The present invention relates to a device consisting of cross-linked nanofibrillary
fibrin supported on and rooted to a microporous
nonwoven fabric consisting of a biocompatible
synthetic polymer material. An
active ingredient is advantageously dispersed in the
fibrin layer. The
fibrin layer does not have a haemostatic function, but is suitable for retaining the
active ingredient and releasing it with controlled
kinetics. The device forming the object of the invention, preferably in the form of patches, is useful for
in vitro cell cultures or for treating tissues damaged by wounds or
necrosis, such as cardiac walls bearing the sequelae of
infarction, or a tissue damaged by a
diabetic ulcer. The patch according to the invention can be manufactured by inducing the polymerisation of the fibrin, under suitable conditions, directly on the support layer, which is suitably impregnated with
thrombin (at least in a superficial portion of its thickness), and which has been conveniently prepared by means of a spray phase-inversion technique.