The invention provides compound lidocaine nano-liposome gel and a preparation method thereof. The nano-liposome gel is prepared from the following raw materials: lidocaine hydrochloride, tetracaine hydrochloride, tetracaine base, lidocaine base, dyclonine hydrochloride, procaine hydrochloride, soyabean lecithin, cholesterol, xanthan gum, carbomer and sodium carboxymethyl cellulose. The preparationmethod of the nano-liposome gel comprises the following steps: S1, preparing raw materials; s2, mixing soyabean lecithin and cholesterol to obtain a mixture A; s3, dissolving carbomer to obtain a mixture B; and S4, adding lidocaine hydrochloride, tetracaine hydrochloride, dyclonine hydrochloride, procaine hydrochloride and the mixture B into the mixture A, performing stirring, adding tetracaine alkali and lidocaine alkali, performing cooling, adding xanthan gum and sodium carboxymethyl cellulose, performing stirring, and performing homogenizing to obtain the compound lidocaine nano-liposome gel. The nano-liposome gel provided by the invention is good in stability in a normal-temperature state and a low-temperature state.