Preparation method of polyurethane foam dressing and wound dressing patch

A technology of wound dressing and polyurethane, which is applied in the medical field, can solve the problem of insufficient moisture regulation ability of wounds and normal skin, and achieve the effect of accelerating the healing speed

Pending Publication Date: 2021-12-17
昆山优瑞森医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the manufacturing process of the existing self-adhesive silicone foam dressing patch needs to form a polysiloxane coating on the polyurethane foam, and it and the existing polyurethane dressing patch are not ideal for the moisture regulation ability of the wound and normal skin. Requires frequent debridement and dressing changes

Method used

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  • Preparation method of polyurethane foam dressing and wound dressing patch
  • Preparation method of polyurethane foam dressing and wound dressing patch

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preparation example Construction

[0020] The preparation method of polyurethane foam dressing, comprises the steps:

[0021] Step A: mixing and stirring the hydrophobic polyol with a molar ratio of 1:3 to 1:8 and the hydrophilic diisocyanate, and reacting to obtain a prepolymer containing 3 to 6 isocyanate groups;

[0022] Step B: the prepolymer obtained in step A, hydrophilic polyether polyol, foaming agent, end-capping agent, strengthening agent and catalyst are 1:(0.5-2):(0.2-0.8) in molar ratio :(0.2-0.8):(0.2-0.8) Mix and stir, react to form polyurethane foam dressing.

[0023] On the basis of the above, the hydrophobic polyol is prepared by the following steps:

[0024] Step a1: mixing and stirring the branched trihydric alcohol with a molar ratio of 1:2 to 1:5 and the first diisocyanate to obtain a triisocyanate intermediate;

[0025] The branched trihydric alcohol can be 1,1,1-trimethylolpropane (trimethylolpropane), triethanolamine, glycerin, 1,2,6-hexanetriol, 1,2,4-butanetriol, Polyoxyethyl glyce...

Embodiment 1

[0037] Step a1: In a closed nitrogen environment, mix 1,1,1-trimethylolpropane (TMP) and hexamethylene diisocyanate (HDI) at a molar ratio of 1:3, and add 0.05wt% Triethylenediamine (triethylenediamine, TEDA) (with the total weight of TMP and HDI as 100wt%) was used as a catalyst, stirred and reacted at 80°C for 90min, and the presence of the NCO characteristic peak at 2270cm-1 was monitored by FT-IR. To obtain triisocyanate intermediates;

[0038] Step a2: In a closed nitrogen environment, mix the triisocyanate intermediate with polypropylene glycol triol (PPG4000triol) at a molar ratio of 1:3, and add 0.05wt% TEDA (based on the total of the triisocyanate and PPG triol) Weight is 100wt%) as catalyzer, stirred and reacted 90min in 80 ℃, utilized FT-IR to monitor the disappearance of the NCO characteristic peak at 2270cm-1 place, to obtain the hydrophobic hexahydric alcohol containing polypropylene glycol;

[0039] Step b: In a closed nitrogen environment, mix polyethylene gly...

Embodiment 2

[0044]Step a1: In an airtight nitrogen atmosphere, mix triethanolamine and methylene dicyclohexyl diisocyanate (H12MDI) at a molar ratio of 1:4, and add 0.05wt% triethylenediamine (triethylenediamine , TEDA) (with the total weight of TMP and HDI as 100wt%) as a catalyst, stirred and reacted at 70°C for 100min, and used FT-IR to monitor the presence of the NCO characteristic peak at 2270cm-1 to obtain a triisocyanate intermediate ;

[0045] Step a2: In a closed nitrogen environment, mix the triisocyanate intermediate with poly(tetramethylene ether)glycol triol] at a molar ratio of 1:2, and add 0.05wt %TEDA (with the total weight of the triisocyanate and PPG triol as 100wt%) was used as a catalyst, stirred and reacted at 70°C for 100min, and used FT-IR to monitor the disappearance of the NCO characteristic peak at 2270cm-1 to obtain poly Hydrophobic hexaol of propylene glycol;

[0046] Step b: In an airtight nitrogen environment, mix polyethylene glycol (PEG 1000diol) with met...

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Abstract

The invention discloses a preparation method of a polyurethane foam dressing and a wound dressing patch, and relates to the medical field. The preparation method of the polyurethane foam dressing comprises the following steps: the step A, mixing and stirring hydrophobic polyol and hydrophilic diisocyanate according to a molar ratio of 1: 3-1: 8, and reacting to obtain a prepolymer containing 3-6 isocyanate groups; and the step B, mixing and stirring the prepolymer obtained in the step A, hydrophilic polyether polyol, a foaming agent, an end-capping reagent, an enhancer and a catalyst according to a molar ratio of 1: (0.5-2): (0.2-0.8): (0.2-0.8): (0.2-0.8), and reacting to form the polyurethane foam dressing. The wound dressing patch comprises a waterproof breathable film, a polyurethane foam dressing and an adhesion layer, and the waterproof breathable film is adhered to the polyurethane foam dressing through the adhesion layer. According to the invention, formation of tiny gaps through which water and gas can penetrate is facilitated, moisture of a wound and normal skin can be fully adjusted, and the wound healing speed is accelerated.

Description

technical field [0001] The invention relates to the medical field, in particular to a preparation method of a polyurethane foam dressing and a wound dressing patch. Background technique [0002] Existing self-adhesive silicone foam dressing patches or polyurethane dressing patches used to cover wounds have a fixed and supportive effect on the wound, and are waterproof and have a good moisturizing effect. [0003] However, the manufacturing process of the existing self-adhesive silicone foam dressing patch needs to form a polysiloxane coating on the polyurethane foam, and it and the existing polyurethane dressing patch are not ideal for the moisture regulation ability of the wound and normal skin. Frequent debridement and dressing changes are required. Contents of the invention [0004] The technical problem to be solved by the present invention is to provide a preparation method of polyurethane foam dressing and wound dressing patch which can fully adjust the moisture of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/10C08G18/48C08G18/78C08J9/08A61L15/26A61L15/42C08G101/00
CPCC08G18/10C08G18/4833C08G18/7843A61L15/425A61L15/26A61L15/42C08L75/08C08G18/48C08G2110/00C08G18/12C09D175/04C09J175/04C08G18/3203C08G18/735C08G18/4841C08G18/289C08G18/66C08G18/20C08G18/246A61F13/0203A61F2013/00855A61F2013/00336A61F2013/00659A61F2013/530802C08G18/73B32B2535/00C08G18/6677C08G18/4829C08G18/3206C08G18/302C08G18/14C08G18/244C08G18/2063A61F13/00B32B7/12B32B27/065B32B27/40B32B2266/0278B32B2307/7265B32B2307/724C08G18/6692C08G2110/0083
Inventor 陈思贤陈敬伦陈盈珊张腊梅
Owner 昆山优瑞森医疗科技有限公司
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