Preparation technology and product of paclitaxel freeze-dried powder
A preparation process, paclitaxel technology, applied in freeze-dried transportation, powder transportation, drug combination, etc., can solve the problems of paclitaxel freeze-dried powder particle size, complex process, etc., to avoid adverse reactions, simplify the preparation process, and reduce production costs Effect
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[0038] The preparation method of composition among the present invention comprises the following steps:
[0039] ① Weigh paclitaxel and mPEG-PLA-phenylalanine as raw materials according to different feeding ratios (see Table 1 for feeding ratios). Among them, paclitaxel (CAS 33069-62-4) is produced by Xi'an Ruilin Biotechnology Co., Ltd., with a purity greater than 95%, and mPEG-PLA-phenylalanine is produced by the inventor according to the process described in the patent number PCT-CN-2013000453 Self-prepared;
[0040] ②Put the above-mentioned raw materials into a container, and add organic solvents such as ethanol or acetonitrile at a temperature of 15-45°C until they are completely dissolved. The dissolving process can adopt means such as stirring or shaking.
[0041] ③ Rotate the above solution at 30-50°C for 2 hours until the organic solvent evaporates to dryness. Then vacuum drying at 10-40° C. for > 12 hours to remove residual organic solvents to obtain a paclitaxel-...
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