83results about How to "Good amphipathy" patented technology

The invention discloses glycosylated boron dipyrromethene fluorophore derivatives as well as a preparation method and application of the glycosylated boron dipyrromethene fluorophore derivatives. The method comprises the following steps: by taking glucose and glucosides thereof as action targets, connecting covalent bonds of the action targets to boron dipyrromethene fluorophore derivatives for photodynamics therapy, so that a third generation photosensitizer against cancer which can be used for targeted therapy is obtained. The dipyrromethene fluorophore derivatives containing glucose and glucosides are taken as study researches, activity study of in-vitro breast cancer-resistant cells MBA-MD-231 is expanded, a prodrug suitable for molecular targeted therapy is screened, and a foundation is laid for applying the glycosylated boron dipyrromethene fluorophore derivatives to targeted therapy of cancers. Moreover, the compound synthesis method is simple, readily available in raw materials, low in cost, few in side reactions, high in yield and simple in purification, and industrial production is promoted.

The invention discloses a preparation method of ionic-type amphiphilic functionalized graphene.The preparation method includes the steps of subjecting expanded graphite to oxidation treatment by strong acid concentrated sulfuric acid, potassium permanganate and strong oxidizer-hydrogen peroxide according to a Hummers method so as to obtain oxidized graphene; performing silanization treatment, namely forming an Si-O-C bond between surface hydroxyl of the oxidized graphene and a high-activity silane coupling agent of an ionic structure; subjecting silanized oxidized graphene to reducing preparation, namely using a reducing agent reducing agent for reducing the silanized oxidized graphene, and reducing off oxygen-bearing groups such as epoxy, carbonyl and carboxyl, not participating in silanization reaction, on the surface of the silanized oxidized graphene so as to obtain silanized graphene; performing ion exchange, namely subjecting anionic surfactants and anions on the surface of the silanized graphene to ion exchange so as to obtain final functionalized graphene.High-quality uniformity and stripping dispersion of the ionic-type amphiphilic functionalized graphene with high dispersion stability in composites can be improved beneficially.

The invention discloses an axially substitutive silicon phthalocyanine complex and a doxorubicin conjugate thereof and a preparation method and application of the axially substitutive silicon phthalocyanine complex and the doxorubicin conjugate thereof, and belongs to the technical field of photosensitizer and drug preparation.The complex can be prepared into a novel efficient photodynamic drug or photosensitizer, and the complex and doxorubicin can be prepared into the silicon phthalocyanine-doxorubicin conjugate.The coupling agent has both a photodynamic therapy effect and a chemotherapy effect and can be prepared into a novel anti-cancer drug.

The invention discloses a polysulfo-functionalized heteropolyacid ionic hybrid with multiple heteropolyacid negative ions as well as a preparation method and an application thereof. Two ionic hybrids with novel structures are built by taking aliphatic polyamine, 1,4-butanesultone, phosphotungstic acid and silicotungstic acid as starting materials and carrying out two steps of atomic economic reaction through quaternization and acidification. Positive ions of the ionic hybrid comprise four or three bissulfo-functionalized long-chain quaternary ammonium positive ions; negative ions matched with the positive ions comprise three Keggin configuration silicotungstic acid negative ions or two Keggin configuration phosphotungstic acid negative ions; the prepared ionic hybrid can be used for preparing cyclohexyl carboxylate. The ionic hybrid has high acid strength and high acid content; the ionic hybrid also shows high amphipathy, so the reaction between substrate cyclohexene and organic carboxylic acid is facilitated; the ionic hybrid has the characteristics of atom economy, mild reaction condition, no backflow water diversion, high separation probability of products and high purity.

The invention discloses a polyaryletherketone resin-based suspension sizing agent for carbon fibers and a preparation method thereof. The suspension sizing agent is composed of a polyaryletherketone resin, a dispersant, a stabilizer and deionized water. The suspension sizing agent has stable properties and can be used for preparing carbon fibers. The prepared sizing carbon fibers are suitable forintermediates such as carbon fiber fabrics and prepregs for polyaryletherketone resin-based composite materials, and have good processing performances and interface binding ability.

