47results about How to "Meet clinical application requirements" patented technology

The invention provides a letrozole tablet and a preparation method thereof. The letrozole tablet comprises a tablet core comprising the following components, by weight: 1-4% of letrozole, 20 to 40% ofmicrocrystalline cellulose, 40 to 65% of lactose, 11.5%-16.5% of a disintegrating agent, and 1 to 1.5% of a lubricating agent. On the basis of the total weight of the tablet core, the lubricating agent comprises 0.3%-0.5% of magnesium stearate and 0.7%-1.0% of superfine silica powder; and the disintegrating agent comprises 3%-7% of sodium carboxymethyl starch and 8.5%-9.5% of corn starch. After controlling of the use amounts of the corn starch and the sodium carboxymethyl starch, on the one hand, the disintegration time of the letrozole tablet is regulated and controlled;and on the other hand, the mixing uniformity of the superfine silica powder in the mixing and tabletting processes is ensured and the demixing phenomenon is avoided. The dosage ratio of the superfine silica powder, the lactose and the corn starch is strictly controlled, so that the mixing uniformity of the materials and the dissolution rate of the letrozole are guaranteed. The clinical application requirements are met.

An intracranial pressure monitoring instrument based on ultrasonic wave acoustoelastic effect comprises a computer, an ultrasonic wave transmitting drive module, an ultrasonic wave transmitter, an ultrasonic wave receiver and a receiving signal circuit module, wherein the ultrasonic wave transmitting drive module is used for generating initial high-frequency signals, the ultrasonic wave transmitter is connected with the ultrasonic wave transmitting drive module and converts the initial high-frequency signals output by the ultrasonic wave transmitting drive module into elastic mechanical waves transmitting to a cranial cavity, the ultrasonic wave receiver is used for receiving the elastic mechanical waves penetrating the cranial cavity and converting the received elastic mechanical waves into tail-end high-frequency signals, the receiving signal circuit module is connected with the ultrasonic wave receiver and used for performing frequency discrimination and phase locking to the tail-end high-frequency signals and outputting the phase, with the same frequency as the initial high-frequency signals, of the tail-end high-frequency signals to the computer, and the computer is connected with the ultrasonic wave transmitting drive module and the receiving signal circuit module and used for demodulating the tail-end high-frequency signals and calculating intracranial pressure. By the intracranial pressure monitoring instrument, noninvasive monitoring of intracranial pressure of patients is achieved, measuring data is accurate, the clinical application requirements can be satisfied, and long-term online monitoring is achieved.

The invention relates to a plant polysaccharide cleaning solution mainly composed of sodium carboxymethyl cellulose for intestinal cleaning, which comprises the following components: sodium carboxymethyl cellulose with a mass percentage of 0.1% to 2% , 0.7% to 1.2% by mass of sodium chloride, 0.01% to 0.1% by mass of pH value buffer substances and optional magnesium chloride, mannitol, phenolphthalein and carboxymethyl chitosan, the rest The amount is water for injection, wherein the mass percentage of magnesium chloride is 0.1% to 5%, the mass percentage of mannitol is 1% to 10%, the mass percentage of phenolphthalein is 0.01% to 0.1%, and the mass percentage of carboxymethyl chitosan The percentage content is 0.1%-0.4%, and the pH range of the plant polysaccharide cleaning solution is 6.5-7.8. The plant polysaccharide cleaning solution provided by the invention has good cleaning effect, no adverse reaction, and the cleaning solution is stable and difficult to degrade.

The invention discloses a method for surface modification of biodegradable iron and iron alloy by zinc ion implantation, which belongs to the technical field of surface treatment. In the present invention, a modified layer doped with zinc is formed on the surface of iron and iron alloy by zinc ion implantation. In the surface modified layer, a mixture phase of iron-zinc second phase, iron oxide and zinc oxide is formed, with a thickness of 50 ~100nm, the implanted element zinc shows a Gaussian distribution. The zinc surface modification layer prepared by the invention has good bonding strength with the substrate, improves the corrosion rate of iron and iron alloy, and has good biocompatibility at the same time.