331results about How to "Has anti-tumor effect" patented technology

The invention provides a compound feed capable of improving the fatty liver and body colour of the marine fish. The compound feed comprises a premixed feed, a bile acid, curcumin and betaine, wherein the premixed feed comprises fish meal, soya bean meal, corn gluten meal, high protein flour, corn, shrimp shell meal, monocalcium phosphate, fish oil, liquid phosphatide, vitamin premixes, mineral premixes, and the like. Artificial marine-fish breeding experiments prove that the compound feed provided by the invention can meet the nutritional needs of marine-fish growth, effectively enhance the physique of the marine fish, improve the immunity of the marine fish, reduce the incidence of a fatty liver disease, and improve the body color of the marine fish, so that the body color of the marine fish is bright-colored and close to a wild natural color, thereby enhancing the quality of artificially cultured marine fish.

The present invention relates to medicine technology, and provides one kind of compound Chinese medicine preparation for treating hysteromyoma. The compound Chinese medicine preparation includes medicine bolus and medicine powder. The medicine bolus has recipe comprising 29 kinds of Chinese medicinal materials, including cassia twig, burreed rhizome, zedoary, etc.; and the medicine powder has recipe comprising 17 kinds of Chinese medicinal materials, including speranskia herb, myrrh, frankincense, etc. By means of oral taking and external application, the present invention has determined and obvious curative effect and no side effect.

The present invention relates to a method for extracting ganoderic spore polysaccharide. It is characterized by that firstly, it uses CO2 supercritical extraction method to extract ganoderic spore oil for another application, and makes the residue obtained after the ganoderic spore oil is extracted undergo the processes of removing fat, water extraction, alcohol precipitation, filtration and drying so as to obtain the invented ganoderic spore polysaccharide.

The invention relates to an antitumor traditional Chinese medicinal composition, which comprises the following bulk drugs by weight: 5-15 of Radix Astragali; 10-20 of ginseng; 5-10 of Coleus forskohli; 5-15 of ganoderma; 10-25 of barbed skullcap herb; 5-25 of hedyotis diffusa; and 5-10 of dried orange peel. The traditional Chinese medicinal composition of the invention has an obvious tumor inhibition effect, and is suitable for treating various malignant canceration including liver cancer, stomach cancer, kidney cancer, esophageal cancer, lung cancer, leukemia and the like.

The invention relates to a tumor binding specific gamma delta TCR gene modified alpha beta T cell and cancer suppression application thereof. The alpha beta T cell expresses the tumor binding specific gamma delta TCR; the tumor binding specific gamma delta TCR comprises a gamma 4 chain and a delta 1 chain; the amino acid sequence of the delta 1 chain CDR3 is shown as SEQ ID NO: 1. Experiment results prove that the cell has cytotoxicity for a plurality of tumor cells, and a novel method and a novel strategy are provided for adoptive immunotherapy of tumors.

A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R 1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc, R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.

The present invention provides a new application of tanshin polyphenolic acid B in preparing medicine for treating tumor. Extraneous research shows that tanshin polyphenolic acid B has the function of killing tumor cell and animal test shows its antineoplastic effect. In the present invention, the cation in the salt of tanshin polyphenolic acid B may be Fe ion, Na ion, K ion, Ca ion or Mg ion, preferably Mg ion. The said medicine may be in any medicine form, oral liquid, injection, tablet or capsule.

The present invention relates to a dynamic imine bond polysaccharide polymer-based injectable hydrogel and a preparation method and an application thereof. The dynamic imine bond polysaccharide polymer-based injectable hydrogel comprises the following raw material components in weight percentages: 5-18% of a component A: oxidized sodium alginate, 0.1-20% of a component B: a mixture of one or two of water-soluble chitosan and 3,3'-dithiobis(propanohydrazide), and the balanced solvent. The materials are prepared into an even solution according to the ratio. Compared with the prior art, "Schiff base", amide bonds and other dynamic imine bonds are used to realize cross-linking and can form a gel under mild conditions of human body temperature and acid and alkali, and no biotoxic initiators areneeded. The hydrogel is fast in gel-forming speed and injectable after forming. The hydrogel is mild in the preparation conditions, and excellent in compression properties, biocompatibility and injectability, and has broad application prospects in the field of cartilage repair.

