30 results about "Etamsylate" patented technology

The invention relates to a synthetic method of etamsylate. The synthetic method comprises the following steps of (1) preparation of 2,5-dihydroxybenzenesulfonic acid; (2) preparation of a etamsylate crude product; and (3) purification. Compared with a conventional synthetic process of the etamsylate adopting concentrated sulfuric acid as a sulfonating agent, the synthetic method has the following advantages that the synthetic method employs chlorosulfonic acid as the sulfonating agent, and performs azeotropic dehydration on benzenediol and an organic solvent until anhydrous before sulfonation to ensure that no water is in the reaction system, thereby increasing product yield; hydrogen chloride gas produced during the sulfonation process can be absorbed by water to make hydrochloric acid, thereby decreasing discharge of three wastes (waste gas, waste water and waste residues); and usage amount of the sulfonating agent is decreased during the sulfonation process, so that production cost is reduced.

The invention discloses an air pressure type artery postoperation hemostat and relates to the technical field of medical care instruments. The hemostat comprises an upper tank and a lower ring, wherein the upper tank is divided into an inner circular cavity A and an outer ring cavity A, and the inner circular cavity A and the outer ring cavity A open downwards; a one-way air inlet valve is mounted on one side of the top face of the inner circular cavity A, and a one-way air release valve is mounted on the top face of the outer ring cavity A; a puller bolt is arranged at the center of the top face of the inner circular cavity A in a threaded connection mode, and the outer side of the puller bolt is sleeved with a telescopic sealing sleeve; the lower end of the upper tank and the upper end of the lower ring are sealed in a loose joint mode; the lower ring is divided into an inner circular cavity B and an outer ring cavity B, the inner circular cavity B and the inner circular cavity A are identical in size and are sealed in a butt joint mode, and the outer ring cavity B and the outer ring cavity A are identical in size and are sealed in a butt joint mode; a cotton pad is arranged in the inner circular cavity B and soaked with etamsylate. The air pressure type artery postoperation hemostat has the advantages that negative pressure of the outer ring cavity A enables the device to be tightly adsorbed to the body of a patient without a bandage, positive pressure of the inner circular cavity A is used for balancing blood pressure to reduce bleeding, operation is easy, and time is saved.

The invention provides a creatinine detection kit and a use method thereof. The kit comprises a reagent R1 and a reagent R2, wherein the reagent R1 comprises creatinase, sarcosine oxidase, peroxidase,ascorbic acid oxidase, 2, 4, 6-tribromo-3-hydroxybenzoic acid and 3, 5-dichloro-2-hydroxybenzenesulfonic acid; and the reagent R2 comprises creatinase, peroxidase, potassium ferrocyanide and 4-aminoantipyrine. The creatinine detection kit provided by the invention can resist interference of etamsylate with the concentration of 300mg/L (the highest blood concentration) or below in a to-be-detectedsample, has a wider linear range (0-6000 millimoles/L), is applicable to detection of samples with high creatinine content and can correctly evaluate renal functions of surgical patients.

The invention relates to a creatinine kit capable of eliminating negative deviation interference in a creatinine determination caused by calcium dobesilate and etamsylate drugs in serum and a preparation method thereof. Key points of a technical scheme of the invention are that the creatinine kit includes a reagent R1 and a reagent R2, wherein the reagent R1 includes buffer, creatinase, sarcosineoxidase, ascorbic acid oxidase, peroxidase or catalase, serum albumin, nonionic surfactant, preservative, Trinder's reagent A, laccase or metalic acid salt; and the reagent R2 includes buffer, serum albumin, creatinine enzyme, preservative and Trinder's reagent B. The invention overcomes a defect of inaccurate creatinine determination due to the presence of the negative deviation caused by calciumdobesilate and etamsylat in serum samples when the clinical tests of creatinine determination are being carried out in various hospitals, and the invention is suitable for the detection of serum creatinine by an automatic biochemical analyzer.

The invention relates to corallite herbal tooth powder. The corallite herbal tooth powder comprises active corallite powder, pollen typhae, folium artemisiae argyi, herba ecliptae, radix boehmeriae, radix glycyrrhizae, borneol, etamsylate, lauryl sodium sulfate and water. The active corallite powder obtained after corallite powder is activated and the rest of the raw materials are added into a ball grinder for wet grinding, milling is performed after drying, and the corallite herbal tooth powder is obtained. The corallite herbal tooth powder is good in stability, free of caking, and cool, refreshing, soft and smooth in taste, can effectively reduce the wear of enamel on the surfaces of teeth in the tooth brushing process and is suitable for removing ozostomia and preventing oral diseases.

