102 results about "Molecular aggregation" patented technology

A method and formulation are provided for the treatment of medical conditions associated with the formation and / or deposition of macromolecular aggregates, particularly those associated with adverse ocular conditions. The formulation contains a non-cytotoxic chelating agent containing at least three negatively charged chelating atoms and a charge-masking agent containing at least one polar group and having a molecular weight of less than about 250, wherein the polar group contains at least one and preferably at least two heteroatoms having a Pauling electronegativity greater than about 3.00, and further wherein the molar ratio of the charge-masking agent to the chelating agent is sufficient to ensure that substantially all negatively charged chelating atoms are associated with a heteroatom on the charge-masking agent.

An ink jet ink is disclosed which includes water, a water-soluble organic solvent and a coloring material and has excellent properties. The coloring material is a specific phthalocyanine derivative and is contained in a specific amount in the ink. The water-soluble organic solvent includes a specific amount of 2-pyrrolidone. In addition, a d75 value is in a specific range where the d75 value corresponds to 75% of a dispersion distance distribution, measured by a small angle X-ray scattering method, of molecular aggregates in the ink jet ink whose coloring material concentration is adjusted to 0.5 mass %.

The invention discloses a preparation method of a double-sensitivity cyclodextrin supermolecule aggregate, belonging to the technical field of functional materials. The preparation method comprises the following steps of preparing a host molecule-photosensitive 4-hydroxycinnamic acid-cyclodextrin (4HCA-CD) by using 4-hydroxycinnamic acid (4HCA) to modify beta-cyclodextrin (beta-CD); using trithioester with adamantine (AD) at tail end as a chain transfer agent, and preparing temperature-sensitive object polymer-double-arm adamantine-poly(N-isopropyl acrylamide)-adamantine (AD-PNIPAM-AD) by using a reversible addition-fragmentation chain transfer free radical polymerization (RAFT) method; constructing a double-sensitivity supermolecule inclusion complex 4HCA-CD / AD-PNIPAM-AD by utilizing comprehensive performance of a beta-CD dewatering cavity and AD; and self-assembling the 4HCA-CD / AD-PNIPAM-AD to form the supermolecule aggregate which is capable of realizing reversible conversion in shape and size by changing light and temperature. The supermolecule aggregate prepared by the preparation method disclosed by the invention has good light / temperature double sensitivities and is capable of carrying out smart response onto external stimulus, so that the supermolecule aggregate has a wide application prospect in the fields of drug loading, controlled release, and the like.

A method of preparing low water-soluble medicine into solid nanometer pharmaceutical formulation is disclosed. According to the characters of molecular aggregates such as supramolecular chemical micelles and vesicles, the formulation, which based on the hydroxypropyl-beta-cyclodextrin and phospholipid, is prepared under the condition of hyperthermia sterilization and decompression. Such nanometer formulation is sterile particle or powder with loose porosity. For directly intravenous use, the formulation has targeting activity, sustained release and long circulating characters. While as a solid oral product, it is fast-release, fast-effective, and improved bioavailability characters, and is readily melted in mouth. The formulation utilizes secure accessories, traditional equipments and methods, thus, it is suited to be used and manufactured widely. Also disclosed is intravenous formulation of anticancer paclitaxel, which characterized that there has no polyoxyethylenated castor oil in it. Such intravenous formulation is nonallergic so that it has higher security and efficiency compared to present commercially available paclitaxel formulations.

The present invention provides a silicon compound represented by Formula (1) and a polymer obtained by using the same, and this makes it possible not only to obtain an organic-inorganic composite material having a distinct structure but also to control the structure of the above polymer as a molecular aggregate. wherein R1 is a group independently selected from hydrogen, alkyl having a carbon atom number of 1 to 40, substituted or non-substituted aryl and substituted or non-substituted arylalkyl; in this alkyl having a carbon atom number of 1 to 40, optional hydrogens may be substituted with fluorine, and optional —CH2— may be substituted with —O—, —CH═CH—, cycloalkylene or cycloalkenylene; in alkylene in this arylalkyl, optional hydrogens may be substituted with fluorine, and optional —CH2— may be substituted with —O— or —CH═CH—; and A1 is a group having an α-haloester bond.

