231 results about "Anesthetic Effect" patented technology

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

An implantable medical device such as a catheter with a controlled-release outer layer including a pharmacologically active ingredient for helping to relieve pain associated with the implantation of the device. The device includes a base material with an outer bioactive material layer including, for example, an analgesic or a local anesthetic.

The invention discloses a quaternary ammonium salt compound and a preparation method and application thereof. The invention provides a compound shown in a formula I with a novel structure, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof. The compound has the advantages of rapid onset of action, long-termlocal anesthesia effect after single administration, sensory nerve block time greater than motor nerve block time, and both long-term local anesthesia effect and selective local anesthesia effect, remarkably reduces side effects of QX314 and QX314 compositions and quaternary ammonium salt compounds with surfactant structural characteristics, and has better safety. Namely, the compound of formula Iand the pharmaceutically acceptable salt thereof can be used for preparing safe drugs with long-term local anesthesia and selective local anesthesia effects, and have the advantages of long-term local anesthesia, good local anesthesia selectivity, less nerve damage and high safety.

The invention relates to a preparation method of ropivacaine mesylate injection packed by a soda-lime glass bottle, which comprises the following processing steps of ingredient preparation, liquor preparation, soda-lime glass bottle and rubber plug cleaning, filling, capping, sterilization, lamp test, labeling, packing and finished product inspection. The injection is subject to a filtration sterilization processing step once and a flowing steam sterilization processing step once, wherein microorganisms larger than 0.22 microns in liquid medicine are removed by a filter method, microorganismssmaller than 0.22 microns are killed by flowing steam sterilization, and insoluble particles in the liquid medicine are removed during filtration sterilization simultaneously, thereby greatly reducingthe occurrence of phlebitis; and the invention is packed by the soda-lime glass bottle which has the advantages of heat resistance, acid and alkali resistance, large strength, and the like, thereby ensuring the stability of the medicine. Clinic comparison tests show that the ropivacaine mesylate injection packed by a soda-lime glass bottle has the advantages of quicker effect, long action time, reliable anesthetic effect, small toxicity to heart, separate blocking pf sensory and motor nerves, and the like, thereby being suitable for anesthesia in surgeries and postoperative analgesia.

The invention discloses an N-substituted imidazole carboxylic ester compound with an ultrashort-acting anesthetic effect. The structure is shown in formula (I), wherein R is shown in the specification, or -(CH2)nOR'; n is an integer from 1 to 3; R' is selected from C1-4 alkyl and acyl; R' is not methyl when n is 2. The compound can generate a quick and reversible general anesthesia effect. An animal experiment shows that the compound and a pharmaceutically acceptable salt compound thereof have the characteristics that the effects are shorter than the etomidate anesthetic effect, can be prompted to carry put quick metabolism inside a body, can be used as ultrashort-acting general anesthesia drugs, and have significant advantages and good application prospects; shortening of the inhibition time on cortical hormone is also facilitated; the compound can be obtained from an N-substituted imidazole carboxylic acid compound, and corresponding alcohol and haloalcohol or ester, halide and the like thereof by condensation or substitution reaction.

The invention relates to an N-substituted imidazolecarboxylic acid ester chiral compound containing an ether side chain, a preparation method and an application thereof. The structure of the compound is shown in the formula (I). The compound can produce rapid and reversible general anesthesia effect. Animal experiments show rapid and short-acting pharmacological characteristics of the compound, so that the compound can be used as a rapid and short-acting general anesthesia medicine, meanwhile, compared with etomidate, the compound can reduce the inhibition effect on synthesis of adrenal cortical hormone, recovery is rapid and thorough, and the compound has obvious advantages and good application prospect. The only chiral carbon in the structure of the compound must be of R type. An imidazole ring in the structure of the compound has acidifiable N atoms, so that the compound and medicinal salt molecules thereof can be applied to the preparation of central inhibitory medicines which can produce sedative and hypnotic and / or anesthetic effects on animals or persons through veins or paths outside veins.

The invention discloses a herbal anesthetic which is prepared from the following raw materials in parts by weight: 13-15 parts of venenum bufonis, 8-13 parts of raw szechuan aconite, 7-13 parts of raw wild aconite, 20-25 parts of pepper, 16-20 parts of asarum, 15-18 parts of radix zanthoxyli, 7-10 parts of borneol, 20-30 parts of murraya jasminorage, 4-6 parts of houttuynia, 2-4 parts of gallnut, 6-8 parts of Chinese mugwort leaf, 4-6 parts of bistorta, 4-6 parts of dandelion, 4-6 parts of brucea javanica, 100-130 parts of notoginseng and 600-700 parts of alcohol the concentration of which is 75%. The herbal anesthetic disclosed by the invention is convenient to use and simple to operate, has the advantages of good anesthetic effect, no side effects, safety, reliability and the like, eliminates the pain of patients in the processes of extracting and treating teeth, eliminates the fear of patients, is popular among patients, especially enables the deciduous teeth of children to be replaced painlessly, conveniently and quickly, lowers the allergic probability, reduces the postoperative hemorrhage, and prevents the infection.

