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Etamsylate tablet and preparation method thereof

A technology of ethylamine tablets and ethylamine tablets, applied in the field of medicine, can solve the problems of enhancing platelet aggregation and adhesion, not easy to store, and inconvenient to carry, so as to achieve improved bioavailability, high bioavailability, and maintenance The effect of medicine

Inactive Publication Date: 2018-03-23
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pharmacokinetic studies have shown that fensulfame can increase the number of platelets, enhance the aggregation and adhesion of platelets, and promote the release of coagulation active substances, thereby producing a hemostatic effect. It can last for 4 to 6 hours. It is suitable for the prevention and treatment of surgical bleeding, thrombocytopenic purpura or allergic purpura and other causes of bleeding, such as cerebral hemorrhage, gastrointestinal bleeding, urinary tract bleeding, fundus bleeding, gum bleeding, Epistaxis, etc., can be used together with other hemostatic drugs such as aminomethylbenzoic acid and vitamin K, and has low toxicity. At present, most of the fensulfame injections on the market are inconvenient to carry and not easy to store. In order to solve the above problems, the present invention provides a Etamine tablets and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of ethyl sulfate tablet, is made up of tablet core and coating layer, calculates according to parts by weight, and tablet core comprises following raw material: 50 parts of phensulfame, low-substituted hydroxypropyl cellulose with substituent group accounting for 10% 2 parts, 0.5 parts of pectin, 3 parts of sorbitol, 1 part of dextrin, 0.5 parts of animal glue; the coating layer includes the following raw materials: 3 parts of microcrystalline cellulose, 5 parts of sucrose, 10 parts of magnesium stearate, lemon Acrylic acid triethyl ester 10 parts, acrylic resin 15 parts, ethyl cellulose 3 parts.

[0022] Among them, animal glue is extracted from the skins of cattle, donkeys, horses, rats, fish, rhinos, and antelopes.

[0023] Among them, the preparation method of animal glue is as follows: choose animal skin and wash it with 75% ethanol for 5-10 minutes, then wash it with sterile water for 15-20 minutes, and dry it in vacuum at 50°C; cut the animal skin into 5×5...

Embodiment 2

[0031] A kind of ethyl sulfate tablet, is made up of tablet core and coating layer, calculates according to parts by weight, and tablet core comprises following raw materials: 60 parts of ethyl sulfate, low-substituted hydroxypropyl cellulose whose substituents account for 15% 5 parts, 0.5 parts of pectin, 5 parts of sorbitol, 3 parts of dextrin, 1 part of animal glue; the coating layer includes the following raw materials: 3 parts of microcrystalline cellulose, 8 parts of sucrose, 10 parts of magnesium stearate, lemon Acrylic acid triethyl ester 10 parts, acrylic resin 15 parts, ethyl cellulose 3 parts.

[0032] Other conditions and preparation steps are the same as in Example 1.

Embodiment 3

[0034] A kind of ethyl sulfate tablet, is made up of tablet core and coating layer, calculates according to weight part, tablet core comprises following raw material: 55 parts of phensulfame, substituting group accounts for 15% low-substituted hydroxypropyl cellulose 4 parts, 1 part of pectin, 4 parts of sorbitol, 2 parts of dextrin, 1 part of animal glue; the coating layer includes the following raw materials: 3 parts of microcrystalline cellulose, 8 parts of sucrose, 10 parts of magnesium stearate, lemon 10 parts of triethyl ester, 20 parts of acrylic resin, 5 parts of ethyl cellulose.

[0035] Other conditions and preparation steps are the same as in Example 1.

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PUM

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Abstract

The present invention provides a kind of ethylamine tablet and preparation method thereof, relate to the field of medical technology, consist of a tablet core and a coating layer, comprising the following steps: (1) combining ethylamine, low-substituted hydroxypropyl cellulose, Sorbitol and dextrin are mixed together, add 5 times the volume of distilled water, and ultrasonically treat for 2-3min to obtain a mixture. Add pectin and animal glue to the mixture, ultrasonically treat for 5-10min, and vacuum-dry to obtain solid particles. The granules are subjected to tabletting treatment to obtain a core pre-finished product; (2) magnesium stearate is evenly coated on the outside of the chip pre-finished product, and compressed again to obtain a tablet core; (3) microcrystalline cellulose, sucrose, citric acid Add triethyl ester and acrylic resin to 10 times the volume of distilled water, and ultrasonically treat for 2-3min to obtain a coating solution; (4) put the tablet core into the coating solution for coating to obtain phensulfame tablets. The phensulfame tablet of the present invention is beneficial to maintaining the stability of the drug effect, and has higher bioavailability after use by users.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a phensulfame tablet and a preparation method thereof. Background technique [0002] Etamine, also known as hemostatic, has a molecular formula of C10H17NO5S and a molecular weight of 263.3107. Pharmacokinetic studies have shown that fensulfame can increase the number of platelets, enhance the aggregation and adhesion of platelets, and promote the release of coagulation active substances, thereby producing a hemostatic effect. It can last for 4 to 6 hours. It is suitable for the prevention and treatment of surgical bleeding, thrombocytopenic purpura or allergic purpura and other causes of bleeding, such as cerebral hemorrhage, gastrointestinal bleeding, urinary tract bleeding, fundus bleeding, gum bleeding, Epistaxis, etc., can be used together with other hemostatic drugs such as aminomethylbenzoic acid and vitamin K, and has low toxicity. At present, most of the fensulfame inj...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/205A61K47/38A61K47/46A61P7/04
CPCA61K31/205A61K9/2054A61K9/2068A61K9/2866
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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