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Drug-loaded absorbable anti-adhesion barrier and preparation method thereof

An anti-adhesion and barrier technology, which is applied in the fields of medical science, surgery, cellulose/protein conjugated artificial filament, etc., can solve the problems of non-environmental protection, high cost of preparation process, unstable degradation performance of anti-adhesion products, etc., and achieve reduction Degradation burden, effect of reducing thickness and dosage

Pending Publication Date: 2022-04-05
YANCHENG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a drug-loaded absorbable anti-adhesion barrier and a preparation method thereof, so as to overcome the unstable degradation performance, poor biocompatibility, high cost of the preparation process and inconvenient anti-adhesion products in the prior art. Defects such as environmental protection

Method used

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  • Drug-loaded absorbable anti-adhesion barrier and preparation method thereof

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Embodiment 1

[0050] Bacterial cellulose is prepared by the fermentation of acetic acid bacteria. Its appearance is a round or oval thin wet film with a diameter of 1 meter and a thickness of 2 mm.

[0051] The regeneration process of bacterial cellulose is pre-dissolved with sodium hydroxide / urea solvent system at a volume ratio of 1:20 at low temperature, and then the solution is slowly coagulated in a coagulation bath formed by 5g / L sulfuric acid solution through microfluidic technology for 5min , to form regenerated cellulose, which is then fully washed with water, freeze-dried, and ground into regenerated cellulose powder.

[0052] The oxidation process of regenerated bacterial cellulose is to carry out TEMPO carboxylation (TEMPO reagent 5g / L, temperature 50 ℃, time 6h) and sodium periodate (NaIO 4) formylation (reagent 5g / L, temperature 50°C, time 6h) modification to improve its surface activity, and then use carbon tetrachloride / nitrogen dioxide mixed solvent system (dinitrogen tetro...

Embodiment 2

[0062] Bacterial cellulose is produced by the fermentation of acetic acid bacteria. Its shape is a round or oval thin wet film. The diameter of the wet film is about 0.5 meters, and the thickness of the wet film is 0.5 mm.

[0063] The regeneration process of bacterial cellulose is pre-dissolved with sodium hydroxide / urea solvent system at a volume ratio of 1:20 at low temperature, and then the solution is slowly coagulated in a coagulation bath formed by 6g / L sulfuric acid solution through microfluidic technology for 8 minutes , to form regenerated cellulose, which is then fully washed with water, freeze-dried, and ground into regenerated cellulose powder.

[0064] The oxidation process of regenerated bacterial cellulose is to carry out TEMPO carboxylation (TEMPO reagent 5g / L, temperature 50 ℃, time 6h) and sodium periodate (NaIO 4 ) Formylation (reagent 5g / L, temperature 50°C, time 6h) modification to improve its surface activity, and then further fully oxidized (temperature...

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Abstract

The invention relates to a drug-loaded absorbable anti-adhesion barrier and a preparation method thereof. The anti-adhesion barrier includes oxidized regenerated cellulose, gelatin, and a drug. The preparation method comprises the following steps: mixing and stirring a gelatin gel solution and an ORC semi-gel solution, adding a drug solution to obtain a drug / collagen / ORC mixed gel solution, and carrying out electrostatic spinning. The anti-adhesion barrier has the advantages of being small in thickness, short in degradation period, high in hemostasis and anti-adhesion efficiency and capable of achieving a drug slow release effect.

Description

technical field [0001] The invention belongs to the field of medical materials and their preparation, in particular to a drug-loaded absorbable anti-adhesion barrier and a preparation method thereof. Background technique [0002] Cellulose is an important organic polymer resource, and its output and application are of great significance to industrial production, economic development and people's life. According to statistics, the amount of cellulose produced in the world every year is 700000000000000 tons. Due to its fiber shape, good biocompatibility, high rigidity, and low cost, cellulose is widely used in various fields, and medical materials are one of the important applications of cellulose. As the most abundant biomass resource on the earth, it has been widely used to prepare biomedical materials such as dressings, dialysis membranes, scaffold materials, drug carriers, etc. [0003] As an absorbable anti-adhesion film in the body, the most widely used clinically is t...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14A61L31/16D01F8/02
Inventor 吴焕岭郑成辉林玲王乃涛蒙丽娟谢周良王宇航
Owner YANCHENG INST OF TECH
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