31results about How to "Shorten the gelation time" patented technology

The invention discloses a method for in-situ preparing antibacterial supermolecule aquogel. The method comprises the following operation steps: silver nitrate crystal and polyethyleneglycol-polypropylene glycol-polyethyleneglycol triblock copolymer solution are mixed and stirred to obtain mixed solution; the steps of stirring the mixed solution for 15 minutes and ultrasonically dispersing the mixed solution for 5 minutes are alternatively carried out for 2-4 hours to obtain nano silver sol; and the nano silver sol and Alpha-cyclodextrin solution are mixed, stirred and stands at the room temperature to obtain hydrogel. The hydrogel can be used for preparing injectable drug carriers. The invention has the advantages of simple operation, adjustable gel strength and the gelation time, room temperature forming, no involvement of chemical cross linking reaction and the usage of organic solvent, favorable biocompatibility and antibacterial property of obtained gel, and the like and is prospective to be widely applied in the field of biomedical engineering materials.

The present invention provides a method for the real-time continuous monitoring of a change or density and / or viscosity within a test sample. Such methods can be used to determine the occurrence of a chemical reaction within a test sample where the same causes and increase or decrease in the density and / or viscosity of the sample due to, for example, a gelation, precipitation or coagulation occurring within the test sample. There is further provided a multi-resonator apparatus for use in measuring the density and / or viscosity of a test sample in which the multi-beam resonator is immersed.

This invention provides a preparation, composition, product, and application of a photo-coupled synergistically crosslinked hydrogel material. The preparation includes dissolving Component A including a photosensitive polymer derivative having o-nitrobenzyl phototriggers and Component B including a polymer derivative having amine or alkene (double group) or sulfhydryl group in a biocompatible medium to obtain solution A and solution B, respectively; mixing the solution A and solution B homogeneously to obtain a hydrogel precursor solution; initiating photo-coupled synergistic crosslinking under an irradiation of a UV light to form the hydrogel. The irradiation causes the o-nitrobenzyl phototriggers to generate an aldehyde group / keto group or a nitroso group to initiate photo-coupled synergetic crosslinking. The photo-coupled synergistically crosslinked hydrogel has applications in tissue engineering, regenerative medicine, 3D printing and as a carrier of cell, protein or drug.

The invention discloses a supramolecular structural hydrogel gene vector material and a preparation method and application thereof. The method comprises the following operation steps: synthesizing a multi-block copolymer with cation chain segments through modification of a terminal group of triblock copolymer of a polyethylene glycol-polypropylene glycol-polyethylene glycol which is modified by polylysine; then, mixing the copolymer with DNA solution to obtain DNA compound micelle; further, mixing and then stirring the micelle solution and solution of alpha-cyclodextrin; and keeping mixed solution at the room temperature to obtain hydrogel. The hydrogel can be used for preparing an injectable gene vector. The method has the advantages that the method has simple operation, can adjust the strength of the hydrogel and the gelatination time, can mold at the room temperature and does not relate to chemical crosslinking reaction and the use of organic solvent; and the obtained hydrogel has the advantages of temperature sensitivity, good bio-compatibility, obvious transfection effect and the like; and the method is hopeful to be widely applied in the field of a biomedical engineering material.

The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying polymer, and gelation agent into a hydrocarbon reservoir. Delays of weeks are observed.

The invention discloses a method for producing an alumina silica gel anchoring agent for corundum mullite composite ceramic, which comprises: using silicasol and alumina colloid as raw materials, controlling PH of the alumina colloid, using sol-gel processing to produce the alumina silica gel, controlling the content of alumina silica by dewatering in the alumina silica gel producing process, and controlling the gelling time by adding ammonial solution or acetylacetone, controlling the crystal system of mullite phase produced from burning process of the alumina silica gel by adding the aluminun trifluoride mineralization agent. The alumina silica gel can be used in the ceramic and fire resistive materials producing process as the anchoring agent, also can be used in production of mullite super fine. The crystal form can be controlled by adding the mineralization agent to improve the capacity of the ceramic and fire resistive materials.

