48results about How to "Little change in particle size" patented technology

The invention belongs to the technical field of medicine preparations, and particularly relates to a taxol freeze-dried powder preparation process and a product. The taxol freeze-dried powder preparation process is simple in route, production cost is low, transportation and storage is simple and convenient, and adverse reaction caused by addition of excipients is avoided. In-vitro stability of taxol micelle freeze-dried powder is higher, redissolved taxol solution is stably kept 12 hours or than at room temperature, and drug treatment requirements are met. Blood stability is higher, grain diameter is small, an EPR effect is more easily played, taxol freeze-dried powder can be redissolved by the aid of common normal saline or glucose injection, and drug administration processes are greatlysimplified.

The invention discloses a dispersible pH sensitive cationic polymer gel sub-micron particle and making method, which comprises the following steps: allocating raw material through non-ion soluble macromolecular monomer, cation monomer, crosslinking agent and initiator weight rate at 20%-70%25%-75% 0.7%-3%0.7%-3%; dissolving in the acetonitrile or alcohol; aerating nitrogen to reflux; evaporating solvent; dripping secondary distill water; cooling dispersing liquid naturally; centrifuging to separate; dialyzing upper supernatant layer; freezing to drying; making the gel sub-micron particle disperse in the pure water, physiological saline and buffer as drug control carrier releasing material.

The invention provides a microemulsion droplet of a W / O / W type PCR amplified product based on a microfluidic system and a preparation method of the microemulsion droplet, the microemulsion droplet includes an amplified W / O type microemulsion droplet , an oil phase A and an outer water phase, wherein the amplified W / O microemulsion droplets include an inner water phase and an oil phase B, prepared by a microfluidic system, and the amplified W / O microemulsion droplets, oil phase A The volume ratio of the inner water phase to the outer water phase is 1:3:1000; the volume ratio of the inner water phase to the oil phase B is 40:3. The present invention provides a preparation method of W / O / W microemulsion droplets. The obtained microemulsion droplets can effectively establish a new type of microemulsion droplet sorting platform, and can effectively solve the problem of tissue The conundrum of cellular heterogeneity that samples cannot crack. In the present invention, by strictly screening the formula ratio and preparation parameters, the average particle diameter is 70 μm, all of which are spherical particles with uniform particle size distribution, and the stability experiment shows that the microemulsion droplets prepared by the present invention can be stored at room temperature, and The particle size changes little in a short time at room temperature.

The present invention discloses hyaluronic acid- g ‑Folic acid amphiphilic polymer and its application, the main chain is hydrophilic hyaluronic acid, and the side chain is hydrophobic folic acid, which can efficiently and stably load small molecule anticancer drugs and prolong the blood circulation time of drugs; The enrichment amount is high, reaching 12.0%ID / g. After reaching the tumor tissue, the dual-targeted nanomedicine tightly binds to the surface of tumor cells and effectively enters the tumor cells through receptor-mediated endocytosis, and then realizes The drug is released quickly, resulting in a highly effective therapeutic effect. The polymer of the present invention has good biocompatibility and degradability, and is convenient to be excreted from the body; it overcomes the shortcomings of low drug delivery efficiency, less accumulation in tumor sites, low cell endocytosis efficiency, and slow intracellular release; and the method is simple to prepare , the source of raw materials is abundant, and the obtained nanomedicine has excellent freeze-drying redispersibility, which is conducive to large-scale production and application.