The invention discloses an explosion-proof sentry box, which is composed of a framework, a top board, an explosion-proof composite glass wallboard, an explosion-proof composite glass door and a floor; the explosion-proof composite glass wallboard consists of a bulletproof composite transparent glass, a polycarbonate transparent board, interlayer transparent glass, a molecular sieve rack, a molecular sieve, double-sided sponge adhesive tapes, sealing agent and a U-shaped clamping groove, wherein the framework is formed by welding section steels and is provided with a plurality of screw holes, a hinge base connected with the explosion-proof composite glass door, a steel.-made plane bonded with the periphery of the explosion-proof composite glass wallboard and screw holes connected with the floor, the top board is composed of three layers of galvanized iron boards arranged in a parallel, superposed and combined manner, the peripheries of hollow cavities between corresponding planes in the top board are provided with steel square tubes, and a steel board of each plane is fastened with the steel square tube via a sunk head rivet. The explosion-proof sentry box can be extensively applied to important places, such as military base, scientific research site, prison, customs, frontier, etc., and public security places, and lives and properties of staff on duty can be effectively protected by using multi-layer composite glass.