The method for preparing electrochemical biological transducer with TiO2 gel film includes the following steps: a) preparing TiO2 film, soaking ITO electrode in 2-8 mol / L of sodium hydroxide solution for 5-12 hour, immersing the electrode in 50-300 mM butyl exter titanate for 2-5 minute, immersing the electrode in anhydrous alcohol for 1-3 minute and then in secondary water for 1-3 minute; b) immersing electrode obtained from step a) in aqueous solution of zyme (concentration of 2-4 mg / L) for 30-120 minute. The prepared transducer can hold its activity for 14 days and it can be reused.

A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.

The invention belongs to the field of resin preparation, and especially relates to a benzoxazine intermediate, and a preparation method and an application thereof. The invention provides a benzoxazine intermediate, a preparation method of the benzoxazine intermediate, and an application of the benzoxazine intermediate or a product prepared by the abovementioned preparation method in the preparation of high Tg and / or highly heatproof resin. The provided benzoxazine intermediate has a more stable chemical structure and can be stored for a longer time. The experiment results show that compared with the conventional products, the provided benzoxazine intermediate has a higher crosslinking density after being cured, and thus has higher Tg and longer storage time. The technical shortages of short storage time and insufficient Tg in the prior art are overcome, the industrial production can be realized, and the application range is enlarged.

The invention discloses a totarol antibacterial nano hydrogel with a whey protein as a matrix and a preparation method thereof, and belongs to the bacteriostatic gel biological technical field. Preparation raw materials comprise a whey protein gel, totarol and absolute ethyl alcohol. The preparation method adopts a sol-gel technique and comprises the steps of whey protein gel preparation, totarol embedding, ultrasonic treatment and standing and sterilization. According to the antibacterial nano hydrogel formula, a novel food-borne bacteriostatic agent is achieved. At the same time, the antibacterial nano hydrogel has the characteristics and advantages of the whey protein and the totarol. A whey protein polymer plays dispersion stabilizer, gel matrix and multiple roles in the antibacterial nano hydrogel system, no any crosslinking agents and initiators are added, toxic effects on a human body cannot be produced, and the use is safer and more effective; the preparation method has the advantages of simple equipment and technological process for producing the antibacterial nano hydrogel, mild conditions, low cost and easy popularization, and is suitable for industrialized production.

The invention provides a nanometer metal oxide and a preparation method thereof, and belongs to the fields of preparation technologies of nanometer inorganic compound photocatalysis materials and dyes. A halide or inorganic salt containing metal ions is selected as a metal ion source, a complexing agent, sucrose, glucose, acrylamide, bisacrylamide, agar, gelatin and carboxymethyl cellulose are selected as gel raw materials, the metal ions are uniformly dispersed, an industrial irradiation device is used to irradiate a raw material solution or emulsion in order to form a gel with a spatial network structure, the nanometer metal oxide is prepared through later grinding and sintering technologies, and the nanometer metal oxide can be used as an excellent photocatalyst or dye. The preparation method has the advantages of simplicity, stable process, strong operability, great reduction of the use amount of the gel raw materials, no need of heating, no need of special treatment of the raw materials, and realization of large batch production by using the industrial irradiation device.

The present invention provides a biocompatible hydrogel composition comprising glycolipids and silk fibroin (SF) wherein glycolipid is preferably sophorolipids (SL). The said composition is useful in preparation of 3D scaffold for use in tissue engineering, and in the biomedical field. The present invention also provides a process for preparing such a composition and a process for acceleration of gelation time of silk fibroin (SF) in the presence of sophorolipid.

The invention discloses a super-molecular hydrogel double-medicament carrier for simultaneously loading hydrophilic and hydrophobic medicaments and a preparation method as well as application thereof. The method comprises the following operating steps of: performing chemical modification on the hydrophobic medicament by using methoxypolyethylene glycol to synthesize a water-soluble macromolecularprodrug; physically mixing prodrug molecules with the hydrophilic medicament; further mixing the mixed solution with an alpha-cyclodextrin solution and stirring; and standing at room temperature to obtain the super-molecular hydrogel double-medicament carrier for simultaneously loading the hydrophilic and the hydrophobic medicaments. The carrier has the advantages of easiness in operation, adjustable gel strength and gelation time, forming at room temperature, no chemical crosslinking reaction or organic solvent, high bioavailability, sustainable and controllable release of the medicament andthe like, and is expected to be widely applied to the field of biomedical engineering materials.

