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41 results about "Pyruvaldehyde" patented technology
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An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
Compositions for improving the organoleptic qualities of cooked foodstuffs
Compositions for generating a cooked flavor in a foodstuff, comprising specified flavor precursors that react on heating to generate the flavor and maintain a reactive association after inclusion in the foodstuff. The compositions may include combination of a sulphur source, e.g. hydrogen sulphide, methane thiol, a sulfur-containing amino acid, thiamine, cystine, sodium sulphide, ammonium sulphide, ammonium polysulphide, onions, garlic, shallots, eggs, methionine, and mixtures thereof, and at least one reductone, e.g. a furanone, a ketone, a pyrone, an aldehyde, a carbonyl compound, isomaltol, maltol, pyruvaldehyde, hydroxyacetone, 3-deoxyglucosone, 5-hydroxy-5,6-dihydromaltol, 2,3-butanedione, 3-hydroxy-2-butanone, a process flavor, cooked vegetable concentrates, soy sauce, and mixtures thereof.
Owner:KERRY INGREDIENTS UK
Preparation method of nilvadipine intermediate
InactiveCN102816110AHigh purityAvoid purification processOrganic chemistryDimethyl acetalNitrobenzene
The invention provides a preparation method of 3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-formyl-1, 4-dihydropyridine-5-isopropyl carbonate. The method comprises the following steps that condensation and amination reactions between pyruvic aldehyde dimethyl acetal and dimethyl carbonate are carried out under the catalysis of a strong base to obtain 3-amino-4, 4-dimethoxyl-methyl crotonate; dehydration condensation reaction between isopropyl acetoacetate and nitrobenzaldehyde is carried out under the catalysis of a weak base to obtain 2-(3-nitrobenzylidene)-isopropyl acetoacetate; dehydration condensation and hydrolysis reactions between 3-amino-4, 4-dimethoxyl-methyl crotonate and 2-(3-nitrobenzylidene)-isopropyl acetoacetate are carried out to obtain 3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-formyl-1, 4-dihydropyridine-5-isopropyl carbonate. The method provided by the invention solves the technical problems in the prior art including complex preparation process, low purity and less yield during the preparation of nilvadipine intermediate 3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-formyl-1, 4-dihydropyridine-5-isopropyl carbonate.
Owner:HUNAN FANGSHENG PHARMACEUTICAL CO LTD
Method for preparing lactate by catalyzing pyruvic aldehyde
ActiveCN111253248AImprove conversion rateHigh yieldOrganic compound preparationCarboxylic acid esters preparationMolecular sievePtru catalyst
The invention relates to a method for preparing lactate by catalyzing pyruvic aldehyde. The method comprises the following steps: contacting pyruvic aldehyde and alcohol with a catalyst in a reactor,and reacting to obtain a lactate-containing product, wherein the molar ratio of pyruvic aldehyde to alcohol is 1:(50-225), the reaction temperature is 30-180 DEG C, the reaction time is 1-10 h, the reaction pressure is 0.1-3 MPa, the catalyst contains a tin-titanium-silicon molecular sieve, and the weight ratio of pyruvic aldehyde to the tin-titanium-silicon molecular sieve based on dry basis weight is 1:(1-6). According to the method, the catalyst containing the binary tin-titanium-silicon molecular sieve is adopted, framework tin atoms and framework titanium atoms of the molecular sieve synergistically catalyze pyruvic aldehyde and alcohol to generate lactate, and the reaction efficiency is improved.
Owner:CHINA PETROLEUM & CHEM CORP +1
Folic acid synthesis method
InactiveCN106046005AAvoid it happening againMild reaction conditionsOrganic chemistryWastewaterFolic acid synthesis
The present invention relates to a folic acid synthesis method. According to the present invention, with the method, a 2,4,5-triamino-6-hydroxypyrimidine salt, 3-halogenated pyruvaldehyde oxime and N-(4-aminobenzamide)-L-glutamic acid are subjected to a reaction to prepare the folic acid; and the 3-halogenated pyruvaldehyde oxime is used to replace the low purity 1,1,3-trichloroacetone, such that the generation of a large amount of waste water in the traditional method is avoided, the reaction conditions are mild, the operation is easy, the reaction selectivity is good, the product purity is high, the advantages of safety and environmental protection are provided, and the method is suitable for the industrial requirements on environmental protection.
