71 results about "4-Aminophenol" patented technology

The present invention relates to a photocatalyst using a semiconductor-carbon nanomaterial core-shell composite quantum dot and a method for preparing the same, more particularly to a microparticle in which a semiconductor-carbon nanomaterial core-shell composite quantum dot is self-assembled using 4-aminophenol, capable of improving photoelectochemical response and photoconversion efficiency when used as a photocatalyst or a photoelectrode of a photoelectochemical device, a photoelectochemical device using the same and a method for preparing the same.

A wholly aromatic polyester amide liquid crystal resin including repeating units of: (I) a 6-hydroxy-2-naphthoic acid residue: 1 to 15 mol %, (II) a 4-hydroxybenzoic acid residue: 40 to 70 mol %, (III) an aromatic diol residue: 5 to 28.5 mol %, (IV) a 4-aminophenol residue: 1 to 20 mol %, and (V) an aromatic dicarboxylic acid residue: 6 to 29.5 mol %, and having a melting point of 270° C. to 370° C., and having a melt viscosity of 60 Pa.s to 200 Pa.s at a shear rate of 1000 / sec at a temperature higher by 10° C. to 20° C. than this melting point is molten at a temperature of the melting point +40° C., and extruded at a rate of 0.3 kg / min or more and less than 5 kg / min to form a parison. A pair of molds arranged with the parison interposed there between are closed under a prescribed mold closing pressure, so that air is blown into the interior of the parison.

Preparation method and application of a phenyl phosphate flame retardant containing DOPO. The method is as below: under the action of methanol, reacting 4-amino phenol, 2-hydroxy benzaldehyde, DOPO and formaldehyde in one pot to synthesize an intermediate I; reacting phenyl dichlorophosphate and resorcinol to synthesize an intermediate II (resorcinol bisphenoxyl phosphoryl chloride); and reacting the intermediate I and intermediate II to obtain a white solid which is the phenyl phosphate flame retardant containing DOPO. The initial decomposition temperature of the flame retardant was about 363, and the rate of residual carbon was 49% at 468, 800, and the flame retardant had good thermal stability, high residual carbon ratio and good flame retardant effect, which can be used for the non halogen flame retardant of polypropylene and ABS.

A purpose of the present invention is to obtain a hollow extruded article by easy blow molding or extrusion molding to give a draw down resistance and a uniform wall thickness of the article without damaging low gas permeability which is a characteristic property of a liquid-crystalline polymer. A resin composition for extrusion molding which is prepared by melting and kneading 99-70 wt. % of wholly aromatic polyester amide liquid crystal resin (A) having a melting point of 270-370° C. and a melt viscosity at 1000 / sec. shear rate of 20-60 Pa·s at Temperature T1 which is higher than 20° C. from said melting point, and containing (I) 1-15 mole % of 6-hydroxy-2-naphthoic acid residue, (II) 40-70 mole % of 4-hydroxybenzoic acid residue, (III) 5-28.5 mole % of aromatic diol residue, (IV) 1-20 mole % of 4-aminophenol residue, and (V) 6-29.5 mole % of aromatic dicarboxylic acid residue; and 1-30 wt. % of epoxy modified polyolefin type resin (B), and has a melt viscosity at 1000 / sec. shear rate of 60-4000 Pa·s at said Temperature T1, and a melt tensile strength of 20 mN or more at 14.8 m / min. draw rate is used.

The invention belongs to the technical field of nano-materials, and relates to a preparation method of recyclable supported nano-silver catalyst materials and an application of the materials, in particular to a silver nano-catalyst preparation method based on surface-functionalization cellulose paper base and application of the preparation method to circular catalysis and transformation of environmental pollutants. The preparation method of the recyclable cellulose paper base nano-silver catalyst materials includes the steps: taking cellulose paper base materials as a support; performing amino modification on support surfaces by the aid of silane coupling agents; enabling amino of the modified support surfaces and metal precursor ions to chelate; adding reducing agents to reduce to form the cellulose paper base nano-silver catalyst materials. The prepared cellulose paper base nano-silver catalyst materials serve as a catalyst to reduce 4-aminophenol by the aid of 4-nitrophenol, are high in catalytic activity and good in reusable performance and still keep higher catalytic activity when continually and circularly being used by 20 times or more, support stability and silver nano-stability are high, and catalysts are easily recycled.

