116 results about "Aniline hydrochloride" patented technology

The invention relates to a method for synthesis of 2,2,4-trimethyl-1,2-dihydroquinoline and a polymer thereof by high-throughput microchannel reactors. A mixture of acetone and aniline hydrochloride is used as a starting reaction raw material and is injected into a microchannel reactor system for reaction, wherein the microchannel reactor system is composed of 1-10 pieces of microchannel reactors which are connected together in series and can be used for continuous flowing, the single-piece reactors are connected together in series by microchannels having the shape similar to a heart shape, and the liquid holdup amount is 8-10 ml; and a continuous flowing reaction is carried out. Through a heat carrier circulation system, the reaction temperature is set to 90-120 DEG C, the pressure is set to 0-10 bar, and the reaction standing time is set to 20-200 s; the obtained solution is cooled by a condenser and is collected, unreacted acetone is removed by distillation, and the target product is obtained. The preparation method provided by the invention has the advantages of continuous reaction performing, short required reaction time, no amplification effect, and strong versatility, does not require to remove generated water during the reaction process, and can be applied to various liquid-liquid, gas-liquid and other chemical reactions.

In particular, rizatriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of aniline hydrochloride (II); followed by reduction and acidification to give the hydrazine (III); b) reaction in situ of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole reaction of the hydrazone (IV), to give the pyranoindolone (V), optionally followed by a hydrolysis reaction to give (VI); d) Transesterification of (V) or esterification of its hydrolysis product (VI), to give (VII), where R means straight or branched C1-C4 alkyl chain; e) Conversion of the hydroxyl group of (VII) into dimethylamino, to give the indolecarboxylate (VIII), where R has the meaning defined above; f) Saponification of the 2-carboalkoxy group of (VIII) to give indolecarboxylic acid (IX); and g) Decarboxylaton of the indolecarboxylic acid (IX) to give rizatriptan and, eventually, to obtain a pharmaceutically acceptable salt thereof. The invention also relates to synthesis intermediates to obtain rizatriptan.