The invention relates to a novel partial deep layer pressurizing type vacuum preloading soft soil foundation processing method. According to the technical scheme, the method comprises a vertical drainage system, a transverse drainage system, vacuum extraction equipment, a pressurizing system, pressurizing equipment and a sealing system; a vertical drainage board adopts a novel anti-clogging drainage board, the vertical drainage board is divided into two parts to be driven, one part is driven into a soil body, and the other part is exposed out of the surface of the soil body. The technology enables a deep soil body to obtain higher air pressure, enables a larger pressure difference to be formed among the deep soil body, an upper soil body and the vertical drainage board, and enables the free water in the deep soil body to fast flow to the upper soil body and the drainage boards. In addition, the flow direction of airflow from a jet head obliquely upwards points to the drainage boards, therefore the seepage of the pore water in the deep soil body to the drainage boards can be accelerated, and the deep soil body can obtain better reinforcement effect.