The invention provides a phenanthro-carbazole donor-acceptor organic dye and application thereof in a dye-sensitized solar cell, and belongs to the field of organic dyes. The organic dye utilizes the characteristics of phenanthro-carbazole structural units such as a large plane conjugated system and higher fluorescence quantum yield to be connected with the structural units with different electronic withdrawing abilities so as to realize step-by-step regulation and control to the dye molecular energy level; meanwhile, a molecular non-conjugated skeleton is connected with a long alkyl chain, so that the solubility of phenanthro-carbazole units is improved, the difficulty in molecular synthesis and device processing is reduced, and charge transfer among molecules caused by molecular aggregation is reduced; meanwhile, raw materials of phenanthro-carbazole compounds are abundant in source, low in price and easy to cut structurally.

The invention relates to a continuous large-scale production method for p-aramid nanofiber dispersion liquid, and belongs to the technical field of novel polymer materials. A proper aid is added in a process of generating poly-p-phenylene terephthamide (PPTA) through a reaction of p-phenylenediamine and paraphthaloyl chloride, so that the PPTA can directly generate nanofiber instead of random particles under control. Double screws are taken as a main reactor of PPTA polymerization, and an aid damaging molecular molecular aggregation of the PPTA is added into a PPTA polymerization system, so that successful proceeding of a PPTA polymerization process can be ensured on the one hand, interaction between the aid and the PPTA can be accelerated under the strong shear stirring action of a screw element on the other hand, and uniform nanofiber is formed instead of random particles by the PPTA. Moreover, a dispersing process of the nanofiber is finished directly in the screws under the shearing action of the double screws. The method is simple in equipment and is urgent in production links, major reaction and dispersion processes are finished in the double screws, and the production stability and continuity are enhanced greatly.

The invention relates to a blue-fluorescence material and an application thereof. The blue-fluorescence material and the application thereof start from the perspective of molecular design, tetraphenyl ethylene is taken as the core, and an electron-donating structure and an electron-withdrawing structure which are provided with anthryl groups are introduced to the two sides of a molecule. The tetraphenyl ethylene has the property of aggregation-induced emission, and the fluorescence quenching phenomenon produced by molecular aggregation can be effectively avoided; anthracene is a stable and efficient blue-fluorescence group, and the two anthracene structures are introduced, so that the number of chromophoric groups is increased, the relative molecular mass of the molecule is increased, the glass-transition temperature of the molecular is increased, and the heat stability of the molecule is enhanced. The D (electron-donating) group and the A (electron-withdrawing) group are introduced, transfer of electric charges inside the molecule can be effectively facilitated, and the luminescence property of the molecule is improved. Experiment results show that the blue-fluorescence material has good heat stability and electroluminescene properties, and when the blue-fluorescence material is used as luminescent layers of blue organic electroluminescence devices, blue-light with better color purity and emitting efficiency can be obtained.

The invention provides a pure blue light material of a conjugated branchlike molecular and an organic electroluminescence device by using the blue light material as an emitting layer. The blue light material of the invention is a conjugated branchlike molecule, which takes a trimeric indene as a nuclear and a trans 1, 2-stilbene as a bridge; the blue light material is obtained through Homer-Wadsworth-Emmons reaction or Wittig reaction of three phosphonate and single-aldehyde derivative of the trimeric indene; conjunction length and molecular weight of the material are rapidly increased, and emission of the pure blue light and film forming capability of the material are correspondingly regulated. Furthermore, the branchlike structure of the material and an replaced alkyl chain effectively reduce molecular aggregation, thereby obtaining high-purity blue light. By using the conjugated branchlike molecular as the emitting layer material of the organic electroluminescence diode device, the organic electroluminescence diode device can be prepared by simple spin coating process and membrane making; the invention can successfully emit the pure light, with good photoelectric stability.