Owner:CHANGZHOU XINHONG PHARMA & CHEM IND TECHOLOGIES
Compound, preparation method and application thereof as near-infrared region-II fluorescent probe for detecting pyruvaldehyde
The invention provides a compound, a preparation method thereof and an application of the compound as a near-infrared region-II fluorescent probe for detecting pyruvaldehyde. The compound has a structure as shown in a general formula I, and has good response to pyruvaldehyde. Therefore, the compound is expected to be used as a near-infrared region-II fluorescent probe for in-vivo detection of pyruvaldehyde, such as detection of pyruvaldehyde in blood, lymph nodes and tumors.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof
ActiveCN103274943AEasy to manufactureImprove economyOrganic compound preparationCarboxylic acid esters preparationBenzaldehydeMetal catalyst
The invention discloses a novel medical compound 4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate (I) and a preparation method thereof. The preparation method comprises the following steps of carrying out an addition reaction on 4-carbalkoxy benzaldehyde (II) and 3-propargyl bromide (III) to generate 4-(1-hydroxyl-3-butyne) benzoate (IV); and carrying out a coupled reaction on an intermediate (IV) and pyruvaldehyde dialkyl acetal (V) after being subjected to enolization under the action of a metal catalyst to form the 4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate (I). According to the intermediate (I) and the preparation method thereof, a novel preparation way for the antineoplastic pralatrexate is provided and the economic and technological development of the pralatrexate is promoted.
![4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/fd4ad065-e481-4d91-bfa4-fa6d020df7a1/FDA00003240551000011.png "4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof")
![4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/fd4ad065-e481-4d91-bfa4-fa6d020df7a1/BDA00003240551100011.png "4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof")
![4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/fd4ad065-e481-4d91-bfa4-fa6d020df7a1/BDA00003240551100021.png "4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof")
Owner:临沂经开财金投资发展有限公司
Biological reducing preparation method of catalyst used for synthesizing pyruvaldehyde
InactiveCN101773829AEvenly dispersedImprove stabilityOrganic compound preparationMicroorganism based processesOrganic solventMass ratio
The invention provides a biological reducing preparation method of a catalyst used for synthesizing pyruvaldehyde, which relates to a catalyst used for synthesizing pyruvaldehyde. The invention provides the biological reducing preparation method of the catalyst used for synthesizing the pyruvaldehyde. The biological reducing preparation method comprises the following steps of: preparing microorganisms with expanded culture into bacterium powder for later use by drying and grinding; preparing the bacterium powder into bacterium suspension, then mixing with an alkali solution and a silver compound and obtaining mixed liquid containing biomass and nano silver sol after reacting; separating the mixed liquid centrifugally and collecting supernatant liquid to obtain silver sol wrapt with the biomass; after drying a lower-layer precipitate, obtaining lower-layer silver powder; evaporating and concentrating the silver sol, adding an organic solvent to dewater and precipitate silver colloidal particles, filtering or centrifugally separating and collecting a precipitate; after drying, obtaining upper-layer silver powder; and dissolving the upper-layer silver powder or the lower-layer silver powder into deionized water, adding a carrier according to the mass ratio of 1:(0.1 to 0.4) of the carrier to the silver powder and obtaining a product after soaking, drying and calcining.