The invention relates to the field of biomedical materials, and discloses a preparation method of an artemisinin liposome-loaded alginate-silk fibroin composite hydrogel. The preparation method comprises the following steps that an artemisinin drug and other lipids are dissolved in ethanol according to a proper proportion by an ethanol injection method, and injecting and evaporating are carried out to prepare an artemisinin drug-loaded liposome; degumming is carried out by using a sodium carbonate solution, silk fibroin is stirred and dissolved by selecting a CaCl2-ethanol-H2O ternary system, and centrifugal dialyzing and freeze-drying are carried out to obtain silk fibroin; and sodium alginate solution is prepared, then a mixture is formed from drug-loaded liposome, silk fibroin and sodium alginate, and centrifugal ultrasonic treatment is carried out to prepare the hydrogel. The artemisinin liposome-loaded alginate-silk fibroin composite hydrogel has excellent drug controlled release ability and extremely high drug bioavailability, the hydrogel prepared by compounding sodium alginate and silk fibroin is further very good in biocompatibility, and the sodium alginate and the silk fibroin form synergistic complementation, so that the mechanical property of the silk fibroin hydrogel is improved.

Disclosed are a biodegradable, biocompatible hydrogel that can be used for sealants of suppressing the leakage of blood or air during surgical operation, tissue adhesives, anti-adhesive agents and drug delivery carriers, and a method for producing the same

The invention provides a cobalt-doped gel and a preparation method thereof. The preparation method is achieved by a sol-gel method combined with a technical route containing an acid catalytic hydrolysis and a base catalytic hydrolysis to prepare a cobalt-doped sol. The method is as below: preparing the raw materials of tetraethoxysilane and tributyl borate under the conditions of 60-70 DEG C, pH value of 3-5, and deionized water in substoichiometry into a silicon-boron sol; meanwhile, preparing a salt solution of alkali metal, aluminum and cobalt; adding the salt solution into the silicon-boron sol by multiple times, and further hydrolyzing the borosilicate sol under basic conditions to obtain a homogeneous cobalt-doped sol; and sealing the cobalt-doped sol and allowing to stand at 80-120 DEG C for gelation, aging and drying. By changing the composition and content of raw materials, the method can obtain the cobalt-doped gel with controllable compressive strength and half-life insurance of the cobalt-doped hollow glass microspheres.

The invention provides a cobalt-doped gel and a preparation method thereof. The preparation method is achieved by a sol-gel method combined with a technical route containing an acid catalytic hydrolysis and a base catalytic hydrolysis to prepare a cobalt-doped sol. The method is as below: preparing the raw materials of tetraethoxysilane and tributyl borate under the conditions of 60-70 DEG C, pH value of 3-5, and deionized water in substoichiometry into a silicon-boron sol; meanwhile, preparing a salt solution of alkali metal, aluminum and cobalt; adding the salt solution into the silicon-boron sol by multiple times, and further hydrolyzing the borosilicate sol under basic conditions to obtain a homogeneous cobalt-doped sol; and sealing the cobalt-doped sol and allowing to stand at 80-120 DEG C for gelation, aging and drying. By changing the composition and content of raw materials, the method can obtain the cobalt-doped gel with controllable compressive strength and half-life insurance of the cobalt-doped hollow glass microspheres.

The invention discloses temperature-sensitive hydrogel as well as a preparation method and application thereof, and relates to the field of pharmaceutical preparations. The temperature-sensitive hydrogel is prepared from poloxamer 407, chitosan, silicon modified polyacrylamide, a biological solution and acid. The method has the effect of shortening the gelation time of the poloxamer.

The present invention provides a biocompatible hydrogel composition comprising glycolipids and silk fibroin (SF) wherein glycolipid is preferably sophorolipids (SL). The said composition is useful in preparation of 3D scaffold for use in tissue engineering, and in the biomedical field. The present invention also provides a process for preparing such a composition and a process for acceleration of gelation time of silk fibroin (SF) in the presence of sophorolipid.

The object of the present invention is a composition in powder form comprising the following polysaccharides alginic acid or sodium alginate,—pectin, chitosan, wherein the % by weight of the polysaccharides is at least 20% with respect to the total weight of the powder. The process for preparing said powder by an atomization process and its use in the treatment of cutaneous wounds and in the sector of food preservation are additional objects of the invention. Moreover, additional objects of the invention are the composition in the form of solution or liquid suspension that represents the starting material to obtain said powder and the process for preparing said liquid composition.

