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Amino-methyl dual-functionalized SBA-15 material as well as preparation method and application thereof

A bifunctional, amino-based technology, applied in the direction of crystalline aluminosilicate zeolite, can solve the problems of cumbersome steps and uneven distribution of functional groups, and achieves the treatment of hyperbilirubinemia, the preparation method is simple and feasible, and the high The effect of adsorption capacity

Inactive Publication Date: 2013-09-18
SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods have disadvantages such as cumbersome steps or uneven distribution of functional groups.
Therefore, it is still a challenge to synthesize bifunctional mesoporous materials with short channels and uniform distribution of functional groups by facile methods.

Method used

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  • Amino-methyl dual-functionalized SBA-15 material as well as preparation method and application thereof
  • Amino-methyl dual-functionalized SBA-15 material as well as preparation method and application thereof
  • Amino-methyl dual-functionalized SBA-15 material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Under magnetic stirring, add 4g of commercially available surfactant P123 (triblock copolymer P123) and 8.8g of inorganic salt KCl into 120mL of 2mol / L hydrochloric acid solution, stir until a transparent solution is formed, then add 9.0mL of TEOS and 0.932 mL of aminopropylmethyldiethoxysilane. The reaction mixture was stirred at a constant temperature for 24 hours at 40°C, then transferred to a polytetrafluoroethylene autoclave, and hydrothermally treated in an oven at 100°C for 48 hours. After cooling, the resulting product was repeatedly washed with deionized water and ethanol. After suction filtration and washing, dry at 80°C, and finally extract the product with ethanol for 48 hours in a Soxhlet extractor to remove surfactant P123, and dry at 80°C to obtain short-channel, functional group Amino-methyl bifunctional SBA-15 mesoporous material with evenly distributed clusters, and its texture parameters and pore lengths are shown in Table 1.

[0038] figure 1 is th...

Embodiment 2

[0050] Under magnetic stirring, add 4g of surfactant P123 and 13.2g of inorganic salt KCl into 120mL of 2mol / L hydrochloric acid solution, stir well until a transparent solution is formed, then add 9.0mL of TEOS and 0.932mL of aminopropylmethyldiethyl Oxysilane. The reaction mixture was stirred at a constant temperature for 24 hours under the condition of 40° C., then transferred into a polytetrafluoroethylene autoclave, and left standing in an oven at 100° C. for hydrothermal treatment for 24 hours. After cooling, the obtained product was repeatedly suction-filtered and washed with deionized water and ethanol, dried at 80°C, and finally the product was extracted with ethanol in a Soxhlet extractor for 48 hours to remove surfactant P123, at 80°C The amino-methyl bifunctional SBA-15 material with short channels and uniform distribution of functional groups can be obtained by drying at the bottom. The texture parameters and channel lengths are shown in Table 1.

[0051] Figur...

Embodiment 3

[0053] Under magnetic stirring, add 4g of surfactant P123 and 8.8g of inorganic salt KCl into 120mL of 2mol / L hydrochloric acid solution, stir well until a transparent solution is formed, then add 8.5mL of TEOS and 1.398mL of aminopropylmethyldiethyl Oxysilane. The reaction mixture was stirred at a constant temperature for 24 hours under the condition of 40° C., then transferred into a polytetrafluoroethylene autoclave, and left standing in an oven at 100° C. for hydrothermal treatment for 72 hours. After cooling, the obtained product was repeatedly suction-filtered and washed with deionized water and ethanol, and dried at 80°C. Finally, the product was extracted with ethanol for 48 hours in a Soxhlet extractor to remove the surfactant P123, 80 The amino-methyl bifunctional SBA-15 material with short channels and uniform distribution of functional groups can be obtained by drying at ℃. The texture parameters and channel lengths are shown in Table 1.

[0054] Figure 5 It is ...

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Abstract

The invention discloses an amino-methyl dual-functionalized SBA-15 material as well as a preparation method and an application thereof. The SBA-15 material has a submicron-grade short mesoporous channel, wherein the mesoporous channel ranges from 0.25 to 0.45 mu m in length; the mesoporous structure is a two-dimensional hexagonal structure; the specific surface area of the mesoporous structure ranges from 420 to 460 m<2> / g; the mesoporous diameter ranges from 5.0 to 5.1nm; the mesoporous volume ranges from 0.5 to 0.7 cm<3> / g; amino and methyl functional groups are uniformly distributed on the surface of the material. The preparation method comprises the following steps: adding surfactants P123 and KCl into a hydrochloric acid solution; then adding tetraethyl orthosilicate and aminopropyl diethoxymethylsilane; stirring for 24 hours at the temperature of 35 to 40 DEG C; standing in a self-pressure kettle; standing and performing a hydro-thermal treatment in a baking oven at the temperature of 90 to 100 DEG C; cooling, filtering, washing and drying; extracting an obtained product by using ethyl alcohol and drying, thereby obtaining the SBA-15 material. The SBA-15 material can be applied to bilirubin adsorption in PBS (Phosphate Buffer Solution) simulation plasma.

Description

technical field [0001] The present invention relates to a SBA-15 (Santa Barbara Amorphous-15, a mesoporous molecular sieve) material, in particular to an amino-methyl bifunctional SBA-15 material with short pores and uniform distribution of functional groups and its formulation and application. Background technique [0002] Bilirubin is the catabolism product of hemoglobin in the human body, and exists in blood, bile, etc. Many diseases, especially liver disease, can cause abnormally high bilirubin concentration in the blood, hyperbilirubinemia, and severe death of the patient. A large number of studies have shown that the use of hemoperfusion therapy can effectively treat hyperbilirubinemia. The key to this therapy is the adsorption properties of the bilirubin adsorbent. At present, the commonly used adsorbents are mainly activated carbon, resin and polysaccharide materials (CN1289183C, CN1985844A, CN1317068C). However, these materials have large pore sizes and uneven po...

Claims

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Application Information

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IPC IPC(8): C01B39/02
Inventor 孙予罕李小安唐涛
Owner SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI
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