47 results about "Gelatin gel" patented technology

Nanoparticles are disclosed, consisting essentially of an aqueous gelatin gel, wherein the average diameter of the nanoparticles is at the most 350 nm, the polydispersity index of the nanoparticles is less than or equal to 0.15 and wherein a gelatin is used as starting material for the production process. A process for the production of these nanoparticles is also disclosed.

The invention provides a low-cost light mullite-based heat preservation material and a preparation method thereof. The method comprises the following steps: (1) adding pulverized fuel ash, bauxite, glass powder, a dispersing agent and a foam stabilizer into water for mixing, performing ball milling, thereby obtaining primary slurry; (2) adding an aqueous solution of gelatin, and stirring, thereby obtaining ceramic slurry; (3) adding a foaming agent, and stirring, thereby obtaining foam slurry; (4) pouring the foam slurry into a mold, and performing gel solidification at room temperature, thereby obtaining a wet green body; (5) demolding after moisture on the surface of the wet green body evaporates, and performing air drying, thereby obtaining a green body; and (6) sintering the green body in a high-temperature sintering furnace, thereby obtaining the mullite-based thermal insulation material. The industrial waste powder pulverized fuel ash and mineral bauxite are taken as main raw materials, a method for combining mechanical foaming and gelatin gel solidification molding is utilized, the cost is saved, and the environment is protected; and moreover, the prepared material has the advantages of low thermal conductivity, low specific gravity and high thermal stability and has the unique advantages of good creep resistance, erosion resistance and the like.

Development of a physiologically relevant 3D model system for cancer research and drug development represents quite a challenge. We have adopted a 3D culture system based on a transglutaminase-crosslinked gelatin gel (Col-Tgel) to mimic tumor 3D microenvironment. The system has several unique advantages over other alternatives which include cell-matrix interaction sites provided by collagen derived peptides, a 3D construct suitable for reproducing the solid tumor microenvironment including multicellular tumor spheroids and metabolic gradients. In addition the controllable gel stiffness provides a wide range of mechanical restrictions; and compatibility with imaging based screening due to its transparent properties. In addition the Col-Tgel provides a cure-in-situ delivery vehicle for tumor xenograft formation in animals with a high take rate. Overall, this unique 3D system could provide a platform to accurately mimic in vivo situations to study tumor formation and progression both in vitro and in vivo, as well as for screening antineoplastic drugs and assessing the occurrence of drug resistance related to cancer cell stress.

A multi-layer crosslinked gelatin gel structure having a layer structure that plural layers of crosslinked gelatin gel crosslinked by irradiating gelatin or a gelatin derivative with electron beam under an oxygen-containing atmosphere are arranged adjoiningly to each other, a preparation for release of a bioactive factor with the bioactive factor contained in the multi-layer crosslinked gelatin gel structure, and production processes thereof.

Belonging to the technical field of concrete additive preparation, the invention relates to a preparation method of a stable alkali-free setting accelerator. The method includes: firstly conducting gelatinization treatment on black fungus chaff powder, them performing mixing heating with an acrylic monomer, ammonium persulfate and other substances to obtain fungus chaff water-absorbent resin, then subjecting the fungus chaff water-absorbent resin and a self-made gelatin gel solution to mixing grinding so as to obtain mixed water-absorbent resin powder, then subjecting the mixed water-absorbent resin powder and calcium carbonate powder to mixing pressing, and performing ball milling to obtain calcium carbonate resin composite powder, then using aluminum sulfate and benzylamine as the raw materials to prepare an organic amine dispersion solution, and finally heating the organic amine dispersion solution, calcium carbonate resin composite powder and other substances, and then performing cooling. The stable alkali-free setting accelerator prepared by the method provided by the invention has good stability, does not hydrolyze easily, enhances the setting time to a initial setting time of less than 2min and a final setting time of less than 4min, is free of alkali component, does not cause harm to human body, also is environment-friendly, and improves the concrete strength, thus being widely applicable to bridges, underground engineering and other fields.

