55results about How to "Has anticoagulant effect" patented technology

The invention discloses an anticoagulation coating material and a preparation method thereof. The anticoagulation coating material comprises sodium hyaluronate and hirudin, wherein the sodium hyaluronate is formed into a gel network; the hirudin is in covalent binding with the sodium hyaluronate. The preparation method of the anticoagulation coating material comprises the following steps: (1) preparing an MES (Fatty Acid Methyl Ester Sulfonate) buffer solution; (2) preparing a sodium hyaluronate solution with the concentration of 1mg / ml to 20mg / ml; (3) preparing a hirudin solution with the concentration of 1mg / ml to 10mg / ml; (4) uniformly mixing up the two solutions so as to enable the mass ratio of the hirudin to the sodium hyaluronate to be 1:1 to 1:10; (5) adding a crosslinking agent into the mixture solution obtained in the step (4), uniformly mixing up so as to covalently crosslink the hirudin and the sodium hyaluronate. The anticoagulation coating material disclosed by the invention is high in anticoagulation activity, stable in effect, long in lasting time, good in biocompatibility, simple in preparation method, gentle in condition and applicable to large-scale industrial production.

The invention provides an agaric health care cake, relating to a health care cake. The technical scheme of the invention is as follows: the agaric health care cake comprises the following raw materials in parts by weight: 15-60 parts of agaric powder, 110-130 parts of cake flour, 70-90 parts of milk, 2-4 parts of baking powder, 160-200 parts of egg white, 60-80 parts of egg yolk, 20-50 parts of berry sugar and 0.03-0.05 part of potassium acid tartrate. The agaric health care cake provided by the invention increases a new fresh and cool cake taste; and agaric is rich in nutrition and has the effects of resisting coagulation, resisting platelet aggregation, resisting thrombosis, resisting radiation, resisting aging, resisting tumors, reducing blood sugar, resisting bacteria and the like, so that the functions of nutrition and health care of the cake are enhanced.

A methyltriglycosid salicylate and its preparing process, a salicylate glycoside compound and its preparing process and a medicine containing salicylate glycoside for antipyresis, relieving pain and inflammation and preventing thrombocyte coagulation are disclosed.

The invention discloses a pharmaceutical composition for control of diabetes and complications thereof. The pharmaceutical composition comprises: sea cucumber polypeptide, alginate oligosaccharide, a kudzu vine root extract, a common duckweed extract, a radix trichosanthis extract, an extract of peach kernel and safflower, a ginkgo leaf extract, hirudin and nattokinase. The pharmaceutical composition provided by the invention can treat insulin resistant diabetes, the effective components are compounded to achieve better prevention and treatment effect on diabetes than single component, and the pharmaceutical composition also can prevent and treat some chronic complications associated with blood glucose rise. The pharmaceutical composition provided by the invention has the advantages of simple production process, low cost, high benefit, and obvious economic and social benefits.

The invention discloses a hemofiltration solution and a preparation method thereof. The hemofiltration solution contains phosphorus, a variety of trace elements and citrate radical ions besides water, sodium, potassium, magnesium, chlorine and glucose, can prevent hypophosphatemia and loss of considerable micronutrient elements, has anticoagulation action, is capable of effectively reducing mortality of patients and simple to operate, hardly poses pollution, provides a better option for clinical practice and has wide application prospects.

The invention discloses a double-layer closed sacculus tube for the digestive tract. The double-layer closed sacculus tube comprises an inner-layer sacculus and an outer-layer sacculus which are coaxial and concentric and have different wall thicknesses, wherein the inner-layer sacculus is sleeved by the outer-layer sacculus; the inner-layer sacculus and the outer-layer sacculus are fixedly connected with the head part of a catheter in a sealed mode; the catheter is ofthe structure of sleeving three single-cavity tubes together; and two sides of the tail of the catheter are respectively connected with two sealing connectors, wherein one sealing connector is communicated with the injection hole of the inner-layer sacculus, and the other sealing connector is communicated with the injection hole of the outer-layer sacculus. According to the three-cavity double-layer sacculus catheter with the closed cavities, the double layers of sacculi are adopted, the pressure of the inner-layer sacculus and the pressure of the outer-layer sacculus are different, the inner-layer sacculus is used for hemostasis by compression and adhesion prevention, and the outer-layer sacculus is used for the filling display of the digestive tract. The whole catheter contains a developing material, so that the position of the catheter in the digestive tract can be distinguished under X rays, CT, MRI and ultrasound. Guide wires can be inserted from a wire guide hole, for pushing the catheter to reach a set position in the digestive tract easily, and the operation is simple and feasible.

