54 results about "Gastric mucous membrane" patented technology

The invention pertains to the field of medical technology and provides triterpenoid saponin in camellia seeds, and a preparation method and medical application thereof. The triterpenoid saponin is shown in a general formula (1), wherein, R1 is hydrogen or oxhydryl or acyloxy; R2 is the hydrogen or the acyloxy; R3 is the hydrogen or the acyloxy; R4 is the hydrogen or the acyloxy; R5 is methyl or methylol or aldehyde group or carboxyl or metheyl carboxyl; R6 is the hydrogen or orglycosyl; the preparation method comprises the following steps: macroporous resins are degreased, extracted by ethanol, decocted in water, desugared and decolored to obtain crude total saponins and then go though an opened ODS chromatographic column and repeated HPLC method to obtain the total saponins of camellia seeds and monomer theasaponin. The triterpenoid saponin compounds in the camellia seeds have the functions of protecting gastric mucosa, being antineoplastic, reducing blood sugar and blood fat and thelike and are used for preparing medicaments or health-care foods having the functions of protecting gastric mucosa, being antineoplastic and reducing blood sugar and blood fat.

The present invention is flurbiprofen ester injection as antiphlogistic and analgetic medicine and its preparation process. Main medicine and supplementary material including solvent, emulsifier, isotonic agent, buffering agent and pH regulator are mixed to compound the injection. Compared with available oral flurbiprofen preparation, the flurbiprofen ester injection has even high curative effect, even fast action, long lasting effect and less stomach mucous membrane damage and other negative effect. The present invention is used in treating chronic rheumarthritis, etc and is especially suitable for relieve post-operational pain and pain caused by cancer, and it has high effect and no addiction.

Methods of treating, reducing, or preventing a disease or symptom relating to a disease such as oral mucositis, gingivitis, periodontitis, gastric mucositis, inflammatory fibrosis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, inflammation associated with cancer, cancer treatment, or radiation, and / or pain that include: identifying a patient in need of treatment; and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.

The invention discloses rhizoma bletillae stomach-nourishing noodles. The rhizoma bletillae stomach-nourishing noodles are prepared from the following raw materials: rhizoma bletillae starch, millet meal, hericium erinaceus, flour, salt, edible alkali and quail eggs. The rhizoma bletillae stomach-nourishing noodles are prepared by the following steps: preparing materials: a, mixing the rhizoma bletillae starch, the millet meal, the flour and the edible alkali; b, washing and cutting the hericium erinaceus into blocks and adding water and the salt; putting the hericium erinaceus into a soup pot and boiling for 1h to 2h; putting the boiled hericium erinaceus and soup into a mashing machine and mashing to obtain paste for later use; pouring the cooled paste and the quail eggs into a mixture of the rhizoma bletillae starch, the millet meal, the flour and the edible alkali; after kneading dough, fermenting; ageing the dough; slicing the aged dough to prepare noodles; standing and airing; after disinfecting, sealing and preserving to prepare the rhizoma bletillae stomach-nourishing noodles. The rhizoma bletillae stomach-nourishing noodles take the rhizoma bletillae starch as a main raw material and the effects of protecting gastric mucous membrane, resisting bacteria and resisting fungi of the rhizoma bletillae starch are coordinated with stomach-nourishing foods including millets, the hericium erinaceus, the quail eggs and the like; when the rhizoma bletillae stomach-nourishing noodles are used for nourishing stomach, diseases, caused by bleeding, of gastrointestinal tracts are treated and alleviated.

The present invention relates to a kind one active enzymes, including lysozyme, glycose oxidase and casease, and their composition capable of constituting medicine and health food for preventing and treating gastric ulcer, duodenal ulcer and chronic gastritis and enzyme containing cosmetics. The present invention discloses the medicine recipe for treating gastric ulcer, duodenal ulcer and chronic gastritis effectively, and the medicine has obvious functions of sterilizing, inhibiting gastric acid secretion and repairing gastric mucous membrane to cure the said diseases radically. The present invention also discloses the cosmetic composition containing active enzyme and the cosmetic composition can nourish and care skin and sterilize to prevent bacterial infection.