Owner:XIAMEN UNIV
Preparation method of glycosylated glutenin
InactiveCN110720544AImprove solubilityGood emulsifying effectFood freezingMulti-step food processesMaillard reactionFreeze-drying
The invention discloses a preparation method of glycosylated glutenin. The method comprises the following steps: crushing and sieving wheat, removing starch, performing freeze-drying, performing degreasing, removing albumin and globulin, performing desalting, removing alcohol-soluble protein, performing freeze-drying, performing grinding, performing homogenizing, carrying out a saccharification reaction on pyruvic aldehyde and glutenin, carrying out ultrafiltration, carrying out vacuum freeze-drying and the like. The method for glycosylating glutenin is simple, and the solubility, emulsifyingproperty and emulsifying stability of glutenin are remarkably improved. The pyruvic aldehyde is an intermediate product obtained by a Maillard reaction of glutenin and reducing sugar, and interacts with glutenin to reduce the hydrophobicity of glutenin, so that the solubility, emulsifying property and emulsifying stability of glutenin are improved.
Owner:TIANJIN UNIV OF SCI & TECH
Method for detecting AGEs (Advanced Glycation End Products) and application
The invention discloses a method for detecting AGEs (Advanced Glycation End Products) and application. The method comprises the following steps: firstly preparing a glassy carbon electrode modified bygraphene-chitosan / N(epsilon)carboxymethyl lysine, and then realizing multi-residue detection on five AGEs comprising the N(epsilon)carboxymethyl lysine, N(epsilon)carboxyethyl lysine, pentosidine, pyruvaldehyde imidazolinone and argpyrimidine by combining an indirect competition method on the basis of a principle that cross immunoreaction can be generated by a pentosidine monoclonal antibody andmultiple AGEs. According to the method for detecting the AGEs, disclosed by the invention, the problem that a current AGEs detecting method just can be used for detecting a single substance is solved,higher sensitivity (of which the detecting limit is 0.06 to 0.1 ng / mL) and wider linear range (0.1 to 1000 ng / mL) are obtained, the operation is simple, the cost is lower, the demands on clinical AGEs detection of a human body can be completely fitted, and important practical application value is obtained.
Owner:NANJING NORMAL UNIVERSITY
Preparation method of polysubstituted bromomethyl benzo nitrogenous heterocyclic compound
ActiveCN112028828AFix fixSolve the problem of demulsificationOrganic chemistryLiquid solutions solvent extractionNitrogenous heterocyclic compoundDimethyl acetal
The invention relates to a preparation method of a polysubstituted bromomethyl benzo nitrogenous heterocyclic compound. The preparation method is carried out by using an ultrasonic extraction device,and is characterized by comprising the following steps: reacting pyruvic aldehyde dimethyl acetal with o-bromobenzylamine in toluene to obtain N-(2-bromophenyl)-1,1-dimethoxypropan-2-imine; and carrying out five steps to obtain 3-methyl-8-bromomethyl isoquinoline hydrobromide which is a final product. Extraction is implemented by an ultrasonic extraction device, and a preparation step, a coveringstep, a vibration shaking step, a repeating step and a receiving step are included. The ultrasonic extraction device comprises an extraction part (1), a shell part (2), an ultrasonic part (3), a transverse rod part (4), a left supporting part (5), a right supporting part (6), a glass device (7) and a demulsification assembly (8).
Owner:烟台宁远药业有限公司
4-(diethoxy-phosphoryl)-2-methyl-but-2-enoate preparation method
ActiveCN110655533AHigh yieldEasy to operateGroup 5/15 element organic compoundsAlcoholPyruvate lactate
The invention discloses a 4-(diethoxy-phosphoryl)-2-methyl-but-2-enoate preparation method, which comprises: (a) carrying out an oxidation reaction on a pyruvic aldehyde aqueous solution to obtain a pyruvic acid / pyruvate aqueous solution; and (b) carrying out a reaction on the pyruvic acid / pyruvate aqueous solution and tetraethyl ethylene diphosphate, and performing an esterification reaction withan alcohol to obtain 4-(diethoxy-phosphoryl)-2-methyl-but-2-enoate. The method of the invention has advantages of cheap and easily available raw materials, simple operation of each step, high yield of the whole route, and high industrial application value.
