38results about How to "Large dosage" patented technology

The invention provides a compound shown in the formula I in the specification and pharmaceutically acceptable salts of the compound, the preparation method of the compound and pharmaceutically acceptable salts of the compound and a medicine composition containing the compound shown in the formula I or the pharmaceutically acceptable salts of the compound. In the compound provided by the invention, each end group of the polyethylene glycol molecule is capable of bonding with a plurality of rapamycin molecules through cactus oligopeptide, and the medicine loading rate is improved. The compound can be used for inducing immunosuppression and treating transplant rejection, self-immune diseases, solid tumors, fungal infection and cardiovascular and cerebrovascular diseases.

The invention discloses a green biological active feed, which relates to the technical field of feeds. The green biological active feed is prepared from the following materials in part by weight: 40 to 80 parts of straw, 5 to 30 parts of corn four, 5 to 25 parts of cake dregs, 5 to 25 parts of wheat bran, 0.1 to 0.2 part of complex bacteria and 0.1 to 0.2 part of complex enzyme. During preparation, the straw is crushed and then is uniformly mixed with the corn flour, the cake dregs and the wheat bran; the complex bacteria and the complex enzyme are mixed into the mixture; water is added into the mixture to ensure that the water content reaches 45 to 50 percent, and the mixture is filled in a big tank, sealed and stored for later use; or the mixture is baked or dried by natural wind for storage and later use. The green biological active feed has the following advantages of: (1) improving the balance of intestinal flora, and improving the feed utilization rate; (2) promoting the growth of meat livestock and poultry, and shortening the breeding cycle; (3) strengthening the body conditions of laying hens, ducks and geese, and having a significant strengthening action on prolonging theegg-laying peak period; (4) strengthening the body condition of female domestic animals, and improving the yielding rate; (5) strengthening the body conditions of the livestock and poultry, enhancingthe disease prevention and disease resisting capacities, and reducing the sickness rate; and (6) purifying the culture environment, and improving the meat quality due to no public nuisances and no residues.

The invention relates to a use of PNAS-4 gene in aspects of preparing antineoplastic in the tumour gene treatment field. The invention with PNAS-4 recombinant vector can limit the growth and the migration of the endocytosis effectively, which can limit the growth of various tumors and extend the survive time of mouse. The antineoplastic of the invention with PNAS-4 recombinant vector liposome andchemotherapy drug cisplatin and magnolol as the active component has better effect than the single application and can reduce the usage of both parties. The product has the appreciable effect, the little toxic and side effect and the easy preparing method, which compensates the defect of protein infusion drug, increases the time interval of medicine, reduces the usage, reduces the economic burdenof the patient, improves the life quality of patient and has the wide market prospect.

The invention discloses a biology and chemistry coupled sludge conditioning method and belongs to the technical field of environment engineering. The invention aims to solve the problem that the conventional municipal sludge processing technology has the disadvantages of bad dehydration effect, high cost, and long period under a low temperature condition. The method comprises the following steps: mixing processed materials, returned sludge, and a mixed solution of medicament A in a contact area, carrying out reactions in a reaction area; returning part of mixed sludge to the contact area, mixing the other part of mixed sludge with a mixed solution of medicament B in next reaction area, and carrying out biochemical reactions. Two-point medicament addition technology is adopted, the addition amount of medicament is little, and the cost is low. The efficiency of biological reactions is high. The reaction period of biological acidification required by bioleaching is shortened by 25% or more. The sludge dehydration effect under a low temperature condition is improved. The water content of sludge is less than 60% after deep hydration at a temperature less than 10 DEG C and the sludge conditioning time is shorter than 36 hours. The provided method is beneficial for the subsequent recycling of dehydrated sludge and the treatment of press-filtered acidic liquid.

An indapamide sustained-release capsule and a preparation method thereof. It is composed of indapamide, slow-release materials and auxiliary materials in a weight ratio of 0.5-3.0:5-20:131-165 to form slow-release pellets with different release degrees. The slow-release materials are acrylic resin, hydroxyl Any one to four of propyl methylcellulose, ethyl cellulose, cellulose acetate phthalate and polyvinylpyrrolidone; the content of indapamide in a single capsule is 0.5-3.0 mg. The preparation method adopts the method of rolling into pellets. The capsule can maintain a balanced and long-lasting effective blood drug concentration within the same dosage and time interval, or reduce the dosage and reduce side effects while maintaining the same drug effect; especially it is a dispersed preparation, which can not only improve the The contact area of ​​the channel can make the drug absorb completely and have high bioavailability, and different combinations of pellets can be used to obtain the ideal drug release rate, and the cost is low. The adopted preparation method has simple process and is easy to operate and control.

The present invention involves a pressure supply device and drug storage core layer, which is suitable for external use and meridian skin administration.It has a negative pressure shell. On one side of the negative pressure shell is a closed shell equipped with a negative pressure exhaust port, and the other side is the open end. On one side of the open end of the negative pressure shell, at least one cross -section line is installed.For 0 to multiple concave types, the dating end or a cross -section line is 0 to multiple concave feed on the middle of the administration plate, and the cross -side side is equipped with an cross -section of 0 to multiple matching convex types.Drug storage core layer.The beneficial effect of the present invention is the increase in the surface area of the stratum corneum, thinning thickness, small skin damage, uniform pressure on dose, large administration, deep administration, large administration area, uniform distribution of administration, uniform distribution of administration, gradually improving, gradually given.Drug processes, low dose particle size requirements, large dosage range, low cost, and simple operation.

The invention discloses nano-drug carrier particles capable of controlling drug release. The particles have a core-shell structure, wherein a gold nano-cage (1) which is provided with a mesoporous surface and has a hollow structure is arranged in the innermost layer; a polymer PAH layer (2) carrying positive electricity is used for modifying the surface of the gold nano-cage (1); a pH sensitive lipid layer (3) is arranged on the outer surface coating layer of the polymer PAH layer (2). Under pH and light external excitation trigger, gating is switched from a 'closed' state to an 'open' state, and drug molecules are released. The carrier particles can be used for effectively improving the efficiency of cancer chemotherapy.