Sustained release high calcium formulation and preparation process thereof
A slow-release, high-calcium technology, applied in pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, and medical preparations with non-active ingredients, etc. Fully absorbed, easy to operate and control effects
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Embodiment 1
[0011] Based on 1000 slow-release high-calcium preparations, place 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully wetted; Mix 100g of calcium through a 100-mesh sieve, 20g of lactose through a 80-mesh sieve and 20g of starch powder through a 100-mesh sieve, and then add them to the above-mentioned granulator and process for 50 minutes to obtain the main drug granules with a smooth surface. After the completion, continue to spray 50% sucrose syrup, and add 8g of starch to wrap the main drug protective layer, and then dry the wrapped main drug granules in a vacuum drying oven at 80°C for 3 hours, or ordinary electric drying at 80°C Dry in the box for 6 hours; dissolve 10g of the acrylic resin slow-release material EUDRAGIT RS100 with an appropriate amount of 95% ethanol, and add 3 g of talcum powder, an auxiliary material for coating, into an appropriate amount of ...
Embodiment 2
[0013] Based on 1000 slow-release high-calcium preparations, place 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully wetted; 100g of calcium passed through a 100 mesh sieve, 15g of polyethylene glycol 6000 passed through a 80 mesh sieve and 13g of pregelatinized starch powder passed through a 100 mesh sieve were mixed evenly and added to the above-mentioned granulator for 50 minutes to obtain a smooth surface. Medicine granules, after the main medicine granules are wrapped, continue to spray 50% sucrose syrup, and add 5g of starch to wrap the main medicine protective layer, and then place the wrapped main medicine granules in a vacuum drying oven at 80°C to dry for 3 hours. Or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 8g of polyvinylpyrrolidone and 12g of hydroxypropyl methylcellulose with 5mL of water respectively with an appropriate amo...
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