Owner:SHANGYU NHU BIOCHEM IND +1
Synthesis method of 13-methyl berberine alkaloid
ActiveCN114057723AThe synthesis steps are simpleEasy to operateOrganic chemistryBulk chemical productionBerberine AlkaloidsPtru catalyst
The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of 13-methyl berberine alkaloid. The method comprises the following steps: reaction a: taking arylethylamine and aryl formaldehyde as main starting raw materials, and reacting in the presence of other auxiliary materials to obtain secondary amine hydrochloride; and reaction b: taking secondary amine hydrochloride and pyruvic aldehyde as main raw materials, and reacting in the presence of other auxiliary materials to obtain the 13-methyl berberine alkaloid. According to the invention, aryl ethylamine and aryl formaldehyde are used as raw materials to synthesize secondary amine hydrochloride, and then the secondary amine hydrochloride and pyruvic aldehyde are subjected to Pickering-Schengger reaction / Friedel-Crafts hydroxyalkylation reaction / dehydration reaction / oxidation reaction in an anhydrous formic acid solution under the assistance of a dewatering agent and an oxidizing agent, so that the 13-methylberberine alkaloid is prepared at the yield of more than 80%, and the synthesis steps are simplified and easy to operate; and various expensive metal catalysts and excessive acid catalysis are not needed, the productivity is high, and the cost is low.
Owner:SICHUAN UNIV +1
Method for preparing lactic acid by catalyzing pyruvic aldehyde
ActiveCN111253239AImprove conversion rateHigh yieldMolecular sieve catalystsChemical recyclingMolecular sievePtru catalyst
The invention relates to a method for preparing lactic acid by catalyzing pyruvic aldehyde. The method comprises the following steps: contacting pyruvic aldehyde, water and a catalyst in a reactor, and reacting to obtain a product containing lactic acid, wherein the molar ratio of the pyruvic aldehyde to the water is 1:(40-350), the reaction temperature is 30-180 DEG C, the reaction time is 1-10 hours, the catalyst contains a tin-titanium-silicon molecular sieve, and the weight ratio of the pyruvic aldehyde to the tin-titanium-silicon molecular sieve based on dry basis weight is 1:(1-6). The method provided by the invention has high pyruvic aldehyde conversion rate and high lactic acid yield.
Owner:CHINA PETROLEUM & CHEM CORP +1
Preparation method of pyruvic aldehyde glycol
PendingCN113493373AOrganic compound preparationCarbonyl compound preparationAlcoholCombinatorial chemistry
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA) +1
Novel paddy rice D-lactate dehydrogenase, coding gene and application thereof
InactiveCN103820409AIncreased stress resistance of riceBoost agricultural productionMicrobiological testing/measurementOxidoreductasesBiotechnologyNucleotide
The invention discloses a novel paddy rice D-lactate dehydrogenase (OsD-LDH), a coding gene and application thereof, and belongs to the field of plant bioengineering. The novel paddy rice D-lactate dehydrogenase is D-lactate dehydrogenase which is cytochrome C depended, the amino acid sequence of the novel paddy rice D-lactate dehydrogenase is shown in SEQ ID NO.1, the nucleotide sequence of the D-lactate dehydrogenase coding gene is shown in SEQ ID NO.2. The OsD-LDH gene provided by the invention participates in the pyruvic aldehyde pyruvaldehyde metabolism generated under a stress condition in a plant body, and can be used for improving the adversity stress resistance of the plant and cultivating high stress resistance plants. The OsD-LDH gene provided by the invention can be further used as a selection marker and applied in transgenic selection through adopting pyruvic aldehyde pyruvaldehyde or D-lactate acid as selection pressure. The D-lactate dehydrogenase provided by the invention can be used for cultivating high stress-resistance plants and can be used for transgenic selection, and has great importance for increasing agricultural production and improving transgenic methods.