The invention discloses temperature-sensitive calcium phosphate bone cement and a preparation method thereof. The temperature-sensitive calcium phosphate bone cement comprises solid-phase powder and aliquid-phase component. The solid-phase powder is calcium salt. The liquid-phase component is prepared by mixing the following components: a gamma-glycidyl ether oxypropyl trimethoxysilane aqueous solution, a chitosan acetic acid aqueous solution, a sodium glycerophosphate aqueous solution and a bletilla striata polysaccharide aqueous solution. According to the temperature-sensitive calcium phosphate bone cement, a temperature-sensitive bone cement system prepared from chitosan, beta-disodium glycerophosphate and alpha-tricalcium phosphate is adopted and sol-gel conversion temperature sensitization is realized by regulating and controlling the interaction between the temperature-sensitive calcium phosphate bone cement and water molecules. After component optimization, the beta-sodium glycerophosphate is reduced, the toxicity is reduced, the gelation time of the hydrogel is shortened, the mechanical property of the bone cement is enhanced, the collapse resistance is improved, and the defect of poor mechanical property of the hydrogel is improved.

A method for preparing a titanium dioxide gel film electrochemical biosensor, which mainly consists of the following steps: Step 1, preparing TiO 2 Membrane: Soak the ITO electrode in 2-8mol / L sodium hydroxide solution for 5-12 hours, then immerse the electrode in 50-300mM butyl titanate solution for 2-5 minutes, then put the electrode into absolute ethanol Soak in water for 1-3 minutes, finally soak the electrode obtained in step 1.3 in secondary water for 1-3 minutes, step 2, immerse the electrode obtained in step 1 in the aqueous solution of enzyme (concentration: 2-4 mg / mL) for 30-120 A titanium dioxide gel membrane electrochemical biosensor is fabricated in minutes. The sensor prepared by the method of the present invention can reach the maximum response within 10s, and the detection limit of detecting hydrogen peroxide reaches 10 -6 mol / L, detection linear range is 2×10 -6 mol / L~3×10 -3 mol / L, and the sensor can be stored for 14 days without losing activity and can be reused.

The invention discloses a supramolecular structural hydrogel gene vector material and a preparation method and application thereof. The method comprises the following operation steps: synthesizing a multi-block copolymer with cation chain segments through modification of a terminal group of triblock copolymer of a polyethylene glycol-polypropylene glycol-polyethylene glycol which is modified by polylysine; then, mixing the copolymer with DNA solution to obtain DNA compound micelle; further, mixing and then stirring the micelle solution and solution of alpha-cyclodextrin; and keeping mixed solution at the room temperature to obtain hydrogel. The hydrogel can be used for preparing an injectable gene vector. The method has the advantages that the method has simple operation, can adjust the strength of the hydrogel and the gelatination time, can mold at the room temperature and does not relate to chemical crosslinking reaction and the use of organic solvent; and the obtained hydrogel has the advantages of temperature sensitivity, good bio-compatibility, obvious transfection effect and the like; and the method is hopeful to be widely applied in the field of a biomedical engineering material.

A sealing agent hydrogel, and a kit and preparation method therefor. The sealing agent hydrogel is prepared from the following raw material components: an electrophilic raw material as a first component; a nucleophilic material as a second component; a bioadhesive material as a third component, comprising 4-arm-PEG-DA; a physiological diluent as a fourth component, containing an alkaline buffer having a pH value of 7.5 to 12.5 and an acidic buffer having a pH value of 2.0 to 6.5. The sealing agent hydrogel features the addition of a chemically modified polyethylene glycol macromolecule monomer on the basis of a conventional two-component hydrogel, so that during use, a hydrogel which has a certain adhesion force is rapidly generated in situ after being mixed. The generated hydrogel features not only excellent biocompatibility, bioadhesion, biodegradability, and degradation performance adjustability, but also significantly shortened gelation time and significant improvements in important indicators such as gel content and swelling rate; and the degradation speed may be adjusted according to the requirements of an application scenario.