The invention belongs to the technical field of chemical products and preparation thereof, and specifically relates to a B / L dual acidic heteropolyacid ion hybrid and a preparation method and applications thereof. The B / L dual acidic heteropolyacid ion hybrid has organic positive ions with one bisulfonic acid functionalized long chain quaternary ammonium structure and transition metal positive ions at the same time. The matched heteropolyacid negative ion is Keggin type phosphotungstic acid or silicotungstic acid negative ions. The organic positive ions with one bisulfonic acid functionalized long chain quaternary ammonium structure and the transition metal positive ions are wrapped on the surface of the heteropolyacid negative ion through electrostatic force so as to form a core-shell structure. The B / L dual acidic heteropolyacid ion hybrid can be used as a heterogeneous catalyst to prepare five acetal (ketal) perfumes: series of benzaldehyde acetal, series of cyclohexanone ketal, fructone, fraistone, and [2-(1-ethoxyethoxy)ethyl]benzene. The heterogeneous catalyst has the characteristics of high catalytic activity, good selectivity, mild conditions, large operation elasticity, easy product separation, and high purity, and the catalyst system can be circularly used.

The invention belongs to the field of medical technology and relates to preparation and application of a series of curcumin analogues. The curcumin analogues have structures as shown in the formula I, formula II and formula III, wherein R, R1 and R2 are as mentioned in the specification. Pharmaceutically acceptable salt and solvate of the curcumin analogues and a medicine containing the curcumin analogues or the pharmaceutically acceptable salt used as active components can be used in treatment of cancer. The curcumin analogues and the pharmaceutically acceptable salt have a good anticancer activity. A preparation method of the curcumin analogues is simple and feasible and is easy to operate.

The invention relates to a preparation method of a high internal phase Pickering emulsion with stable egg white protein, which comprises the following steps: stirring egg white at a medium speed, filtering to obtain an egg white protein solution, and carrying out ultrasonic treatment to obtain a modified egg white protein solution; carrying out high-speed shearing on the gel obtained by egg whiteprotein heat treatment, carrying out pre-homogenization, and carrying out ultrasonic crushing by using an ultrasonic probe to form egg white protein microgel particle dispersion liquid; the dispersionliquid and vegetable oil are homogenized under the condition of stirring for 2-4 min at the speed of 12,000 rpm to 15,000 rpm, and stable high internal-phase Pickering emulsion is obtained; the egg white protein microgel particles have good emulsibility, and the prepared high internal-phase emulsion has high safety and good stability and is still stable after being stored at 4 DEG C for more than30 days. The method can be applied to the fields of food, cosmetics and medicines.

The invention discloses two-block low molecular polymer-grafted nano-silicon dioxide particles, a preparation method and polyester. Overall design is conducted on nanoparticles and application requirements thereof, the surface of nano-silicon dioxide is modified, a short soft polyester chain segment is grafted to the surface of nano-silicon dioxide, a relatively-lengthened linear polyester low molecular chain with the certain rigidity is introduced, and then modified nano-silicon dioxide which has the advantages that the rigidity and softness combined polymer molecular chains with the proper length and different properties are grafted to the surface, the chemical structure is stable, and amphipathicity, chemical activity, dispersibility and organic compatibility are all significantly improved is obtained; modified nano-silicon dioxide has the very good compatibility with most resin matrixes and improves the mechanical property of linear polyester, the polyester chain segment can be crystallized and nucleated, and then an excellent nucleation inducing effect on the linear polyester resin matrixes is achieved.

The invention discloses axial nucleoside asymmetrically-modified silicon phthalocyanine and a preparation method and application thereof, belonging to the preparation field of a photodynamic medicine or a photosensitizer. The axial nucleoside asymmetrically-modified silicon phthalocyanine disclosed by the invention can be applied to photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer, has the structural characteristic of axial asymmetric substitution, and shows good amphipathicity and excellent photodynamic activity.