The invention pertains to the technical field of organic and organometalic electro-active material, which more particularly relates to a hyperbranched polyfluorenes material comprising steric blockade and a preparation method thereof. The material introduces high blockade on the basis of hyperbranched polyfluorenes structure to distort considerately the synthesis molecular chain, thus efficiently inhibiting molecular aggregation, avoiding formation of excimer and fluorescence quenching, improving the material with luminous efficiency. As organic electro-active material with high inoxidability, thermal shock resistance and photostability, the material can be widely used in organic electronics industry such as organic / synthesis electroluminescent, photovoltaic cell, organic field-effect transistor and laser etc.

The invention discloses treatment equipment for treating blood-induced diseases. The treatment equipment comprises a first detection system for detecting the blood consistency and the temperature of blood led out of a body, a high-intensity narrow-spectrum (HINS) sterilization system used for killing bacteria and viruses in the blood detected by the first detection system, an ultrasonic decomposition system, a vacuum air exhaust system, a magnetization and energy-increasing system, a carbon monoxide input system, a temperature control cancer killing system and a second detection system. The treatment equipment has the beneficial effects that the treatment equipment for treating the blood-induced diseases can be used for confronting with tumors and controlling the spreading of cancer cells, so that the purpose of enabling cancerous patients to live with cancers for long time is achieved; and the treatment equipment achieves the purpose of lowering the blood pressure through breaking molecular aggregation, lowering the blood viscosity, reducing the blood flow resistance, increasing the blood cell deformation force and reducing microcirculation disturbance. The treatment equipment has the advantages of rapidity, high efficiency, no side effect and low cost.

The invention relates to a water-soluble cationic biphenyl aromatic hydrocarbon as well as an inclusion compound and a preparation method thereof. The compound has a structural formula as shown in thedescription, wherein n is equal to 4-7. The inclusion compound is molecular aggregate formed by the steps: taking water-soluble cationic biphenyl [4] aromatic hydrocarbon as a macrocyclic host compound, taking an ATP molecule (Adenosine Triphosphate) as an individual guest molecule, enabling the ATP molecule to enter a cavity of the water-soluble cationic biphenyl [4] aromatic hydrocarbon, and forming the aggregate by virtue of electrostatic interaction and pi-pi interaction. A molar ratio of the water-soluble cationic biphenyl [4] aromatic hydrocarbon to the ATP molecule is 1 to 1. A bindingconstant measured by a thermostatic calorimetric titration experiment (ITC) experiment is (1.05+ / -0.07)*10<4>M<-1>. The method has the advantages of being simple in operation and mild in reaction conditions, improves the biological stability of the ATP, and provides a new thought for reducing multidrug resistance (MDR) produced by tumor cells to anticancer drugs.

Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.

The invention discloses a demodulation method in molecular communication. The demodulation method is characterized by comprising the following steps: assuming that an originating party adopts a time-slot on-off keying (OOK) method to represent a digital signal, judging whether a molecular concentration received in a time slot has an obvious rising process or not during the demodulation process, if the molecular concentration has the obvious rising process, demodulating the molecular concentration to be information bit '1', and otherwise demodulating to be information bit '0'. By adopting the demodulation method, the defect of unreliability caused by demodulation by virtue of detection of the molecular concentration can be overcome; and moreover, the molecular concentration only needs to be sampled in a period of time after the beginning of each time slot rather than in the whole time slot, so that the calculation burden of the demodulation algorithm is alleviated. Meanwhile, the technical scheme is realized according to a variation rate of the molecular concentration, so that the influence of the intersymbol interference caused by a molecular aggregation problem on a demodulation result can be effectively alleviated, the reliability of the demodulation algorithm is improved, and the demodulation method is generally suitable for demodulating information in the molecular communication based on a diffusion way.