The present invention discloses the use of tremella heteropolysaccharide or its extract in preparing medicine, food, beverage and health product for protecting or repairing gastric mucous membrane.

The invention provides a method for preparing food by using a fish maw, which comprises the following steps: (1) taking the deep water fish maw and rinsing residues in the maw in water for standby; (2) treating the cleaned deep water fish maw in ozone water with an ozone concentration of 4 mg / L for 30 minutes; (3) modulating the treated deep water fish maw by using ginger juice formed by pressing and squeezing fresh ginger of which the mass percent is 3 percent of that of the fish maw and 2 percent of honey; and (4) crushing the modulated deep water fish maw to 3-5 mum. The method for preparing the food by using the fish maw has the beneficial effects that all nature of the fish maw as well as a gastric mucous membrane on the inner wall of the fish maw and other matters for digesting the food is kept, i.e. all nutrient substances of the deep water fish maw are kept, so that the functions of nourishing and supplementing a stomach are fully displayed; not only is a new way opened up for developing fish processing leftovers and deepening the utilization of sea resources, but also compared with the prior art, a product obtained by the invention is closer to the demands of supplementing the stomach with another stomach and is more effective to the stomach nutrition supplement of an eater.

The invention relates to a method for preparing colloidal bismuth pectin and a method for controlling the adhesiveness of a medicine composition of colloidal bismuth pectin. The method for preparing colloidal bismuth pectin includes the steps that firstly, a bismuth salt solution is prepared; secondly, colloidal bismuth pectin is prepared; thirdly, colloidal bismuth pectin is purified. The method for controlling the adhesiveness of a dry suspension of the medicine composition of colloidal bismuth pectin includes the step of measuring and controlling one or more indexes including the intrinsic viscosity, bismuth ion content uniformity and galacturonic acid content. Colloidal bismuth pectin prepared through the method is reasonable in galacturonic acid content, bismuth ion content, bismuth ion content uniformity and other index contents, high in intrinsic viscosity, and good in clinical effect. The treatment effect of colloidal bismuth pectin is improved, the gastritis cure rate and the Hp eradication rate of colloidal bismuth pectin are greatly increased, and the gastric mucosa protection function of colloidal bismuth pectin is greatly improved.

The invention relates to a traditional Chinese medicine composition for preventing and treating chronic atrophic gastritis and gastric precancerous lesions, and a preparation method and application ofthe traditional Chinese medicine composition. The composition comprises the following raw materials in parts by weight: radix angelicae sinensis, radix angelicae dahurioae, paeoniae alba radix, herbarhodiolae, coicis semen, rhizoma alismatis, rhizoma curcumae, gecko, bombyx batryticatus, fructus citri sarcodactylis, herba taraxaci, radix bupleuri, pinelliae rhizoma praeparatum, fructus akebiae,actinidia arguta (Sieb. et Zucc) planch. ex miq. roots and cremastrae pseudobulbus. The traditional Chinese medicine composition has the efficacy of dispersing stagnated liver qi to relieve depression, eliminating stasis and stagnation, removing turbidity and detoxifying, can effectively prevent disease courses of the chronic atrophic gastritis and the gastric precancerous lesions from progressing, reverses gastric mucosal atrophy, protects the chronic atrophic gastritis from canceration, has a clear curative effect, and has a low cost.

The invention discloses a hangover-relieving beverage produced using Camellia chrysantha and Caulis dendrobii as raw materials and a production method thereof. Active ingredients of the hangover-relieving beverage are composed of, by weight, 15-25 parts of Camellia chrysantha leaf or Camellia, 20-40 parts of Pueraria leaf or flower, 15-20 parts of Calendula officinalis, 10-20 parts of Dendrobium nano powder, 10-20 parts of Rhizoma imperatae and 15-30 parts of Flos chrysanthemi. The hangover-relieving beverage contains ingredients like Camellia saponin, Camellia flavone, Dendrobium polysaccharide, dendrobine, various amino acids, trace element selenium, plant protein and vitamins, thereby having efficacy of relieving hangover, clearing heat for detoxification, calming, clearing lung and brain and protecting liver, gallbladder and stomach. The active ingredients of the hangover-relieving beverage can be quickly decomposed in vivo to metabolize alcohol, have functions of promoting liver for detoxification and kidney for excretion, can restore gastrointestinal mucous membrane and normal flora and promote health of a digestive system and have biological functions of activating blood to remove stasis, lowering blood sugar, blood pressure and blood lipid, improving immunity and resisting lipid peroxidation, tumor and senility.

