The invention belongs to the field of
organic chemistry, and particularly relates to a method for preparing a
bipyridine derivative with substituted multiple functional groups. The method includes mixing halogenated
pyridine derivatives and activated
copper powder with one another to obtain first mixtures, carrying out
reflux cooling, adding
ammonia water into the first mixtures to obtain second mixtures, filtering, abstracting and extracting the second mixtures, combining organic phases with one another,
drying the organic phases, and carrying out chromatographic purification by the aid of silica columns to obtain the
bipyridine derivative (shown as a formula I) with the substituted multiple functional groups; dissolving products shown as the formula I in
methanol, sequentially adding
ferric trichloride and
activated carbon into the
methanol to obtain third mixtures and carrying out heating
reflux for 10 minutes; adding hydrazine
hydrate into the third mixtures to obtain fourth mixtures, carrying out
reflux, filtering the fourth mixtures while the fourth mixtures are hot, washing the fourth mixtures, combining organic phases with one another,
drying the organic phases and carrying out chromatographic purification by the aid of silica columns to obtain products shown as a formula II. The method has the advantages that
coupling reaction is carried out under the
catalytic effect of
copper, and accordingly the
bipyridine derivative with the substituted multiple functional groups can be efficiently synthesized; the method is simple and is important supplement to existing
pyridine coupling reaction, and the obtained bipyridine derivative with substituted
electron withdrawing groups further can be converted into a bipyridine derivative with substituted
electron donating group amino.