The invention relates to an eye protection plaster which is composed of a supporting layer, a gel layer and an isolating layer. The preparation technique comprises the following steps: evenly mixing and dispersing 4-8.5% of polyacrylic acid polymer, 0-1.5% of CMC (carboxymethyl cellulose), 0.03-0.3% of crosslinking agent, 0.02-0.3% of crosslinking regulator, 0-1% of bacteriostat and 0-5% of filler in 5-30% of humectant to obtain a solution A; evenly dispersing 0.1-0.4% of tartaric acid and 0.01-0.08% of polyvinylpyrrolidone in a proper amount of deionized water, spreading 0.4-3% of carbomer on the liquid surface, standing to swell for 12-24 hours, adding 0.1-1% of polyvinyl alcohol into a proper amount of water, dissolving by heating, and evenly mixing with the previous solution to obtain a solution B; and dispersing the solution A in the solution B to form a gel substrate, regulating the pH value to 6.5-8.0, adding deionized water to 100%, evenly mixing, coating, cutting, hardening and packaging to obtain the finished product. The eye protection plaster is used for protecting eyes of general anesthesia patients and patients in deep coma.