The invention discloses a cetirizine hydrochloride oral solution, which comprises cetirizine hydrochloride, mannitol, hydroxy propyl cellulose and water. The oral solution provided by the invention effectively covers up the strong titter taste of the active component cetirizine, obviously improves the stability of the oral solution, effectively reduces the chemical degradation and the toxic or side effects of the cetirizine, reduces the molecular aggregation phenomenon of the active component, reduces the using risk and improves the medicine safety.

The invention relates to the technical field of silane coupling agents, in particular to a fluorine-containing silane coupling agent and a preparation method thereof. A formula of the fluorine-containing silane coupling agent comprises the following components in percentage by weight: 98-99 percent of silane coupling agent, 0.001-0.09 percent of fluorine surfactant and 0.01-1.91 percent of catalyst. A liquid prescription of the fluorine-containing silane coupling agent comprises the following components in percentage by weight: 0.5 percent of silane coupling agent, 0.01 percent of fluorine surfactant and 99.49 percent of water. Compared with the prior art, as the adopted fluorine surfactant is resistant to acid, base and high temperature, and the surface tension of a water solution of the fluorine-containing silane coupling agent is generally lower than 20mN / m, the invention can avoid molecular aggregation in a hydrating solution of the silane coupling agent, increase the stability and the permeability of inorganic materials, promote the homogeneity of the silane coupling agent due to low surface tension and further reduce the using amount.

The present invention relates to stable liquid pharmaceutical compositions of curcumin or its pharmaceutically acceptable salts or its derivatives with higher curcumin concentration and improved bioavailability without the use of buffer and / or molecular aggregation inhibitor(s). In accordance with present invention the curcumin is in the solubilized form to make a stable liquid pharmaceutical composition.

The disclosure relates to a pH-induced drug sustained-release deoxyribonucleic acid (DNA) nanostructure as well as a preparation method and application thereof. Long single-stranded DNA is synthesizedby using a rolling circle amplification technology, and is complemented and hybridized with G and C-rich DNA single strand (loading strand) so as to obtain DNA molecular aggregates with alternating single and double strands; the DNA molecular aggregates can carry a large amount of Dox. When the pH of the system decreases, the rolling circle amplification product is folded to form a triple helix configuration, the double strands of the DNA molecule aggregates are melted, the G and C-rich DNA single strand is released, and the inserted Dox is also released, so that the drug release is completed. The reversible intercalation and release of the Dox can be achieved by adjusting the pH. The method utilizes the DNA nanostructure with good biocompatibility as a drug carrier to increase the drug loading amount, and has the advantages of being low in cost, simple to operate, high in sensitivity to pH response, rapid in response, and the like.

The invention discloses a triazine compound containing a fluorene structure and an organic luminous device thereof and relates to the technical field of organic optoelectronic materials. On the one hand, triazine group structures are stable and have high glass transition temperature, high electronic mobility and a low energy level, fluorene groups are three-dimensional spatial structures and can effectively prevent molecular aggregation and inhibit crystallization of molecules, and by means of the advantages of the fluorene groups that the fluorene groups are easy to modify and high in rigidness, the structure of the compound is stable. On the other hand, the triazine groups are combined with the fluorene groups and connected with the fluorene groups through benzene rings or biphenyl rings, conjugated systems are increased, continuous pi-conjugated systems bring great electronic mobility, and therefore high electronic mobility is achieved. Moreover, through the combination of the two kinds of groups, transmission of carriers is balanced. By applying the compound in the organic luminous device to serve as an electronic transmission layer or a cavity blocking layer for use, the device has the advantages that the driving voltage is low and the luminous efficiency is high, and is superior to existing frequently-used OLED devices.

