116results about How to "Narrow particle size" patented technology

The invention discloses a polypeptide drug sustained-release microsphere preparation and a preparation method thereof. The method comprises the following steps of: dissolving the polylactic acid-glycollic acid copolymer or polylactic acid, a protective agent and a polypeptide drug in an organic solvent to form a completely uniform mixed solution; adding the mixed solution into an oil phase to form emulsion; removing the organic solvent; and performing centrifugal washing and freeze drying to obtain the polypeptide drug sustained-release microsphere. In the invention, an O / O method is adopted, the problem that the drug spreads toward the outer aqueous phase in the multiple-emulsion preparation method is solved, and the drug encapsulation efficiency is improved to 60-95%. The biological active polypeptide drug is degraded in the body and slowly released with the polymer material of the microsphere through the pores on the microsphere surface; the release time can be as long as several weeks and even several months; and the in-vitro release test indicates that the release conforms to similar zero-order release.

The invention provides a method for largely preparing superfine spherical titanium aluminium-based alloyed powder, which belongs to the technical field of powder preparation. The method comprises the following steps: smelting high-purity aluminium and titanium sponge as main raw materials and Al-Nb intermediate alloy, Ti-B alloy, tungsten powder and high-purity yttrium scraps as auxiliary raw materials into an alloy cast ingot in a vacuum consumable electrode arc skull furnace or a vacuum induction furnace; then carrying out coarse crushing and vortex airflow milling to prepare irregular superfine alloy powder; and finally carrying out plasma spheroidization of radio frequency (RF) and the like to prepare the superfine spherical titanium aluminium-based alloyed powder. The prepared alloy powder has the advantages of high purity, fine particle size, narrow particle size distribution, good uniformity, high sphericity, good flowability and the like and can meet the demands of the technical industrial production of injection forming, gel injection molding forming, thermal spraying and the like.

A transition metal composite hydroxide can be used as a precursor to allow a lithium transition metal composite oxide having a small and highly uniform particle diameter to be obtained. A method also is provided for producing a transition metal composite hydroxide represented by a general formula (1) MxWsAt(OH)2+α, coated with a compound containing the additive element, and serving as a precursor of a positive electrode active material for nonaqueous electrolyte secondary batteries. The method includes producing a composite hydroxide particle, forming nuclei, growing a formed nucleus; and forming a coating material containing a metal oxide or hydroxide on the surfaces of composite hydroxide particles obtained through the upstream step.

A method in which a metal powder is produced by ejecting a thermally decomposable metal compound powder into a reaction vessel through a nozzle together with a carrier gas under the condition V / S>600, where V is the flow rate of the carrier gas per unit time (liter / min), and S is the cross-sectional area of the nozzle opening part (cm2), and heating this metal powder at a temperature which is higher than the decomposition temperature of the metal compound powder and not lower than (Tm−200)° C., where Tm is the melting point of the metal, in a state where the metal compound powder is dispersed in the gas phase at a concentration of 10 g / liter or less. The method provides a fine, spherical, highly-crystallized metal powder which has a high purity, high density, high dispersibility and extremely uniform particle size, at low cost and using a simple process.

The invention provides kiwi fruit micro-powder and a preparation process thereof, and relates to fruit powder and a preparation method of the fruit powder. According to the technical scheme provided by the invention, the preparation process of the kiwi fruit micro-powder comprises the following steps: cleaning kiwi fruit, draining off, and cutting into slices for later use; enclosing the cut kiwi fruit into a charging tray; putting into a vacuum drying room, dewatering and drying; crushing the dried kiwi fruit in a fully-closed state under the protection of nitrogen, and then sieving, so as to obtain micro-powder; and bagging the micro-powder in a low-temperature environment, and sealing in vacuum. The preparation process disclosed by the invention is advanced; 100% of skin, pulp and seeds of the kiwi fruit are utilized; raw materials are fully saved; the utilization efficiency is improved; and the kiwi fruit micro-powder is good in keeping of nutritional ingredients, good in color and luster, and convenient to store and transport for a long period of time.

The invention aims to provide nanometer zirconia powder and a synthesis method thereof. The nanometer zirconia powder is high in crystallinity degree, slight in agglomeration, small in grain size, narrow in distribution and large in specific area. The nanometer zirconia powder is prepared from, by weight, 96.5-97% of ZrO2 and 3-3.5% of Y2O3. The synthesis method for the nanometer zirconia powder comprises the following sequentially-executed steps of preparing a zirconium compound and a yttrium oxide solution; preparing an oxalic acid solution; carrying out filtering; carrying out a precipitation reaction; carrying out a thermal decomposition reaction after washing and drying; carrying out wet grinding; carrying out a supercritical hydrothermal reaction. The synthesis method is applied to the technical field of synthesis of the nanometer zirconia powder.

Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin photosensitizer, particularly the hydro-mono benzoporphyrins (BPD) having light absorption maxima in the range of 670-780 nanometers, a disaccharide or polysaccharide and one or more phospholipids.

