The invention discloses a medicinal liquor, comprising the following crude drugs: angelica sinensis, astragalus membranaceus baked with honey, codonopsis pilosula, tuckahoe, dogwood, ligusticum wallichii, roasted white atractylodes rhizome, schisandra chinensis, pericarpium citri reticulatae, fruit of Chinese wolfberry, radices sileris, notopterygium root, poria with hostwood, radix ophiopogonis, dried rehamnnia root, prepared rehmannia root, Chinese-date and colla carapacis. The invention also discloses a preparation method of the medicinal liquor. The medicinal liquor disclosed by the invention is prepared from more than ten natural traditional Chinese medicines in a refining manner, the prescription is reasonable in composition, simple in preparation method, and free of any corrosion remover, and accords with the traditional Chinese medicine theory, and the ingredients are effective and matched in function, and have synergistic effects. The medicinal liquor is brownish red transparent liquid, is low in alcohol content, sweet and tasty, and sweet and aromatic, has the functions of reinforcing qi and nourishing blood, tonifying the spleen and nourishing the kidneys, and clearing damp and activating collaterals, and is applied to mental fatigue caused by deficiency of qi and blood and deficiency of liver and kidney, dizziness, insomnia and forgetfulness, inappetence, much night urination, soreness and weakness of waist and knees, and joint sore. The medicinal liquor disclosed by the invention is wide in adaptive surface, and is a good item for prevention and treatment of a plurality of diseases of the middle aged and elderly people and aging delaying.