The invention discloses preparation of a hydroxyl / sulfo bifunctional vanadium-doped heteropolyacid ionic hybrid and application thereof. In the structure of the hydroxyl / sulfo bifunctional vanadium-doped heteropolyacid ionic hybrid, a long-chain quaternary ammonium structure cation simultaneously has hydroxyl / sulfo bifunctional groups, and the matched heteropolyacid anions are respectively [P2Mo17VO62]-7, [P2Mo16V2O62]-8 and [P2Mo15V3O62]-9; and 7 or 8 or 9 bifunctional organic cations are coated on the surface of nano-scale polyoxoanions due to electrostatic interaction so as to present a core-shell structure. The prepared ionic hybrid serving as a heterogeneous catalyst is applied to a phenol cleaning preparation method. The phenol preparation method provided by the invention has the characteristics of being high in reaction activity of the catalytic system, excellent in selectivity, mild in reaction conditions, high in operating flexibility, easily separable in products, high in purity, recyclable in catalytic system and the like.

The invention discloses a silicon phthalocyanine axially bonded with a piperidine or morpholine derivative with an ester bond as well as a preparation method and application of the silicon phthalocyanine and belongs to the field of preparing photodynamic drugs or photosensitizers. The silicon phthalocyanine can be used as a photosensitizer used for carrying out photodynamic antibacterium, photodynamic cancer resistance, photodynamically treating other diseases, photodynamic disinfection and photodynamic diagnosis and has the advantages of simple preparation, strong photosensitization and the like, and the maximum absorption spectrum is located in a near infrared region.

The invention discloses silicon phthalocyanine axially modified by aminoethyl phenoxyl and polyethylene glycol oligomer as well as a preparation method and application of silicon phthalocyanine, belonging to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, has the structural characteristic of axially asymmetrical substitution and shows favorable amphipathy and extremely high photodynamic activity.

The invention discloses a star-shaped multi-arm amphiphilic polymer formed by connection of multiple hydroxyl groups of a disaccharide molecule and polycaprolactone and a preparation method thereof. The main steps are as follows: a. hydroxyl silane protection, to be more specific, using a silane agent for partial protection of the hydroxyl groups on the disaccharide molecule to obtain silanated disaccharide; b. hydroxyl-initiated ring-opening polymerization of caprolactone, to be more specific, using the remaining unprotected hydroxyl groups on the disaccharide molecule to initiate the ring-opening polymerization of the caprolactone; c. deprotection of the hydroxyl groups, to be more specific, adding excess acid inro a solution of a polycaprolactone grafted silanized disaccharide intermediate, dissolving and stirring for more than 1 hour to finally obtain the star-shaped multi-arm amphiphilic polymer with the disaccharide molecule as a head and the connected polycaprolactone polymer asarms. Duo to the poly hydroxyl head and the multi-arm polycaprolactone molecular structure of the star-shaped multi-arm amphiphilic polymer, the star-shaped multi-arm amphiphilic polymer has excellent hydrophilic-hydrophobic property and physical and chemical properties, and can be used as an auxiliary, dispersant, emulsifier, and the like, and has broad application prospects in the bio-medicine,chemical, energy and other fields.

The invention relates to a preparation method of dampproof building mortar, and belongs to the technical field of preparation of building materials. According to the preparation method, river sand isused as a raw material; firstly, an ethanol solution is used for soaking the river sand; next, the soaked river sand, organic silane and water are mixed to obtain a pre-mixed material; then, the pre-mixed material and organic acid are mixed at high temperature for reaction so as to obtain a modified pre-mixed material for use; then, waste duck feather is used as a raw material, and through acid soaking and sodium sulfite solution soaking treatment, disulfide bonds in duck feather protein are partially opened, so that the dissolution performance of the duck feather protein is improved; next, analkali solution is used for dissolving the duck feather protein to obtain reaction filter liquid rich in the duck feather protein; and finally, the modified pre-mixed material, portland cement, the reaction filter liquid and water are mixed, and after stirring, the dampproof building mortar is obtained. The dampproof building mortar prepared by the invention has the advantages that the anti-seepage dampproof performance is excellent, and wide application prospects are realized.

The invention discloses non-peripheral quaternary ammonium group modified zinc phthalocyanine as well as a preparation method and application thereof, and belongs to the field of preparation of photodynamic medicines or photosensitizers. The non-peripheral quaternary ammonium group modified zinc phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic therapy andphotodynamic diagnosis, and can also be used for photodynamic-immune synergistic therapy. The unique structure of the polypeptide enables the polypeptide to be combined with an immune checkpoint blocking agent for use, so that the polypeptide has an excellent synergistic anti-tumor effect and has a remarkable application prospect in treatment of metastatic tumors.