Owner:WUHAN UNIV
Preparation method of polysubstituted benzo nitrogen-containing heterocyclic methylamine
ActiveCN112121463AFix fixSolve the problem of demulsificationOrganic chemistryLiquid solutions solvent extractionDimethyl acetalQuinoline
The invention relates to a preparation method of polysubstituted benzo nitrogen-containing heterocyclic methylamine, which is carried out by using an ultrasonic extraction device and is characterizedby comprising the steps of preparing N-(2-bromophenyl)-1, 1-dimethoxypropane-2-imine from pyruvic aldehyde dimethyl acetal and o-bromobenzylamine; and preparing a red viscous oily matter 3-methylisoquinoline-8-methylamine through four steps to obtain a final product. The extraction is implemented by an ultrasonic extraction device, and comprises a preparation step, a covering step, a vibration shaking step, a repeating step and a receiving step. The ultrasonic extraction device comprises an extraction part (1), a shell part (2), an ultrasonic part (3), a transverse rod part (4), a left supporting part (5), a right supporting part (6), a glass device (7) and a demulsification assembly (8).
Owner:烟台宁远药业有限公司
Method for preparing lactate
ActiveCN111253251AHigh yieldImprove reaction efficiencyMolecular sieve catalystsOrganic compound preparationMolecular sievePtru catalyst
The invention relates to a method for preparing lactate. The method comprises the following steps: contacting pyruvic aldehyde and alcohol with a catalyst in a reactor, and reacting to obtain a lactate-containing product, wherein the molar ratio of the pyruvic aldehyde to the alcohol is 1:(20-225), the reaction temperature is 30-180 DEG C, the reaction time is 1-10 hours, the catalyst contains a mixture of a titanium-silicon molecular sieve and a tin-silicon molecular sieve, and the weight ratio of the pyruvic aldehyde to the mixture of the titanium-silicon molecular sieve and the tin-siliconmolecular sieve based on dry basis weight is 1:(0.1-6). The method provided by the invention has high pyruvic aldehyde conversion rate and high lactate yield.
Owner:CHINA PETROLEUM & CHEM CORP +1
Method for preparing pyruvic aldehyde
ActiveCN111253232AImprove reaction efficiencyImprove sugar conversion rateMolecular sieve catalystsOrganic compound preparationMolecular sievePtru catalyst
The invention relates to a method for preparing pyruvic aldehyde. The method comprises the following steps of: contacting sugar with a catalyst in a reactor in the presence of alcohol, and reacting toobtain a pyruvic aldehyde-containing product, wherein the molar ratio of the sugar to the alcohol is 1:1, the reaction temperature is 100 DEG C or above and lower than 150 DEG C, the reaction time is10-50 h, the catalyst contains a mixture of a titanium-silicon molecular sieve and a tin-silicon molecular sieve, and the weight ratio of the sugar to the mixture of the titanium-silicon molecular sieve and the tin-silicon molecular sieve based on the dry basis weight is 1:(0.1-6). The method provided by the invention has high sugar conversion rate and high pyruvic aldehyde yield.
Owner:CHINA PETROLEUM & CHEM CORP +1
Polycation capable of being degraded into spermine, and synthesis method and nanoparticles thereof
InactiveCN102516534AReduce acidityPromote escapeOther foreign material introduction processesVector-based foreign material introductionProtonationSynthesis methods
The invention discloses a polycation capable of being degraded into spermine, and a synthesis method and nanoparticles thereof, belonging to the technical field of medicines. The polycation can be used for conveying nucleic acids. Spermine and pyruvaldehyde are utilized to construct and degrade the polycation returningto the initial state of multi-ammonia molecules. The synthesis method of the polycation comprises the following steps: slowly dropwisely adding a pyruvaldehyde water solution into a spermine ethanol solution, and simultaneously adding the mixture into a dry molecular sieve; and stirring with a magnetic stirrer at room temperature to carry out condensation reaction on primary amino group, aldehyde group and keto-carbonyl group. The polycation is degradable, and can release spermine containing unprotonated amino group in the degradation process; and the degradation product can not generate acidic group like other degradable polymers. The polycation is beneficial to lysosome escape, and also beneficial to releasing genes in cytoplasm with low surface charges. As for the proton sponge effect, the lysosome cracks due to the osmotic pressure generated by the proton sponge effect. The amino key of the polycation has the action of proton sponge.
