64results about How to "No stringent conditions" patented technology

The invention discloses a coal-based anode material, a preparation method and a lithium-ion battery. The coal-based anode material consists of a coal-based material graphitized inner layer, a middle layer and an outer layer distributed on the surface. The preparation method of the coal-based anode material comprises steps as follows: crushing a coal-based material; then adding a binder or mixing the binder and a modifier; then performing pressing and high-temperature graphitization to form a finished product. The coal-based anode material adopts a stable graphite structure, the surface has good compatibility with an electrolyte, and the coal-based anode material has the high specific capacity, the high conductivity, the high rate capability as well as excellent electrolyte absorbing performance and cycle performance. According to the preparation method, the anode material is prepared from the low-price coal-based material used as a raw material, the technology is simple, industrialization is easy to realize, and meanwhile, the application of the coal-based anode material in the field of the lithium-ion battery is promoted.

The invention relates to a ZnFe2O4-based nanometer composite. The zinc ferrite-based nanometer composite is a ZnFe2O4 / MO nanometer composite in which MO is a metal oxide. The ZnFe2O4-based nanometer composite comprises secondary particles formed by aggregating ZnFe2O4 nanoparticles with spinel structures and MO nanoparticles; and the metal oxide is ZnO, Fe2O3, CoO, NiO, CuO, MnO, TiO2, CrO3 and / or VO2. Compared with the prior art, the zinc-ferrite-based nanometer composite has the beneficial effects that the ZnFe2O4-based nanometer composite provided by the invention has high capacity and high cycle stability as a negative electrode material of a lithium ion battery, and the electrochemical performance of pure-phase ZnFe2O4 is greatly improved; the particles are uniform in size and good in dispersion; and a preparation method of the composite is simple, a production process is short without severe conditions, the cost is low, and the industrialization is easy.

The invention provides a preparation method of mesotrione. The preparation method comprises is capable of preparing the target product from raw materials such as ortho-nitrotoluene, chlorosulfonic acid, sulfoxide chloride, sodium sulfite, chloroactic acid, 1,3-cyclohexanedione in the presence of a catalyst and acid-base. The preparation method is based on common chemical raw materials, the reaction flow of each step is implemented under conventional operation conditions, the amount of three wastes is low, the total yield is above 61%, the purity of the product is high, the purity of the coarse product of the mesotrione is greater than 98%, and the coarse product of the mesotrione can be further purified; as a result, the preparation method of mesotrione is applicable to large-scale industrial production.

The invention relates to a natural graphite composite material, a preparation method thereof and a lithium ion battery. The natural graphite composite material comprises natural graphite and an amorphous carbon shell coating the surface of natural graphite, wherein the amorphous carbon shell is made from a bonding agent and an additive through thermal treatment. The amorphous carbon shell is made from the bonding agent and the additive through thermal treatment, can uniformly coat the surface of natural graphite, and provides the natural graphite composite material with characteristics of high capacity, good compaction, low circulation expansion ratio and long circulation life. The natural graphite composite material is stable in performance and excellent in overall performance. The preparation method of the natural graphite composite material is mild in condition, simple in process and low in cost.

The invention relates to the field of medicine detection, in particular to a high-performance liquid chromatography detecting method for measuring the content of flavonoid compounds and terpene lactone compounds in ginkgo leaves (or ginkgo leaf extract) or preparations of the ginkgo leaves at the same time. The HPLC-DAD-ELSD method is set up, the method can measure the eight flavonoid compounds and three terpene lactone compounds in the ginkgo leaves (or the leaf extract) or preparations of the ginkgo leaves at the same time, the measurement result is analyzed, and a new analysis method and a basis are provided for quality control over the ginkgo leaf extract and the preparations of the ginkgo leaf extract.

The present invention relates to a method for preparing 2-amino-4, 6-dimethoxypyrimidine (ADMP). According to the method, malononitrile is uses as a raw material, special solvents are adopted, and in the action of a specific catalyst, after reactions of imidization, cyanamide substitution, aromatic cyclization, etc., 2-amino-4, 6-dimethoxypyrimidine of high purity is synthesized in a high yield. The method has no harsh conditions in all the steps, is simple in operation, little in the amounts of waste water, waste gas and industrial residues, and environmentally friendly, thereby having significant social and economic benefits, and being suitable for industrial production.

