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Etamsylate induced rat hypercoagulable state animal model and establishment method thereof

A technology for constructing methods and animal models, applied in the field of experimental zoology, can solve the problems of availability, non-availability, unfavorable long-term observation, etc., and achieve the effects of long duration, high model success rate and simple operation.

Active Publication Date: 2017-11-03
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the zygomatic arch of the animal is removed, which affects the animal's eating, and is not conducive to long-term observation. This method needs to be improved (Liu Xiaoguang, Xu Lina. A rat brain that can evaluate thrombolytic and antithrombotic drugs Model of arterial thrombosis. Acta Pharmaceutica Sinica. 1995,30:662-667; Zhang Yuzhen. Protective effect of ginkgo biloba extract (EGB) on rat local cerebral ischemia and jugular vein thrombosis. Acta Pharmaceutical Sinica. 1998,33(12): 901-905)
The current animal model of thrombosis cannot meet the needs of this type of research, and does not meet the conditions required for this type of research
There are currently no established off-the-shelf model systems available for animal models of hypercoagulable states

Method used

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  • Etamsylate induced rat hypercoagulable state animal model and establishment method thereof
  • Etamsylate induced rat hypercoagulable state animal model and establishment method thereof
  • Etamsylate induced rat hypercoagulable state animal model and establishment method thereof

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Experimental program
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Effect test

Embodiment 1

[0048] Embodiment 1, construct rat hypercoagulation state animal model

[0049] 1. Experimental materials and reagents

[0050] (1) Experimental animals

[0051] SPF-grade male Wistar rats, 180-220 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and the experiment began after one week of adaptive feeding under standard conditions.

[0052] (2) Reagents

[0053] The reagents used are shown in Table 1.

[0054] Table 1 Reagents used in the establishment of animal models of rat hypercoagulation state

[0055]

[0056] (3) Instruments and consumables

[0057] The instruments and consumable reagents used are listed in Table 2.

[0058] Table 2 Instruments and consumables used in the establishment of animal models of rat hypercoagulation state

[0059]

[0060] 2. Experimental steps

[0061] Twenty male wistar rats were randomly divided into two groups, 10 in each group, and weighed. One group of rats was intraperitoneally injected ...

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Abstract

The invention discloses an etamsylate induced rat hypercoagulable state animal model and an establishment method thereof. According to the model, etamsylate is adopted for interference, three times of intraperitoneal injection are implemented, then a hypercoagulable state is achieved within 1.5-9 hours, the operation is simple, the model success rate is high, and the hypercoagulable state can last for a relatively long time. The rat hypercoagulable state animal model based on an etamsylate medicine is successfully established, a base for related rat hypercoagulable state research is made, and the establishment method is a novel rat hypercoagulable state animal model method.

Description

technical field [0001] The invention relates to an animal model of hypercoagulation state of rats induced by ethanamine and a construction method thereof, belonging to the field of experimental zoology. Background technique [0002] The hypercoagulable state, also known as the pre-thrombotic state, refers to a state in which the body exhibits an increased tendency to coagulate blood. It is generally believed that the emergence of hypercoagulable state is related to the serious abnormality of the coagulation function of the coagulation system, and the reasons are complex and diverse. There is also a view that hypercoagulable states can be divided into hereditary hypercoagulable states and acquired hypercoagulable states. Hereditary hypercoagulability is due to specific genetic mutations that lead to thrombosis, the onset age is relatively low, and the site of thrombosis is relatively special. In terms of general pathological distribution, the range of acquired hypercoagulab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/205A61P7/02
CPCA61K31/205
Inventor 井健高友鹤杜震环
Owner BEIJING NORMAL UNIVERSITY
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