation has significant curative effects in the treatment of coronary disease, hyperpiesis, cerebral thrombosis, cerebral infarction, apoplexy, dizziness, psychosis, nephritis, bronchitis, Parkinson's disease, diabetes, tumor, leukemia and other diseases.

The invention discloses a pill for treating bronchitis. The pill comprises the following ingredients by weight: 28 to 32 parts of radix adenophorae, 14 to 16 parts of cortex lycii, 10 to 12 parts of mix-fried mulberry bark, 28 to 30 parts of cordate houttuynia, 18 to 22 parts of folium eriobotryae, 2 to 4 parts of red ginseng, 28 to 32 parts of dioscorea rhizome, 28 to 32 parts of coix seeds, 5 to 6 parts of Pummelo Peel, 5 to 6 parts of poria cocos, 5 to 6 parts of bitter apricot kernels, 3 to 4 parts of fired perilla seeds, 3 to 4 parts of aster, 2 to 3 parts of tussilago, 5 to 6 parts of trichosanthes bark, 5 to 6 parts of thunberg fritillary bulbs, 5 to 6 parts of rehmannia glutinosa, and 5 to 6 parts of radix polygonati officinalis. The pill of the invention is used for treating bronchitis, has the efficacy of tonifying qi, clearing away lung-heat, reducing phlegm, invigorating spleen, and helping kidney to control qi, and has a good curative effect, a short treatment course, and no toxic or side effect in treating bronchitis.

The invention discloses a rhizoma bletillae extract and application thereof. The rhizoma bletillae extract is prepared by the following steps: carrying out backflow extraction on dried rhizoma bletillae powder with a 60-90% ethanol solution, filtering, and collecting filtrate so as to obtain a rhizoma bletillae alcohol extract; adsorbing the rhizoma bletillae extract with polyamide and a D101 macroporous resin in sequence, collecting a 35-45% ethanol eluant, and carrying out vacuum evaporation drying, thereby obtaining the rhizoma bletillae extract. In-vivo SD (Sprague Dawley) rat chronic bronchitis mode experiments show that rhizoma bletillae and an effective part EFB have a treatment function on chronic bronchitis by inhibiting inflammatory factors such as TNF-alpha, IL-1 beta and IL-6,and by increasing oxidation stress levels.

The invention relates to a method to prepare a combined inactive vaccine of newcastle disease and infectious bronchitis vaccine for chicks. The invention is characterized in that: firstly, concentrate and inactivate the NDVLaSota virus strains (10 per cent to 22 per cent weight ratio) and IBVM41 virus strains (10 per cent to 22 per cent weight ratio) respectively; and then add white oil and immune additives including tween, span and stearic acid to prepare the combined vaccine.

The invention discloses a visual protein chip for detecting serum antibody of new-castle disease virus of chickens, infectious bronchitis virus of chickens, avian influenza virus and infectious bursal disease virus of chickens , which is prepared by the following steps: purifying and diluting whole proteins of the four virus respectively; pointing samples of the positive control serum, the negative control serum and the four virus proteins onto a chip carrier respectively; drying, fixing, sealing and washing the samples to obtain the visual protein chip. The visual protein chip uses the purified whole proteins as capturing antigens to detect the virus-specific antibodies in chicken serum so as to simplify the preparation technology and reduce the production cost, and the visual protein chip has better specificity but no cross, has high reliability of results and has the advantages of quickness, simplicity and convenience, high sensitivity, good specificity and the like. When the serum is diluted by 6,400 times, the visual protein chip still can detect the antibodies, the sensitivity is 400 times of that of the prior AGP detection method. According to the detection to serum samples in-place, the detection rate of the visual protein chip is higher than the proir AGP method remarkably.

The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.

The invention relates to the industrial field of biological feed, in particular to the method of feed containing ganodenic acid produced by converting medicinal ganodermalucidum into cornstock, and the effect of the functional feed produced through the method. In the invention, liquid submerged culture, seeding tank extended culture and solid-state fermentation culture are conducted with the ganodermalucidum as the starting bacterial strain and the cornstock as the auxiliary material, to obtain the functional feed rich in ganodenic acid. The feed of the invention is light yellow powder and has fragrance; the content of crude ganodenic acid in the feed is up to 0.06 percent to 0.3 percent, and the content of protein is 12 percent to 14 percent. The feed containing ganodenic acid can be used as the additive of animal feed and for preparing medicine or health care food which have the functions of regulating blood sugar and lipid, and preventing cardio-cerebrovascular diseases or bronchitis. The invention not only develops a new approach for deeply developing and utilizing the ganodermalucidum, but also provides ideal biological additive for developing the functional feed.

The invention discloses honeycomb vinegar and a preparation method thereof and relates to a vinegar seasoning product. The vinegar comprises the following components in parts by weight: 0-8 parts of myotonin, 0-8 parts of black rice, 0-2 parts of red dates and 2-12 parts of honeycomb. The honeycomb vinegar is prepared by an acetic fermentation method of liquid backflow or solid fermentation. In the invention, the honeycomb, the myotonin, the black rice and the dates are used as raw materials, thus the vinegar has effective active substances of the honeycomb, the myotonin, the black rice and the dates. The product has good curative effect in the aspects of improving the immunity and treating the bronchitis, the rhinitis, the scirrhus, pain subcutaneous ulcer pyogenic infections, the benignprostatic hyperplasia, the arthritis, the hepatitis B, obstetrical and gynecological diseases, the impotence, the enuresis, the bone tuberculosis, stomach diseases, the pertussis and foot ringworms and has no toxic and side effects. Compared with the traditional table vinegar, the honeycomb vinegar has the advantages of gentle vinegar smell, pleasant fragrance and clear brownish red color. With the honeycomb vinegar, people can enjoy delicious food and also achieve the effect of medical health care.

The invention discloses application of chloro-substituted tetrahydrophenethyl chromone derivatives and a pharmaceutical composition thereof which are extracted and separated from agilawood in prevention or treatment of inflammation-related diseases, autoimmune diseases and organ transplantation rejection, especially prevention or treatment of systemic inflammatory response, pneumonia, bronchitis, hepatitis, enteritis, rheumatoid arthritis, systemic lupus erythematosus, kidney transplantation rejection, liver transplantation rejection and hematopoietic stem cell transplantation rejection.