The invention discloses an imidazole ionic liquid electromigration antirust agent and a preparation method thereof. By the electromigration antirust agent, a perssad which has static effect or coordination on iron is introduced on an imidazole ring, and adsorption capacity can be improved, so that the antirust efficiency is improved effectively. The preparation method comprises the following steps: (1) preparing N-alkyl substituted imidazole by using imidazole and halohydrocarbon of C1-C12; and (2) reacting the N-alkyl substituted imidazole with a quaternized reagent to obtain the imidazole ionic liquid electromigration antirust agent. The synthesis method of the imidazole ionic liquid electromigration antirust agent provided by the invention is simple, harsh conditions are not required, antirust efficiency is excellent, the antirust agent can be migrated into a test piece under the effect of an electric field, and volume of migration is not affected by the pH value of the test piece.

The invention belongs to the field of composite materials, and particularly relates to a cyclodextrin-metal organic framework complex loading vitamin A and a derivative thereof, and a deep processing method of the vitamin A and the derivative thereof. The cyclodextrin-metal organic framework complex is prepared from a cyclodextrin-metal organic framework, and vitamin, wherein the vitamin is loaded on the framework, and is vitamin A and / or the derivative thereof. The cyclodextrin-metal organic framework complex has the advantages that the cyclodextrin-metal organic framework is used as solid medicine reservoirs, the safety is high, and the biocompatibility is good; the vitamin fills the cyclodextrin-metal organic framework, and the stability is higher; experiment results show that the degrading amount is less than or equal to 40% after heat treatment is performed on the complex for 10 days at the temperature of 60 DEG C, and is less than or equal to 20% after the complex is placed for 90 days at the temperature of 40 DEG C, and the heat stability is better than that of of Basf vitamin A powder.

The invention relates to the field of medicine detection, in particular to a high-performance liquid chromatography detecting method for measuring the content of flavonoid compounds and terpene lactone compounds in ginkgo leaves (or ginkgo leaf extract) or preparations of the ginkgo leaves at the same time. The HPLC-DAD-ELSD method is set up, the method can measure the eight flavonoid compounds and three terpene lactone compounds in the ginkgo leaves (or the ginkgo leaf extract) or preparations of the ginkgo leaves at the same time, the measurement result is analyzed, and a new analysis method and a basis are provided for quality control over the ginkgo leaf extract and the preparations of the ginkgo leaf extract.

The invention relates to a composite material of a lithium ion battery, a preparation method thereof and the lithium ion battery. The composite material of the lithium ion battery is isotropic and comprises a carbon material which is used as a supporting skeleton and graphite particles which are embedded into the carbon material, wherein the carbon material is a product from thermal treatment of a binder; the graphite particles are formed by natural graphite or natural composite graphite which is formed by compounding natural graphite and auxiliary materials, and the mass of the graphite particles accounts for 50.0 to 99.9 percent of the total mass of the composite material. The composite material is high in orientation, high in capacity, high in rate capacity and long in service life; the preparation method is moderate in condition, simple in process and low in cost.

The invention relates to a novel synthesis process of 2-substituted-4,6-dialkoxy pyrimidine. The novel synthesis process adopting malononitrile as the raw material and adopting a special solvent comprises the following steps of: obtaining hexaalkoxy propane through imidization and alcoholysis under the action of the special catalyst; carrying out nucleophilic addition onto intermediate and urea / thiourea / guanidine to construct a pyrimidine ring framework; and eliminating and rearranging aromatization to obtain the target compound 2-substituted-4,6-dialkoxy pyrimidine. The synthesis process disclosed by the invention has the characteristics of being cheap and easily available in materials, free of severe conditions for all steps, smooth and safe in operation steps, small in the amount of the three wastes and lower in production cost, and therefore, the synthesis process is suitable for being applied to the industrial production.

The invention relates to a preparation method of 2-(2-nitryl-4-methyl sulfuryl-benzoyl) cyclohexane-1,3-diketone (methyl mesotrione, mesotrione). The preparation method adopting 2-nitryl-4-methyl sulfuryl benzaldehyde and 1,3-cyclohexanedione as the materials comprises the following steps of: carrying out the reactions including nucleophilic addition, oxidation and the like to prepare the high-purity 2-(2-nitryl-4-methyl sulfuryl-benzoyl) cyclohexane-1,3-diketone. The preparation method disclosed by the invention is short in route; all steps are free of severe conditions, simple to operate, environment-friendly, remarkable in innovative significance and economic value and extensive in industrial production prospect.