The invention provides a medicated diet for improving functions of spleen and stomach and enhancing the immunoregulation capability and a preparation method of the medicated diet. The medicated diet comprises the following components: fructus jujubae, radix astragali preparata, ginseng, fried bighead atractylodes rhizome, poria cocos, fried semen coicis, agastache rugosus, radix paeoniae alba, fructus citrus sarcodactylis, fructus citri, Chinese yam, paederia scandens, caulis bambusae in taeniam, scorched medicated leaven, scorched malt, scorched hawthorn fruit, platycodon grandiflorum, radix aucklandiae, fructus aurantii, fructus amomi, pericarpium citri reticulatae, cassia twig, ginger, semen allii tuberose, radix saposhnikoviae, angelica sinensis, wolfberry fruit, rhizoma polygonati, lingzhi mushroom, rhodiola rosea, walnut meat, taraxacum, radix tinosporae, liquorice, brown granulated sugar and starch syrup. The medicated diet takes natural food materials, materials used as medicines and foods and materials used as health foods as the main raw materials, has the functions of invigorating spleen-stomach and replenishing qi, fortifying spleen and nourishing stomach, supporing Yang for consolidating superficies, reinforcing deficiency and strength, regulating qi function of human body, improving sub-health habitus and the like, can be used for improving functions of spleen and stomach and enhancing immunoregulation capability and has a good effect.

The invention relates to an artificial cultivation method and the usage of trametes lactinea berk, which respectively carries out the culture of the trametes lactinea berk by a solid culture medium and a liquid culture medium via the purification of a bacterial strain, so as to obtain an artificially cultivated trametes lactinea berk. The method can realize the large-scale artificial cultivation of the trametes lactinea berk; the drug which takes the trametes lactinea berk or the extract thereof as the main ingredient has the better functions of improving immunity and anti-tumor function, thetrametes lactinea berk obtained by the invention can be used as an additive to be added into the feed to promote the growth of the livestock and poultry, strengthen immunity and reduce diseases.

The invention relates to a formula donkey milk formula with an anti-tumor efficacy. The formula donkey milk powder is characterized in that donkey milk powder is taken as the main material, and components, including lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus plantarum, lentinan, pachymaran, grifolan, fructo-oligosaccharide, galactooligosaccharide, isomaltose hypgather, synanthrin, polysaccharides in reed rhizome, apricot kernel meal, walnut powder, Chinese yam powder, lotus seed powder, lily root flour, wolfberry powder and the like are added. The formula donkey milk powder has the effects of inhibiting the growth of tumor cells and prolonging the living time of tumor-bearing mice.

The invention relates to 2-aryl-1,3-isoquinoline diketone anti-tumor compound and a synthesis method and application thereof. The 2-aryl-1,3-isoquinoline diketone anti-tumor compound has the chemical structural formula I and the chemical structural formula II, wherein R represents the hydrogen, the hydroxy or the methoxyl, and Ar is phenyl, one or more of the halogen-atom substituted phenyl, the trifluoromethylphenyl, the 3-acetylenyl phenyl, the 6-benzothiazolyl, the 2-acetylamino pyridine and the like. The 2-aryl-1,3-isoquinoline diketone anti-tumor compound has a novel structure, and the synthesis method of the 2-aryl-1,3-isoquinoline diketone anti-tumor compound is easy to implement. The antiproliferative activity assay shows that most compounds have significant functions of inhibiting the growth of human prostate cancer cells PC3 and human kidney cancer cells 786-0, and the in vivo anti-S180 tumor activity test shows that the activity of the compound 21 is significantly stronger than that of Gefitinib.

The invention discloses a nitrogen mustard phospholipid compound and a preparation method thereof. The compound expressed as the following formula in the specification and salts of pharmaceutically acceptable acids formed by the compounds are obtained through a chemical synthesis method, wherein R1 represents either -H or -CH3, R2 represents (ClCH2CH2)2NR3, R3 represents one or more of alkylene, aryl, aromatic alkylene and the like, and R1 and R2 can be identical or different; and the acids include inorganic acids such as hydrochloric acid, sulfuric acid, hydrobromic acid, phosphoric acid, carbonic acid and the like, as well as organic acids such as formic acid, acetic acid, citric acid, lactic acid, fumaric acid, tartaric acid, gluconic acid and the like. The compounds can be used as a liquid preparation, a solid preparation, a semisolid preparation, a sterilizing preparation and a sterile preparation.