The invention discloses an anti-infection hemodialysis tube, which relates to the field of medical equipment. The anti-infection hemodialysis tube of the present invention comprises a dialysis outer tube, a dialysis inner tube, and a dialysis membrane. Covering the outer wall of the dialysis inner tube; the dialysis inner tube has a U-shaped or V-shaped structure, and the openings are respectively a liquid inlet and a liquid outlet; the tubes of the dialysis outer tube and the dialysis inner tube are made of polyester Tetrafluoroethylene-polyurethane-nanosilver composite. In the present invention, the dialysis tube is directly placed in the blood vessel, without taking the blood out of the body and then performing hemodialysis through a machine. The nano-silver of the tube can effectively reduce the risk of infection in the hemodialysis process, and the chitosan quaternary ammonium salt in the dialysis membrane Make the composite membrane positively charged, form a positively charged barrier, effectively resist the bacteria in the dialysate from entering the blood, and further reduce the chance of blood infection during dialysis.

The invention discloses an Nd2O3-containing gradient bioactive ceramic coating material and a preparation method thereof. The coating material comprises the following raw materials in parts by weight: 0 to 70 parts of titanium powder and 30 to 100 parts of compound ceramic powder, wherein the compound ceramic powder is prepared through the steps of mixing 72 to 80 parts of CaHPO4.2H2O with 28 to 20 parts of CaCO3 so as to obtain 100 parts of ceramic powder, and then adding 0.1 to 0.8 parts of Nd2O3 powder into the obtained ceramic powder. In the invention, because of adding the Nd2O3 powder into the ceramic powder, the ceramic coating has the function of catalyzing the synthesis of hydroxyapatite and beta-calcium phosphate, and compared with the actions of the ceramic powder added with CeO2, La2O3 and Y2O3 powder, a biological ceramic coating prepared by adding Nd2O3 powder has better biocompatibility and biological activity, has the function of anticoagulation and can prevent canceration; meanwhile, compared with the action of the ceramic powder added with CeO2, La2O3 and Y2O3 powder, more micro-pores are formed on the surface of the biological ceramic coating prepared through adding Nd2O3 powder, thereby providing more channels for a bone tissue ingrowth coating.

The invention provides a device for controlling animal follicle development and preventing and treating reproductive tract inflammation and a preparation method thereof. The device is internally provided with a nylon support, and a sustained-release material layer with estrogen, progestational hormones and antibacterial peptide is wrapped around the outer part of the support. The device is provided with a connecting part and two long arms, the bottom ends of the two long arms are connected to the connecting part, a certain included angle is formed between the two long arms, and the portions, at the long arms, of the sustained-release material layer protrude to form a plurality of sheet structures which are orderly arranged. According to the device and the preparation method thereof, medicines and silicone rubber raw materials are mixed according to a certain ratio, and after low-temperature vulcanization forming is carried out, the medicines combined with silicone rubber and a high polymer material support are prepared into a special vaginal embedding bolt; the medicines combined with the silicone rubber can be slowly released for a long time (10 days or more), so that the effectsof effectively controlling the animal follicle development and preventing and treating the vagina and uterine inflammation can be achieved; the adopted materials are non-toxic, harmless and smooth andsoft in texture and have a good compatibility with animal tissues; and the pick-and-place operation of the device is simple.