The invention discloses a catalyst for SCR denitration of cement kiln flue gas, a preparation method of the catalyst and a denitration system. The catalyst comprises 20-50 parts of silicon carbide, 5-15 parts of metal oxide, 3-8 parts of a vanadium-titanium composite oxide, 1-2.5 parts of an adhesive and 0.5-2 parts of a lubricant. The metal oxide is lanthanum oxide or cobalt oxide. The vanadium-titanium composite oxide is a titanium dioxide / vanadium pentoxide composite oxide. The denitration system comprises a preheater system, an intercepting net system, a ceramic filter pipe integrated system, an SCR denitration system and a waste heat power generation system, which are arranged in the flowing direction of flue gas. According to the invention, the catalyst carrier is prepared from silicon carbide and metal oxide, and the self-made composite oxide is used as the catalyst, so that the catalyst with good low-temperature activity, high sulfur resistance and good activity retention is prepared. The denitration system can greatly reduce one-time investment and operation cost of downstream desulfurization and dust removal equipment.

The invention discloses a synthetic method of substituted indol-2-formic acid. Substituted phenylhydrazine hydrochloride or phenylhydrazine is used as a raw material, hydrazone is formed through ethyl pyruvate, then substituted indol-2-ethyl formate is obtained through a Fischer indol synthetic reaction, and the substituted indol-2-formic acid is obtained after hydrolysis. The product purity is greater than 97%, and the reaction yield is 64%. The synthetic method disclosed by the invention has the characteristics of being free of severe conditions, simple to operate and environment-friendly, and has certain economic benefit. According to the synthetic method of the indol-2-formic acid, the raw materials are easily obtained, the operation is simple and convenient, three wastes are few, and the yield is high.

The invention discloses a micro-molecular fluorescent probe taking CS as a fluorophore, a preparation method and application thereof. Coumarin is used as a fluorophore and salicyloyl hydrazine is taken as a basic substance, so that the fluorescent probe has very strong conjugated [Pi] electrons; wherein salicyloyl hydrazine and aldehyde groups are condensed to form chelation sites of metal ions. After the micromolecular fluorescent probe is combined with copper ions, the fluorescence is quenched, and electron transfer in probe molecules is hindered by the micromolecular fluorescent probe in the presence of the copper ions, so that the fluorescence of the micromolecular fluorescent probe is changed from existence to absence, the ultraviolet absorption peak red shift occurs, and new absorption occurs at the wavelength of 470 nm. Along with the increase of the concentration of the copper ions, the absorption peak is gradually increased and transferred, which indicates that the metal ionsare strongly combined with the probe. According to the technical scheme, the copper ions are accurately detected through the fluorescence technology, and the indigenous copper ions and the indigenouscopper ions of living cells can be detected, so that the method has a good application prospect in the aspect of copper ion detection. The synthesis method disclosed by the invention is simple and convenient to operate, and does not need rigorous conditions.

The invention provides a glucoside flavonereinforcing steel bar corrosion inhibitor and a preparation method thereof. The glucoside flavonereinforcing steel bar corrosion inhibitor is stable in structure, high in corrosion inhibiting efficiency, and meanwhile is simple in preparation method, easy for industrialization, friendly to environment, and low in production cost. The glucoside flavonereinforcing steel bar corrosion inhibitor is prepared by mixing the following components in percentage by weight: 15-30% of glucoside flavone with a specific structure, 5-15% of organic amine and the balance of water, wherein the organic amine is one or more of ethanolamine, diethanolamine, triethanolamine, N,N-dimethylethanolamine, N-methyldiethanolamine, diethylenetriamine, triethylene tetramine, tetraethylenepentamine, polyethylene polyamine, and polyethyleneimine.

The invention provides a high performance liquid chromatography detection method of a cangrelor related substance. The method comprises the following steps: adopting a reversed-phase chromatographic column; the filler being octadecyl bonded silica gel; and carrying out gradient elution by taking a phosphate sodium perchlorate buffer solution as a mobile phase A and acetonitrile as a mobile phase B. The method has the advantages of strong specificity, high sensitivity and accurate quantitative determination result; the analysis method is simple, convenient and rapid, can better separate all impurities in a short time, has a separation degree between each chromatographic peak of more than 1.5, can comprehensively detect the cangrelor related substance and the cangrelor related substance in the preparation of the cangrelor, improves the safety of the medicine, and provides a basis for formulating the quality standards of the cangrelor bulk drug and the preparation of the cangrelor.