The invention relates to a preparation method and application of multiple magnetic mesoporous catalysts, and belongs to the technical fields of material science, nanometer materials, chemical industries, catalysis and the like. The method disclosed by the invention comprises the following steps: performing ultrasonic treatment for Fe3O4 microspheres of which the surfaces are carboxylated, zinc nitrate, cyanuric chloride tribasic carboxylic acids H3L and ethyl orthosilicate in one step to obtain Fe3O4@-MOF@SiO2, dipping the composite materials in a silver nitrate solution, and illuminating the composite materials with ultraviolet rays to reduce Ag<+> to obtain the multiple magnetic mesoporous catalysts, wherein nanometer Ag is anchored on the surfaces of the catalysts. The catalysts have excellent properties of catalyzing and reducing 4-nitrophenol to 4-aminophenol and catalyzing styrene to be oxidized as phenyl ethylene oxide, and the catalysts have a favorable application prospect in heterogeneous catalysis oxidation and reduction reactions.

The invention relates to a preparation method of a molybdenum disulfide coated titanium dioxide hollow core-shell structure composite photocatalyst, and application of the photocatalyst. The problems that the composite photocatalyst synthesized by the existing method is expensive and has bad 4-nitrophenol treatment effect are solved. According to the method, MoS2 grows on the surface of hollow TiO2 in situ by a hydrothermal method, the specific surface of the composite photocatalyst is increased, and the interfacial charge transfer rate is increased; furthermore, the preparation method has the advantages of simple, green and efficient synthesis method. The molybdenum disulfide coated titanium dioxide hollow core-shell structure composite photocatalyst is used for performing photocatalytic reduction on 4-nitrophenol into 4-aminophenol.

The invention discloses a regorafenib synthesis method by one kettle way, which is characterized in that 4-chlorine-trifluoro- tolyl isocyanate and 3-fluorine-4-aminophenol are added in a solvent, the temperature is controlled, a condensation reaction is carried out to generate a regorafenib intermediate 1-(4-chlorine-3-(trifluoromethyl)phenyl)-3-(2-fluorine-4-hydroxyphenyl)carbamide, then alkali is added in a same reactor for stirring, 4-chlorine-N-methyl-2-pyridine methanamide hydrochloride or 4-chlorine-N-methyl-2-pyridine methanamide are subjected to a replacement reaction, and finally purifying processing is carried out to obtain regorafenib. The method has the advantages of short process flow, simple operation, high utilization rate of raw material, and low generation cost, and has better production and utility value.

The invention provides a thermoplastic resin composition which has high rigidity and high flowability, gives less peeling of molding surface, and provides excellent appearance, and which can be suitably used for mechanical parts of automobile and mechanical parts of electrical and electronic products. Provided is the thermoplastic resin composition comprising: 100 parts by weight of (A) a sole polybenzimidazole resin or a mixed thermoplastic resin composed of 70 to 20% by weight of a polybenzimidazole resin and 30 to 80% by weight of a polyether ketone resin; and 5 to 100 parts by weight of (B) a liquid crystalline polyester amide resin containing one or more types of structuring monomer of 4-aminophenol, 1, 4-phenylenediamine, 4-aminobenzoic acid, and a derivative thereof, and containing 3 to 35% by mole of an amide component in the total bonds.

The invention discloses a high-performance liquid chromatographic analysis method of 2-methoxymethyl-4-aminophenol and impurities thereof. The method comprises the following steps of: selecting reverse high-performance liquid chromatography; setting chromatographic conditions, wherein the chromatographic column is C18, 5 mum, 150*4.6 mm (I.D.), the mobile phase includes acetonitrile: phosphoric acid -phosphate buffer solution (pH 7.0) at a volume ratio of 45:55 with a flow rate of 0.8 ml / min, the column temperature is 30 DEG C, the detection wavelength is 232 nm, the injection dose is 5 to 10 mul, and (NH4)2HPO4 20 mmol / l is added into the mobile phase; adding phosphoric acid to adjust pH to 7.0; diluting the concentration of the injection sample to 1 / 50; and determining the contents of 2-methoxymethyl-4-aminophenol and the impurities thereof. The invention provides a simple and reliable method for quality control and analysis of 2-methoxymethyl-4-aminophenol.

