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Phyllanthus emblica leaf or fruit anticancer Chinese medicine and preparation method and use thereof

A technology of cotyledon leaves and fruits, applied in antitumor drugs, pharmaceutical formulations, drug combinations, etc., can solve the problems of separation and identification of chemical structures of flavonoids, flavonoids are not very clear, etc., and achieves reduction of component damage and simple equipment. , the effect of safe operation

Inactive Publication Date: 2009-03-25
广西中医学院
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AI Technical Summary

Problems solved by technology

However, before 2005, this patent only extracted Amla emblica, and the obtained extracts were flavonoids. The flavonoids were directly tested for their anti-tumor effects, and the active ingredients of these flavonoids were not separated and the specific chemical However, the mechanism of anti-tumor action of the extracted flavonoids is still not very clear

Method used

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  • Phyllanthus emblica leaf or fruit anticancer Chinese medicine and preparation method and use thereof
  • Phyllanthus emblica leaf or fruit anticancer Chinese medicine and preparation method and use thereof
  • Phyllanthus emblica leaf or fruit anticancer Chinese medicine and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, 50kg of cotyledon emblica or fruit is crushed into leaves of 50 mesh size with a pulverizer, soaked in 95% ethanol for 48h, and extracted by percolation with fresh 95% ethanol after 48h, collecting 10 times the amount of percolation liquid; Then use 50% ethanol to soak for 48 hours. After 48 hours, use fresh 50% ethanol to percolate, collect 10 times the amount of percolation liquid, and recover the ethanol in the percolation liquid to obtain 5785 g of 50% ethanol extract.

[0047] Mix well with 6000g of silica gel (100-200 mesh), then reflux and extract with petroleum ether, chloroform, and ethyl acetate in sequence, recover the solvent, and concentrate to obtain a dry paste of ethyl acetate (228.4g).

[0048] Chemical composition pre-test

[0049] In order to clarify the types of dry paste components of the ethyl acetate fraction and to propose a reasonable extraction and separation process, a small amount of ethyl acetate fraction was taken for a pre-te...

Embodiment 1

[0062]Take 10 grams of the ethyl acetate part compound extracted from the cotyledon emblica or fruit obtained by the above extraction method, add appropriate amount of water to dissolve, add 60 grams of sucrose powder, dissolve, sterilize, and subpackage to obtain 100 ml of oral liquid. Every 100ml of oral liquid is equivalent to 100g of emblica.

Embodiment 2

[0064] Take 10 grams of the ethyl acetate part compound extracted from the cotyledon emblica or fruit obtained by the above extraction method, add pure water to dissolve, filter through micropores, divide into freeze-dried bottles, freeze-dry, and use for injection. Each bottle is equivalent to 10g emblica raw medicinal material.

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Abstract

The invention discloses an active ingredient which is extracted from the leaves or fruits of oil oranges and has antitumor and antibacterial effects. After the leaves or fruits of the oil oranges are treated with percolation extraction respectively by using ethanol of 95 percent and ethanol of 50 percent, extract of ethanol of 50 percent is treated with part separation respectively by using sherwood oil, chloroform and ethyl acetate, the ethyl acetate part is treated with separation and purification by using the silicagel column chromatography, thus obtaining the pure crystalline compounds, crystal I and crystal II. Different traditional Chinese medicine preparations prepared by using the compound have better anti-liver cancer, anti-cervical carcinoma, anti-stomach cancer, anti-melanoma and anti-leukemia effects.

Description

technical field [0001] The invention relates to an anti-tumor (anti-cancer) traditional Chinese medicine, in particular to a method for preparing the anti-tumor (anti-cancer) drug from compounds extracted from Emlical emblica. technical background [0002] Phyllanthus emblica L. is a small deciduous tree or shrub of the genus Phyllanthus in the Euphorbiaceae family. In my country, Phyllanthus emblica L. is mainly distributed in Fujian, Guangdong, Yunnan, Guizhou, Sichuan, Hainan, and Guangxi. Such provinces and regions are rich in resources. Since ancient times, the fruit of emblica fruit has been regarded as having a health care effect by the people of our country and has been used. The fruit is sweet and sour and crisp when eaten raw. At present, there are about 17 countries in the world that use emblica in the traditional medicine system; in my country, about 16 ethnic groups use this medicine, among which Han and Tibetan are especially used. Some provinces and cities in C...

Claims

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Application Information

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IPC IPC(8): C07C69/94C07C67/48C07C65/03C07C51/42A61K31/192A61K31/216A61K36/47A61P35/00
Inventor 钟振国李学坚董明姣
Owner 广西中医学院
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