The invention relates to a dust removal and sterilization device for shoes, in particular to a dust removal and sterilization device for paint-surface shoes. The dust removal and sterilization device for the paint-surface shoes can remove dust from the paint-surface shoes effectively without manual wiping, is simple to operate, quick, effective, safe and reliable and can sterilize the paint-surface shoes while removing dust from the paint-surface shoes. In order to solve the problems, the dust removal and sterilization device for the paint-surface shoes comprises a left side plate, an operating table, a right side plate, a two-way air cylinder, rubber blocks, a guide sleeve, a slide rail, a slide block, a first spring, a stop block, a duster, a top plate, a first rotating shaft, a wedge block, a compression cylinder, an air inlet pipe, a second one-way valve and the like. The device combines dust removal and sterilization, can remove dust from the paint-surface shoes effectively without manual wiping, is simple to operate, quick, effective, safe and reliable and can sterilize the paint-surface shoes while removing dust from the paint-surface shoes.