The invention discloses a synthetic method of 2-chloro-4-aminophenol. The synthetic method comprises the following steps: obtaining the 2-chloro-4-nitrophenol by carrying out a chlorination reaction on nitrophenol and chlorine in inertia organic solvent; and firstly adding sodium hydroxide into the 2-chlorine-4-nitrophenol under the existence of a catalytic agent such as activated carbon and ferric trichloride hexahydrate, and then slowly adding hydrazine hydrate to carry out a reduction reaction so as to synthesize the 2-chloro-4-aminophenol. The catalytic agent in the synthetic method of the 2-chloro-4-aminophenol can be recycled and used mechanically for at least ten times. Therefore, the synthetic method of the 2-chlorine-4-aminophenol has the advantages of being high in yield, high in purity, less in environmental pollution and extremely strong in market competitiveness.

The invention provides a preparation method for 2,3,5,6-tetrafluorohydroquinone, comprises the reaction step of: hydrolyzing the heavy nitride of 2,3,5,6-tetrafluoro-4-aminophenol to obtain the target compound 2,3,5,6-tetrafluorohydroquinone. In the method, the total yield can reach at least 85 percent, and the product purity is high (higher than 98 percent). The invention is suitable for the industrial requirement. The reaction formula is shown in the specification.

Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.

The invention relates to a method for synthesizing 3-amino-4-bromophenol. The method comprises the following steps of: (1) diazotization reaction: dissolving 3-nitro-4-aminophenol used as a raw material into hydrobromic acid, and dropping a sodium nitrite aqueous solution at 0-10 DEG C for reacting for 1-3 hours to obtain a 3-nitrophenol-4-diazonium brine solution; (2) bromination reaction: dropping the solution obtained in the step (1) into a hydrobromic acid aqueous solution of cuprous bromide, stirring at 40-50 DEG C for reacting, and crystallizing and filtering to obtain a 3-nitro-4-bromophenol solid; and (3) reduction reaction: dissolving the solid obtained in the step (2) into alcohol, adding an iron oxide catalyst, heating up to 50-100 DEG C, and adding a hydrazine hydrate aqueous solution to the mixture for reacting for 2-5 hours to obtain the 3-amino-4-bromophenol. The synthesis method of the 3-amino-4-bromophenol has the advantages of reasonable design, moderate condition, easiness of operation and higher product yield and is suitable for industrial production.

The invention relates to hydrogenation preparation of 4-aminophenol from nitrobenzene, especially a method for hydrogenation preparation of 4-amino-3-fluorophenol from o-fluoro-nitrobenzene and device therefore. The reaction is carried out in autoclave with acid medium at 50í½300C.,0.1í½10.0MPa, and the stirring rate is 100í½900 r / min, and the catalytically hydrogenated product is separated, distilled, filtered, and dried to prepare the product. O-fluoro nitrobenzene can be converted into 4-amino-3-fluobenzene by said method with conversion approaching 100%. 4-amino-3-fluobenzene is colourless crystallisate with selective around 92% and purity up to 99%. The catalytic process in the invention can be used for heterogeneous catalysis process of hydrogenation preparation of aminophenol from o-fluoro nitrobenzene and its substituted nitrobenzene.