The invention provides prepared pseudo-ginseng, as well as a preparation method and application thereof. Based on weight percentage, the total amount of notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1 in the prepared pseudo-ginseng is not less than 5.0 percent, wherein the content of notoginsenoside R1 is not less than 0.4 percent, the content of ginsenoside Rg1 is not less than 2.0 percent and the content of ginsenoside Rb1 is not less than 1.5 percent; the total amount of ginsenoside Rh4, ginsenoside 20(S)-Rg3 and ginsenoside 20(R)-Rg3 is not less than 0.5 percent, wherein the content of ginsenoside Rh4 is not less than 0.3 percent, the content of ginsenoside 20(S)-Rg3 is not less than 0.06 percent, and the content of ginsenoside 20(R)-Rg3 is not less than 0.03 percent.

The invention relates to a compound metagen solid beverage and a preparation method thereof. The solid beverage is prepared from the following components in percentage by mass: 15-20% of sulforaphane, 20-25% of sodium butyrate, 25-30% of metagen solid powder, 18-22% of an adhesive, 4.5-6.0% of a sweetening agent and 3.5-6.0% of a sour agent, wherein the metagen solid powder comprises lactobacillus paracasei G15 and Q14 powder, lactobacillus rhamnosus powder and bifidobacterium powder; and the four kinds of lactobacillus powder are obtained by drying supernatants of respective bacilli. The metagen solid beverage is especially suitable for crowds with special requirements, such as crowds with hyperlipidemia, crowds with fatty liver and crowds with weight loss.

The invention relates to gene engineering and virology, in particular to a proliferous type recombination oncolytic adenovirus containing 11-type adenovirus cilia protein gene of a human B subset, a construction method and application thereof. The oncolytic adenovirus can be 11 type adenovirus or heterozygous adenovirus constructed by utilizing the coding sequence of 11-type adenovirus cilia protein to replace the coding sequence of non-11 type adenovirus cilia protein. The adenovirus has selective multiplication capacity by carrying out effective control or mutation on genes essential to proliferation. As a conditional proliferous type combination virus with wider spectrum of infection and improved infectious ability, the recombination oncolytic adenovirus of the invention can be used for gene treatment, in particular to tumor gene treatment.

The invention discloses an active ingredient which is extracted from the leaves or fruits of oil oranges and has antitumor and antibacterial effects. After the leaves or fruits of the oil oranges are treated with percolation extraction respectively by using ethanol of 95 percent and ethanol of 50 percent, extract of ethanol of 50 percent is treated with part separation respectively by using sherwood oil, chloroform and ethyl acetate, the ethyl acetate part is treated with separation and purification by using the silicagel column chromatography, thus obtaining the pure crystalline compounds, crystal I and crystal II. Different traditional Chinese medicine preparations prepared by using the compound have better anti-liver cancer, anti-cervical carcinoma, anti-stomach cancer, anti-melanoma and anti-leukemia effects.

The invention relates to a probiotics cereal yogurt and a preparation method thereof. The yogurt is composed of the following components by weight: 600-800 parts of cow's milk, 60.0-240.0 parts of tremella pulp, 20.0-80.0 parts of barley puffed powder, 5.0-20.0 parts of honey, 3.0-8.0 parts of whey protein powder and 0.2-0.8 part of composite bacteria. The preparation method of the yogurt is as follows: pretreating the cow's milk, inoculating lactobacillus, fermenting, mixing the barley puffed slurry with tremella slurry, inoculating probiotics, fermenting, adding the mixture to the fermented milk, mixing well and fermenting again; or mixing the pretreated main ingredients and accessories, inoculating lactobacillus and probiotics, and conducting mixed fermentation. The prepared probiotics cereal yogurt has unique flavor, smooth delicate taste, contains dietary fiber, tremella polysaccharide and microelement selenium, and has the health effects of relieving constipation and preventing and resisting cancer.