The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.

The invention relates to a local anesthetic which belongs to the field of a biological medicine. The local anesthetic is prepared from the following raw materials: borneol, flos lonicerae, radix paeoniae rubra, caulis spatholobi, gelatin, angelica sinensis, microcrystalline cellulose, fructus gardeniae, mountain dew and herba schizonepetae. The product provided by the invention is not added with any preservative, which belongs to the natural medicine product, and the traditional Chinese medicine components are free from any side effect, stimulation and hurt, and the anesthetic effect is ideal, so that the local anesthetic can be widely applied to family life and medical use, etc.

The invention discloses a digital anesthesia control system which is characterized by comprising a sensor, a host computer, a control software unit and an electronic infusion micro-pump, wherein the host computer comprises a medicine digital module, the control software unit comprises an input end and an output end, the input end of the control software unit is connected with the sensor and the medicine digital module, and the output end of the control software unit is electrically connected with the electronic infusion micro-pump. The digital anesthesia control system can realize accurate medical treatment to ensure that an anesthetic can be used more accurately, a small amount of the anesthetic can achieve an effective anesthetic effect, the anesthesia quality and the operation safety are improved, and postoperative complications caused by anesthetic overdose are also avoided.

The invention discloses medical lubricant. The medial lubricant comprises the following components in percentage by weight: 0.02%-0.8% of organic silicon antifoaming agent, 0.2%-3% of dyclocaine hydrochloride, 0.1%-25% of glycerol, 0.1%-10% of xanthan gum and the balance of water. The medical lubricant can be used for realizing good lubricity, a good antifoaming effect and good water solubility; and moreover, the medical lubricant has the effects of a quick surface anesthetic effect and the like.

The invention discloses traditional Chinese medicine with an anesthetic effect. The traditional Chinese medicine anesthetic comprises the following traditional Chinese medicine components by weight ratio: 3-20 parts of datura flower, 4-18 parts of mentha haplocalyx, 1-3 parts of secretio bufonis, 1-5 parts of pepper, 2-15 parts of asarum sieboldi, 3-15 parts of radix aconite, 5-20 parts of ligusticum wallichii, 2-10 parts of Chinese angelica, 2-20 parts of fried arisaema consanguineum schott and 5-30 parts of pericarpium papaveris. According to the invention, although the components are common traditional Chinese medicines, small toxic and side effects and high safety are achieved due to the adoption of special proportion.

The present invention relates to the use of a low frequency ultrasonic device for the delivery and activation of collagen based foam sealants to a human and / or animal patient for sealing puncture wounds in vascular tissues. The ultrasonic vascular closure device comprises an ultrasonic generator, an ultrasound transducer, a chamber containing a foam sealant, a transducer tip, a radiation surface, an orifice located at the distal end of the chamber. The foam sealant is ejected into a puncture wound and activated with ultrasonic waves emitting from the radiation surface. The ultrasonic waves induce vibrations within the foam sealant, slightly warming the foam sealants to assist the rapid sealing the puncture. The ultrasonic waves also provide and anesthetic effect for the pain and discomfort from the puncture site.

A composition for local anesthesia which comprises a local anesthetic such as lidocaine hydrochloride as an active ingredient and an agent for sustaining anesthetic action selected from the group consisting of antihistamines such as diphenhydramine hydrochloride or hydroxyzine hydrochloride, and does not substantially contain catecholamines such as epinephrine, which has increased durability of anesthetic action without using catecholamines, and is useful as a safe composition for local anesthesia for performing short-time dental operations such as tooth extraction or oral surgery operations.

The invention discloses an electronic pain sense measuring pen, which belongs to the field of medical instruments. The electronic pain sense measuring pen is characterized by being manufactured according to a principle that electric stimulation pain is generated when a high-voltage low-current electron impulse acts on human skin. The electron impulse is generated by adopting a piezoelectric effect principle of ceramic crystals. The electronic pain sense measuring pen consists of a pen head, a shell, a trigger switch, a piezoelectricity generator and a conducting wire. The electronic pain sense measuring pen has the advantage of measuring the level of anesthesia to determine the anesthetic effect and guide the anesthesia dosage when applied to intravertebral anesthesia and nerve blocking anesthesia. The electronic pain sense measuring pen avoids inaccurate feeling of pain stimulation of a patient because of the non-constant needling force in a needle punching method, ensures that the measurement result is more accurate, and cannot burn skin and do harm to a body at the same time of safe electric stimulation, thereby eliminating pains of patients, and reducing the probability of infection and blood-source spread diseases.