Owner:SHANGHAI JIAO TONG UNIV
The preparation method of 4-(diethoxy-phosphoryl)-2-methyl-but-2-enoate
ActiveCN110655533BEasy to separateSignificant environmental benefitsGroup 5/15 element organic compoundsAlcoholPyruvate lactate
The invention discloses a preparation method of 4-(diethoxy-phosphoryl)-2-methyl-but-2-enoate, comprising the following steps: (a) obtaining pyruvic acid by an oxidation reaction of an aqueous solution of methylglyoxal / pyruvate aqueous solution; (b) pyruvic acid / pyruvate aqueous solution reacts with ethylene diphosphate tetraethyl ester and then carries out esterification reaction with alcohol to obtain 4-(diethoxy-phosphoryl)-2-form The raw materials used in the method of phenyl-but-2-enoic acid ester are cheap and easy to obtain, each step is simple to operate, the yield of the whole route is higher, and it has higher industrial application value.
Owner:SHANGYU NHU BIOCHEM IND +1
Application of dragon blood a in the preparation of drugs for preventing or treating diabetic vascular disease
ActiveCN110755416BHas the ability to clear MGOSignificant effectMetabolism disorderKetone active ingredientsMetaboliteVascular endothelium
The invention discloses the application of dragon blood A in the preparation of drugs for preventing or treating diabetic vascular disease. The present invention is based on the invention that the inventors of the present invention firstly found that dragon blood A has obvious curative effect on diabetic vascular disease caused by vascular endothelial injury caused by methylglyoxal. Methylglyoxal is a highly active glucose-toxic metabolite, which is greatly increased in diabetic patients, especially in patients with diabetic complications. The curative effect of dragon blood element A on diabetic vascular disease caused by endothelial injury caused by methylglyoxal is embodied in improving cell morphology, increasing cell survival rate, reducing cell apoptosis rate, alleviating cell oxidative stress damage, clearing methylglyoxal and reducing sugar residues. Chemical end product content and so on.
Owner:JINAN UNIVERSITY
Processes and cataylsts for the selective hydrogenation of compounds having carbonyl carbon atoms
PendingUS20220064136A1Reduce utilizationIncrease volumeOrganic compound preparationHydroxy group formation/introductionPtru catalystAcetone
Selective hydrogenation processes are disclosed that can upgrade impure feeds, such as those obtained from biomass and containing a number of small (e.g., 2-6 carbon atom) molecules having aldehyde and / or ketone carbon atoms. For example, whereas glycolaldehyde and its methylated derivative, hydroxyacetone (acetol) are both high value intermediates for certain downstream processing reactions, they are normally recovered in a condensate from pyrolysis of carbohydrates (e.g., aldose-containing sugars) together with glyoxal and its methylated derivative, pyruvaldehyde. The selective hydrogenation of these compounds bearing two carbonyl carbon atoms, without over-hydrogenation to ethylene glycol and propylene glycol, can increase the concentration of the desired intermediates. These beneficial effects of selective hydrogenation may be achieved through the use of a hydrogenation catalyst comprising noble metals such as Ru and Pt.
Owner:ARCHER DANIELS MIDLAND CO
Novel paddy rice D-lactate dehydrogenase, coding gene and application thereof
InactiveCN103820409BIncreased stress resistance of riceBoost agricultural productionMicrobiological testing/measurementOxidoreductasesNucleotideHigh stress
Owner:WUHAN UNIV
Method for genetically modifying bacillus subtilis, strain obtained by method and application of strain
PendingCN111471634AEasy to synthesizeReduce consumptionBacteriaTransferasesO-Phosphoric AcidEnzyme Gene
The invention discloses a method for genetically modifying bacillus subtilis. The method comprises the following steps: (1) constructing an original strain MK3-MEP123-delta dhbB; (2) carrying out overexpression on a glycerol kinase gene glpK and a glycerol-3-phosphate dehydrogenase gene glpD; and (3) knocking out the encoding gene mgsA of the pyruvic aldehyde synthetase and the encoding gene araMof glycerol-1-phosphate dehydrogenase. According to the method, glpK and glpD are overexpressed in sequence, the utilization rate of glycerol is increased, synthesis of dihydroxyacetone phosphoric acid is promoted, and then synthesis of MK-7 is increased; mgsA and areM are knocked out in sequence, synthesis of pyruvic aldehyde and synthesis of glycerol 1-phosphoric acid are blocked, so that consumption of dihydroxyacetone phosphoric acid is reduced, and synthesis of MK-7 is promoted. After the obtained recombinant strain BSMK_4 is fermented in a 500 mL shake flask for 96 hours, the yield of the MK-7 is 70.3 mg / L and is increased by 26.4% compared with that of a starting strain MK3-MEP123-delta dhbB (55.6 mg / L).
