The invention discloses a brewing method of melastoma dodecandrum lour fruit wine. The brewing method comprises the following steps: selecting mature and disease-free melastoma dodecandrum lour, washing, pulping, performing compound enzyme treatment, juicing, filtering, performing yeast fermentation, ageing, packaging, and sterilizing to obtain a finished product of melastoma dodecandrum lour fruit wine. According to the brewing method, a compound enzyme hydrolysis technology is adopted, the separation rate of nutrients of the melastoma dodecandrum lour is effectively increased, the nutrients of the melastoma dodecandrum lour are well reserved, and the utilization rate of raw materials is increased; the fruit wine is heavy in wine fragrance, mellow in mouth feel, stable in color and rich in nutrition, and has the effects of activating blood, arresting bleeding, clearing heat and toxic materials, relaxing tendons, activating collaterals, maintaining beauty, keeping young and the like.