The invention discloses fish gelatin / sodium alginate double-network complex hydrogel, a preparation method thereof and an obtained probiotic microcapsule, and belongs to the field of microcapsules. When the fish gelatin and sodium alginate gel as single network gel is used, the disadvantages of poor mechanical performance and stability are shown, and embedding of probiotics is not facilitated so as to cause the problems of low embedding ratio of the probiotics and small protection degree of the probiotics. According to the technical scheme, a sodium alginate solution is prepared and is fully hydrated; the fish gelatin is added into the hydrated sodium alginate solution to obtain a mixed solution; the mixed solution is heated, subjected to induction treatment, and is cooled to obtain a gelmixed solution; the gel mixed solution is added into a first calcium ion solution at constant speed and is molded, and then the molded gel is added into a second calcium ion solution and is hardened.The fish gelatin / sodium alginate double-network complex hydrogel disclosed by the invention can be applied to embedding of the probiotics and has the advantages of high embedding ratio and high survival rate of the probiotics.

The invention provides a continuous gradient bionic manufacturing method based on a pneumatic accurate control active cartilage scaffold. Based on sodium alginate SA ionic crosslinking and gelatin Gel low-temperature solidification forming mechanisms, SA, Gel, hydroxyapatite HA and cartilage cell suspension liquid are used as scaffold base materials, and according to the morphological characteristics of natural soft tissues, an extrusion deposition 3D printing technology based on high-pressure controllable gas is adopted to realize the preparation of an embedded living cell three-dimensional soft scaffold; and in the preparation process, the pressure applied to different charging barrels is dynamically and accurately regulated and controlled in real time, so that the accurate controllability of the component content is realized, then real-time dynamic mixing and continuous gradient laying of different component materials are realized through a dynamic mixing spray head, and the scaffold is crosslinked under the combined action of a CaCl2 solution and a low-temperature platform. The problems that an existing cartilage scaffold material is single in concentration, and the single material components of each layer in a layered structure do not conform to the anatomical characteristics of the continuous gradient of natural cartilage are solved.

The invention discloses an alcohol dehydrogenase embedded gelatin-silica hybrid gel and a preparation method thereof. According to invention, the grain diameter of the alcohol dehydrogenase embedded gelatin-silica hybrid gel is 3-4mm, and a silica coating is coated on a gelatin core. The preparation method comprises the following steps of: preparing a mixed solution of gelatin and alcohol dehydrogenase; preparing a mixed solution of sodium silicate and a glutaraldehyde solution precursor; adding the mixed solution of gelatin and alcohol dehydrogenase into deionized water at a temperature of 0-4 DEG C droplet by droplet to generate alcohol dehydrogenase embedded gelatin gel particles; stirring and incubating to obtain the alcohol dehydrogenase embedded gelatin-silica hybrid gel. The preparation method has the advantages that the preparation condition is mild, the preparation process is simple and feasible, and the alcohol dehydrogenase embedded gelatin-silica hybrid gel has a strong fixing capability; compared with gelatin gel, the hybrid gel has a lower leakage rate of immobilized alcohol dehydrogenase, and lower swelling degree and better recycling stability.

A scented sheet member, in which a gelatin gel including at least one of a perfume and a perfume-containing microcapsule is enclosed in a space between film sheets in at least one of which a perfume-permeating hole is formed, is affixed to an inner surface of an upper surface of the containing box so that the at least one of the film sheets having the micropore faces a stack of paper tissues. This can provide a scented paper tissue container that can strengthen a scent when necessary.

The invention discloses a polylactide electrospinning composite film for in-situ gel encapsulating and a preparation method of the polylactide electrospinning composite film. The electrospinning composite film consists of poly(lactide-co-glycolide) or polyethylene glycol-b-poly(lactide-co-caprolactone) fibers and chitosan or gelatin gel particles in the fibers. The preparation method comprises the steps that: sulfydryl chitosan or sulfydryl gelatin and polyethyleneglycol diacrylate are dissolved in phosphate buffer liquid to be used as water phases; the poly(lactide-co-glycolide) or the polyethylene glycol-b-poly(lactide-co-caprolactone) is dissolved in mixed organic solvents to be used as oil phases; and the water phases are added to the oil phases, water / oil (W / O) dispersing liquid is formed through adding emulsifying agents under the stirring condition, and the electrospinning composite film is obtained through the electrospinning of the dispersing liquid. The polylactide electrospinning composite film and the preparation method have the advantages that the preparation process is simple, the prepared composite film has good biocompatibility, degradability, hydrophily and mechanical property, the medicine dumping is reduced, and the medicine release speed is adjustable and controllable. The polylactide electrospinning composite film and the preparation method are used for the tissue engineering and medicine release fields.