The invention discloses an application of butyric acid and salts thereof in the preparation of medicines for treating or preventing gastric ulcer, and belongs to the field of medicine. According to the above application, the butyric acid and salts thereof, through anti-inflammation and antioxidation, promote the secretion of gastric mucus, upregulate the apoptin BCL2, downregulate the pro-apoptotic protein Bax, have positive curative and preventive effects on gastric ulcer injury, effectively reduce falling, defect, atrophy and bleeding of the gastric mucous membrane, and have important significance to the prevention or treatment of gastric ulcer.

The invention discloses a medicine composition for treating infant spleen deficiency type diarrhea and a preparation method thereof. The medicine composition comprises the following raw medicinal materials: Chinese peashrub root , ventilago leiocarpa, radix pseudostellariae, fructus amomi, radix campanumoeae, polygonum polystachyum, radix glycyrrhizae, jasminum laurifolium, radix salviae miltiorrhizae, fructus forsythia, rhizoma cimicifugae, rhizoma ligustici, vandellia cordifolia, rhizoma atractylodis macrocephalae, potentilla anserina, acanthopanax senticosus, thlaspi arvense, fructus setariae germinatus, dioscorea althaeoides, papaver nudicaule, chinaroot greenbier rhizome, herba lycopi, clove, radix cynanchi paniculati, daimyo oak seeds, coffee senna seeds, rhizoma curcumae, semen euryales, fructus piperis longi, lyonia ovalifolia and copperleaf herb. The medicine composition has the benefits of having the efficacies of strengthening spleen, recuperating stomach, benefiting qi, checking diarrhea and aiding digestion, having the effects of protecting gastrointestinal mucous membrane, enhancing resistance and relieving pain, and having the advantages of taking effect quickly, and being high in efficiency, accurate in curative effect, short in treatment course, free of toxic and side effects, low in price, and the like.

Methods of treating, reducing, or preventing a disease or symptom relating to a disease such as oral mucositis, gingivitis, periodontitis, gastric mucositis, inflammatory fibrosis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, inflammation associated with cancer, cancer treatment, or radiation, and / or pain that include: identifying a patient in need of treatment; and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

The invention discloses yoghourt capable of neutralizing the effect of alcoholic drinks and a preparation method of the yoghurt. The yoghourt capable of neutralizing the effect of alcoholic drinks comprises the following raw materials in parts by weight of 70-85 parts of pure milk, 0.2-0.5 part of a fermentation agent, 0.2-5 parts of antrodia cinnamomea powder, 0.1-0.5 part of taurine, 3-10 partsof white granulated sugar and 15-20 parts of honey. The preparation method mainly comprises the following steps of enabling the antrodia cinnamomea powder, the taurine and the white granulated sugar to dissolve in the pure milk, performing stirring until the antrodia cinnamomea powder, the taurine and the white granulated sugar are uniformly distributed, removing impurities through a filter net, performing rapid sterilization, performing lactic acid bacteria inoculation and fermentation, making a honey seasoning bag, performing packing and the like so as to obtain the yoghourt. The yoghurt canachieve the effects of protecting the gastric mucous membranes, wherein the components of the antrodia cinnamomea, the taurine and the honey have obvious effects of neutralizing the effect of alcoholic drinks and protecting the liver.