The invention discloses a method for recovering 2,4-dinitrophenol hydrogenation reduction byproduct to prepare 2-amino-4-acetamidoanisole. The method comprises the following steps: separating a 2-amino-4-nitrophenol and 2-nitro-4-aminophenol mixture to obtain a 2-nitro-4-aminophenol single component; mixing the 2-nitro-4-aminophenol with an alkylation reagent, and carrying out a phenolic hydroxyl group alkylation reaction and an amino group acylation reaction to obtain 2-nitro-4-acetamidoanisole; and carrying out nitro group reduction on the 2-nitro-4-acetamidoanisole to obtain the 2-amino-4-acetamidoanisole. The method provides a brand new method for the synthesis of the fine chemical engineering intermediate 2-amino-4-acetamidoanisole with important uses, reduces the content of organic matters in 2-amino-4-nitrophenol production wastewater, reduces the treatment difficulty of enterprises' industrial wastewater, converts wastewater components into the fine chemical engineering intermediate with important production uses, and increases the enterprises' economy income.

This invention discloses a method for rapidly detecting E. coli concentration in water body. The method comprises: utilizing IrO2 / Pd decorative electrode as the electrochemical detector for flow injection-Ampere analysis, adding inducer isopropyl beta-D-thiogalactoside (IPTG), penetrant polymixin B nonapeptide and lysozyme into E. coli solution, releasing beta-D-galactosidase from E. coli cells induced by IPTG and catalytically hydrolyzing substrate 4-aminophenol-beta-D-galactopyranose in E. coli solution to obtain 4-aminophenol. Since the E. coli concentration in E. coli solution is in linear relationship with the amount of 4-aminophenol, rapidly detecting the amount of 4-aminophenol can realize rapid detection of E. coli concentration. The method has such advantages as short detection time, easy operation and high detection accuracy.

The invention provides an aromatic diamine monomer simultaneously containing four lateral substituents and having a twisted non-coplanar structure: 2,2'-di[3,5-di(4-trifluoromethylphenyl)-4-(4-aminophenoxy) phenyl] sulfone. A preparation method comprises: reacting 2,2'-di(3,5-dibromo-4-fluorophenyl) sulfone and 4-trifluoromethylphenyl boracic acid under an alkali condition in the presence of a catalyst to obtain an intermediate difluoride, further reacting the intermediate difluoride and 4-aminophenol under an alkali condition, and purifying a crude product to obtain the aromatic diamine monomer containing big tetra (4-trifluoromethyl) phenyl lateral substituents. The diamine monomer, which simultaneously contains a few big lateral substituents and has a highly twisted non-coplanar structure, can be applied to preparation of high-performance polyimide gas separation membrane materials.

The invention belongs to the field of chemical pharmacy, and specifically relates to a method for synthesizing lenvatinib. The method comprises the following steps: step 1, taking 4-aminosalicylic acid as a raw material, and preparing 4-chloro-7-methoxyquinoline-6-formamide through methylation, condensation with meldrum's acid, high-temperature cyclization, chlorination and ammoniation; step 2, taking 3-chloro-4-aminophenol as a raw material, and reacting with phenyl chloroformate and cyclopropylamine to obtain 1-(2-chloro-4-hydroxy phenyl)-3-cyclopropyl urea; and step 3, enabling the 4-chloro-7-methoxyquinoline-6-formamide prepared in step 1 to react with the 1-(2-chloro-4-hydroxy phenyl)-3-cyclopropyl urea prepared in step 2 under action of potassium tert-butoxide to obtain the lenvatinib. The invention provides a brand-new route for synthesising the lenvatinib. The used reagent is cheap and is easily available, is simple in operation, has a yield higher than that of other methods, and is easy for industrial production.

The invention discloses a preparation method of a block nanometer silver loading silica aerogel catalyst, and an application of the catalyst to preparation of 4-aminophenol from 4-nitrophenol through catalytic hydrogenation. A sol-gel method is adopted, and trimethylhexamethylene diisocyanate is used for cross-linking to obtain enhanced silica-based wet gel, which is dried at a normal pressure to prepare silica-based aerogel with the block shape well kept. The impregnation method is used to prepare the nanometer silver loading silica aerogel catalyst. The catalyst can have the block shape well kept. Silver is loaded on silica aerogel having a three-dimensional network porous structure, so that the dispersity of silver is increased. The chemical stability of the catalyst and the catalytic activity of the catalyst are improved. Further, the block is convenient to recycle and reuse. The catalyst is adopted to catalyze 4-nitrophenol to prepare 4-aminophenol through hydrogenation and is high in catalytic activity and good in stability.

