76results about How to "Great development and application value" patented technology

The invention relates to a method for simultaneously preparing total caffeoylquinic acid and stevioside by taking stevia as a raw material. The method comprises the following steps that: the stevia is extracted with water or an organic solvent under the action of heating, microwave or ultrasound-assisting, and a stevioside and caffeoylquinic acid extraction liquid is obtained after solid-liquid separation, and then is subjected to extraction separation; and finally, a pure product of total steviol glycoside and total caffeoylquinic acid is obtained after purification. On the basis of the traditional stevia production process, a total caffeoylquinic acid extraction process is added, so that the two types of products, i.e., the stevioside and the total caffeoylquinic acid, can be simultaneously obtained by taking the stevia as the raw material, the raw material source of the total caffeoylquinic acid substance is broadened, and the two types of high-value-added products can be simultaneously produced by the same raw material, and thus the production costs of the two types of products can be greatly reduced, the waste of resources and the environmental pollution can be reduced, the requirements of the sustainable development strategy can be met, and the application prospect is good.

The invention relates to a preparation method for extracting general flavone from Chinese medicinal herbs, belonging to the technical field of plants. The preparation process comprises the following steps of: percolating and extracting dense cornel as a raw material by using aqueous ethanol as a solvent; flashing the extract, concentrating and recovering the solvent; separating and enriching the concentrated solution through macroporous resin columns, carrying out gradient elution with an aqueous solvent, mixing a certain proportion of aqueous solvent eluate, flashing, concentrating and recovering the solvent; and continuously drying in vacuum to form dry powder. The invention has the advantages of simple process, superior extraction and concentration methods, convenience for operation, environmental protection and high efficiency; the extractive contains 6.12-15.58 percent of general flavone, the extraction rate of the general flavone is up to 5.25-10.43 percent, and the transfer rate of the general flavone is up to 45.63-62.88 percent. Proved by primary in-vitro bioassay tests, the dense cornel general flavone extractive has certain activities, such as oxidation resistance, bacteriostasis, and the like, can be used as a food additive, an antioxidant, a preservative, and the like and has certain development and application values.

The invention relates to a high-iron, high-manganese and high-ammonia nitrogen underground water integral treatment apparatus and a method thereof, and belongs to the field of water supply purification. The problem of unable effective synergistic removal of iron, manganese and ammonia nitrogen of high-ammonia nitrogen underground water treatment, and the problems of low iron and manganese removal rate, long treatment process, long running cycle, complex running management and large investment due to unstable manganese removal when the ammonia nitrogen content is high are solved in the invention. The apparatus is composed of an underground water aeration tank, an integral two-stage filtration pot, an inlet water submersible pump, a filtration pot water inlet pipe, a filtration pot water outlet pipe, a backwashing pipe, a backwashing pump and a clear water tank. The method comprises the following steps: 1, starting a filter column; 2, culturing the filter column; and 3, carrying out an underground water treatment stage to complete efficient and stable purifying treatment of the high-iron, high-manganese and high-ammonia nitrogen underground water. The apparatus and the method have the advantages of simple process flow, small occupied area, strong impact resistance, low running cost, and high water yield; and the apparatus and the method allow the iron content, the manganese content and the ammonia nitrogen content of outlet water to be respectively reduced to 0.1mg / L, 0.05mg / L and 0.1mg / L or below.

The invention relates to an ibuprofen slow release solid composition and a preparation method thereof, in particular to a method for loading ibuprofen into a pore canal by using medicinal grade porous silicon dioxide and coating under the assistance of an acrylic resin. An ibuprofen slow release solid composition prepared with the method has remarkable in-vivo and in-vitro slow release effects; and the preparation method is simple, has high product yield and high repeatability, is easy for industrial production, and has a good development application value.

The invention discloses a beta-amino ketones compound with anti-diabetic activity, particularly the compound which has the general formula (I) as shown on the right or a pharmaceutically acceptable salt thereof. The invention can increase insulin sensitivity and / or decrease postprandial blood glucose level, and prevent and delay the outbreak and the development of diabetes mellitus and complications thereof, has simple preparation method, low cost and good potential application value and can be prepared to be anti-diabetic medicine for preventing and treating the diabetes mellitus.