Owner:TIANJIN UNIV MARINE TECH RES INST
A kind of preparation method of 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecadendial
ActiveCN107056596BEasy to solveReduce the use effectOrganic compound preparationGroup 5/15 element organic compoundsDiethyl phosphatePhosphorous acid
The invention provides a preparing method of 2,6,11,15-tetramethyl 2,4,6,8,10,12,14 hexadecene heptaene dialdehyde. The preparing method comprises the first step of using 1,2-dihalogenated ethane as a raw material, making 1,2-dihalogenated ethane react with triethyl phosphite under the effect of a catalyst through Michaelis-Arbuzov to obtain tetraethyl ethylenebisphosphonate; the second step of making phosphonate react with pyruvic aldehyde dimethyl acetal under an alkali effect and through Horner-Wadsworth-Emmons to obtain 3-methyl-4,4-dimethoxy-2-butylene-1-diethyl phosphate; the third step of making 3-methyl-4,4-dimethoxy-2-butylene-1-diethyl phosphate directly react with 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde through a 'one pot method' without separation to obtain 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecene heptaene dialdol methanol; the fourth step of making the acetal compound be subjected to hydrolysis protection under an acid condition to obtain the target compound 2,6,11,15-tetramethyl 2,4,6,8,10,12,14 hexadecene heptaene dialdehyde. According to the 'one pot method' processing technology, the raw materials are easy to obtain, and the preparing method is simple and coherent, simple in operation, mild in condition, good in yield, less in three wastes, and is thus suitable for industrialized production.
Owner:GUANGZHOU LEADER BIO TECH
Molecularly imprinted mixed ligand lanthanide trimetal-organic framework and preparation method thereof
PendingCN114773616AEasy to prepareNo pollution in the processFluorescence/phosphorescenceAgainst vector-borne diseasesFuranLanthanide
The invention discloses a molecular imprinting mixed ligand lanthanide series trimetal-organic framework and a preparation method thereof, the molecular imprinting mixed ligand lanthanide series trimetal-organic framework is called NKU-66-EuGdTb-P for short, the chemical formula of the molecular imprinting mixed ligand lanthanide series trimetal-organic framework is {[Eu < 0.0067 > Gd < 0.992 > Tb < 0.0013 > (BETC) < 0.5 > (FDA) < 0.5 > (H2O) < 2 >]. 0.25 CH3OH. 2H2O} n, and in the formula, n is a positive integer which is at least 1; bETC is 1, 2, 4, 5-benzene tetracarboxylic acid radical; and FDA is 2, 5-furandicarboxylic acid radical. The preparation method of the molecularly imprinted mixed ligand lanthanide series trimetal-organic framework is simple, pollution-free and low in cost, and the molecularly imprinted mixed ligand lanthanide series trimetal-organic framework can be used for rapidly and sensitively detecting an unstable senile disease marker-pyruvic aldehyde; the material has low detection limit on the pyruvic aldehyde and covers the physiological plasma concentration of the pyruvic aldehyde of a human body.
