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A pharmaceutical preparation for preventing surgical bleeding and its preparation method

A technology of pharmaceutical preparations and surgical bleeding, applied in the field of medicine, can solve problems such as unqualified foreign objects, plug jumping, and decreased yield of finished products, and achieve the effects of reducing product yield, improving safety, and simple process

Inactive Publication Date: 2018-05-08
王爱美 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, phensulfame mainly contains tablet, injection and freeze-dried powder, and the inventor finds in the test, because phensulfame has its own physical and chemical properties, its injection will have a large amount of foam to occur in the filling process, If the ampoule is used for filling, the foam will stick to the mouth of the bottle, and black spots will appear due to the carbonization of the liquid medicine during the high-temperature fusion sealing process, resulting in unqualified visible foreign matter; if the vial is used for filling, the foam will stick to the mouth of the bottle, which is prone to plugging , resulting in a decrease in the yield of finished products

Method used

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  • A pharmaceutical preparation for preventing surgical bleeding and its preparation method
  • A pharmaceutical preparation for preventing surgical bleeding and its preparation method
  • A pharmaceutical preparation for preventing surgical bleeding and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] prescription

[0036]

[0037] Preparation Process

[0038] Step a, Ampoule treatment: Wash the ampoule through an ultrasonic bottle washing machine, sterilize and dry it in a tunnel-type sterilizing dryer at a temperature not lower than 290°C, and transfer it to the filling room for standby;

[0039] Step b, preparation: 1. Weigh sodium metabisulfite and sodium edetate calcium sodium in the prescribed amount and dissolve them in 20% water for injection, stir to dissolve;

[0040] ②. Weigh the prescription amount of methylparaben and etamsulfame into 50% water for injection, stir and dissolve for 15 minutes;

[0041] ③. Add the solution in ① to the solution in ②, stir and mix evenly, adjust the pH value with a pH regulator, after the pH adjustment is completed, use water for injection to make up the volume to the full amount, test the intermediate product solution, and prepare for potting after passing the test;

[0042] Step c, potting: the solution is filtered to...

Embodiment 2

[0051] prescription

[0052]

[0053] Preparation Process:

[0054] Step a, Ampoule treatment: Wash the ampoule through an ultrasonic bottle washing machine, sterilize and dry it in a tunnel-type sterilizing dryer at a temperature not lower than 290°C, and transfer it to the filling room for standby;

[0055] Step b, preparation: 1. Weigh the sodium metabisulfite and calcium sodium edetate in the prescribed amount and dissolve them in 15% water for injection, stir to dissolve;

[0056] ②. Weigh the prescribed amount of methylparaben and etamsulfame into 45% water for injection, stir and dissolve for 10 minutes;

[0057] ③. Add the solution in ① to the solution in ②, stir and mix evenly, adjust the pH value with a pH regulator, after the pH adjustment is completed, use water for injection to make up the volume to the full amount, test the intermediate product solution, and prepare for potting after passing the test;

[0058] Step c, potting: the solution is filtered to the...

Embodiment 3

[0067] prescription

[0068]

[0069] Preparation Process:

[0070] Step a, Ampoule treatment: Wash the ampoule through an ultrasonic bottle washing machine, sterilize and dry it in a tunnel-type sterilizing dryer at a temperature not lower than 290°C, and transfer it to the filling room for standby;

[0071] Step b, preparation: 1. Weigh the sodium metabisulfite and calcium sodium edetate in the prescribed amount and dissolve them in 25% water for injection, stir to dissolve;

[0072] ②. Weigh the prescribed amount of methylparaben and etamsulfame and dissolve it in 55% water for injection, stir and dissolve for 20 minutes;

[0073] ③. Add the solution in ① to the solution in ②, stir and mix evenly, adjust the pH value with a pH regulator, after the pH adjustment is completed, use water for injection to make up the volume to the full amount, test the intermediate product solution, and prepare for potting after passing the test;

[0074] Step c, potting: the solution is f...

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PUM

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a medicinal preparation for preventing operative bleeding and a preparation method thereof. The medicinal preparation is prepared from active ingredients etamsylate, sodium metabisulfite, sodium calcium edetate, methylparaben, a pH regulator and water for injection. The phenomenon that bubbles are produced in the filling process of etamsylate injections is avoided, the problem of product yield reduction caused by bubbles is solved, the safety of the injection in clinical application is greatly improved, and the medicinal preparation is simple and easy to operate and facilitates large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation for preventing operation bleeding and a preparation method thereof. Background technique [0002] Postoperative bleeding can occur in surgical incisions, hollow organs, and body cavities. Bleeding after surgery includes primary bleeding and secondary bleeding. Primary bleeding generally occurs within 24 hours after surgery. Hemostasis during surgery is not complete and perfect, such as loose sutures for ligating blood vessels; The coverage of spasms and blood clots temporarily stops wound bleeding and some bleeding points are missed. These are the main reasons for primary bleeding. However, due to factors such as infection and digestive juice extravasation in the later stage of the operation, part of the blood vessel wall is necrotic and ruptured, leading to postoperative hemorrhage, which is called secondary hemorrhage. [0003] Bleedi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/02A61K47/18A61K47/14A61K31/205A61P7/04
CPCA61K9/0019A61K9/08A61K31/205A61K47/02A61K47/14A61K47/183
Inventor 王爱美任芳
Owner 王爱美
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