The invention relates to a pyrene D-pi-A type asymmetric disc dye compound, and a preparation method of a pyrene derivative material. A length-controllable flexible chain of the asymmetric pyrene derivative material serves as a donator (alkyl or alkoxy phenylacetylene and bis-alkylaniline), and a carboxy side chain serves as a receptor (benzoic acid or iso-cyanoacrylate). The prominent advantages of the pyrene disc compound applied to a dye-sensitized solar cell are simple synthesis and separation, low cost, better photoelectric conversion efficiency, and the like. In addition, electron-withdrawing and electron-donating groups are added through a coupled reaction to form the asymmetric D-pi-A type disc dye compound, and the problem of efficiency reduction caused by dye molecular aggregation is solved by controlling positions of the electron-withdrawing and electron-donating groups. The compound has very high ultraviolet absorption and photoelectric conversion efficiency, and has a wide application prospect in organic-dye-sensitized solar cells.

The invention discloses an organic light-emitting molecule and application thereof in an organic light-emitting diode. The molecule has the characteristics of wide band gap, high fluorescence quantumyield, high electron mobility, high hole mobility, high exciton utilization rate, and the like. The molecule has an asymmetric structure, and can inhibit molecular aggregation and reduce exciton quenching. In addition, the emission spectrum can be adjusted by changing the connection sites of two units. The organic light-emitting molecule can be used for preparing high-efficiency blue light organiclight-emitting devices with different emission wavelengths.

The invention discloses an organic nanomaterial based on spirofluorene-xanthrene mono-substituted carbazole, a preparation method and application thereof. The organic nanomaterial is prepared by adding a surfactant to the compound SFX-2-Cz, SFX-3'-Cz, or SFX-2'-Cz. The structural formulas of the compounds SFX-2-Cz, SFX-3'-Cz and SFX-2'-Cz are shown as the specification. The nano-structure preparedaccording to the invention has the advantages of regular structural morphology and uniform size, realizes controllable preparation of one-dimensional to two-dimensional organic nanostructures. Corresponding photoluminescence characterization means proves that the optical properties of the organic nanomaterial are strongly dependent on the molecular structure and molecular aggregation mode. The invention shows the application potential of the organic semiconductor materials in future optoelectronic devices.

Disclosed is a macromolecule-crystal forming apparatus and method capable of obtaining a macromolecule crystal in a simplified and efficient manner. The device comprises a first container containing a sample of macromolecule, a second container containing a gel acting as a buffer material during the crystallization of the macromolecule, and a third container containing a precipitant solution having a function of facilitating the aggregation of molecules during the crystallization of the macromolecule. These containers are connected together in a given manner so as to allow the macromolecule sample and the precipitant to be brought into contact with one another through the gel to induce the crystallization of the macromolecule.

The present invention relates to a beverage including dissolved and partially dissociated carbon dioxide present in an amount of 2-10 g / liter, such as 3-8 g / liter, preferably 4-6 g / liter, most preferably about 5.5 g / liter and establishing an equilibrium pressure at 10° C. of 0.5-3 bar above atmospheric pressure, such as 1-2 bar, preferably about 1.5 bar. The present inventions further relates to a water insoluble or hydrophobic constituent present in molecular form or in molecular aggregated form and in an amount capable of generating ultra fine bubbles including gaseous carbon dioxide. The ultra fine bubbles are present in an amount exceeding 1010 ultra fine bubbles per milliliter, such as 1012-1018 ultra fine bubbles per milliliter, preferably 1015-1017 ultra fine bubbles per milliliter, most preferably about 1016 ultra fine bubbles per milliliter, when the beverage is exposed to an external isostatic pressure exceeding the equilibrium pressure of the beverage by at least 1.0 bar, preferably 1.2-60 bar, more preferably 1.5-10 bar, most preferably about 2 bar, the ultra fine bubbles having a major dimension smaller than 100 nm, such as 20-60 nm, preferably about 40 nm.

