The invention relates to a nano-whisker-reinforced multifunctional diatom ooze coating. The nano-whisker-reinforced multifunctional diatom ooze coating is characterized in that 30 to 65wt% of diatomite, 0.5 to 2.5wt% of tetrapod-like nano-zinc oxide whiskers, 10 to 16wt% of superfine magnesium hydroxide, 5 to 15wt% of at least one crystalline aluminum salt, 10 to 40wt% of quartz sand, 0.5 to 1.5wt% of hydroxyethyl cellulose, 2 to 4.2wt% of one or two inorganic pigments and 0.5 to 3wt% of calcium hydroxide are mixed into the nano-whisker-reinforced multifunctional diatom ooze coating at a rotation rate of 500 to 800rpm. The nano-whisker-reinforced multifunctional diatom ooze coating has functions of resisting mildew and bacteria, purifying air in a room, and adjusting humidity. Compared with like products obtained by the existing technology, the nano-whisker-reinforced multifunctional diatom ooze coating has the advantages of strong adhesion to a wall surface, good durability, no falling-off of powder, no color fading and no cracking and falling-off, and is suitable for build interior decoration of airports, hospitals, office buildings, conference centers, hotels, villas, high-grade residential areas and entertainment places, and inner wall decoration of public places having forced flame-resistance requirements.