The invention discloses a phthalocyanine metal complex containing piperazine ethyoxyl modification group and a preparing method thereof and belongs to the field of photodynamic drug preparing or photosensitizer preparing. The phthalocyanine metal complex containing piperazine ethyoxyl modification group is characterized in that the phthalocyanine metal complex has amphipathy and absorbs and sends spectrums to the wavelength position where the spectrums can pierce through human tissues in red shift mode, and photosensitizer is high in reactive oxygen production capacity. The preparing method is simple and has remarkable economic effect and social effect.

The invention belongs to the technical field of protein modification, and particularly discloses a casein-soybean polysaccharide crosslinked product and a preparation method and application thereof. Transglutaminase catalyzed soybean polysaccharide and casein are used to be in Maillard reaction to prepare the casein-soybean polysaccharide crosslinked product. Soybean polysaccharide has high physiological activity, and the crosslinked product can be quickly formed in a mild condition through Maillard reaction by adding transglutaminase, so that casein is enabled to carry soybean polysaccharide,amphiphilicity of casein is improved, and physical stability of an oil-in-water emulsion of casein is improved.

The invention discloses novel substituted zinc phthalocyanine and their conjugates with doxorubicin, discloses their preparation methods and applications, and belongs to the field of preparation of photosensitizers and drugs. The compound is a novel high-efficiency photosensitizing drug. The zinc phthalocyanine-doxorubicin conjugate is an anticancer drug with the dual effects of photodynamic therapy and chemotherapy. The zinc phthalocyanine-doxorubicin conjugate is linked through a substrate peptide which can be specifically recognized and hydrolyzed by a tumor-associated fibroblast activationprotein, and can be used as an enzyme-targeting activated anticancer prodrug.

The invention discloses a water-soluble anticancer photosensitizer and preparation and application thereof. Firstly, mother nucleus of monocarboxyl substituted fluoroboron dipyrrol is prepared from the raw materials of carboxybenzaldehyde, 2,4-dimethyl pyrrole and the like; secondly, two heavy atomic iodines are introduced to the 2th and 6th sites to increase the oxygen quantum yield in triplet and singlet states; thirdly, the compound is further subjected to a condensation reaction with carboxybenzaldehyde, the conjugated system is expanded, the compound is absorbed and moved to a red region,and two carboxyl groups are simultaneously introduced to obtain a water-soluble fluoroboron dipyrrol anti-cancer photosensitizer. The synthetic method of this compound is simple, the raw material iseasy to obtain, the cost is low, the side reactions are few, the yield is high, the purification is easy, and the compound is conducive to industrial production.

The invention relates to a preparation method of a biomass concrete shrinkage reducing agent, and belongs to the technical field of preparation of building additives. After the prepared shrinkage reducing agent is added into concrete slurry, due to the fact that the number of disulfide bonds in chicken feather proteins is large and the flexibility is good, the viscosity of protein colloid is high,part of peptide chains can extend on a gas-liquid interface, closed bubbles have the buffering and pressure relieving effects, the drying shrinkage value of concrete is reduced, and the obvious shrinkage reducing effect is achieved; the chicken feather proteins of the shrinkage reducing agent and the soyabean lecithin in an enzymolysis product have amphiphilic functions and can be adsorbed on a gas-liquid interface, in contact with a concrete pore solution, of air; enzymolysis products are rich in hydrophilic enzymolysis products, water molecules in concrete capillary tubes can be firmly fixed in concrete in the presence of the hydrophilic enzymolysis products, and the shrinkage reducing effect is improved; the prepared concrete shrinkage reducing agent is based on biomass raw materials,does not contain organic solvents, is not prone to volatilization and has wide application prospects.