The invention relates to a manufacturing method of an edible sodium alginate / gelatin 3D gel scaffold adopting a tea polyphenol coating for cultured meat, the 3D gel scaffold manufactured by the method can be used for proliferation, differentiation and culture of skeletal muscle stem cells, which provides organized support for the cultured meat, and belongs to the field of future food science and technology. The method comprises the following steps: uniformly mixing sodium alginate and gelatin with a certain concentration according to a certain ratio, fully reacting at room temperature for more than 2 hours, refrigerating overnight, and soaking in a calcium chloride / tea polyphenol solution to obtain the sodium alginate / gelatin 3D gel scaffold coated by the tea polyphenol. The manufacturing method is simple and efficient, and no toxic cross-linking agent is used. The obtained sodium alginate / gelatin 3D gel scaffold with the tea polyphenol coating has good cell adhesion and compatibility, and can be used for proliferation, differentiation and culture of skeletal muscle stem cells. The invention provides a manufacturing method of a novel and edible 3D scaffold for the research of cultured meat.

Belonging to the field of gelatin preparation, the invention relates to a method for preparation of gelatin by a composite bioorganic acid and a composite bio-enzyme. The method includes: 1) putting the composite bioorganic acid composed of pyroligneous liquor, citric acid and hydrogen peroxide and the composite bio-enzyme composed of protease, lipase and catalase into a reaction tank for reaction, and performing stirring at intervals; 2) washing the product at the end of the reaction in step 1), then transferring the product into a neutralization tank containing a neutralizer so as to adjustthe pH value of the product; and 3) when the pH of the product regulated in step 2) reaches the standard, transferring the product into a glue pot for multi-pass boiling so as to obtain gelatin gel liquid, and then carrying out filtering, evaporation, skin cutting, refrigeration and crushing, thus obtaining the product. The method provided by the invention utilizes natural bioorganic acids and bio-enzymes to prepare gelatin, and can greatly reduce the production cost, shorten the production cycle and improve the production efficiency.

The invention discloses a gel matrix, and the formula of the gel matrix comprises the following components in parts by mass: polyvinyl alcohol, chitosan, aloe gel, gelatin gel, glycerol, polyethylene glycol, a humectant, a cross-linking agent, a pH regulator, deionized water, plant extract essence, a bacteriostatic agent, carbomer, a cellulose derivative and alginic acid powder. The invention also provides a gel matrix and a preparation method thereof, which comprises the following steps: stirring at normal temperature, stirring at low temperature, subpackaging into molds, and repeatedly freezing, thawing and curing. The aloe gel, the gelatin gel, the polyethylene glycol and other components are added in the formula, and the gel can be combined with polyvinyl alcohol, carbomer and the like in the formula components during coagulation, so that the adhesion effect of the mask produced by the gel matrix is improved; under the action of the gel, the alcohol and the humectant, the gel matrix can adsorb moisture and essence, so that the facial mask produced by the gel matrix is relatively good in skin friendliness, and a user can obtain relatively good use experience.

The invention discloses a vital-energy-tonifying and blood-nourishing composition as well as a preparation method and application thereof, belonging to the technical field of traditional Chinese medicine processing. The composition contains the following raw materials in parts by weight: 24-35 parts of a donkey skin extract, 21-30 parts of a mixed extract of red ginseng and haws and 35-55 parts ofa mixed extract of radix rehmanniae praeparata and radix codonopsis. Compared with a donkey-hide gelatin gel prepared by virtue of a conventional process, the composition is remarkably different andis capable of remarkably increasing the contents of erythrocyte, leukocyte and hemoglobin in blood. The composition has relatively good vital-energy-tonifying and blood-nourishing effects.

The present invention relates to a gelatin product comprising a core component, wherein the core component is encased partially or fully by a gelatin gel. The gelatin gel is produced from a homogeneous casting compound containing the following constituents dissolved in water:3 to 20 wt % of gelatin having a mean molecular weight, determined by gel chromatography, of at least 130 kDa, wherein the proportion of the molecular weight fraction above 100 kDa is at least 35 wt %;up to 60 wt % of glucose syrup with a viscosity of less than 1000 mPa·s, measured with a dry matter content of 80 wt % and at a temperature of 60° C.; andup to 60 wt % of sucrose,wherein the casting compound comprises a dry matter content of at least 70 wt %.