The invention discloses a small-molecule fluorescent probe, a preparation method and application thereof. A connecting part in the small-molecule fluorescent probe is easily oxidized by hypochlorous acid to cause falling of a 2-thiophenecarboxylic hydrazide group, so that a coumarin derivative is generated, and meanwhile, the fluorescence of the probe is also converted from green to blue. Therefore, the hypochlorous acid or hypochlorite ions can be accurately and rapidly detected in an ultraviolet and fluorescence ratio mode, and the fluorescent probe can be used for detecting exogenous hypochlorous acid or hypochlorite ions in solutions, bacteria, living cells and zebra fishes. The synthesis method is simple and convenient to operate, does not need harsh conditions, and is very high in synthesis yield and purity. Therefore, the probe has a good application prospect in the aspect of hypochlorous acid or hypochlorite ion detection.

The invention discloses a small-molecule fluorescent probe, and a preparation method and application thereof. According to the invention, a parent structure formed by connection of triphenylamine oxime and a spiropyran aldehyde structure through nitrogen-nitrogen bonds has strong conjugate pi electrons; a spiropyrane ring is easy to open, and after the spiropyrane ring in the structure is opened,strong fluorescent light can be emitted; the small-molecule fluorescent probe can realize precise detection of hypochlorous acid via a fluorescence technology and can detect endogenous hypochlorous acid in living cells, bacteria and zebra fish bodies; so the small-molecule fluorescent probe has good application prospects in the hypochlorous acid detection. The preparation method of the invention is simple in process and convenient to operate and does not need harsh conditions.

The invention discloses an off-on type molecular fluorescent probe CMTAH and a preparation method and application thereof. The probe is used for detecting copper ions and zinc ions in a sample and applied to biological imaging. A main body of the probe comprises coumarin aldehyde and 2-thiophene hydrazide, the molecular probe can realize accurate detection of copper ions and zinc ions by ultraviolet and fluorescence, the method can be used for detecting exogenous copper ions and zinc ions in solutions, living cells and zebra fishes, is simple in synthesis method and convenient to operate, doesnot need harsh conditions, is high in synthesis yield and purity, and has good application prospects in the aspect of copper ion and zinc ion detection.

The invention discloses a method for preparing a spherical bimetallic MCo-MOFs catalytic material through microwave-ultrasonic synergistic assistance, which comprises the following steps: firstly, preparing a spherical bimetallic MCo-MOFs precursor through synergistic assistance of a metal salt I (metal cobalt salt), a metal salt II and aromatic dicarboxylic acid in a microwave-ultrasonic combinedmode; and further the precursor solution is crystallized through a hydrothermal rotation method to prepare the spherical bimetallic MCo-MOFs catalytic material. The method is simple in process, low in cost, convenient to operate and high in yield, and the prepared product is uniform in particle size, controllable in form and high in catalytic activity.

The invention relates to a synthesis method of 2-chloro-4,6-dibutoxypyrimidine, which uses malononitrile as a raw material, undergoes reactions such as alcoholysis into salt, cyanamide substitution, chlorination and cyclization, and is synthesized in high yield. With high content of 2-chloro-4,6-dibutoxypyrimidine, all steps have no harsh conditions, simple operation, environmental friendliness, significant social and economic benefits, and are suitable for industrial production.

The invention discloses a detection method for the dissolution determination of flunarizine hydrochloride capsules. The method is characterized in that a dissolution method is a paddle method in whichthe speed is 100 revolutions per minute; a medium of lauryl sodium sulfate is added to serve as a dissolution medium; a dissolved matter is detected by high performance liquid chromatography; octadecyl silane bonded silica gel is taken as a filling agent; the detection wavelength of an ultraviolet detector is 251 to 255nm; the column temperature is 25 to 45 DEG C; the flow rate is 0.9 to 1.1ml / min; and a flowing phase is prepared from methane and a phosphate Buffer solution. Through adoption of the method, the problem concerned with flunarizine hydrochloride capsule filter membrane adsorptionis solved; an obtained chromatographic peak has a good peak pattern; high column efficiency and a more accurate result can be achieved; the service life of a chromatographic column is prolonged; andthe test cost is lowered.

The invention discloses a novel preparation method of dimethoxy propyl diimine dimethyl bisulfate. Cheap propane diamide is taken as the raw material, then O-methylation of propane diamide can be achieved in the presence of a methylation agent (dimethyl sulfate) under the catalytic conditions of Lewis acid, dimethoxy propyl diimine dimethyl bisulfate can be obtained stably, and the yield is high. Moreover, the production cost is low, the operation is simple, and the method is environment-friendly and equipment-friendly, and is suitable for industrial production. The prepared dimethoxy propyl diimine dimethyl bisulfate can be used to produce 2-amino-4,6-dimethyoxy pyrimidine and 2-chloro-4,6-dimethyoxy pyrimidine, the reaction activity is equivalent to that of dimethoxy propyl diimine dihydrochloride, and moreover, the stability is better.