The invention belongs to the technical field of medicine, and particularly relates to novel application of Plerixafor in preparation of drugs for treating or preventing diseases related to GSDMD protein. The affinity between Plerixafor and the human GSDMD protein is detected through an MST technology, and the effects of Plerixafor on the mortality of macrophages of humans and mice and secretion amount of IL-1 beta inflammatory factors and the control effect of Plerixafor on mouse EAE and mouse sepsis are evaluated through pharmacodynamic tests. It is shown that the mortality of macrophages ofhumans and mice can be reduced significantly by Plerixafor, secretion of the IL-1 beta inflammatory factors can be reduced, and Plerixafor has a high binding force on the human GSDMD protein; meanwhile, the symptoms of mouse EAE can be alleviated significantly, and the survival rate of sepsis model mice can be improved; and it is indicated that Plerixafor is a human GSDMD protein-targeting drug, the symptoms of MS and sepsis can be alleviated through prevention of cell pyrolysis and inflammatory factor release, and therefore Plerixafor can be used as novel and optional drugs for prevention ortreatment of MS, sepsis and other autoimmune diseases and infectious inflammatory diseases, and has a broad development and application value.

The invention discloses a troxerutin amide derivative as well as a synthetic method and use thereof, belonging to the medicinal chemistry field. The method comprises the step of respectively reacting troxerutin vinyl ester as a raw material with a 1,2,3,4-tetrahydroisoquinoline compound or phenylethylamine, 4-fluoro-phenylethylamine and a benzylamine compound at 40-70 DEG C in ionic liquid, so as to obtain the troxerutin amide derivative. The troxerutin amide derivative has anti-tumor activity. The ionic liquid simultaneously serving as a solvent and a catalyst is utilized for synthesizing the troxerutin amide derivative, so that reaction conditions are mild, the operation is simple, the synthetic cost is low, the yield is relatively high, and a new way is provided for the structural modification of flavonoid compounds.

The invention belongs to the field of biological pesticides, and discloses a sugarcane endogenous Bacillus amyloliquefaciens CGB15 strain and application thereof. The Bacillus amyloliquefaciens CGB15 strain was deposited in the Guangdong Microbial Culture Collection Center on October 17, 2019, with the preservation number GDMCC No: 60742. The preservation address is: 5th Floor, Building 59, Compound, No. 100 Xianlie Middle Road, Guangzhou City. The bacillus amyloliquefaciens CGB15 strain has a strong inhibitory effect on sugarcane whip smut, rice blast fungus, lychee perinospora, lychee anthracnose and banana wilt, and has excellent biological control effect. The preparation and use method of the microbial preparation obtained by the bacterial strain is simple, has broad-spectrum disease resistance, has little impact on the ecological environment, does not affect the quality of crops, and has excellent application prospects.

The invention belongs to the technical field of organic synthesis and particularly discloses a series of substituted azole penta-heterocyclic derivatives and a solvothermal one-pot synthesis method thereof. By the adoption of the solvothermal one-pot synthesis method for preparing the target product, reaction time is short, a solvent is not prone to volatilization in an airtight system, recycling can be realized, production cost is effectively reduced, the advantages of energy conservation and environment friendliness are achieved, operation is easy, yield is high, and the prepared substituted azole penta-heterocyclic derivatives have good anti-microbial biological activity and excellent photophysical properties such as electron conductivity, the fluorescence property and the ultraviolet property, thereby having very high development and application value.

The invention discloses a natural fruit and vegetable sterilizing fresh-keeping agent, preparation and a use method thereof, which belongs to the technical filed of sterilizing fresh-keeping agent. Every 1L sterilizing fresh-keeping agent comprises the following compositions by weight: 0.1 to 20 grams of grape seed extract, 1 to 50 milliliters of absolute ethyl alcohol, 0 to 0.5 milliliter of Tween-80, and the balance being sterilized water. The method for preparing the sterilizing fresh-keeping agent comprises the following steps: under the conditions of normal temperature and normal pressure, the grape seed extract, the absolute ethyl alcohol are added into the sterilized water, the Tween-80 is added to the mixed solution, and the sterilized water is added into the mixed solution for constant volume; and a glass rod is used for stirring the mixed solution uniformly to obtain the natural fruit and vegetable sterilizing fresh-keeping agent. The use method comprises the following steps: fruits and vegetables are soaked in the natural fruit and vegetable sterilizing fresh-keeping agent, or are soaked at negative pressure, and then the fruits and vegetables are taken out and are dried for further storage. The natural fruit and vegetable sterilizing fresh-keeping agent well solves the problems of rot and reduced quality after picking for the fruits and the vegetables, has low cost, and can effectively reduce use and residual quantity of chemical agents without causing environmental pollution, thereby having great value for development and application.

The invention relates to an ibuprofen slow release solid composition and a preparation method thereof, in particular to a method for loading ibuprofen into a pore canal by using medicinal grade porous silicon dioxide and coating under the assistance of an acrylic resin. An ibuprofen slow release solid composition prepared with the method has remarkable in-vivo and in-vitro slow release effects; and the preparation method is simple, has high product yield and high repeatability, is easy for industrial production, and has a good development application value.