The invention provides noodles capable of reducing high blood pressure, high blood lipid and high blood sugar. The noodles are made by kneading raw materials and a proper amount of water into dough and then stretching the dough into noodles, wherein the raw materials include, by weight, 10-30 parts of seabuckthorn leaf powder, 10-30 parts of mulberry leaf powder, 40-80 parts of flour and a proper amount of water. The noodles have the effect of reducing high blood pressure, high blood lipid and high blood sugar, and can stably relieve the symptoms of a patient as the staple food of the patient; meanwhile, the noodles contain other ingredients with extremely high healthcare value, seabuckthorn leaves have the inflammation diminishing and anti-inflammation effect, and mulberry leaves have the anti-coagulation effect.

The present invention relates to a health-care medicine composition for improving sleep. Said medicine composition is made of clove, nutmeg, bark of Chinese cassia tree, asafetida, resurrection lily rhizome and black pepper, and it can be made into any dosage form described pharmaceutically.

The invention discloses a medical material for inducing tissue repair as well as a preparation method and application thereof, and relates to the technical field of a medical material. The preparationmethod of the medical material for inducing tissue repair comprises the following steps that a zinc salt solution and a polylysine solution are mixed; then, the mixed solution and a heparinate solution are mixed to obtain nanoparticle turbid liquid; materials to be loaded deposited with a polydopamine coating are soaked in the nanoparticle turbid liquid. For the medical material for inducing tissue repair, nanoparticles with zinc ions are loaded on the materials to be loaded with the polydopamine coating; the formed material has an anticoagulating effect; the cell viability of endothelial cells and smooth muscle cells can be improved. The medical material can be applied to the preparation of intravascular stents; the prepared intravascular stents can promote the proliferation of the endothelial cells and the smooth muscle cells; the problem of artery restenosis in the material implantation later period and very late period is avoided.

The invention discloses a cardiac or vascular patch with an anticoagulant effect. The surface of a substrate of the patch is modified on the surface of the woven polyamide (PA), polyethylene terephthalate (PET) or polytetrafluoroethylene (PTFE) substrate for artificial blood vessels by a coprecipitation method, and nanometer polyurethane (PU) microspheres of which the surfaces are modified by phosphorylation and which have the diameters of between 100 and 300nm into the surface of the substrate of the patch through a binder, namely polyurethane (PU), wherein the concentration of the nanometer PU microspheres is between 0.3 and 1.0mg / cm<2>. The cardiac or vascular patch has remarkable anticoagulant effect when keeping excellent mechanical properties, flexible performance and bending performance of the substrate of the patch.

The invention discloses a Chinese medicinal compound with function of treating diabetes and a preparation method and application thereof. The Chinese medicinal compound consists of the following raw materials in part by weight: 8 to 20 parts of sealwort, 5 to 15 parts of roasted stiff silkworm, 5 to 15 parts of winged euonymus twig, 8 to 20 parts of Chinese wolfberry and 10 to 20 parts of hiraute shiny bugleweed herb. The Chinese medicinal compound provided by the invention is prepared and formulated by adopting the theory of syndrome differentiation and treatment according to the Chinese medicinal theory; experimental results show that the Chinese medicinal compound provided by the invention has multi-link and multi-target combined action, and can correct glucose metabolism turbulence, reduce blood sugar, improve pancreatic B cell function, improve insulin resistance and enhance immunologic function; and the experimental results show that the Chinese medicinal compound provided by the invention can effectively reduce serum total cholesterol, triglyceride, serum free fatty acid and urine micro-albumin, has good effects of resisting lipid peroxidation, improving blood flowage and preventing or delaying atherosclerosis, and can be used for preventing and treating diabetes mellitus associated with hyperlipaemia and cardiovascular diseases.

The invention relates to a production process of instant kelp and Spanish mackerel foods. The production process comprises the following steps: checking and accepting raw materials, thawing the raw materials, removing heads, slicing, removing belly bones, washing, cutting the bones, feeling the bones and checking, disinfecting, burying salt, washing the salt, carrying out primary curing, immersing with vinegar, peeling off skins, carrying out secondary curing, putting blocks, conveying the blocks into a flat plate machine, cutting, immersing kelps, boiling the kelps, putting into a plate, freezing, chopping, bagging, re-weighing, vacuumizing, enabling the products to pass through a metal detector, packaging and storing. The instant kelp and Spanish mackerel foods produced by the process can be instantly eaten; meanwhile, the instant kelp and Spanish mackerel foods do not need to be cooked, so that the loss of nutrition substances is extremely less; and double requirements for nutrition and health of instant consumer goods of consumers are met. Moreover, adopted seasonings are sour and sweet and any preservative is not added, so that the instant kelp and Spanish mackerel foods are safe and healthy. The foods produced by the process are convenient and simple to eat, have a good taste and also have the effects of lowering blood pressure, lowering blood glucose, lowering blood lipid, resisting coagulation and resisting radiation and are of good foods for dietary therapy and health maintenance.