The invention discloses a pharmaceutical combination for treating children enteritis and a preparing method thereof. The pharmaceutical combination is composed of main materials and auxiliary materials, wherein the main materials include saruma henryi, artemisia apiacea, coptis chinensis, humifuse euphorbia herb, radix sophorae flavescentis, eucalyptus leaves, radices sileris, bighead atractylodes rhizome, pericarpium papaveris, agastache rugosus, poria cocos, pericarpium arecae, folia perillae acutae, radix angelicae, orange peel, mangnolia officinalis, liquorice, cassia twig, round cardamom fruit, hedyotis chrysotricha, the root of Chinese pulsatilla and caulis lonicerae, and the auxiliary materials include pearl powder, pectin powder, tannalbin, pepsin, polyzyme tablets, lactasin, yeast tablets, calcium lactate powder and multivitamins. The medicine is made from materials with mild properties, is capable of protecting gastrointestinal mucous membranesm, stopping diarrhea, aiding digestion, stopping vomiting, supplementing essential nutrients and clearing heat and promoting diuresis, has a definite curative effective for children enteritis, and is convenient to take, safe, free of toxic and side effect, and suitable for bulk production.

The invention discloses a shrimp chili sauce and a preparation method thereof. The shrimp chili sauce is characterized by being prepared from the following raw materials in parts by weight: 200-220 parts of dry chili, 30-35 parts of shrimp flesh, 10-11 parts of white vinegar, 9-10 parts of orange peel, 10-11 parts of red kojic rice, 4-5 parts of astragalus membranaceus, 2-3 parts of rehmannia glutinosa, 2-3 parts of Chinese wolfberry fruits, 4-5 parts of polygonum multiflorum, 10-11 parts of mesona chinensis, 35-40 parts of milk powder, 10-11 parts of lactobacillus plantarum, 30-35 parts of table salt, 25-30 parts of cane sugar, and 0.4-0.5 part of CaC12. According to the shrimp chili sauce disclosed by the invention, because the red chili is used as raw materials, the technological process of concentration can be omitted; the lactobacillus plantarum for fermenting the chili sauce is resistant to acid and salt, so that the fermented chili sauce is high in quality; the adding amount of the CaC12, the table salt and the cane sugar is appropriate, so that the shrimp chili sauce is moderate in hardness, tastes salty and delicious, and has a good color; the milk powder, which is added in the later period of fermentation, is fermented and formed into gel coating the surface of chili, so that the stimulation to gastric mucous membranes can be decreased; the mesona chinensis can avoid internal heat; in addition, the shrimp chili sauce disclosed by the invention can strengthen the immunity of human bodies.

The invention provides a wheat germ protein hydrolysate and a preparation method and application thereof, and relates to the technical field of wheat germ protein derivatives. The preparation method of the wheat germ protein hydrolysate adopts wheat germ powder as a raw material to carry out alkali extraction and acid precipitation so as to obtain wheat germ protein, and then the obtained wheat germ protein is enzymatically decomposed by pronase or protease N so as to obtain the wheat germ protein hydrolysate. Tests show that the wheat germ protein hydrolysate has the remarkable activity of resisting adhesion of helicobacter pylori to gastric mucosal cells, and can be used for preventing helicobacter pylori infection. Compared with existing medicine, the medicine has the advantages of being natural, safe, low in price, high in efficiency, mild, not prone to production of generate drug-resistant bacteria and the like. A new utilization way for wheat processing by-products, and the additional value of wheat processing is increased.

A method for managing or treating an inflammatory, erosive, dyspeptic or reflux disorder of the proximal digestive tract of a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor. A therapeutic combination, useful to treat any disease or condition in which an NSAID is indicated, comprises an NSAID in an anti-inflammatory, analgesic or antipyretic effective amount and a gastroprotective agent that comprises an ACE2 inhibitor in an amount effective to protect mucosal surfaces of the proximal digestive tract from erosion or ulceration induced by the NSAID.

