32 results about "Cyclohexylisocyanate" patented technology

The invention relates to a novel synthesis route of glipizide, which is characterized by comprising the following steps of protecting 4-(2-amino ethyl)benzenesulfonic acid ammonia (II) by Boc anhydride to obtain a compound (III); reacting the compound (III) with cyclohexyl isocyanate to obtain a compound (IV); carrying out deprotection on the compound (IV) to obtain a compound (V); and reacting the compound (V) with 2-methyl-5-pyrazine carboxylic acid to obtain the glipizide (I) with the single impurity which is less than or equal to 0.5% and the high purity which is more than or equal to 99%. The process is simple, the yield is high, the purity is high and the single impurity is low; and the process is environment-friendly and industrial production is easy to realize.

The invention discloses a preparation method of Glimepiride raw material, which comprises the following steps in sequence: in the presence of K2CO3, a condensation reaction is carried out between a compound A: 4-[2-(3-ethyl-4-methyl-2-keto-3-pyrroline-1-formamido)-ethyl]-benzene sulfonamide and a compound B: trans-4-methyl-cyclohexyl isocyanate of the same molar weight in an organic solvent. The mass ratio of the compound A and K2CO3 is 1:0.8-0.9; the mixture synthetic fluid of a crude Glimepiride product and K2CO3 is filtered in a suction way, and then an extract is added into pure water anddissolved to form a solution. The solution is filtered for removing impurities to obtain the aqueous solution of Glimepiride; a hydrochloric acid solution is added into the aqueous solution of the Glimepiride for acidification and then a crude product is separated; acetone is added into the crude Glimepiride product and then refined, filtered in a suction manner, dried in a vacuum environment to obtain a pure Glimepiride product. The method has the advantages of simplifying the synthetic route, selecting mature intermediates as raw materials, adding K2CO3 for promoting the condensation reaction, avoiding the use of chloroform, reducing the residual organic solvent, and being applicable to industrialized production.

The invention provides a compound and method of producing the same. The method of the invention includes the following steps. First of all, Polycaprolactone (PCL), dimethylol propionic acid (DMPA), 4,4′-methylenebis (cyclohexyl isocyanate) (H12MDI), and dibutyltin dilaurate (DBT) are mixed in a solvent in the first place and a solution is formed. This solution is then mixed with triethylamine (TEA) and triethylene tetramine (TETA). After that, amino-terminated anionic waterborne polyurethane (WPU) is produced. A sol-gel process is proceeded with a mixture of amino-terminated anionic waterborne polyurethane, tetraethylorthosilicate (TEOS) without any extra catalyst, and a compound, waterborne polyurethane-silica nanocomposite materials, is eventually produced.

The invention discloses an acrylic carboxyl polyurethane powder coating for ceramic. The coating is prepared from the following raw materials: 1, 6-hexanediol, dehydrated castor oil, dibutyltin dilaurate, glycerol, cyclohexyl isocyanate, lithium hydroxide, an imitator, linseed oil, hexahydrophthalic anhydride, calcium boheic acid, pigments, rosin, dimethyl adipate, toluene diisocynate and methyl methacrylate. The product density is 135-155g / cm<3>, and the coating soaked in water for 60-70 days is free from soaking and falling phenomena. The tensile strength is 20-30MPa, the shore hardness is 40-60, and the coating soaked in a 5% hydrochloric acid solution for 40-60 days is free of abnormalities. The adhesive force is levels 1-2, the impact strength is 550-650N / cm, and the coating soaked in saturated calcium hydroxide for 25-35 days is free from bubbling and wrinkling; the glossiness is 110-130%, and the gloss retention is 92-96% after being manually accelerated and aged for 500 hours.

The invention discloses a high-solid low-viscosity mirror synthetic leather treatment agent and a preparation method thereof. The high-solid low-viscosity mirror synthetic leather treatment agent comprises a main agent and a curing agent, wherein the main agent adopts 3-isocyanate methylene-3,5,5-trimethylcyclohexyl isocyanate, 3-isocyanatopropyltrimethoxysilane and (1S,2S)-(+)-2-benzyl cyclohexylisocyanate as a mixed base material, adopts dibutyltin dilaurate as a catalyst, adopts a mixture of dimethyl carbonate and vinyl acetate as a solvent, and also comprises polyether polyol and micromolecular polyols. The curing agent comprises a flatting agent, a foaming agent, tetrabutyl titanate, butyl butyrate and dibutylester nylon acids. The main agent and the curing agent are uniformly mixedto obtain the high-solid low-viscosity mirror synthetic leather treatment agent disclosed by the invention. The solid content of the synthetic leather treatment agent reaches 80 percent at most. The synthetic leather treatment agent is relatively low in initial viscosity, thereby facilitating the manual operation, and improving the utilization rate of the treatment agent; and after a period of time, the viscosity is greatly improved, so that the actual production and life requirement can be met.

The invention discloses a method for synthesizing hexazinone through continuous solvent-free reaction, which comprises preparation of cyclic ester compound, synthesis of hexazinone and purification of hexazinone. This application uses N-ethylcarbonyl-N,N',N'-trimethylguanidine and cyclohexyl isocyanate in a certain ratio (molar ratio 1:1) after the static mixer A reacts at room temperature, and the mixed solution passes through static Mixer B generates hexazinone under the action of catalyst sodium methoxide. After the generated hexazinone is pickled and neutralized by the static mixer, the organic phase enters the melting crystallizer and crystallizes. After passing the test, it can be sliced ​​to obtain a content greater than 99%. , the yield of hexazinone is about 95%. This application does not need to add n-hexane and toluene solvents, and there is no need to consider the problem of solvent volatilization in the process of neutralization, washing, distillation and drying of hexazinone, which can save production cost, and there is no need to consider the problem that a part of hexazinone is also taken away in the mother liquor during solvent crystallization, thereby improving the effect of yield.

The invention relates to a preparation method of a resin containing a water-soluble plasticizer and polyurethane. The method comprises the following steps: adding dimethyl glutarate or dimethyl glutarate homologs of which the 2,3,4 carbon sites are provided with methyl or hydroxyl into a closed reaction kettle, charging dimethylamine gas, and carrying out amide ester exchange reaction according to the ratio of the dimethylamine and the dimethyl glutarate or dimethyl glutarate homologs of which the 2,3,4 carbon sites are provided with methyl or hydroxyl of 2.1-2.4; adding a phosphoric acid water solution into the reaction kettle to generate dimethylamine phosphate and sodium phosphate; transferring the mixture treated in the step 2 into a filter kettle, and filtering to remove the dimethylamine phosphate and sodium phosphate; carrying out reduced pressure distillation to remove methanol and water; adding cyclohexyl isocyanate to remove the dimethylamine and water, thereby obtaining the water-soluble plasticizer; adding the water-soluble plasticizer prepared by the steps 1-5 into molten-state polyurethane.