The invention discloses a Hericium erinaceus sulfate proteoglycan, its preparation method thereof and pharmaceutical compositions with the same as active component, whose molecular weight is 1.6í½2.6í

The invention especially relates to identified alkaloid compounds with novel skeletons extracted and separated from purslane and an extraction and separation method thereof, belonging to the field of extraction and separation of traditional Chinese medicines. The alkaloid compounds with novel skeletons have molecular formulas of C18H26N2O, C18H24N2O2 and C18H28N2O2, respectively, and are named as oleracimine, oleracimine A and oleracone A, respectively. The invention also provides an extraction and separation method for the novel components. The extraction and separation method successively carries out extraction through water decoction, ethyl acetate extraction and column chromatography on silica gel, an ODS medium-pressure column and Sephadex LH-20 so as to successfully extract and separate the novel alkaloid compounds with unique skeletons. The novel alkaloid compounds have anti-inflammatory, pain-easing and antineoplastic effect. The compounds and salts or derivatives thereof can be used as lead compounds for synthesis of other compounds and as raw materials for development of novel drugs and research on pharmacological activity, and are applicable to preparation of anti-inflammatory, pain-easing and antineoplastic drugs or health products.

The invention discloses an application of functionalized nano-selenium in tumor angiogenesis inhibiting and antitumor drugs. The inventor finds that the functionalized nano-selenium not only has an antitumor effect, but also has a tumor angiogenesis inhibiting effect, so that the functionalized nano-selenium can be used as an active component to be applied in tumor angiogenesis inhibiting and antitumor drugs. The functionalized nano-selenium prepared in the invention, such as heteropoly acid-transferrin modified nano-selenium or gallic acid-transferrin modified nano-selenium, is prepared by directly coupling excessive heteropoly acid or gallic acid with elemental nano-selenium, the preparation process dispenses with addition of other auxiliary reagents, the product system is simple, and the product can be directly preserved and used. The modifier adopted in the invention improves the targeting property and the transport and transmembrane absorption in cells of the functionalized nano-selenium, and can increase the drug intake of cells and reduce drug efflux, thereby guaranteeing that the drug in the cells is maintained at a higher level.

The rabdosia extract is a kind of Chinese medicine for treating upper respiratory tract inflammation and cancer. The rabdosia extract includes coarse extract, effective part and single components. During the extraction, the cleaned rabdosia is refluxed in 8-18 times ethanol for 20 hr, filtered and depression concentrated to produce dense extractum; the dense extractum is depression dried, crushed and 100-mesh sieved to obtain the coarse extract; the dense extractum is dissolved in methanol, active carbon decolored, concentrated, dissolved in acetone, filtered and concentrated to obtain diterpene compound; the dense extractum is methanol dissolved, active carbon decolored, concentrated, dissolved in acetone, filtered, concentrated and alumina column eluted to obtain rabdosia extract A and rabdosia extract B.

The invention discloses a black tea fungus beverage. The black tea fungus beverage is prepared from water, fermented black tea juice, black tea powder, concentrated lemon juice, vitamins C, white granulated sugar, high fructose corn syrup, sodium benzoate, sodium citrate, citric acid monohydrate, malic acid, acesulfame k, sucralose and essence. The black tea fungus beverage is characterized in that the fermented black tea juice is prepared in the mode that Assam tea is brewed, anaerobic fermentation is carried out through mixed strains of lactobacillus plantarum LP28, lactobacillus plantarum LP198, streptococcus thermophilus GRX02 and lactobacillus lactis LLD965, and then inactivation is carried out. Compared with the prior art, the black tea fungus beverage contains the inactivated lactobacillus plantarum LP28, the inactivated lactobacillus plantarum LP198 and the inactivated lactobacillus lactis LLD965, immune responses can be adjusted through the inactivated probiotics, and the anti-tumor function and the function of treating ethyl-alcohol-induced acute liver injuries are achieved.

The invention relates to an ursolic acid derivative chemically modified by polyethylene glycol and a preparation method of the ursolic acid derivative. In the method, a novel ursolic acid derivative with anticancer activity is developed by modifying 28 bits of carboxyl of ursolic acid with butanedioic anhydride, ethylene diamine and polyethylene glycol. As proved by a pharmacological test, the ursolic acid derivative has remarkable in-vitro suppressing capabilities on human liver cancer HepG2 cells, human stomach cancer AGS cells, human stomach cancer BGC-823 cells and human prostatic csarcinoma PC-3 cells.