The invention relates to a preparation method and application of a spiro-phosphate flame retardant containing DOPO and benzoxazine. An intermediate I is synthesized by using 4-aminophenol, 2-hydroxybenzaldehyde, DOPO and formaldehyde through a one-pot method under the action of methanol; a second intermediate II (spiro-phosphate oxalyl chloride) is synthesized by using phosphorus oxychloride and pentaerythritol; and the spiro-phosphate flame retardant containing DOPO and benzoxazine and having the appearance of white solid powder is obtained through the reaction of the intermediate I and the intermediate II. The flame retardant has an initial decomposition temperature of about 320 DEG C, the weight loss reaches 9% at 450 DEG C, and the char yield of the flame retardant at 700 DEG C reaches58%. The flame retardant has good thermal stability, high char yield and good flame-retardant effect, and can be used for halogen-free flame retardance of the polypropylene and acrylonitrile butadiene styrene (ABS).

The invention relates to preparation methods of suplatast tosilate and intermediates thereof. According to the method, 4-aminophenol is taken as an initial material, and a target compound is obtainedthrough steps of amidation, addition of epichlorohydrin, ring opening and the like. The method avoids a palladium-carbon catalytic hydrogenation step, comprises a short synthesis route and is high inyield, simple to operate and suitable for industrial application. The invention also provides novel intermediates for preparation of suplatast tosilate and preparation methods of the novel intermediates.

The invention relates to the field of pharmaceuticals, in particular to a preparation method of neratinib. The preparation method specifically includes: successively condensing 6-[(E)-4-(dimethylamino)-2-butenamido]-7-ethoxy-4-chloro-3-cyanoquinoline (I) with 2-chloro-4-aminophenol (II) and 2-(chloromethyl)pyridine hydrochloride (III) through an intermediate (E)-N-{4-[3-chloro-4-hydroxyanilino]3-cyano-7-ethoxy-6-quinoline}-4-dimethylamino-2-butenamide (IV). The materials in the preparation method are easy to obtain, and the preparation method is simple, green and economical and has greatly worthy of application.

The invention discloses a method for preparing three-dimensional bulk-phase graphene-based cobalt-based MOFs (metal-organic frameworks) composite materials and application thereof, and belongs to thetechnical field of inorganic material synthesis. The method particularly includes synthesizing dodecahedral ZIF-67 (Co-based zeolitic imidazolate frameworks-67) by the aid of liquid-phase diffusion processes; sufficiently uniformly mixing the ZIF-67 and ultrasonically dispersed graphene aqueous solution with one another; preparing the novel three-dimensional bulk-phase graphene-based cobalt-basedMOFs (3D GO / ZIF-67) composite materials by the aid of hydrothermal processes. The three-dimensional bulk-phase graphene-based cobalt-based MOFs composite materials can be used as catalysts to be applied to carrying out reduction on 4-nitrophenol to obtain 4-aminophenol. The method and the application have the advantages that as shown by test results, the catalytic activity of the three-dimensionalbulk-phase graphene-based cobalt-based MOFs composite materials can be obviously enhanced as compared with single ZIF-67 materials; the method for preparing the three-dimensional bulk-phase graphene-based cobalt-based MOFs composite materials is simple and convenient, the three-dimensional bulk-phase graphene-based cobalt-based MOFs composite materials are low in usage when used as the catalysts;the three-dimensional bulk-phase graphene-based cobalt-based MOFs composite materials comprise catalytic materials in magnetic bulk phase, accordingly, the catalysts are easy to recycle, and the method is green and is environmentally friendly.

The invention belongs to the field of pharmaceutical chemistry, and relates to a preparation method of Cabozantinib. The preparation method comprises following steps: 4-halogenated-6, 7-dimethoxyquinoline is reacted with 4-aminophenol to prepare a compound represented by formula III; cyclopropane-1, 1-dicarboxylic acid / ester and p-fluoroaniline are reacted to prepare a compound represented by formula V; and then condensation reaction is carried out to obtain the Cabozantinib compound. The preparation method is simple and convenient in operation, high in yield, low in cost, and promising in industrialization prospect.

