The invention relates to a
cefazolin sodium pentahydrate compound of a new
route, and particularly provides a method for synthesizing the
cefazolin sodium pentahydrate compound. The method comprises the following steps: synthesizing tetrazolyl
acetic acid 2-mercapto-5-methyl-1,3,4-thiadiazole ester by using tetrazolyl
acetic acid and 2-mercapto-5-methyl-1,3,4-thiadiazole as raw materials; and generating
cefazolin sodium through the reaction between the tetrazolyl
acetic acid 2-mercapto-5-methyl-1,3,4-thiadiazole ester and 7-aminocephalosporanic acid. Compared with that the method for synthesizing
tetrazole acetic acid 2-mercapto-1,3,4-thiadiazole ester in the prior art uses expensive reagents such as
trifluoroacetic anhydride,
aluminium trimethide or DCC and the like as a condensation agent, the method improves the synthesis method, not only simplifies the operation steps, but also, surprisingly, greatly improves the product yield and the purity, reduces the cost, and lays a foundation for industrialization.