The invention relates to a tracheal tube with an anesthetic spraying structure, and belongs to the technical field of medical instruments.According to the technical scheme, the tracheal tube with the anesthetic spraying structure comprises a tube body, a transparent observation tube is arranged on the lower side of the tube body and connected with the tube body through a fixed seal connector, the upper side of the transparent observation tube is provided with a telescoping regulating tube, the front side of the telescoping regulating tube is provided with telescoping scale marks, the middle of the telescoping regulating tube is provided with a telescoping locking device, and the upper side of the telescoping regulating tube is provided with a folding tube.The tracheal tube is simple in structure and convenient to use and can conveniently and rapidly anesthetize the throat again to enable the throat to keep a long-term anesthetic effect and prevent the phenomenon that tube-intolerant symptoms such as an irritating cough appear on a patient.

The invention discloses a compound as shown in the formula I, or a stereisomer, or pharmaceutically acceptable salt, or a solvate, or a prodrug, or a metabolite, or a deuterated derivative thereof. The compound is an N-substituted imidazole formate derivative with a novel structure and belongs to the field of medicinal chemistry. The invention also discloses application of the N-substituted imidazole formate derivative in the preparation of medicines with sedative, hypnotic and / or anesthetic effects, and application in the preparation of medicines capable of controlling the status epilepticus.The compound has a good inhibitory effect on the central nervous system, and provides a new selection for clinical screening and / or preparation of medicines with the sedative, hypnotic and / or anesthetic effects and capable of controlling the status epilepticus.

The invention discloses a traditional Chinese medicine preparation dedicated to anesthesia before operation and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation disclosed by the invention is prepared from the following raw materials: cajeput, honeycomb, Japanese saussurea herb, dentiferous dendropanax root and stem, poria cocos, folium artemisiae argyi, common achyranthes herb, sedum aizoon, leaf of japanese banana, xanthium sibiricum, tuber fleeceflower stem, vicia faba, canton salomonia herb, radix angelicae pubescentis, ginkgo seed and ovate neolepisorus herb. According to the traditional Chinese medicine preparation, high-grade traditional Chinese medicinal materials are selected so as to be combined, so that the traditional Chinese medicine preparation accords with the theories of the traditional Chinese medicine and pharmacy and the modern medicine and pharmacology, is applicable to local anesthesia and general anesthesia, has an antishock effect, is convenient to use, safe and reliable, has a significant anesthetic effect in clinical practice, can be applied to anesthetization of various clinical operations, and is worthy of extensive popularization and application in clinic.

The invention discloses a headrest suspended anaesthesia device suitable for anesthesiology departments and relates to the field of medical instruments. Aiming at problems that because of inconvenience of handheld operation, a great deal of time is wasted in operation of medical operators, the working efficiency is degraded, a patient is prone to topple in the head administration process, and thelike, the invention discloses the scheme that the headrest suspended anaesthesia device comprises a frame, wherein chutes are formed in both sides of the frame along the height direction of the frame;a push rod motor is fixedly mounted on the inner wall of the top of the frame; a connecting plate is fixedly connected with the output shaft of the push rod motor; sliding blocks are fixedly connected with both ends of the connecting plate; a medicine storage box is fixedly arranged below the connecting plate; and a quantitative hose is connected with one side of the medicine storage box. The headrest suspended anaesthesia device is simple in structure and novel in modeling, the problem that the workload of the medical operators is increased as a conventional device needs to be held by hand to operate is solved, meanwhile, the head of the patient can be fixed, the anesthetic effect can be improved, convenience can be brought to doctors to carry out operation, and popularization can be achieved.

To safely and practically simply anesthetize fish over a long period of time in an underwater environment which contains a high concentration of carbon dioxide having an anesthetic effect. By contacting gaseous oxygen-containing microbubbles with the branchial epithelial cell membrane surface of fish, a difference between partial pressures [(partial pressure of gaseous oxygen) - (partial pressure of oxygen dissolved in branchial capillary vessels)], which is larger than a difference between partial pressures [(partial pressure of oxygen dissolved in water) - (partial pressure of oxygen dissolved in branchial capillary vessels)], is created so that the amount of oxygen taken into branchial plate capillary vessels is remarkably increased. Thus, the fish can be anesthetized with carbon dioxide over a long period of time at a water temperature (about 20 DEG C) commonly employed for handling fishes while avoiding respiratory failure that occurs during spontaneous respiratory movements suppressed by the anesthesia.

