The invention discloses a method for preparing glycyrrhizic acid derivatives by carrying out a subcritical
hydrolysis reaction and belongs to the technical field of
biochemical engineering. Glycyrrhizic acid or liquorice extract is taken as a
raw material, and glycyrrhetinic acid and glycyrrhetinic acid 3-O-
glucuronide are prepared by carrying out the subcritical
hydrolysis reaction. The method for preparing the glycyrrhizic acid derivatives by carrying out the subcritical
hydrolysis reaction comprises the following steps: firstly dissolving raw materials to obtain a glycyrrhizic acid solution, then carrying out the subcritical hydrolysis reaction to prepare a reaction liquid, and centrifuging, separating, concentrating or redissolving and
drying the reaction liquid, so that glycyrrhetinic acid 3-O-
glucuronide and glycyrrhetinic acid are obtained. The method for preparing the glycyrrhizic acid derivatives by carrying out the subcritical hydrolysis reaction has the advantages that a preparation technology is scientific and reasonable, operation is simple and feasible, cost is low,
continuous production can be realized, and the glycyrrhizic
acid derivative products are easy to popularize and have a higher additional value; the amount of acid added in a preparation process is little, no destructive effect is produced to a structure of glycyrrhizic acid, product yield is high, and no
pollution to the environment is produced; and the glycyrrhizic
acid derivative products can be taken as a
food additive and a
medicine precursor substance and raw materials are provided for the food and pharmaceutical industries.