The invention provides a preparation method of a hirudin crude extract. The technical scheme is as follows: by using Whitmania pigra as the raw material, selecting, cleaning, refrigerating, crushing, precipitating, centrifugating and ultrafiltering to prepare the polypeptide compound product hirudin. The hirudin has the anticoagulation action, can be used for improving the treatment effect on neoplastic or thrombotic diseases in clinical veterinary medicine, and is especially suitable for neoplastic or thrombotic diseases of dogs, cats and other animals. The refrigerating crushing and ultrafiltration techniques are combined to extract the hirudin crude product, thereby ensuring the product quality on the premise of controlling the temperature. The method is suitable for the demands of mass production, can easily implement automatic production, and enhances the production efficiency. The prepared hirudin product lays a foundation for further purification and clinical application. The product can be used for neoplastic or thrombotic diseases of cats, dogs and other pets, effectively improves the state of illness, and provides a novel biological product for the pet market.

The invention relates to a compound shown in a general formula (I) or a general formula (II) in the specification and a stereoisomer or physiologically acceptable salts thereof and also relates to a preparation method and application of the compound. Besides, the invention also relates to a drug composition containing the compound and an application of the drug composition. The compound which is provided by the invention and can serve as a thrombin and / or blood platelet GPIIb / IIIa receptor inhibitor has good in-vitro human thrombin inhibiting activity, in-vitro blood platelet GPIIb / IIIa receptor inhibiting effects and in-vitro / in-vivo anti-platelet aggregation effects, and does not have obvious toxicity. The compound provided by the invention has a novel structure and good biological activity, is simple and convenient to synthesize and is a drug with good application prospects and anticoagulation effects.

The invention belongs to the field of polypeptides in biochemistry, and relates to an agkistrodon acutus anticoagulant factor XI polypeptide and application thereof. According to the polypeptide, a Kunitz type polypeptide sequence is screened from an agkistrodon acutus snake venom transcriptome database, the Kunitz type polypeptide sequence is constructed and expressed to obtain the polypeptide with antithrombotic activity, and the polypeptide can be applied to preparation of antithrombotic drugs.

The invention discloses a smokeless column for folium mori moxa-moxibustion. The smokeless column for folium mori moxa-moxibustion is prepared from the following raw materials in parts by weight: 60-80 parts of folium artemisiae argyi, 13-22 parts of folium mori, 2-6 parts of realgar, 4-8 parts of bentonite, 3-7 parts of carbon powder, 3-9 parts of modified starch, 2-3 parts of folia perillae acutae, 1-4 parts of bighead atractylodes rhizome, 2-5 parts of glycyrrhiza, 1-3 parts of astragalus membranaceus, 2-4 parts of pericarpium citri reticulatae, 3-6 parts of longan, 2-5 parts of campsis grandiflora and 1-3 parts of asparagus fern. The folium artemisiae argyi, folia perillae acutae, bighead atractylodes rhizome, glycyrrhiza, astragalus membranaceus, pericarpium citri reticulatae, longan,campsis grandiflora and asparagus fern are added into the raw materials of the smokeless column for folium mori moxa-moxibustion, so that the functions of the product are enriched. The product carried by bentonite, carbon powder and modified starch is smokeless in the using process.