A cleanliness monitor for monitoring a cleanliness of a vacuum chamber. The cleanliness monitor may include a mass spectrometer, a molecule aggregation and release unit and an analyzer. The molecule aggregation and release unit is configured to (a) aggregate, during an aggregation period, organic molecules that are present in the vacuum chamber and (b) induce, during a release period, a release of a subset of the organic molecules towards the mass spectrometer. The mass spectrometer is configured to monitor an environment within the vacuum chamber and to generate detection signals indicative of a content of the environment; wherein a first subset of the detection signals is indicative of a presence of the subset of the organic molecules. The analyzer is configured to determine the cleanliness of the vacuum chamber based on the detection signals.

The invention discloses a synthesis of anionic rare earth complex [RE(III) (DBM) 3bath] (wherein, RE is Eu, Tb, Dy and other rare earth ions; DBM (dibenzoylmethane) is a first ligand; bath (bathophenanthrolinedisulfonic acid disodium salt trihydrate) is a second ligand) which belongs to the field of luminescent material and hydrotalcite composite luminescent ultra slim membrane and preparation method thereof. The concrete steps are as follows: preparing an anionic rare earth organic complex; preparing a hydrotalcite colloidal solution; preparing a rare earth organic complex aqueous solution; assembling substrates after hydrophilic treatment in two solutions alternatively. The invention employs rigid structure of the hydrotalcite layer plate and confinement effect of two dimension space, thereby realizing immobilization of rare earth complex and ordered arrangement on molecule scale, improving homogeneity and continuity of rare earth complex membrane, and reducing fluorescence quenching generated by molecular aggregation between complexes; the membrane preparation process is easy to operate, and accurate controls of luminous intensity of the rare earth complex in the membrane and the membrane thickness can be realized by changing assembling frequencies.

The invention discloses a kind of isoquinolyl triarylated amine cyclic metal complexes and their applications in electroluminescent devices. The isoquinolyl triarylated amine cyclic metal ligand can not only adjust hole injection and transmission performance of metal complexes, but inhibit molecular aggregation and concentration quenching of cyclic metal complexes due to the non-planar structure of triarylated amine. Therefore, metal iridium complexes and platinum ring metal complexes with isoquinolyl triarylated amine as the cyclic metal ligands can improve photoelectric performance, and can be used as red luminescent materials in polymer electroluminescent devices, achieving efficient luminescence.

A large part of conventional organic-inorganic composite materials is obtained by mechanical blending silsesquioxanes with organic polymers, and therefore it has been very difficult to control the structure thereof as the molecular aggregate of the composite materials. An object of the present invention is to provide a novel silicon compound having a living radical polymerization-initiating ability for an addition-polymerizable monomer and a polymer obtained using the same to thereby solve the problem described above regarding the conventional organic-inorganic composite materials. The present inventors have found that a novel silsesquioxane derivative to which a group having an ability to initiate polymerization of a monomer is useful as means for solving the problem described above. That is, the silsesquioxane derivative of the present invention is represented by Formula (1):wherein R1 is hydrogen, alkyl, aryl or arylalkyl; R2 and R3 are alkyl, phenyl or cyclohexyl; and A is a group having an ability to initiate polymerization of a monomer.

The invention discloses a bridged-ring dithiophene-phenothiazine dye and application thereof in a dye-sensitized solar cell. The bridged-ring dithiophene-phenothiazine dye is a pure organic dye by taking phenothiazine as an electron donor, wherein the phenothiazine electron donor is introduced into bridged-ring dithiophene as an extra electron donor, and the bridged-ring dithiophene is 2,2'-bithiophene wrapped with a cyclic alkyl chain, has relatively high steric hindrance, is beneficial to improving of the optical and electrical properties of the dye and has the effects of inhibiting dye molecular aggregation and electron recombination; and meanwhile, cyanoacetic acid groups are introduced as an electron acceptor and anchored groups. The dye is applied to a working electrode of the dye-sensitized solar cell as a sensitizer, constructs a dense layer on the surface of nanometer titanium dioxide of the working electrode, covers the surface of titanium dioxide, can effectively inhibit electron recombination, increases an open circuit voltage and thus effectively improving the optical and electrical properties of the dye-sensitized solar cell.