The invention provides a gelatin / fiber composite antibacterial film and a preparation method and application thereof. The preparation method of the antibacterial film comprises the following steps: adding gelatin particles into deionized water, stirring and heating, so that a gelatin aqueous solution is obtained, pouring the gelatin aqueous solution into a mold to obtain gelatin gel, grounding thegelatin gel through a metal wire to serve as a receiving plane, dissolving a polymer material and an antibacterial agent in a solvent to obtain an electrostatic spinning solution, adjusting parameters to perform electrostatic spinning, forming a fiber layer on the surface of the gelatin gel, and drying. According to the invention, the gelatinous gelatin is used as a receiving plane for electrostatic spinning, the electrostatic spinning fibers are uniformly deposited on the surface of the gelatinous gelatin, and the gelatin / fiber composite antibacterial film with the electrostatic spinning fibers firmly attached to the surface is obtained after drying, and has excellent mechanical properties and barrier properties. The antibacterial essential oil-loaded nano-cyclodextrin MOFs material is added into the electrostatic spinning fiber, so that the composite film is endowed with lasting antibacterial and fresh-keeping characteristics.

The invention discloses a preparation method of a polylactic acid food packaging film with antibacterial and one-way moisture barrier properties, the packaging film is composed of a polylactic acid film layer and an antibacterial gelatin hydrogel film layer, a polylactic acid trichloromethane solution is prepared firstly, then glycerol is added as a plasticizer, stirring and degassing are performed, then the mixture is poured into a glass plate, and the antibacterial and one-way moisture barrier polylactic acid food packaging film is obtained. Naturally airing in a fuming cupboard to prepare a polylactic acid film layer; the preparation method comprises the following steps: adding tannic acid and ferric trichloride into a gelatin solution, regulating the pH value by adopting NaOH, stirring and crosslinking, and then adding AgNO3 to obtain an antibacterial gelatin gel solution; and pouring the antibacterial gelatin gel solution into the surface of the polylactic acid film, and drying to obtain the polylactic acid film with antibacterial and one-way moisture barrier properties. The prepared polylactic acid film has good moisture absorption, humidity regulation and durable antibacterial performance, meanwhile, the adopted preparation method is easy to operate and mild in condition, the used raw materials are wide, easy to obtain and low in price, and the polylactic acid film has wide application prospects in the field of food packaging.

The invention relates to an egg white storage method, which comprises the steps of: separating egg yolk from egg white, filtering the egg white to obtain a uniform egg white liquid, carrying out isovolumetric mixing on the egg white liquid and a gelatin solution with a concentration of 6-8%, completely stirring, uniformly mixing, carrying out cold storage to prepare egg white-gelatin gel, cutting the prepared egg white-gelatin gel into blocks, soaking and washing away the egg white-gelatin gel with clear water to remove impurities in the egg white-gelatin gel, then removing moisture, obtaining pure egg white-gelatin gel, cutting the pure egg white-gelatin gel into 3 blocks with the size of 5-6 cm, enabling the egg white-gelatin gel to be subjected to cold sterilization, putting the sterilized egg white-gelatin gel into a vacuum packaging bag, performing vacuum packaging, refrigerating the packaged egg white, unpacking the packaged egg white, and heating the egg white-gelatin liquid to a solid state for eating. The method has the advantages that the egg white is convenient to store, the quality guarantee period of the egg white is prolonged, large-scale production is facilitated, and the utilization rate of the egg white is increased.

The purpose of the present invention is to provide: an eel-like food having excellent texture and flavor, such as eel, and a method of producing the eel-like food. Also, the purpose of the present invention is to provide a frozen eel-like food for frozen foods, which uses the eel-like food, a vacuum-freeze-dried eel-like food for ready-to-eat foods, which can be restored in hot water, and a methodof producing the vacuum-freeze-dried eel-like food. The present invention addresses the problem of providing an eel-like food in which a body layer comprising a layer containing protein raw material,starch, and fat is bonded to a skin layer comprising a heat-resistant gelatin gel layer. Furthermore, a frozen eel-like food can be provided by freezing the eel-like food, and a vacuum freeze-dried eel-like food can be provided by freezing and vacuum freeze-drying the eel-like food.