The invention relates to a method for preparing the traditional Chinese medicine composition for preventing and treating gastropathy, which belongs to the technical field of the traditional Chinese medicine for preventing and treating gastropathy. The traditional Chinese medicine composition is composed of Sichuan fritillary bulb, notopterygium root, purslane speedwell, Chinese yam, coix seeds, white hyaciath bean, cinnamon, angelica, bitter orange, honeysuckle flower, evodia fruit, dahurian angelica root and aucklandia root. The preparation method comprises the following steps: firstly, all the medicines are divided into three groups; secondly, the first group of medicines is pulverized into course powder; thirdly, the second group of medicines is distilled; fourthly, the third group of medicines is ethanol-extracted; fifthly, the medicines and the gruffs are decocted; sixthly, the filtrate, the distillate and the ethanol filtrate are uniformly mixed and concentrated; seventhly, the crude medicine is prepared. The preparation method has the advantages that the gastric mucous membrane is quickly protected, the nidus is inhibited in time, and damaged cell factors of gastric mucous membrane can be quickly recovered; a variety of pathogens can be quickly killed, the alkalinity-acidity balance of the gastrointestinal tracts can be adjusted, the muscular cells can be conducive to being re-generated, the damaged cells of gastric mucous membrane can grow quickly, no toxic or side effect can be caused, the blood circulation can be improved, and the gastric motility can be enhanced; but the treatment effect is relatively slow.

The invention discloses an application of sulfonating dehydrogenated disodium abietic acid on medicine, and relates to the medicine field of preventing from gastrointestinal tract diseases, in particular to medicine for preventing gastrointestinal tract inflammation and ulceration caused by acid stomach. The patent disclosed in CN00818150.0 shows that sulfogroup dehydrogenated rosin mono-sodium salt is better than disodium salt, but the patent does not further disclose the experimental condition and the data result, thus the pharmacological action and the clinical application condition are worthy to further research. Through comparing acid preparation in vitro effect of the mono-sodium salt with the disodium salt, the dissolution rate and the pharmacodynamic test of the mono-sodium salt with the disodium salt in simulated gastric fluid and simulated intestinal fluid, the invention has the result as follows: the sulfonating dehydrogenated disodium abietic acid has stronger acid making property when curing stomach ulcer, acute gastritis, acute attack of chronic gastritis, faster entogastric and intestinal dissolution speed, higher healing effect and quicker deserted effect.

The invention relates to a rebamipide monohydrate crystal form and a preparation method thereof. The invention further relates to a pharmaceutical composition taking a rebamipide monohydrate containing the crystal form as an active compound and application of the pharmaceutical composition in manufacturing of medicaments for treating diseases related to gastric ulcer, acute gastritis, chronic gastritis and gastric mucosal injuries caused by acute exacerbation.

The invention discloses medicine for treating infant damp-heat type diarrhea and a preparation method thereof. The medicine comprises the following raw medicinal materials: eupatorium fortunei, astilbe chinensis, radix salviae miltiorrhizae, adenosma indianum, herba lycopodii, Chinese sage herb, folium viticis negundo, folium et cacumen murrayae, seeds of brassica campestris, lysimachia sikokiana, herba scutellariae barbatae, semen aesculi, latouchea fokiensis, persicaria hydropiper, radix pseudostellariae, radix glycyrrhizae, bulbus allii macrostemonis, aster ageratoides, herba lycopi, common origanum herb, radix rubiae, rhizoma atractylodis macrocephalae, vitis flexuosa juice, mosla Chinensis maxim, herba asari, pittosporumlike nothapodytes, myrrh, radix angelicae, radix astragali, elsholtzia rugulosa, semen raphani, achyranthes aspera, sweet basil herb, greater celandine herb and chinaroot greenbier rhizome. The medicine has the benefits of having the efficacies of relieving exterior syndrome, resolving dampness, regulating qi, regulating the middle warmer, and activating blood circulation to remove blood stasis, having the effects of protecting gastrointestinal mucous membrane, enhancing resistance and relieving pain, and having the advantages of taking effect quickly, and being high in efficiency, accurate in curative effect, short in treatment course, free of toxic and side effects, low in price, and the like.

The invention provides a medicament composition of aspirin and diosgenin in view of the limitations of antithrombotic medicaments. The composition has antithrombotic activity significantly higher than aspirin, can significantly reduce the therapeutic dose of aspirin, simultaneously has gastric mucosal protective effect, and can be safely used for long term.