The invention relates to a method for preparing recombinant human growth hormone entrapped sustained-release drug microcapsules. According to the method, a degradable multi-arm polyethylene glycol-polylactic acid block polymer material with good biocompatibility is taken as a vector material, and raw materials are easily obtained; the multi-arm polymer has relatively small hydrodynamic volume and relatively low viscosity, and the degradation rate of the multi-arm polymer is higher than that of linear polymers, so that the loading and delivery of drugs are more facilitated; a multi-arm polyethylene glycol-polylactic acid block copolymer has good drug loading capacity and unique amphiphilicity, so that protein adsorption can be prevented, the recognition and phagocytosis of a reticuloendothelial system are avoided, and the physiological barrier is easy to pass; the method disclosed by the invention is simple and does not need a complicated re-emulsion formation process; the microcapsules are good in stability, the bioavailability of recombinant human growth hormone is improved, and the content of the recombinant human growth hormone reaches up to 46-81%; the entrapment rate of the recombinant human growth hormone entrapped sustained-release drug microcapsules reaches 91%, the stability is good, the grain size is uniform, and the repeatability is good, so that the recombinant human growth hormone entrapped sustained-release drug microcapsules are suitable for large-scale production.

The invention relates to the technical field of papermaking, aims to solve the problems that transfer printing base paper is poor in universality and resources are wasted, and provides a preparation method of an anti-permeation heat-stable low basis weight transfer printing base paper. The preparation method comprises the following steps: (1) mixing and pulping raw material slurry and an auxiliaryagent to prepare mixed slurry; (2) sequentially carrying out white dextrin solution soaking, net part dehydration, squeezing and pre-drying on the mixed pulp to obtain raw material paper; (3) carrying out surface sizing on the raw material paper by adopting a modified hexadecyl methacrylate-N-hydroxymethyl acrylamide-styrene polymer; and (4) carrying out post-stage drying, calendaring finishing and rolling on the paper sheet subjected to surface sizing treatment to obtain a finished product. The printing base paper has the advantages of being low in basis weight, good in paper toughness, highin thermal stability, capable of preventing ink permeation, good in tensile strength and good in paper uniformity, sizing is conducted by introducing a small amount of polymer macromolecules with a good film-forming property, and the strength of low basis weight paper sheets is enhanced by combining and changing a pulping process.

The invention relates to a preparation method of a sludge conditioner, which belongs to the technical field of sewage treatment. The sulfonated lignin grafted sodium acrylate copolymer is used as a raw material, a magnesium oxide modified zeolite molecular sieve is used as a carrier, and the sulfonated lignin grafted sodium acrylate copolymer is fixed on the carrier to prepare the sludge conditioner. The sulfonated lignin grafted sodium acrylate copolymer has the intermolecular force and reactivity of a polysaccharide compound; the mechanical and biological action stability and the linear chain expansion capability of synthetic macromolecules are also realized; sulfonated lignin contains a large number of -SO3H groups and has strong anionic property and strong hydrophilicity, a sodium acrylate copolymer is used as a graft comonomer, the spatial configuration of lignin is changed, the relative molecular mass is increased, functional groups with flocculation performance are introduced, and the flocculation performance of lignin is further improved.

The invention discloses a polyphenylene sulfide resin-based carbon fiber suspension sizing agent and a preparation method thereof. The sizing agent is composed of polyphenylene sulfide resin powder, sodium polyacrylate, polyethylene glycol and deionized water, wherein the polyphenylene sulfide resin powder accounts for 65-75wt% of the total mass of the solid components, the sodium polyacrylate accounts for 12-17wt% of the total mass of the solid components, and the polyethylene glycol accounts for 13-18wt% of the total mass of the solid components. Sized carbon fibers prepared by the sizing agent are suitable for intermediates such as carbon fiber fabrics, prepregs and the like for polyphenylene sulfide resin-based composite materials, and have good mechanical properties, temperature resistance and two-phase interface bonding force.

The invention relates to a method for preparing an anti-freeze environment-friendly brick and belongs to the technical field of building material preparation. The method comprises the steps of carrying out acid leaching and sodium sulfite solution soaking on raw material waste goose feathers to partially open disulfide bonds in goose feather proteins, thereby improving the solubility of the goosefeather proteins; dissolving the goose feather proteins by using an alkali solution; precipitating the proteins by using an acid solution; mixing the obtained proteins with a potassium chloride solution; forming bridge bonds by utilizing carboxyl groups on the goose feather proteins and potassium salt ions to obtain a salt ion-doped goose feather protein product; mixing the salt ion-doped goose feather protein product with other brick materials to form slurry; drying and solidifying after injection molding to obtain a green brick; depositing a layer of orthosilicic acid on the surface of the green brick; and calcining at a high temperature to obtain the anti-freeze environment-friendly brick. The anti-freeze environment-friendly brick prepared by adopting the method disclosed by the invention is excellent in anti-freeze performance and has a broad application prospect.

