A method for thermal spraying preparation of a coating on a large size bending pipe workpiece is as follows: first the bending pipe workpiece surface is pretreated, a specially-designed bending pipe spraying tooling is used for clamping and fixing, the specially-designed bending pipe spraying tooling mainly includes a tooling body, a supporting frame, a motor, a drive chain wheel, a driven chain wheel, a main shaft, a countershaft, a fixing sleeve and a protection plate, the workpiece is fixed on the main shaft and the countershaft through the fixing sleeve and fastening screws, and can be driven, by the drive chain wheel, the driven chain wheel, the main shaft and the countershaft, to rotate, wherein the drive chain wheel, the driven chain wheel, the main shaft and the countershaft are driven by the motor. When in spraying, a spray gun respectively sprays once along A, B and C track lines to form one spray pass, and sprays by repeated multiple passes until needed coating thickness is obtained, and the workpiece is cooled by high-speed air curtain. The method can ensure uniform coating thickness, texture and property of arc length and outer circumference direction of the bending pipe workpiece, can effectively prevent the component deformation, and is especially suitable for thermal spraying preparation of the coating on large size bending pipe workpiece with the curvature radius greater than or equal to 2m, length less than 2m and diameter between 30-140mm.