The present invention discloses a donkey-hide gelatin gel tea cake prepared from a donkey-hide gelatin jujube processing by-product of donkey-hide gelatin jujube pulp. The donkey-hide gelatin jujube processing by-product of the donkey-hide gelatin jujube pulp is selected to further process donkey-hide gelatin fruit nut gelatin candy, and plays effects of rational use of resources, energy saving and environmental protection. In addition, a reasonable combination of raw materials of walnut kernels, raisins, dried cranberries, cashew nuts, big almonds, etc. improves nutritional value of the product and also forms very good mouthfeel. The donkey-hide gelatin gel tea cake further expands varieties of donkey-hide gelatin snack foods and is suitable for different groups of people to eat. Besides,the product prepared by the method is convenient to store and suitable for industrial production, and has very good market application prospects.

The invention relates to a preparation method of a high-temperature-resistant and sterilizable gelatin film and a product, and belongs to the technical field of food packaging. The method prepares the gelatin film through a simple soaking method and comprises the eight procedures of swelling, dissolving, transglutaminase blending and defoaming, film liquid pouring, heat preservation treatment, low-temperature treatment, alcohol precipitation dehydration film forming and alcohol elimination. According to the method, transglutaminase is utilized to catalyze covalent interaction between glutamine gamma-amino and lysine epsilon-amino in gelatin, so that the gelatin forms a stable gel network, the gelatin gel is further soaked with absolute ethyl alcohol, non-covalent interaction of the gelatin gel is induced, and the gelatin film which is resistant to high-temperature sterilization, high in mechanical property and excellent in sensory quality is obtained. The method is simple in process, easy to operate and suitable for industrial production. The gelatin film produced by the method is a faint yellow / colorless film, has excellent thermal stability, keeps the integrity of the film during boiling water treatment and sterilization treatment, and can be used as a film material for foods and medicines.

The invention relates to a drug-loaded absorbable anti-adhesion barrier and a preparation method thereof. The anti-adhesion barrier includes oxidized regenerated cellulose, gelatin, and a drug. The preparation method comprises the following steps: mixing and stirring a gelatin gel solution and an ORC semi-gel solution, adding a drug solution to obtain a drug / collagen / ORC mixed gel solution, and carrying out electrostatic spinning. The anti-adhesion barrier has the advantages of being small in thickness, short in degradation period, high in hemostasis and anti-adhesion efficiency and capable of achieving a drug slow release effect.

A preparation method of gelatin-stearic acid composite gel belongs to the technical field of functional materials, which can solve the problem of defects in the prior art when gelatin and stearic acid are used alone. A certain mass fraction of gelatin aqueous solution is heated and dissolved, and then Stearic acid with a certain mass ratio (gelatin:stearic acid) is added to the co-solvent ethylene glycol to dissolve the stearic acid, and the two are fully stirred and mixed evenly, and finally a certain amount of cross-linking agent citric acid is added to react at 60°C for a certain period of time , and then, utilize freezing-thawing method to obtain gelatin-stearic acid composite gel. The gel of the present invention can combine gelatin and stearic acid organically, and the prepared gel is uniform, and its mechanical strength is increased compared with that of pure gelatin gel; the raw materials used are all intermediate products of biological metabolism, have good biocompatibility, and are nontoxic; The process is simple and the conditions are mild, and it can be used as a slow-release drug carrier, tissue engineering material, etc., expanding the application range of gelatin.

The invention discloses a silk protein / gelatin composite material, which is prepared by a method comprising the following steps: immersing silkworm cocoons in a soap salt solution for degumming, drying to make degummed silk, dissolving the degummed silk in a lithium bromide solution, and dialysis for desalting , concentrated to make a silk protein solution; mix the silk protein solution with the gelatin solution, add horseradish peroxidase, hydrogen peroxide solution and transglutaminase, and form a gel after mixing to obtain a silk protein / gelatin gel; The silk protein / gelatin gel is respectively soaked in alcohol and ammonium sulfate solution to obtain a silk protein / gelatin cross-linked gel, which is then dried. The silk protein / gelatin composite material can be used to prepare internal fixation systems used in trauma orthopedics and maxillofacial plastic surgery, and has high industrial production and clinical application prospects.