The present invention relates to a kind of ethylamine injection and preparation method thereof, the components of ethylamine injection are proportioned according to the following concentration: ethylamine is 120g/L to 130g/L; sodium bisulfite 1.65g/L to 1.85g/L; sodium sulfite 0.23g/L to 0.27g/L; solvent is water for injection.

The invention relates to a preparation method of etamsylate. The etamsylate is prepared by virtue of three steps, namely sulfonating, salifying and refining, and the entire preparation process is free from an organic solvent, so that cost and pollution are reduced; in addition, a crude product is refined by virtue of absolute ethyl alcohol which serves as a solvent; therefore, the entire process is not only lower in cost but also more environment-friendly; the etamsylate prepared by the method is relatively higher in mass percentage; in conclusion, the preparation method disclosed by the invention has the advantages of being simple in design, low in cost, environment-friendly and high in mass percentage.

The invention belongs to the technical field of medicine and particularly relates to a medicinal preparation for preventing operative bleeding and a preparation method thereof. The medicinal preparation is prepared from active ingredients etamsylate, sodium metabisulfite, sodium calcium edetate, methylparaben, a pH regulator and water for injection. The phenomenon that bubbles are produced in the filling process of etamsylate injections is avoided, the problem of product yield reduction caused by bubbles is solved, the safety of the injection in clinical application is greatly improved, and the medicinal preparation is simple and easy to operate and facilitates large-scale production.

The invention discloses local anesthesia gel preparation and a preparation method thereof. The local anesthesia gel preparation is prepared from, by weight, 8-20 parts of Celastrus orbiculatus, 8-20 parts of benzoin, 2-2.8 parts of bee venom, 0.1-2.0 parts of etamsylate, 0.3-1.0 part of benzoate, 3-5 parts of menthol, 2-3.6 parts of diclofenac, 1.0-1.5 parts of sodium fusidate, 1.5-3.5 parts of local anesthetic, 2.3-4.0 parts of viscous polymer, 0.05-0.3 part of preservative, 0.05-0.1 part of antioxidant, 0.2-0.6 part of surfactant and 10-16 parts of gel matrix. The local anesthesia gel preparation can be used for local administration of trauma or during small external surgery, can play a good role in controlling pain, resisting bacteria, diminishing inflammation and preventing wound infection, can reduce local damage, has high affinity with skin and is convenient to use and quick in action; anesthetic action generated by the local anesthesia gel preparation can quickly seep into collenchyme and can last for a long time, and the local anesthesia gel preparation is safe and nontoxic, simple in preparation process and low in cost.

The invention discloses a medicine for treating rheumatism. The medicine for treating the rheumatism contains the following main raw materials in parts by weight: 8-13 parts of tea polyphenol, 10-16 parts of etamsylate, 4-11 parts of diazepam, 20-30 parts of lidocaine, 5-10 parts of ofloxacin, 8-12 parts of corn sterol, 4-10 parts of lycopene and 6-9 parts of lucidum polysaccharide. The medicine is capable of effectively relieving swelling and pains of limbs and joints caused by rheumatism and rheumatoid diseases and effectively improving the life quality of patients with rheumatism and rheumatoid diseases, the symptoms relief cycle is short after the medicine is taken, and obvious toxic and side effects are not found at present.

The invention discloses a western medicine for curing a cold of a bamboo rat and a preparation method of the western medicine. The western medicine for curing the cold of the bamboo rat comprises the following components by weight: 5-8 parts of chlortrimeton, 20-25 parts of calcium gluconate, 4-8 parts of cetirizine, 10-15 parts of ephedrine, 2-8 parts of acetylspiramycin, 4-10 parts of roxithromycin, 15-20 parts of promethazine, 8-15 parts of omeprazole, 10-15 parts of etamsylate, 8-10 parts of cedilanid, 2-6 parts of bromhexine, and 2-8 parts of aminophylline. Compared with the prior art, the western medicine is mixed into a feed to feed the bamboo rat and has good effects of preventing and treating the cold of the bamboo rat, the marked effective rates of the prevention and the treatment are up to 99% and 95%, and in addition, the western medicine has no strong flavor of the western medicine, is mixed into the feed to feed the bamboo rat, does not affect the feeding of the bamboo rat, and is convenient to use.

The invention discloses an etamsylate induced rat hypercoagulable state animal model and an establishment method thereof. According to the model, etamsylate is adopted for interference, three times of intraperitoneal injection are implemented, then a hypercoagulable state is achieved within 1.5-9 hours, the operation is simple, the model success rate is high, and the hypercoagulable state can last for a relatively long time. The rat hypercoagulable state animal model based on an etamsylate medicine is successfully established, a base for related rat hypercoagulable state research is made, and the establishment method is a novel rat hypercoagulable state animal model method.