The object of the present invention is a composition in powder form comprising the following polysaccharides alginic acid or sodium alginate, - pectin, chitosan, wherein the % by weight of the polysaccharides is at least 20% with respect to the total weight of the powder. The process for preparing said powder by an atomization process and its use in the treatment of cutaneous wounds and in the sector of food preservation are additional objects of the invention. Moreover, additional objects of the invention are the composition in the form of solution or liquid suspension that represents the starting material to obtain said powder and the process for preparing said liquid composition.

The present invention disclosed a cross-linked plugging agent stimulated by high density brine which comprises main agent: 10 wt %-90 wt %, gelling agent: 0.5 wt %-9 wt % and pure water; wherein the main agent is selected from the group consisting of a Dipotassium phosphate (K2HPO4), a Tripotassium phosphate (K3PO4) and a Potassium pyrophosphate (K4P2O7), a Potassium Dihydrogen Phosphate (KH2PO4), a Sodium dihydrogen phosphate (NaH2PO4); the gelling agent is selected from the group consisting of a Xanthan gum and a kappa carrageenan. The gelling time is controlled within 0.5-12 h under an experiment temperature of 90° C.-160° C. The final gelling strength is controlled within D-H. The density is controlled within 1.0-1.55 g / cm3. The plugging agent is able to be applied in well completion and workover under high temperature, high pressure, multi-pressure series of strata oil and gas environment when temporary blockage and leak proof is required, protection of reservoir near perforations and water plugging.

The invention belongs to the field of biomedical materials and discloses a supramolecular hydrogel medicine and gene dual-carrier material and a preparation method thereof. The preparation method comprises the following steps: modifying end groups of a polyethylene glycol-polycaprolactone segmented copolymer, so as to synthetize a segmented copolymer containing cation chain segments; then mixing the polymer with a hydrophobic medicine solution, and further compounding with nucleic acid, thereby obtaining medicine-gene copolymer compound micelle; and further mixing the micelle solution with an alpha-cyclodextrin solution, stirring, and standing at a room temperature so as to obtain the hydrogel. The hydrogel can be used for preparing an injectable medicine gene carrier. The preparation method has the advantages of simplicity in operation, adjustable hydrogel strength and gelating time, molding at room temperature, and no use of chemical cross-linking reaction and organic solvents; the obtained hydrogel has the advantages of temperature sensibility, favorable biocompatibility, obvious transfection and the like, and is expected to be widely applied to the field of biomedical engineering materials.

The invention relates to the technical field of functional renovation of alginate fibers, in particular to an aquagel alginate fiber and a preparation method for the same. The preparation method for the aquagel alginate fiber comprises the following steps: (1) extracting a sodium alginate raw material from algae; (2) preparing an 8 to 10 mass percent aqueous solution of the alginate, and performing defoaming to obtain an alginate spinning solution; (3) preparing a mixed solution of an aqueous solution of soluble starch and the alginate spinning solution; (4) enabling the mixed solution obtained in step (3) to pass through a metering pump, and extruding the mixed solution into a first coagulating bath from a spinneret plate; (5) introducing as-spun fibers into a second coagulating bath; (6) introducing the fibers into a third coagulating bath, performing drawing forming, squeezing water out, and performing washing and drying to a constant weight, so as to obtain the aquagel alginate fibers. According to the aquagel alginate fiber and the preparation method, a preparation process is improved to improve the strength and the spinnability of the alginate fibers and shorten the gelation time, and the prepared aquagel alginate fiber can be used for preparing medical sanitary dressings and skin-care facial masks.

The invention provides a nanometer metal oxide and a preparation method thereof, and belongs to the field of nanometer inorganic compound photocatalytic materials and dyestuff manufacturing techniques. The present invention selects halides or inorganic salts containing metal ions as the source of metal ions, selects complexing agent, sucrose, glucose, acrylamide, bisacrylamide, agar, gelatin and carboxymethyl cellulose as gel raw materials, and evenly disperses the metal Ions, use industrial irradiation equipment to irradiate the raw material solution or emulsion to form a gel with a spatial network structure, and prepare nanoscale metal oxides through the later grinding and sintering processes. These nanoscale metal oxides can be used as excellent photocatalysts or dyes. The preparation method of the invention is simple, the process is stable, the operability is strong, the consumption of gel raw materials is greatly reduced, no heating is required, no special treatment of raw materials is required, and industrial irradiation devices can be used for mass production.