The present invention relates to an application of ozonized oil in food, health-care products and medicines. Methods of oral administration, intraperitoneal injection, colon administration, intragastric administration, intravenous injection, subcutaneous injection, intramuscular injection, external application and suppositories can effectively prepare the food, health-care products and medicines for improving intestinal flora, promoting digestion, protecting radiation damages, assisting in lowering blood pressure, increasing bone density, protecting chemical liver damages, lowering blood fat,promoting lactation, discharging lead, clearing throat, promoting growth and development, improving visual fatigue, relaxing bowels and protecting gastric mucosal damages.

The invention provides a pantoprazole sodium freeze-dried medicinal composition for injection, comprising the following components by weight: 1 part of pantoprazole sodium and 0.01-0.1 part of sodium citrate. The invention also provides a preparation method of the freeze-dried medicinal composition. The pantoprazole sodium freeze-dried medicinal composition for injection is used for treating peptic ulcer bleeding, acute gastric mucosal injury caused by non-steroidal anti-inflammatory drugs and ulcer hemorrhoea in a stress state, as well as regurgitation of gastric juice and aspiration pneumonia of patients who are subjected to general anesthesia or a major operation and are weak and in coma.

The invention belonging to the technical field of toothpaste discloses medicinal toothpaste capable of resisting helicobacter pylori. The medicinal toothpaste is prepared from the following functionalbasic raw materials, by weight and an added anti-helicobacter pylori medicine raw material; the functional basic raw materials comprise 60-68 parts of a humectant, 13-17 parts of an abrasive, 0.1-0.4part of an adhesive, 2.6-3.0 parts of a foaming agent, 2.2-2.7 parts of a thickening agent, 1.2-1.8 parts of a sweetening agent and 0.6-1.0 part of a flavoring agent; the anti-helicobacter pylori medicine raw material is prepared from the following raw materials, by weight: 0.2 to 0.6 part of metronidazole, 0.03 to 0.08 part of clarithromycin, 2.1 to 2.7 parts of omeprazole and 0.3 to 0.9 part ofan organic colloidal bismuth agent. A trace amount of clarithromycin is specially used for removing helicobacter pylori and a function of preventing wall cells from transferring hydrogen ions is matched, so that secretion of gastric acid is hindered, mucoprotein in gastric mucosa is prevented from being hydrolyzed, and thus a formed membrane barrier is firm and durable.

The invention provides a preparation method of a mouse model for specific expression of Cre enzymes in gastric epithelial cells, and relates to the technical field of mouse models. A Cre-2A gene sequence is inserted to an upper stream of an initiation codon of a Tff1 gene, finally, specific expression of the Cre enzymes in the gastric epithelial cells is realized, the expression specificity of theCre enzymes by stomach tissue is better than that of a similar model which is reported at current, the gastric epithelial cells expressed by the Tff1 gene are consistent with an origin of the gastricepithelial cells, and the mouse model prepared by the preparation method can be used for research in the field of gastric cancer.

The invention discloses a combination for preventing alcohol absorption and boosting alcohol metabolism, wherein the combination is characterized in that: main effective components comprises polyprenol, propolis, royal jelly and bee pollen, the combination comprises 1-5% of polyprenol, 1-5% of propolis, 1-5% of royal jelly and 93-97% of bee pollen, a preparation method comprises: extracting, purifying, adding accessory materials and uniformly stirring, to prepare corresponding dosage form. The composition is mainly used for protecting a gastrointestinal tract mucous membrane, reducing damage on gastric mucosa by ethanol, preventing alcohol absorption of an intestinal tract, raising capability of a liver for relieving or neutralizing the effect of alcohol, boosting alcohol metabolism, and preventing liver damage. A taking method of the combination is that: the combination is taken in 180min before and after drinking each time, and the combination comprises following amounts of the effective components: 10-50mg of polyprenol, 10-50mg of propolis, 10-50mg of royal jelly, and 500-2000mg of bee pollen.

The present technology provides methods and compositions for the treatment of inflammatory and / or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and / or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and / or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.