30 results about "Etamsylate" patented technology

The invention discloses a method for producing high-purity etamsylate. The method comprises the following steps: carrying out a sulfonation reaction on hydroquinone serving as an initial material, a sulfonating agent, a dispersing agent and an organic solvent to obtain 2,5-dihydroxybenzenesulfonic acid; cooling the reaction solution to 45-70 DEG C, adding a mixed solution of diethylamine and waterto form a salt, cooling and crystallizing, so as to obtain the etamsylate. According to the reaction system used in the method, the fluidity of the system is improved, and the three-transfer-one-reaction efficiency is improved, so that the conversion rate of the materials is improved by 5-10%; when the system is cooled to 45-70 DEG C after the reaction is ended, the mixed solution of diethylamineand water is directly added into the system, the operation is simplified, and the after-treatment time is shortened; concentrated water is avoided, the energy consumption is reduced, and the yield ofthe product after salt formation reaches 80-85%; the product does not need to be re-crystallized or subjected to activated carbon discoloration, the purity directly reaches 99.5% or higher, and the content of all single impurities is lower than 0.05%; in addition, the use of a type of solvents and reagents containing genotoxicity warning structures is avoided, and totally safe and low-toxicity class-2 and class-3 solvents friendly to the humans and environment are used.

The invention discloses a compound dimetridazole premix for preventing and treating the poultry enterovirus syndrome. The premix is prepared by uniformly mixing the following components in percentage by weight: 10 to 30 percent of dimetridazole, 4 to 10 percent of neomycin sulfate, 2 to 8 percent of decoquinate econazole nitrate, 10 to 30 percent of lysozyme, 0.5 to 5 percent of etamsylate, 3 to 10 percent of lactic acid TMP and the balance of pharmaceutically applicable auxiliary material. According to the invention, the novel high-efficiency anticoccidial drug decoquinate econazole nitrate, the dimetridazole and the neomycin sulfate which have a special curative effect on intestinal infection, the lysozyme with effects of resisting to bacteria, resisting to viruses, diminishing inflammation, relieving pain and repairing intestinal mucosa, the high-efficiency hemostatics etamsylate and the drug synergist are compounded into a compound preparation; and the compound dimetridazole premix has a high-efficiency treatment effect on the poultry enterovirus syndrome. The compound dimetridazole premix has a reasonable and scientific formula, is simple to prepare, has wide application and can be used as a priority drug for preventing and treating the poultry enterovirus syndrome.

The invention belongs to the technical field of medicine and particularly relates to a medicinal preparation for preventing operative bleeding and a preparation method thereof. The medicinal preparation is prepared from active ingredients etamsylate, sodium metabisulfite, sodium calcium edetate, methylparaben, a pH regulator and water for injection. The phenomenon that bubbles are produced in the filling process of etamsylate injections is avoided, the problem of product yield reduction caused by bubbles is solved, the safety of the injection in clinical application is greatly improved, and the medicinal preparation is simple and easy to operate and facilitates large-scale production.

The invention relates to a uric acid kit for rapidly and simply eliminating drug interference of calcium dobesilate and etamsylate in serum. The uric acid kit is characterized by comprising a reagentR1 and a reagent R2, wherein the reagent R1 comprises a buffer solution, creatinase, creatine oxidase, ascorbic acid oxidase, peroxidase or catalase, serum albumin, a nonionic surfactant, a preservative, a Trinder's reactant A and laccase or metallate; and the reagent R2 comprises a buffer solution, serum albumin, creatininase, a preservative and a Trinder's reactant B. According to the invention,the defect that creatinine determination is inaccurate due to negative deviation caused by the calcium dobesilate and the etamsylate contained in serum samples when creatinine is determined by clinical examination in various hospitals at present is overcome, and the uric acid kit is suitable for detection of serum creatinine by a full-automatic biochemical analyzer.