The invention discloses a cabozantinib preparation method. The target product cabozantinib is prepared by performing five-step reaction on diethyl malonate, 4-fluoroaniline, 4-chloro-6,7-dimethoxyquinoline, 4-aminophenol, 1,2-dibromoethane and the like used as raw materials. The preparation method is simple to operate and friendly to environment; the comprehensive yield is more than 50% and is obviously increased in comparison with the yield of 20% in the prior art; and the preparation method greatly lowers the existing medicine production cost, and is suitable for industrial large-scale production.

The invention relates to an asymmetric sodium benzenesulfonate Gemini surfactant and a preparation method thereof. 4-(dodecanamide) phenol is synthesized from 4-aminophenol and dodecanoic acid through an amidation reaction, and dodecanol monomaleate is synthesized from maleic anhydride and dodecanol through an esterification reaction; then a Gemini surfactant intermediate is synthesized from 4-(dodecanamide) phenol and dodecanol monomaleate through an esterification reaction; finally, the intermediate and NaHSO3 are subjected to a sulfonation reaction, and the asymmetric sodium benzenesulfonate Gemini surfactant is obtained. The surfactant prepared on the basis of cheap and available natural fatty acid as a raw material has the excellent performance of low critical micelle concentration, high surface activity, good grease emulsifying capacity and the like, has good hydrophilicity by means of amphiphilic sulfonic acid groups contained in molecules and is an environment-friendly material with excellent performance.

The invention discloses a colorimetric biosensor for detecting an A beta<1-42> oligomer. The colorimetric biosensor comprises a black phosphorene nano-gold composite, a gold-plated silicon wafer, andan aptamer which is specifically combined with the A beta<1-42> oligomer, wherein the 5' end of the aptamer is modified with SH; the aptamer is connected with the gold-plated silicon wafer and the black phosphorene nano-gold composite through the SH, and the aptamer is specifically combined with the A beta<1-42> oligomer; and a reaction for reducing 4-nitrophenol into 4-aminophenol through sodiumborohydride is catalyzed through the black phosphorene nano-gold composite, the catalysis effect is detected through an ultraviolet visible light spectrum, and the A beta<1-42> oligomer specifically combined with the aptamer is detected. The specificity of the A beta<1-42> oligomer can be detected under the ultraviolet visible light spectrum.

The invention discloses a curcumin-4-aminophenol eutectic crystal which is eutectic crystal prepared from curcumin and 4-aminophenol. The curcumin-4-aminophenol eutectic crystal is prepared by self-assembling, volatilizing and crystallizing the curcumin and the 4-aminophenol in a mixed solvent, wherein a mass ratio of the curcumin to the 4-aminophenol is (1 to 1) to (1 to 5), and the mixed solventis prepared from at least two of dichloromethane, ethyl alcohol and diethyl ether. The invention further provides a preparation method of the eutectic crystal. The eutectic crystal disclosed by the invention inherits self pharmacological activity of traditional bulk pharmaceutical chemicals, and aspects of solubility, stability and the like of the eutectic crystal are all obviously improved.

The invention discloses a method of simultaneously detecting concentrations of paracetamol and 4-aminophenol. The method comprises the following steps: preparing 2,6-diaminopyridine o-carboxybenzaldehyde bis-schiff base cobalt complex modified glassy carbon electrode by an electro-deposition process; simultaneously measuring the oxidation peak current values of paracetamol and 4-aminophenol withina concentration range from 5 to 30mumol.L<-1> by a differential pulse process, wherein the oxidation peak current is in a good linear relationship with the concentration thereof, and the detection limits are 1.64*10<-5>mol.L<-1> and 2.39*10<-5>mol.L<-1> respectively. The method disclosed by the invention can be used for simultaneously detecting the concentrations of paracetamol and 4-aminophenol,and has the advantages of easiness in operation, fast analysis, high sensitivity, stable system and high reproducibility.