The present invention relates to a preparation method of polyporus polysaccharide sulfate. Said method includes the following steps: (1). preparing esterification reagent; (2). selecting and using polyporus polysaccharide powder and anhydrous methanamide or dimethyl methanamide according to mass ratio of 0.4-2.0:36-48, making the polyporus polysaccharide powder be suspended in anhydrous methanamide or dimethyl methanamide to obtain polyporus polysaccharide suspension; (3). making esterification reaction; (4). precipitation; (5). purifications and (6). secondary precipitation. Besides, said invention also provides the concrete requirement of every step.

The invention provides a medicated diet for conditioning the constitution of qi stagnation and a preparation method thereof. The medicated diet comprises Chinese jujube, radix astragali preparata, ginseng, atractylodes macrocephala, rhizoma atractylodis, poria cocos, roasted malt, radix bupleuri, cassia twig, rhizoma cyperi, radix curcumae, fingered citron, fructus citri, mint, cortex albiziae, rose, radix glycyrrhizae preparata, salvia miltiorrhiza, radix paeoniae alba, Chinese angelica, ligusticum wallichii, lily, platycodon grandiflorum, radix aucklandiae, fructus aurantii immaturus, fructus amomi, rhizoma corydalis, the fruit of Chinese wolfberry, eucommia ulmoides, raspberry, fried coix seeds, radix achyranthis bidentatae, cape jasmine, fermented soybean, caulis bambusae in taeniam, herba lycopi, fresh ginger, cumin, fructus cannabis, brown granulated sugar and starch syrup. The product adopts the natural food materials, edible and medicinal substances, and substances capable of being used as heal food as the main raw materials, has the effects of invigorating spleen-stomach, replenishing qi, soothing liver-qi stagnation, regulating qi, strengthening spleen, replenishing blood, nourishing heart, tonifying lung, liver and kidney, clearing heat, removing toxicity and the like, and has good effect on conditioning of the constitution of qi stagnation and improvement of the immune adjustment.

The invention discloses the use of cactus pear fruit polysaccharides extracted from cactus pear fruit in the preparation of medicaments or health-care products for reducing blood pressure, blood fat, blood sugar and resisting tumors. The cactus pear fruit polysaccharides can control the occurrence and development of hypertension, have an active significance for preventing the occurrence and development of hyperlipidemia and fatty degeneration of liver, have potential applications in the prevention and treatment of diabetes and complications and have certain antitumor effect. Therefore, the invention lays a foundation for the development of medicaments or health-care products for preventing and treating hypertension, hyperlipaemia and diabetes and resisting tumors, and promotes the full use of the cactus pear fruit polysaccharides effectively. The cactus pear fruit is a natural plant resource with remarkable medicinal and health-care effects as well as regulation and protection effects on human organs and systems. The price of the cactus pear fruit is relatively low, and the side effects of the cactus pear fruit are relatively fewer. Thus, the cactus pear fruit polysaccharides have good application prospect in the preparation of the medicaments or health-care products for reducing blood pressure, blood fat, blood sugar and resisting tumors.

The invention provides the new application of salvianolic acid B, in particular the application of the salvianolic acid B to the preparation of medicament for treating tumor. The studies on the salvianolic acid B in vitro show that the salvianolic acid B can kill tumour cells, and the studies on the salvianolic acid B in the animal body proves that the salvianolic acid B can resist tumor. The cations in salvianolic acid B salt can be iron ions, calcium ions, sodium ions, potassium ions and preferentially magnesium ions. The medicament for treating tumor can be made into any form of liquid, injection, tablet or capsule in pharmaceutics.

The invention discloses a wooden fish stone hygienic wine and preparing craft, which comprises the following steps: allocating 10-20 wt wooden fish stone and 500-600 wt white wine; getting the product. This invention can replace white wine.

The invention relates to the technical field of tobaccos and in particular relates to a traditional Chinese medicine extract, a preparation method and use of the extract, and cut tobaccos and cigarettes prepared from the extract. The traditional Chinese medicine extract is prepared from agilawood, platycodon grandiflorum and liquorice. According to the invention, the traditional Chinese medicine extract and the cut tobaccos are mixed to obtain the cigarettes; and during a smoking process, the extract is volatilized to smoke at a high temperature and then is sucked by a smoker, so that a health-care purpose is achieved. The cigarettes are pleasant in smell, the stimulation of the cigarettes to the throat of the smoker can be relieved, the bad breath of the smoker can be eliminated, and the cigarettes have the effects of diminishing inflammation, moistening lung and preventing tumors.