The invention discloses a graphite composite negative electrode material for a lithium ion battery, a preparation method of the material, and the lithium ion battery. The graphite composite negative electrode material for the lithium ion battery has a core-shell structure, wherein graphite is used as an inner core; carbon nano tubes and / or carbon nanofibers which are uniformly distributed on the surface of the graphite and are in in-situ growth are used as the shell; the growth root points of the carbon nano tubes and / or the carbon nanofibers are in tight contact with the surface of the graphite; and the other ends of the carbon nano tubes and / or the carbon nanofibers are distributed on the surface of the graphite randomly. The preparation method comprises the following steps of: fully soaking the graphite as a raw material by a catalyst-containing solution, and drying to obtain a graphite composite material precursor; performing chemical vapor deposition to generate the carbon nano tubes and / or the carbon nanofibers; and finally performing the purification and annealing treatment. The graphite composite negative electrode material has high height ratio, conductivity, and rate capability, and excellent solution absorption performance and cycle performance; and the method is simple in production flow, accurate in process control, low in cost, free from severe conditions, and easy to realize the industrialization.

The invention discloses a Satellite sunlight pressure moment high-precision online estimation method. The method comprises the following steps: 1) establishing a sunlight pressure moment fuzzy logic estimation model; 2) according to the sunlight pressure moment fuzzy logic estimation model in the step 1), performing online iterative adjustment by using a gradient descent method to obtain a to-be-adjusted parameter theta j; and 3) obtaining the sunlight pressure moment on line according to the on-line to-be-adjusted parameters in the step 2). According to the invention, direct on-line estimation of the sunlight pressure moment can be realized; on the premise of having no extra requirement for on-orbit data, the accuracy of on-line estimation of the sunlight pressure moment is effectively improved by utilizing prior information obtained through ground analysis.

The invention discloses a preparation method of an anti-migraine drug almotriptan. The method comprises the following steps: (1) N-protected o-haloaniline represented by formula (I) and 4-acetoxycrotonate represented by formula (II), which are used as raw materials, undergo a cascade reaction under the action of the basic skeleton of a palladium catalyst and a phosphine ligand, and an almotriptanbasic skeleton represented by formula (III) is collected from the obtained reaction product; and (2) the almotriptan basic skeleton represented by formula (III) undergoes reduction, deprotection, hydroxyl group activation and amino group substitution to obtain the product almotriptan. The preparation method has the advantages of simple and easily available raw materials and reagents, simplicity inoperation of the preparation, no harsh conditions, convenience in purification of the intermediate and the product, and high overall yield. The reaction formula is shown in the description.

The invention discloses a preparation method of beta-amino acrylonitrile compounds. Beta-aminocyanoacrylate represented by formula I reacts in a solvent under the action of a catalyst to obtain the beta-aminoacrylonitrile compounds represented by formula II; and in the formulas, R<1> is a C1-C12 alkyl group, a halogenated C1-C12 alkyl group, a C3-C12 cycloalkyl group, a C2-C12 alkenyl group, a C2-C12 alkynyl group, an aryl group, a substituted aryl group, a benzyl group or a substituted benzyl group, and R<2> is hydrogen, halogen, a hydroxyl group, an amino group, a cyano group, a nitro group,a C1-C12 alkyl group or a halogenated C1-C12 alkyl group. The method has the characteristics of good stereoselectivity, high yield, simplicity preparation of the raw material beta-aminocyanoacrylate,and great practical value.

The invention discloses a synthesis method of 5-amino-2, 4-dibromophenol, which takes m-aminophenol as a raw material and comprises the following steps: dissolving m-aminophenol in an organic solvent, and dropwise adding anhydride for reaction; dissolving the obtained m-amide phenol in an organic mixed solvent, and then adding a bromination reagent for reaction; and adding alcohol and hydrochloric acid into the obtained 2, 4-dibromo-5-amide phenol, stirring, refluxing and reacting until the solution is clear, and carrying out post-treatment on the reaction solution to obtain the product 5-amino-2, 4-dibromophenol. The raw materials are cheap and easy to obtain; the reaction conditions are simple and mild; the yield is high; the target product quality is high.