The invention relates to a heparin-free anticoagulant infection inhibitor for hemodialysis and a preparation method thereof. The heparin-free anticoagulant infection inhibitor is a preparation comprising the following components in parts by weight: 1 part of sodium citrate, 0.001-0.8 part of methylene blue and 0.001-10.0 parts of chondroitin sulfate as well as a proper amount of adjuvant and an excipient optionally. The heparin-free anticoagulant infection inhibitor has synergetic advantages compared with heparin and other species of single-component dialysis anticoagulants, has no toxic or adverse effect contraindications of heparin, is suitable for more target users than heparin, and provides biological protection for dialysis infection (bacterial or viral infection) which easily occurs in medical care personnel and patients and reduces hemodialysis infection of operators and patients. The heparin-free anticoagulant infection inhibitor has the advantages of easily-accessible raw materials, low price, large market and stable supply, and has good application prospects and social and economic benefits.

Disclosed is an injection for treating coronary heart disease and cerebral infarction which is prepared from the raw material (by weight ratio) of notoginseng 70-30%, haw leaf 30-70% through the conventional preparing processes. The injection may also contains mannitol as the adjuvant.

The invention provides a cavitation device for preparing a palm oil-based submicron emulsion. The cavitation device comprises a stator, a rotor, ultrasonic transducers and a rotating shaft, wherein the stator is provided with a feeding port, a discharging port and an oxidizing agent conveying pipe, the rotating shaft is installed in the stator, the rotor is arranged in the stator, the rotor is fixedly connected with the rotating shaft, blades are distributed on the rotor, and cavitation holes are distributed in the blades. According to the invention, palm oil is used as a dispersion phase and deionized water is used as a continuous phase to prepare an oil-in-water submicron emulsion; a crude emulsion enters the stator, liquid flow in a stator cavitation cavity is coupled with rotor vibration to achieve a strong cavitation effect; through combination of an ultrasonic probe, hydraulic cavitation and ultrasonic cavitation, cavitation efficiency is improved, energy input is much lower; and thus, the device has great potential in the aspect of emulsion preparation.

The invention belongs to the technical field of traditional Chinese medicines and discloses a traditional Chinese medicine ointment for regulating hyperplasia of mammary glands and a preparation method of the traditional Chinese medicine ointment. The traditional Chinese medicine ointment comprises components A and B. The component A is prepared from, by weight, 10-30 parts of Rhizoma Ligustici Wallichii, 10-30 parts of Semen Persicae, 15-40 parts of Squama Manis, 10-30 parts of roasted Semen Brassicae, 10-30 parts of Radix Linderae, 15-40 parts of Spina Gleditsiae, 10-40 parts of Rhizoma Sparganii, 10-30 parts of Rhizoma Curcumae, 15-40 parts of Radix Angelicae Sinensis, 10-20 parts of Radix Curcumae, 5-12 parts of borneol and 3-5 parts of olibanum. The component B is prepared from, by weight, 10-30 parts of Herba Abri, 20-30 parts of Herba Lycopi, 3-5 parts of Natrii Sulfas, 3-5 parts of Rhizoma Corydalis, 0.5-2 parts of Semen Strychni, 1-5 parts of Fructus Polygoni Orientalis, 10-15parts of Caulis Spatholobi, 1-5 parts of Radix et Rhizoma Rhodiolae, 0.5-3 parts of Fructus Psoraleae and 10-15 parts of Radix Dipsaci. The traditional Chinese medicine ointment has functions of blood circulation promoting, stasis removing, Qi circulation promoting and pain alleviating and is effective in treatment of hyperplasia of mammary glands.

The invention discloses a sorghum root extract, and a preparation method and application thereof. The preparation method comprises the following steps of cutting sorghum roots into small sections with a straw cutter, adding water to extract the small sections for 1 to 3 times, wherein the extracting temperature is 70 to 100 DEG C, the weight ratio of materials to liquid is 1:8 to 1:12, and each time lasts for 1.5 to 3 hours, combining water decoctions, and concentrating the water decoctions to a fluid extract; and adding an edible alcohol until the final alcohol concentration is 60 to 80 percent, standing for 12 to 24 hours, filtering, concentrating a filtrate, and drying to obtain the sorghum root extract. The sorghum root extract is applied to the preparation of drugs for treating diseases caused by endovascular embolization or thrombus, and preventing stroke or other thrombotic diseases. The sorghum root extract is good in anticoagulation, high in safety, low in cost, simple in preparation method and low in production cost.

