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High-strength calcium phosphate composite nano material bone cement and preparation method thereof

A composite nanomaterial, calcium phosphate technology, applied in the intersection of nanomaterials and biomedicine, can solve the problem of difficult to meet the requirements of CPC application, and achieve improved biocompatibility, good wear resistance, and good tensile strength. Effect

Active Publication Date: 2015-02-18
连云港格兰特化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these studies are difficult to meet the requirements of different clinical applications of CPC.

Method used

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Examples

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Effect test

Embodiment 1

[0018] Example 1, a high-strength calcium phosphate composite nano material bone cement, the bone cement is composed of solid phase powder and liquid phase, the solid phase powder is composed of raw materials in the following weight ratio: tricalcium phosphate 5, hydroxyapatite 30, γ-alumina nanotubes 1; the liquid phase is an aqueous solution containing 1% citric acid and 5% glucose; the solid phase powder and liquid phase are mixed according to the ratio of liquid phase to solid phase: 1 ml: 0.3g before use .

Embodiment 2

[0019] Example 2, a high-strength calcium phosphate composite nano material bone cement, the bone cement is composed of solid phase powder and liquid phase, the solid phase powder is composed of raw materials in the following weight ratio: tricalcium phosphate 20, hydroxyapatite 70, γ-alumina nanotubes 10; the liquid phase is an aqueous solution containing 10% citric acid, 6% chitosan and 15% glucose; the solid phase powder and the liquid phase are 1 ml according to the ratio of the liquid phase to the solid phase before use : Blended with 0.8g.

Embodiment 3

[0020] Example 3, a high-strength calcium phosphate composite nano material bone cement, the bone cement is composed of solid phase powder and liquid phase, the solid phase powder is composed of raw materials in the following weight ratio: tricalcium phosphate 10, hydroxyapatite 50, γ-alumina nanotubes 5; the liquid phase is an aqueous solution containing 3% citric acid, 1% chitosan and 8% glucose; the solid phase powder and the liquid phase are 1 ml according to the ratio of the liquid phase to the solid phase before use : Blended with 0.5g.

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Abstract

The invention discloses a high-strength calcium phosphate composite nano material bone cement which is composed of a solid-phase powder and a liquid phase, wherein the solid-phase powder is composed of the following raw materials in parts by weight: 5-20 parts of tricalcium phosphate, 30-70 parts of hydroxyapatite and 1-10 parts of gamma-aluminum oxide nanotube; the liquid phase is a water solution containing 1-10 wt% of citric acid, 0-6 wt% of chitosan and 5-15 wt% of glucose; and before use, the solid-phase powder and liquid phase are blended according to the liquid phase:solid phase ratio of 1ml:(0.3-0.8)g. The invention also discloses a preparation method of the bone cement. The bone cement material has the advantages of favorable comprehensive properties and high compression strength, and is convenient to operate; the maximum compression strength can reach 120 MPa, which is much higher than that of the existing calcium-phosphate-base bone cement; and the bone cement material with favorable injectability can satisfy the clinical application requirements, and is suitable for restoring hard tissue bone defects, treating osteoporosis, and fixing and treating fractures.

Description

technical field [0001] The invention relates to a medical bone cement, which belongs to the interdisciplinary fields of nanomaterials and biomedicine, in particular to a high-strength calcium phosphate composite nanomaterial bone cement, and also relates to a preparation method of the high-strength calcium phosphate composite nanomaterial bone cement. Background technique [0002] Calcium phosphate bone cement (CPC) is a new type of artificial bone repair material. In addition to good biocompatibility and osteoconductivity, calcium phosphate bone cement also has the advantages of being able to be shaped arbitrarily during surgery and less heat release during curing. It is widely used in the fields of teeth and plastic surgery. Many scholars have conducted a lot of research on the composition, performance and curing mechanism of phosphate bone cement, and have achieved many valuable results. Although phosphate bone cement has many excellent properties, the CPC bone cement th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/12
Inventor 李明达刘顺强祝桂林
Owner 连云港格兰特化工有限公司
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