The invention discloses a preparation method of leuprorelin microspheres. The method comprises steps of preparation of an oil phase, preparation of an inner water phase, preparation of an outer water phase, preparation of a primary emulsion, preparation of a compound emulsion, drying in a liquid and the like. A total-closed online emulsification and separate tank drying mode is adopted, and the problems of high probability of evaporation and boiling of DCM in the emulsification process are effectively solved by accurately controlling temperatures and pressure; through reduction of the viscosity of the oil phase, the emulsification efficiency is improved, residues of the primary emulsion in tanks are reduced, and the overall yield of a product is increased. Besides, batch production of the leuprorelin microspheres is changed into continuous production, transition from a lab-scale test to a pilot plant test to production is smoother, and room for improvement of the productivity of a workshop is larger.

The invention discloses an acrylate emulsion and a preparation method thereof. The acrylate emulsion comprises the raw materials: a mixed monomer, an emulsifier, an initiator and water. The acrylate emulsion is prepared by semi continuous emulsion polymerization. A latex film formed by the obtained acrylate emulsion has good water resistance, hardness and adhesion force, the preparation process issimple, the raw materials are easy to obtain, the conditions are mild, and the acrylate emulsion is suitable for large-scale industrial production.

The invention discloses an antibacterial botanic liquid detergent .The antibacterial botanic liquid detergent is prepared from, by weight, 0.5-1.5 parts of nanocarbon crystals, 25-35 parts of Chinese honeylocust fruits, 20-30 parts of Chinese soapberry fruit peel, 20-25 parts of tea seeds, 20-30 parts of artemsia argyi oil, 15-25 parts of orange peel, 1-10 parts of egg white powder and 70-90 parts of deionized water .A corresponding preparing method of the antibacterial botanic liquid detergen comprises the following steps that firstly, Chinese honeylocust fruits, Chinese soapberry fruit peel, tea seeds and orange peel are smashed, dried, sterilized, soaked with deionized water for 0.5-1 h and then decocted for 135-270 min, then cooling and filtering are carried out, and an extract solution is obtained; secondly, nanocarbon crystals and egg white powder are added into the extract solution obtained in the first step and are mixed, the mixture is subjected to heating concentration, heat preservation and cooling, then artemsia argyi oil is added, and the antibacterial botanic liquid detergent is obtained .According to the antibacterial botanic liquid detergent and the preparing method thereof, Chinese honeylocust fruits, Chinese soapberry fruit peel, tea seeds, orange peel and the like in the formula come from the nature, contain no chemical ingredient, contain ingredients good in oil contamination washing effect and also contain a large quantity of vitamins and other nutrient elements needed by the human body, and thus the skin can be nourished and protected while articles are cleaned .

A transition metal composite hydroxide can be used as a precursor to allow a lithium transition metal composite oxide having a small and highly uniform particle diameter to be obtained. A method also is provided for producing a transition metal composite hydroxide represented by a general formula (1) MxWsAt(OH)2+α, coated with a compound containing the additive element, and serving as a precursor of a positive electrode active material for nonaqueous electrolyte secondary batteries. The method includes producing a composite hydroxide particle, forming nuclei, growing a formed nucleus; and forming a coating material containing a metal oxide or hydroxide on the surfaces of composite hydroxide particles obtained through the upstream step.

A transition metal composite hydroxide can be used as a precursor to allow a lithium transition metal composite oxide having a small and highly uniform particle diameter to be obtained. A method also is provided for producing a transition metal composite hydroxide represented by a general formula (1) MxWsAt(OH)2+α, coated with a compound containing the additive element, and serving as a precursor of a positive electrode active material for nonaqueous electrolyte secondary batteries. The method includes producing a composite hydroxide particle, forming nuclei, growing a formed nucleus; and forming a coating material containing a metal oxide or hydroxide on the surfaces of composite hydroxide particles obtained through the upstream step.

The invention discloses environment-friendly titanium pigment prepared by using a complexation-precipitation process. The process comprises the following steps: quantitatively weighing titanium dioxide or titanium dioxide and antimonous oxide to be added into a solution into which a surfactant is dissolved, and dispersing uniformly; adding a mixture solution of coloring ions R<+1> and a complexing agent, controlling the contents of the complexing agent and the coloring ions so as to establish a stable system of the coloring irons and the complexing agent, adjusting the pH value of the system and enabling the system to be in a stable state; performing precipitation reaction on the coloring ions and an dropped alkali solution; aging and subsequently washing and filtering the reaction system so as to remove impurity ions; performing spraying drying treatment; adding a mineralizer into the dry powder, uniformly mixing, subsequently calcining in air atmosphere in a muffle furnace, and controlling the temperature and the temperature preserving time so as to obtain expected powder. The pigment overcomes the defects that in the conventional titanium yellow preparation, the particle size of the pigment is large, the distribution interval is wide, the color is not bright, agglomeration happens, the coloring capability is poor, and the like, and the cost of the titanium pigment is greatly lower than that of a developed product in market.