Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Slow-released indapamide capsule and its prepn process

A technology for indapamide and sustained-release capsules, which is applied in the field of indapamide sustained-release capsules and its preparation, can solve the problems of unsuitable popularization, large side effects, and high price, and achieve shortened processing time, complete absorption, and low cost. cheap effect

Inactive Publication Date: 2004-01-21
TIANJIN GUOYAO BOHAI BIOMEDICAL
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the dosage that the patient takes every day is bigger, and the time is longer, thereby the side effect produced by medicine is also relatively bigger; And although the indapamide slow-release tablet that French Servier company produces can reduce the dosage of the patient and improve the bioavailability, but due to the high price of this imported drug, especially for domestic patients who need long-term medication, it is generally unaffordable, so it is not suitable for domestic promotion and use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Slow-released indapamide capsule and its prepn process
  • Slow-released indapamide capsule and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Based on 1000 indapamide sustained-release capsules, put 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully moistened. Wet; mix 1.5g of indapamide through a 100-mesh sieve, 20g of lactose through a 80-mesh sieve, and 20g of starch powder through a 100-mesh sieve, then add it to the above-mentioned granulator and process for 50 minutes to obtain the main ingredient with a smooth surface After the main drug granules are wrapped, continue to spray 50% sucrose syrup, and add 8g of starch to wrap the main drug protective layer, and then dry the wrapped main drug granules in a vacuum oven at 80°C for 3 hours, or Dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 10g of the acrylic resin sustained-release material EUDRAGIT RS100 with an appropriate amount of 95% ethanol, and add 3g of talcum powder, an auxiliary material for coating, into an approp...

Embodiment 2

[0015] Based on 1000 indapamide sustained-release capsules, put 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully moistened. Wet; mix 1.5g of indapamide passing through a 100-mesh sieve, 15g of polyethylene glycol 6000 passing through a 80-mesh sieve, and 13g of pregelatinized starch powder passing through a 100-mesh sieve and add it to the above-mentioned granulator for 50 minutes To obtain the main drug granules with smooth surface, after the main drug granules are wrapped, continue to spray 50% sucrose syrup, and add 5g of starch to wrap the main drug protective layer, and then place the wrapped main drug granules in a vacuum drying at 80°C Dry in an oven for 3 hours, or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 8g of polyvinylpyrrolidone with an appropriate amount of 95% ethanol and 12g of hydroxypropyl methylcellulose with 5mL of wat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The slow-released Indapamide capsule consists of Indapamide, slow-releasing material and supplementary material in the ratio of 0.5-3.0 to 5-20 to 131-165. The slow-releasing material is one to four of polyacrylic resin, hydroxypropyl methyl cellulose, ethyl cellulose, acetyl phthalate cellulose and PVP, and each capsule contains Indapamide in 0.5-3.0 mg. The slow-released Indapamide capsule may be prepared via rolling process. The preparation form of the present invention has lasting effective time, less side effect and high biological utilization, and through the different combination of the micro pellet, ideal release rate may be reached.

Description

technical field [0001] The invention relates to the field of medicine and its preparation, in particular to an indapamide sustained-release capsule capable of treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is a common and frequently-occurring disease with a high morbidity rate. If it is not treated properly or not treated in time, it may lead to serious complications and endanger the patient's physical and mental health, and even life-threatening. Indapamide is a new type of sulfonamide diuretic, which is mainly used clinically to treat hypertension. It has diuretic, calcium antagonism, anti-oxidation and elimination of free radicals, and can stimulate the synthesis and inhibition of prostaglandins with free vasodilation Pharmacological effects such as vasoconstriction. Most of the indapamide currently used clinically is a 2.5mg / tablet immediate-release tablet, and patients need to take it 1 to 3 times a day, and the cours...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/4045A61P9/12
Inventor 贾伟薛京杨恩久
Owner TIANJIN GUOYAO BOHAI BIOMEDICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com