The invention belongs to the field of tissue engineering scaffold materials, and provides a bionic composite scaffold material doped with graphene and an establishment method of the bionic composite support material. The establishment method comprises the following steps: firstly preparing a Cs acetic acid solution, a GP aqueous solution, a Gel aqueous solution and a graphene suspension, and thenmixing the Cs acetic acid solution and the GP aqueous solution to prepare a Cs / GP solution A; adding the Gel aqueous solution into the Cs / GP solution A to prepare a Cs / GP / Gel solution B; and adding the graphene suspension into the Cs / GP / Gel solution B to prepare a Cs / GP / Gel / Gr solution C, transferring the solution C into a low-temperature mold, freeze drying at a low temperature, and performing the subsequent treatment, thus obtaining the bionic cartilage composite support material. A mass ratio of chitosan Cs to beta-sodium glycerophosphate GP to gelatin Gel to graphene Gr in the bionic cartilage composite scaffold material is 1: (5 to 20): (1 to 5): (0.02 to 0.08). The bionic composite scaffold material has the advantages of simple process, easy control and low production cost; and a produced support product is uniform in porosity, has an inter-connective pore structure and has an excellent bionic effect.

The present invention relates to a novel gelatin-free gelled confectionery comprising 2% to 4% of pregelatinized waxy starch and 0.5% to 1.5% of branched maltodextrins, wherein the percentages are expressed in dry weight relative to the total weight of the final product. The invention also relates to a method for preparing such a confectionery.

The present invention provides modified fish gelatin based on low-ester pectin and calcium and a preparation method of the modified fish gelatin. The modified fish gelatin comprises the following components: 6.67% w / w of fish gelatin, 0.8% w / w of low-ester pectin, 2 mM of calcium chloride and the balance deionized water. The low-ester pectin and calcium ions are used to improve gelling propertiesof the fish gelatin. The low-ester pectin, as a plant cell wall polysaccharide, is not absorbed by human body and can reach the intestine to promote reproduction of probiotics in the intestine. Addition of the calcium can also achieve a purpose of calcium supplementation and enriches nutrients of the fish gelatin. The low-ester pectin and calcium are used to improve thermal stability of the fish gelatin. An effect of different concentrations of the calcium chloride on the system is tested. A gelatin-melting temperature increases from 26 DEG C of an initial pure fish gelatin to 43 DEG C of themodified fish gelatin (calcium chloride 3 mM), hardness of the fish gelatin is increased (+32% and calcium chloride 2 mM) and defects of the fish gelatin relative to mammalian gelatin are compensated.

The invention relates to intelligent optical hydrogel and a preparation method thereof. The hydrogel comprises acrylamide, acrylic acid, (E)-N-(4-(2-(2-hydroxybenzylidene)-formylhydrazino)phenyl)methacrylamide, gelatin and aluminum ions, wherein the mass of the (E)-N-(4-(2-(2-hydroxybenzylidene)-formylhydrazino)phenyl)methacrylamide is 1%-3% of the mass of the acrylamide, the mass of the acrylic acid is 10%-20% of the mass of the acrylamide, and the mass of the gelatin is 32%-48% of the total solid content. According to the hydrogel disclosed by the invention, the acrylic acid subjected to metal complexing copolymerization and the (E)-N-(4-(2-(2-hydroxybenzylidene)-formylhydrazino)phenyl)methacrylamide (HHPMA) are utilized to form a polymer network, and gelatin is used as an auxiliary material for gelatinization, so that a semi-interpenetrating structure is obtained; the hydrogel has the advantages of intelligent fluorescence responsiveness, excellent shape memory ability and good self-repairability.

The present invention relates to a gelatin product comprising a core component, wherein the core component is encased partially or fully by a gelatin gel. The gelatin gel is produced from a homogeneous casting compound containing the following constituents dissolved in water:3 to 20 wt % of gelatin having a mean molecular weight, determined by gel chromatography, of at least 130 kDa, wherein the proportion of the molecular weight fraction above 100 kDa is at least 35 wt %;up to 60 wt % of glucose syrup with a viscosity of less than 1000 mPa·s, measured with a dry matter content of 80 wt % and at a temperature of 60° C.; andup to 60 wt % of sucrose,wherein the casting compound comprises a dry matter content of at least 70 wt %.