The invention provides a plaster for cervical vertebra and lumbar vertebra and a preparation method thereof, and relates to the technical field of medicine preparation. The plaster for cervical vertebra and lumbar vertebra comprises raw semen strychni, safflower, rheum officinale, radix aconiti, radix aconiti agrestis, angelica sinensis, eucommia ulmoides, ligusticum wallichii, scorpio, ground beetle, rhizoma atractylodis macrocephalae, frankincense, myrrh, ephedra and centipede. The preparation method of the ointment comprises the following steps: crushing the raw materials, sieving by a 70-80-mesh sieve to obtain fine powder, adding the sesame oil into the fine powder, performing decocting at 50-60 DEG C for 48-72 hours, performing filtering to obtain medicinal oil, adding the rosin, the single garlic, the green Chinese onion, the folium artemisiae argyi and the ginger into the medicinal oil, and performing decocting at 60-70 DEG C for 24-48 hours to obtain the ointment. The plaster disclosed by the invention can be used for quickly diminishing swelling and relieving pain, has a remarkable treatment effect on connective tissue and nervous tissue injury caused by spondylodynia, and is small in irritation, quick in response and good in curative effect. According to the preparation method disclosed by the invention, the raw materials are reasonably treated, so that effective components of the raw materials play a better role, the efficacy of the plaster is further improved, and the curative effect is better.

The invention belongs to a blood-related product, and particularly relates to a human hematopoietic product for oral administration or injection. The main components of the human hematopoiesis comprise essential amino acids, trace elements, vitamins, nutrient substances and growth factors. The preparation method comprises the following steps: synthesizing and sub-packaging in a sterile reaction kettle, diluting with normal saline to form a diluent, mixing with glycerol, lecithin and soybean oil emulsion, inputting into the liquid through mixed gas of medical sterile pure O2 and O3 to enable the oxygen partial pressure to reach 105Kpa or above, filling into an infusion bag at equal pressure to prepare the hematopoietic finished product, and after a pyrogen test is qualified, clinically infusing or orally taking the medicine by a human body. The hematopoietic carbonized fluorine-free compound is prepared from a safe and nontoxic lecithin emulsion; the emulsion which has oxygen carrying capacity, is not limited by blood types, can be stored for a long time, is free of mixing of bacteria or viruses and promotes growth of the hematopoietic stem cells is obtained by diluting a diluent of amino acid, trace elements, vitamins, nutrient substances and growth factors and injecting oxygen at overhigh pressure. The growth factors further promote synthesis of hematopoietic stem cells and division of hemoglobin, the blood recovery capacity is improved through the synergistic effect of multiple raw materials, and the composition is especially suitable for ischemia symptoms such as iron deficiency type anemia.

The invention discloses a pectin-containing private part cleaning enzyme soap and a preparation method thereof and relates to an enzyme soap product and a preparation method thereof. The enzyme soap is prepared from the following components in parts by weight: 10-20 parts of enzyme stoste, 1-3 parts of active protease, 2-5 parts of pectin, 1-3 parts of an essential liquid, 5-8 parts of glycerinum,0.5-2 parts of plant essential oil and 80-120 parts of a plant soap base. The preparation method comprises the following steps: filtering the enzyme stoste for later use; putting the glycerinum intothe plant soap base, heating to 65-70 DEG C, stirring till complete melting to sufficiently mix the two raw materials, sequentially adding the essential liquid and the pectin, sufficiently mixing, cooling, and keeping the temperature of 45-50 DEG C for 5 hours under a constant temperature condition; adding the active protease, the enzyme stoste and the plant essential oil, sufficiently mixing, andleaving to stand for 3 hours; pouring the mixed liquid into a mold, leaving to stand at a cool place, cooling, and drying for 7 days, thereby obtaining the enzyme soap. The enzyme soap has dual functions of cleaning and nursing, is capable of effectively cleaning skin and preventing bacteria on premise that the skin is tendered, and is applicable to daily use of people of different skin qualities.