The invention relates to long chain amine-substituted dimethylanilinium compounds, and a preparation method, a self-assembled structure and a use thereof. The compounds have an ultra-long-acting anesthetic effect and low neuropathological damages, are long chain amine-substituted N-diethylaminoacetyl-2,6-dimethylanilinium compounds, and have a structure represented by formula (I), and salts of thecompounds have a structure represented by formula (II). The compounds are self-assemble in an aqueous solvent to form microscopic particles including spherical micelles, Janus micelles and vesicles,can exert a long-time local anesthetic effect in the living body, allow the local anesthetic and / or analgesic action time to exceed 120 h, have low neuropathological damages, and have a far higher safety than existing disclosed long-acting local anesthetic compounds.

The invention discloses clinical ventilation equipment for general anesthesia. The equipment comprises a box body, a numerical control box, a motor driver and an electronic display screen; the numerical control box is arranged on the wall surface of the outer left side of the box body, the motor driver is arranged in the numerical control box, and the electronic display screen is arranged on the upper wall surface of the numerical control box. The equipment has the advantages that through a gas outlet structure, the flow rate of an oxygen supply tank and an anesthesia steamer can be controlledso that anesthetic gas can be supplied to a patient according to concentration requirements; through a mixing structure, oxygen output from the oxygen supply tank and an anesthetic output from the anesthesia steamer can be fully mixed; through a heating structure, mixed gas can be heated, the situation that since the temperature of steamed gas is too low, the anesthetic effect is poor is avoided,after anesthesia is completed, waste gas generated by the anesthesia is collected and filtered by a waste gas treatment structure, and the cross infection of the patient and medical staff is prevented.

The invention belongs to the technical field of herbal anaesthesia of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with an auxiliary anesthetic effect. The traditional Chinese medicine composition is prepared from the following Chinese medicinal raw materials: 1-3 parts of datura stramonium, 1-3 parts of henbane, 5-10 parts of passion flowers, 3-5 parts of daphne giraldii, 5-8 parts of fourstamen stephania roots, 3-5 parts of radix scutellariae, 3-5 parts of Chinese herbaceous peony, 1-3 parts of olibanum, 1-3 parts of myrrh, 1-3 parts of caulis spatholobi, 1-3 parts of hematoxylon, 1-3 parts of ligusticum wallichii, 3-5 parts of dragon bone, 1-3 parts of nacre, 3-5 parts of oyster, 1-3 parts of platycladi seeds, 1-3 parts of tuber fleeceflower stem and 1-3 parts of liquorice. A decoction is prepared. Due to the efficacies of the traditional Chinese medicines for narcotizing, easing pain, relieving spasm and checking convulsions, combination of the medicinal materials with the effects of relaxing tendons, activating collaterals, and relaxing skeletal muscle, and optimization of the medicine proportion, psychentonia is reduced, and the effect of auxiliary anesthesia analgesia before an operation is achieved.

The invention provides a portable anesthetic needle which includes a needle cylinder, a push rod, a piston, a needle head, a needle body protective sleeve and a push rod protective sleeve. The pistonis arranged in the needle cylinder, the push rod is disposed in the piston, the needle head is arranged at the front end of the needle cylinder, and the needle body protective sleeve is arranged outside the needle cylinder. The push rod protective sleeve is disposed on the left side of the needle body protective sleeve. The push rod protective sleeve comprises a sleeve, a buckle and a connecting plug. The connecting plug is arranged on the lower portion of the right end of the sleeve. The buckle is disposed on the left side of the connecting plug. Through the arrangement of the needle head, the needle body protective sleeve and the push rod protective sleeve, anesthesia liquid can evenly massively enter an anesthesia area, the anesthetic speed is accelerated, the anesthetic effect is improved, the needle inserting depth is precisely adjusted and controlled, the operation is simple, an anesthesiologist's work difficulty is reduced, the anesthetic needle is protected, and the anestheticneedle is convenient to carry while the waste of an anesthetic is avoided.

A method for treating a patient having discogenic pain includes implanting a neurostimulation lead within an anterior portion of the epidural space adjacent to the posterior longitudinal ligament. A plurality of electrodes is attached to the lead and the lead is implanted with at least a portion of the electrodes facing the posterior longitudinal ligament. The lead may be implanted in the lumbar region of the patient's spine, posterior and parallel to the posterior longitudinal ligament. Electrical stimulation energy applied to the patient through the electrode lead implanted in this manner inhibits the pain signals traveling within the posterior longitudinal ligament. Thus, the applied electrical stimulation energy has an anesthetic effect on the pain fibers adjacent to the posterior longitudinal ligament.