The invention discloses a demulsifier rich in various functional groups, and a preparation method thereof. The demulsifier comprises the following components in parts by weight: 15 to 40 parts of hydrogen-containing silicon oil, 10 to 40 parts of allyl polyether, 10 to 35 parts of acrylic acid, 15 to 30 parts of acrylic ester, 0.5 to 4 parts of a catalyst, 0.5 to 6 parts of an initiator, 1 to 2 parts of a chain transfer agent, 1 to 2 parts of a chain terminating agent, 3 to 5 parts of a surfactant, 1 to 2 parts of an accelerant and 10 to 25 parts of deionized water. The demulsifier is single component, HLB can be adjusted by the synthetic raw materials, high amphipathy is achieved, ether bond, ester bond and carboxylate radical exist in the molecular structure of the prepared demulsifier at the same time, silicon various functional groups are introduced, and the demulsifier can act on crude oil emulsion well. The obtained demulsifier has the characteristics of small use amount, good dehydration effect, low demulsification temperature, clean dehydrated water quality, wide use range and the like.

The invention discloses a Pd / FeOOH@RGO Pickering emulsion and an application of the Pd / FeOOH@RGO Pickering emulsion in catalyzing a Suzuki carbon-carbon coupling reaction. Water and an organic solventare used as solvents at the same time; graphite oxide and a metal chloride are reduced with pentacarbonyl iron, no other reducing agent is added, Pd / FeOOH@RGO is prepared through a one-step reaction,then Pd / FeOOH@RGO is used as an emulsifier to stabilize a plurality of water-oil systems to form the Pickering emulsion. The Pickering emulsion prepared by the method is high in stability, is used for catalyzing Suzuki carbon-carbon coupling reaction of halogenated benzene and derivatives thereof; the catalytic reaction effect is excellent; recycling can be realized; the problems that a substrateof an organic chemical reaction system is poor in solubility in a water solution, low in catalyst activity, narrow in application range, difficult to separate and the like are effectively solved; theemulsion can meet requirements of the green and environment-friendly synthesis concept, and has huge application prospects in the field of catalysis.

The invention discloses an antibacterial biological membrane and a preparation method thereof. The preparation method comprises the following steps of firstly, selecting antibacterial peptide amidation pectin, so as to obtain antibacterial peptide-modified pectin; then, dissolving the antibacterial peptide-modified pectin, obtaining an antibacterial peptide-modified pectin solution, mixing with a collagen solution, and homogenizing, so as to form a membrane forming solution; finally, preparing the membrane forming solution to form the antibacterial biological membrane. The antibacterial biological membrane has the characteristics that the pectin is amidated, and then is mixed with collagen to obtain the antibacterial biological membrane; the efficiency is high, and the spectrum is broad; the research prospect and practical value are broad.

The invention discloses a synthesis method of O-quaternized vanilla-based chitosan carbon residue particles based on an amphiphilic biological carbon material, and belongs to the technical field of biology. The synthesis method comprises the following steps: preparing an amphiphilic biological carbon material from beer yeast cells by adopting a hydrothermal synthesis method, grafting chitosan by adopting a covalent binding method by taking the amphiphilic biological carbon material as a carrier, and carrying out structure modification on chitosan carbon residue particles by adopting a chemical method by taking vanillin and glycidyl trimethyl ammonium chloride as modified materials, and obtianing the functionalized carbon residue particles. A series of characterization means verify successful covalent modification of chitosan, vanillin and glycidyl trimethyl ammonium chloride. The functionalized carbon residue particles synthesized by the invention still have high dispersity in polar and non-polar solvents while retaining the advantage of antibacterial property of quaternized chitosan. The synthesis method is simple in process and low in cost. The synthetic product is low in irritation, good in biocompatibility, excellent in antibacterial property and good in amphipathy.