The invention discloses a preparation method of a pressure-resistant aerated brick, and belongs to the technical field of building materials. The preparation method comprises the following steps: sequentially weighing fluorite slag powder, cement, gypsum, modified mixed powder, pretreated vitrified micro beads, mixed nano powder, aluminum powder, sepiolite, graphite oxide, talcum powder, calcium stearate, sodium stearate, a dispersing agent and water according to weight parts, calcining the fluorite slag powder to obtain pretreated fluorite slag powder, mixing the pretreated fluorite slag powder with the gypsum, adding water, carrying out stirring and mixing to obtain pretreated mixed slurry, mixing the pretreated mixed slurry with the cement, adding the modified mixed powder, the pretreated vitrified micro beads, the mixed nano powder, the aluminum powder, the sepiolite, the graphite oxide, the talcum powder, the calcium stearate, the sodium stearate and the dispersing agent, carryingout stirring and mixing to obtain mixed slurry, carrying out moulding by casting on the mixed slurry, carrying out pre-curing and demoulding to obtain a blank, and carrying out autoclaved curing on the blank to obtain the pressure-resistant aerated brick. The pressure-resistant aerated brick obtained by the preparation method provided by the invention has excellent pressure resistance.