Liquid bandage

Abstract

The invention discloses a liquid bandage and belongs to the technical field of medical treatment. The liquid bandage is characterized by comprising the following components in parts by weight: 0.1-0.5 part of chitosan, 0.1-0.3 part of vitamin C, 2-5 part of chitosan oligosaccharide, 0.1-0.3 part of levulose, 0.02-0.2 part of anthocyanin, 2.5-12.5 parts of purified water. The liquid bandage is simple, convenient, free of wound site limitation and easy to store, and meanwhile, has the effect of resisting bacterium, a bump scar caused by wound tissue abnormal proliferation, and purple pigmentation caused by removing of wound tissue infection.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a liquid wound dressing and a preparation method thereof. Background technique [0002] Chitosan, also known as deacetylated chitin, is obtained through deacetylation of chitin that exists widely in nature, and its chemical name is polyglucosamine (1-4)-2-amino-B-D glucose. This natural polymer has excellent properties such as biofunctionality, compatibility, blood compatibility, safety, and microbial degradation. Chitosan can be cross-linked and film-formed after being dissolved in an acidic solution, but it dissolves slowly in an acidic aqueous solution, requires stirring for defoaming, and is easily degraded, which limits its application. Chitosan oligosaccharide, also known as chitosan oligosaccharide and oligochitosan, is a kind of polysaccharide obtained by degrading chitosan by special biological enzyme technology (there are also reports of chemical degradati...

AI Technical Summary

Problems solved by technology

Although chitosan has a strong effect, it degrades quickly after being dissolved in water, and it is easy to deteriorate and change color, so it is not easy to store and other problems, which seriously limit its application.

[0003] At the same time, most of the wound plasters in the existing stage are adhesive plaster wound plasters. Adhesive plaster wound plasters are not tight on the wound, have no effect on concave wounds, and have poor air permeability. Moreover, the effective treatment of wounds with adhesive plasters is superficial and limited in scope. Limited by the shape and area of ​​the wound, the wound healing speed is slow. This wound does not work at all. For wounds that hurt the dermis, adhesive plasters are less effective in inhibiting scars. With the appearance of human body movements near the wound, the gap between the adhesive tape and the wound will be weak or not tight

Although the current liquid wound dressings have antibacterial effects, they are not strong enough to inhibit scars and film-forming or have poor film-forming properties. As a result, the wound needs to be smeared with drugs multiple times to achieve the effect. During the interval between smearing, the wound is re-infected with antigens, resulting in abnormal hyperplasia of scars. Or re-infection, which leads to a weak degree of scar suppression, and the mechanical properties of the wound are not enough, resulting in the wound being exposed to the air

[0004] Existing liquid wound plasters are not viscous enough. For wounds that are scratched and cut, they cannot play the role of skin-to-skin adhesion and cause the wound to crack. Although there is film covering, the toughness and viscosity are not enough. And the toughness is not enough, it is easy to be scratched off by clothes or other parts of the wound, resulting in a decline in the effect and slow healing speed, which will leave opportunities for abnormal proliferation of wound tissue

Secondly, there are few main components that inhibit the abnormal proliferation of wound tissue in the existing liquid bandages, which is also the reason for the abnormal proliferation of wound tissue.

Although the latest technology has antibacterial film-forming sprays of chitosan or traditional Chinese medicine liquid bandages with active ingredients of chitosan, it is not enough to rely solely on the film-forming effect of chitosan. After film formation, the mechanical properties are not strong and the viscosity is not enough.

Chitosan gel has little effect on the treatment of purple scars (it may take a long time if the purple pigment subsides naturally, or even never subsides), and chitosan gel is applied to a large area of ​​wounds, which can easily lead to film formation and peeling , the toughness is not enough, the adhesive bandage will stick to the wound, and there will be pain when it is removed

And it is inconvenient to use, and it is easy to be limited by the position, size and shape of the wound

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