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Method for preparing digitalis floating tablets and use thereof

A technology of gastric floating tablet and digitalis, which is applied in the new field of medicine, achieves the effect of simple method, good stability and increased curative effect

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Longer et al. used bioadhesion to combine chlorothiazide and albumin to make drug-containing albumin particles, which were mixed with polycarbomer (PCP, 3:7) particles and loaded into capsules. The in vivo dissolution showed that the capsules could be released continuously. Drug 8h, but release more than 60% within 2h

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: specification 1000 pieces

[0033] prescription:

[0034] Digitalis 0.1g

[0035] Hydroxypropyl-β-cyclodextrin 5g

[0036] Hydroxypropyl Methyl Cellulose K 4M 20g

[0037] Cetyl Alcohol 80g

[0038] Microcrystalline Cellulose 100g

[0039] Sodium bicarbonate 5g

[0040] Macrogol 4000 20g

[0041] Micronized silica gel 2g

[0042] Preparation method:

[0043] (1) Dissolve the prescribed amount of hydroxypropyl-β-cyclodextrin in 15ml of water

[0044] (2) After dissolving digitalis with 2ml of ethanol, add it into the hydroxypropyl-β-cyclodextrin solution while stirring, and stir at 60°C for 30 minutes.

[0045] (3) the hydroxypropyl methylcellulose K of prescription quantity4M , Cetyl Alcohol, Microcrystalline Cellulose, Sodium Bicarbonate, and Polyethylene Glycol are mixed evenly, and 80-mesh sieve is used for mixing

[0046] (4) Add (2) into (3), stir to make a sof...

Embodiment 2

[0048] Embodiment 2: specification 10000 pieces

[0049] prescription:

[0050] Digitalis 1g

[0051] Hydroxypropyl-β-cyclodextrin 50g

[0052] Hydroxypropyl Methyl Cellulose K 4M 200g

[0053] Cetyl Alcohol 800g

[0054] Microcrystalline Cellulose 1000g

[0055] Sodium bicarbonate 50g

[0056] Macrogol 4000 200g

[0057] Micronized silica gel 20g

[0058] Preparation method:

[0059] (1) Dissolve the prescribed amount of hydroxypropyl-β-cyclodextrin in 150ml of water

[0060] (2) After dissolving digitalis with 15ml of ethanol, add it into the hydroxypropyl-β-cyclodextrin solution while stirring, and stir at 60°C for 30 minutes.

[0061] (3) the hydroxypropyl methylcellulose K of prescription quantity 4M , Cetyl Alcohol, Microcrystalline Cellulose, Sodium Bicarbonate, and Polyethylene Glycol are mixed evenly, and 80-mesh sieve is used for mixing

[0062] (4) Add (2) in...

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PUM

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Abstract

The invention disclosed floating film stomach digitalis preparation method and its application, the invention of new technologies are the drug, involving a new form of digitalis for the treatment of congestive heart failure and certain arrhythmias such as atrial fibrillation, atrial flutter and paroxysmal tachycardia in preparation methods and pharmaceutical preparations. The characteristics of the new formulations is that the gastric floating tablet containing a wide range of hydrophilic polymer material, in contact with gastric fluid temperature, the surface water into a gel, by volume expansion. At this point the weight of tablets is less than the buoyancy gastric juice to pills floating on the gastric juice, gastric retention time has been extended. The present invention has been floating piece of digitalis stomach with a simple, good stability and high bioavailability, compared with the general formulations to reduce the side effects of drug characteristics.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of digitalis, which is used for treating congestive heart failure and certain arrhythmias, such as atrial fibrillation, atrial flutter and paroxysmal tachycardia and its preparation The method is specifically a preparation method and application of digitalis stomach floating tablets. Background technique [0002] Digitalis, the English name is Digitalis, alias: foxglove, digitalis leaf, also known as: poisonous herb, purple foxglove, bell flower. It is derived from the dry leaf powder of the plant Scrophulariaceae digitalis. The main ingredient is Digitoxin (Digitoxin, C 41 h 61 o 13 ) Hydroxydigoxigenin (Gitoxin, Gitoxin, C 41 h 64 o 13 )Wait. 1g potency should be equivalent to 10 digitalis units. Digitalis is a dark gray-green powder; it has a special flavor and a bitter taste. [0003] "Xinhua Compendium of Materia Medica": leaves: cardiotonic. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K31/7048A61K9/20A61K47/38A61P9/04A61P9/06A61K127/00
Inventor 王翰斌
Owner BEIJING HOPE HUGE PHARM SCI
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