Owner:NANKAI UNIV
Rutin-pyruvaldehyde adduct, preparation method and application
The invention discloses a rutin-pyruvaldehydeadduct, a preparation method and application, and belongs to the technical field of standard substance synthesis and food detection. The molecular formula of the rutin-pyruvaldehyde adduct is C33H36O20 or C33H34O20. The preparation method comprises the steps of adding rutin and pyruvaldehyde into a phosphoric acid buffer salt solution according to the molar ratio of (10: 1) to (1: 10); under stirring, performing constant-temperature heating reaction to obtain a mixed solution containing the rutin-pyruvaldehyde adduct, separating and purifying the mixed solution to obtain the high-purity rutin-pyruvaldehyde adduct. The adduct is used for detecting the pyruvaldehyde adduct in food and can be used for rapidly and quantitatively detecting the content of the rutin-pyruvaldehyde adduct in the food. The exposure level of the rutin-pyruvaldehyde adduct in the food is evaluated, so that the safety of the food is comprehensively evaluated.
Owner:JINAN UNIVERSITY
Process for improving product quality and yield of propanediol and glycol
InactiveCN100513370CQuality improvementHigh yieldHydroxy compound separation/purificationPreparation from organic carbonatesChromium trioxideSolvent
A method of preparing pyruvaldehyde by propylene glycol in low temperature liquid phase oxidation highly selectively is characterized in that below 50 to 55 DEG C and in the acidic solvent, taking chromium trioxide as the oxidant and highly selectively oxidizing 1, 2-propylene glycol to pyruvaldehyde. The conversion of the 1, 2-propylene glycol is 100 percent, and the selection of preparing pyruvaldehyde is from 95.6 percent to 99.6 percent.
Owner:北京格瑞华阳科技发展有限公司
Polycation capable of being degraded into spermine, and synthesis method and nanoparticles thereof
InactiveCN102516534BReduce acidityPromote escapeOther foreign material introduction processesVector-based foreign material introductionMolecular sieveNanoparticle
The invention discloses a polycation capable of being degraded into spermine, and a synthesis method and nanoparticles thereof, belonging to the technical field of medicines. The polycation can be used for conveying nucleic acids. Spermine and pyruvaldehyde are utilized to construct and degrade the polycation returningto the initial state of multi-ammonia molecules. The synthesis method of the polycation comprises the following steps: slowly dropwisely adding a pyruvaldehyde water solution into a spermine ethanol solution, and simultaneously adding the mixture into a dry molecular sieve; and stirring with a magnetic stirrer at room temperature to carry out condensation reaction on primary amino group, aldehyde group and keto-carbonyl group. The polycation is degradable, and can release spermine containing unprotonated amino group in the degradation process; and the degradation product can not generate acidic group like other degradable polymers. The polycation is beneficial to lysosome escape, and also beneficial to releasing genes in cytoplasm with low surface charges. As for the proton sponge effect, the lysosome cracks due to the osmotic pressure generated by the proton sponge effect. The amino key of the polycation has the action of proton sponge.
Owner:SHANGHAI JIAO TONG UNIV
A kind of fluorescent probe and its preparation method and application
ActiveCN110117229BHigh detection specificityHigh sensitivityOrganic compound preparationFluorescence/phosphorescenceFluoProbesBenzaldehyde
A fluorescent probe and its preparation method and application relate to a formaldehyde detection fluorescent probe and its preparation method and application, belonging to the technical field of analytical chemistry. This kind of fluorescent probe is based on aggregation-induced luminescent dyes and has a double quenching mechanism, which makes the detection background lower, the signal-to-noise ratio is enhanced, and the simultaneous detection of free and polymerized formaldehyde is realized for the first time. The formaldehyde fluorescent probe of the present invention can resist aceglyoxal, glutathione, benzaldehyde, D-glutamic acid, L-alanine, L-cysteine, hydrogen peroxide, acetaldehyde, glyoxal, Glycine and other molecular interference, good selectivity, high accuracy. In addition, the formaldehyde fluorescent probe of the present invention can also detect biological samples (serum, urine), which embodies formaldehyde fluorescence imaging in the complex environment of body fluids, and has potential practical application value in the fields of environmental monitoring and biomedicine.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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